SAM-Driven Weakly Supervised Nodule Segmentation with Uncertainty-Aware Cross Teaching

Automated nodule segmentation is essential for computer-assisted diagnosis in ultrasound images. Nevertheless, most existing methods depend on precise pixel-level annotations by medical professionals, a process that is both costly and labor-intensive. Recently, segmentation foundation models like SAM have shown impressive generalizability on natural images, suggesting their potential as pseudo-labelers. However, accurate prompts remain crucial for their success in medical images. In this work, we devise a novel weakly supervised framework that effectively utilizes the segmentation foundation model to generate pseudo-labels from aspect ration annotations for automatic nodule segmentation. Specifically, we develop three types of bounding box prompts based on scalable shape priors, followed by an adaptive pseudo-label selection module to fully exploit the prediction capabilities of the foundation model for nodules. We also present a SAM-driven uncertainty-aware cross-teaching strategy. This approach integrates SAM-based uncertainty estimation and label-space perturbations into cross-teaching to mitigate the impact of pseudo-label inaccuracies on model training. Extensive experiments on two clinically collected ultrasound datasets demonstrate the superior performance of our proposed method.

HiLMa-Res: A General Hierarchical Framework via Residual RL for Combining Quadrupedal Locomotion and Manipulation

This work presents HiLMa-Res, a hierarchical framework leveraging reinforcement learning to tackle manipulation tasks while performing continuous locomotion using quadrupedal robots. Unlike most previous efforts that focus on solving a specific task, HiLMa-Res is designed to be general for various loco-manipulation tasks that require quadrupedal robots to maintain sustained mobility. The novel design of this framework tackles the challenges of integrating continuous locomotion control and manipulation using legs. It develops an operational space locomotion controller that can track arbitrary robot end-effector (toe) trajectories while walking at different velocities. This controller is designed to be general to different downstream tasks, and therefore, can be utilized in high-level manipulation planning policy to address specific tasks. To demonstrate the versatility of this framework, we utilize HiLMa-Res to tackle several challenging loco-manipulation tasks using a quadrupedal robot in the real world. These tasks span from leveraging state-based policy to vision-based policy, from training purely from the simulation data to learning from real-world data. In these tasks, HiLMa-Res shows better performance than other methods.

ASPS: Augmented Segment Anything Model for Polyp Segmentation

Polyp segmentation plays a pivotal role in colorectal cancer diagnosis. Recently, the emergence of the Segment Anything Model (SAM) has introduced unprecedented potential for polyp segmentation, leveraging its powerful pre-training capability on large-scale datasets. However, due to the domain gap between natural and endoscopy images, SAM encounters two limitations in achieving effective performance in polyp segmentation. Firstly, its Transformer-based structure prioritizes global and low-frequency information, potentially overlooking local details, and introducing bias into the learned features. Secondly, when applied to endoscopy images, its poor out-of-distribution (OOD) performance results in substandard predictions and biased confidence output. To tackle these challenges, we introduce a novel approach named Augmented SAM for Polyp Segmentation (ASPS), equipped with two modules: Cross-branch Feature Augmentation (CFA) and Uncertainty-guided Prediction Regularization (UPR). CFA integrates a trainable CNN encoder branch with a frozen ViT encoder, enabling the integration of domain-specific knowledge while enhancing local features and high-frequency details. Moreover, UPR ingeniously leverages SAM's IoU score to mitigate uncertainty during the training procedure, thereby improving OOD performance and domain generalization. Extensive experimental results demonstrate the effectiveness and utility of the proposed method in improving SAM's performance in polyp segmentation. Our code is available at https://github.com/HuiqianLi/ASPS.

DiffuseLoco: Real-Time Legged Locomotion Control with Diffusion from Offline Datasets

This work introduces DiffuseLoco, a framework for training multi-skill diffusion-based policies for dynamic legged locomotion from offline datasets, enabling real-time control of diverse skills on robots in the real world. Offline learning at scale has led to breakthroughs in computer vision, natural language processing, and robotic manipulation domains. However, scaling up learning for legged robot locomotion, especially with multiple skills in a single policy, presents significant challenges for prior online reinforcement learning methods. To address this challenge, we propose a novel, scalable framework that leverages diffusion models to directly learn from offline multimodal datasets with a diverse set of locomotion skills. With design choices tailored for real-time control in dynamical systems, including receding horizon control and delayed inputs, DiffuseLoco is capable of reproducing multimodality in performing various locomotion skills, zero-shot transfer to real quadrupedal robots, and it can be deployed on edge computing devices. Furthermore, DiffuseLoco demonstrates free transitions between skills and robustness against environmental variations. Through extensive benchmarking in real-world experiments, DiffuseLoco exhibits better stability and velocity tracking performance compared to prior reinforcement learning and non-diffusion-based behavior cloning baselines. The design choices are validated via comprehensive ablation studies. This work opens new possibilities for scaling up learning-based legged locomotion controllers through the scaling of large, expressive models and diverse offline datasets.

Ultrasound Nodule Segmentation Using Asymmetric Learning with Simple Clinical Annotation

Recent advances in deep learning have greatly facilitated the automated segmentation of ultrasound images, which is essential for nodule morphological analysis. Nevertheless, most existing methods depend on extensive and precise annotations by domain experts, which are labor-intensive and time-consuming. In this study, we suggest using simple aspect ratio annotations directly from ultrasound clinical diagnoses for automated nodule segmentation. Especially, an asymmetric learning framework is developed by extending the aspect ratio annotations with two types of pseudo labels, i.e., conservative labels and radical labels, to train two asymmetric segmentation networks simultaneously. Subsequently, a conservative-radical-balance strategy (CRBS) strategy is proposed to complementally combine radical and conservative labels. An inconsistency-aware dynamically mixed pseudo-labels supervision (IDMPS) module is introduced to address the challenges of over-segmentation and under-segmentation caused by the two types of labels. To further leverage the spatial prior knowledge provided by clinical annotations, we also present a novel loss function namely the clinical anatomy prior loss. Extensive experiments on two clinically collected ultrasound datasets (thyroid and breast) demonstrate the superior performance of our proposed method, which can achieve comparable and even better performance than fully supervised methods using ground truth annotations.

Long-horizon Locomotion and Manipulation on a Quadrupedal Robot with Large Language Models

We present a large language model (LLM) based system to empower quadrupedal robots with problem-solving abilities for long-horizon tasks beyond short-term motions. Long-horizon tasks for quadrupeds are challenging since they require both a high-level understanding of the semantics of the problem for task planning and a broad range of locomotion and manipulation skills to interact with the environment. Our system builds a high-level reasoning layer with large language models, which generates hybrid discrete-continuous plans as robot code from task descriptions. It comprises multiple LLM agents: a semantic planner for sketching a plan, a parameter calculator for predicting arguments in the plan, and a code generator to convert the plan into executable robot code. At the low level, we adopt reinforcement learning to train a set of motion planning and control skills to unleash the flexibility of quadrupeds for rich environment interactions. Our system is tested on long-horizon tasks that are infeasible to complete with one single skill. Simulation and real-world experiments show that it successfully figures out multi-step strategies and demonstrates non-trivial behaviors, including building tools or notifying a human for help.

Learning Visual Quadrupedal Loco-Manipulation from Demonstrations

Quadruped robots are progressively being integrated into human environments. Despite the growing locomotion capabilities of quadrupedal robots, their interaction with objects in realistic scenes is still limited. While additional robotic arms on quadrupedal robots enable manipulating objects, they are sometimes redundant given that a quadruped robot is essentially a mobile unit equipped with four limbs, each possessing 3 degrees of freedom (DoFs). Hence, we aim to empower a quadruped robot to execute real-world manipulation tasks using only its legs. We decompose the loco-manipulation process into a low-level reinforcement learning (RL)-based controller and a high-level Behavior Cloning (BC)-based planner. By parameterizing the manipulation trajectory, we synchronize the efforts of the upper and lower layers, thereby leveraging the advantages of both RL and BC. Our approach is validated through simulations and real-world experiments, demonstrating the robot's ability to perform tasks that demand mobility and high precision, such as lifting a basket from the ground while moving, closing a dishwasher, pressing a button, and pushing a door. Project website: https://zhengmaohe.github.io/leg-manip

Leveraging Symmetry in RL-based Legged Locomotion Control

Model-free reinforcement learning is a promising approach for autonomously solving challenging robotics control problems, but faces exploration difficulty without information of the robot's kinematics and dynamics morphology. The under-exploration of multiple modalities with symmetric states leads to behaviors that are often unnatural and sub-optimal. This issue becomes particularly pronounced in the context of robotic systems with morphological symmetries, such as legged robots for which the resulting asymmetric and aperiodic behaviors compromise performance, robustness, and transferability to real hardware. To mitigate this challenge, we can leverage symmetry to guide and improve the exploration in policy learning via equivariance/invariance constraints. In this paper, we investigate the efficacy of two approaches to incorporate symmetry: modifying the network architectures to be strictly equivariant/invariant, and leveraging data augmentation to approximate equivariant/invariant actor-critics. We implement the methods on challenging loco-manipulation and bipedal locomotion tasks and compare with an unconstrained baseline. We find that the strictly equivariant policy consistently outperforms other methods in sample efficiency and task performance in simulation. In addition, symmetry-incorporated approaches exhibit better gait quality, higher robustness and can be deployed zero-shot in real-world experiments.

OpenMEDLab: An Open-source Platform for Multi-modality Foundation Models in Medicine

The emerging trend of advancing generalist artificial intelligence, such as GPTv4 and Gemini, has reshaped the landscape of research (academia and industry) in machine learning and many other research areas. However, domain-specific applications of such foundation models (e.g., in medicine) remain untouched or often at their very early stages. It will require an individual set of transfer learning and model adaptation techniques by further expanding and injecting these models with domain knowledge and data. The development of such technologies could be largely accelerated if the bundle of data, algorithms, and pre-trained foundation models were gathered together and open-sourced in an organized manner. In this work, we present OpenMEDLab, an open-source platform for multi-modality foundation models. It encapsulates not only solutions of pioneering attempts in prompting and fine-tuning large language and vision models for frontline clinical and bioinformatic applications but also building domain-specific foundation models with large-scale multi-modal medical data. Importantly, it opens access to a group of pre-trained foundation models for various medical image modalities, clinical text, protein engineering, etc. Inspiring and competitive results are also demonstrated for each collected approach and model in a variety of benchmarks for downstream tasks. We welcome researchers in the field of medical artificial intelligence to continuously contribute cutting-edge methods and models to OpenMEDLab, which can be accessed via https://github.com/openmedlab.

Watch Your Head: Assembling Projection Heads to Save the Reliability of Federated Models

Federated learning encounters substantial challenges with heterogeneous data, leading to performance degradation and convergence issues. While considerable progress has been achieved in mitigating such an impact, the reliability aspect of federated models has been largely disregarded. In this study, we conduct extensive experiments to investigate the reliability of both generic and personalized federated models. Our exploration uncovers a significant finding: \textbf{federated models exhibit unreliability when faced with heterogeneous data}, demonstrating poor calibration on in-distribution test data and low uncertainty levels on out-of-distribution data. This unreliability is primarily attributed to the presence of biased projection heads, which introduce miscalibration into the federated models. Inspired by this observation, we propose the "Assembled Projection Heads" (APH) method for enhancing the reliability of federated models. By treating the existing projection head parameters as priors, APH randomly samples multiple initialized parameters of projection heads from the prior and further performs targeted fine-tuning on locally available data under varying learning rates. Such a head ensemble introduces parameter diversity into the deterministic model, eliminating the bias and producing reliable predictions via head averaging. We evaluate the effectiveness of the proposed APH method across three prominent federated benchmarks. Experimental results validate the efficacy of APH in model calibration and uncertainty estimation. Notably, APH can be seamlessly integrated into various federated approaches but only requires less than 30\% additional computation cost for 100$\times$ inferences within large models.