UNISELF: A Unified Network with Instance Normalization and Self-Ensembled Lesion Fusion for Multiple Sclerosis Lesion Segmentation

Automated segmentation of multiple sclerosis (MS) lesions using multicontrast magnetic resonance (MR) images improves efficiency and reproducibility compared to manual delineation, with deep learning (DL) methods achieving state-of-the-art performance. However, these DL-based methods have yet to simultaneously optimize in-domain accuracy and out-of-domain generalization when trained on a single source with limited data, or their performance has been unsatisfactory. To fill this gap, we propose a method called UNISELF, which achieves high accuracy within a single training domain while demonstrating strong generalizability across multiple out-of-domain test datasets. UNISELF employs a novel test-time self-ensembled lesion fusion to improve segmentation accuracy, and leverages test-time instance normalization (TTIN) of latent features to address domain shifts and missing input contrasts. Trained on the ISBI 2015 longitudinal MS segmentation challenge training dataset, UNISELF ranks among the best-performing methods on the challenge test dataset. Additionally, UNISELF outperforms all benchmark methods trained on the same ISBI training data across diverse out-of-domain test datasets with domain shifts and missing contrasts, including the public MICCAI 2016 and UMCL datasets, as well as a private multisite dataset. These test datasets exhibit domain shifts and/or missing contrasts caused by variations in acquisition protocols, scanner types, and imaging artifacts arising from imperfect acquisition. Our code is available at https://github.com/uponacceptance.

DualX-VSR: Dual Axial Spatial$\times$Temporal Transformer for Real-World Video Super-Resolution without Motion Compensation

Transformer-based models like ViViT and TimeSformer have advanced video understanding by effectively modeling spatiotemporal dependencies. Recent video generation models, such as Sora and Vidu, further highlight the power of transformers in long-range feature extraction and holistic spatiotemporal modeling. However, directly applying these models to real-world video super-resolution (VSR) is challenging, as VSR demands pixel-level precision, which can be compromised by tokenization and sequential attention mechanisms. While recent transformer-based VSR models attempt to address these issues using smaller patches and local attention, they still face limitations such as restricted receptive fields and dependence on optical flow-based alignment, which can introduce inaccuracies in real-world settings. To overcome these issues, we propose Dual Axial Spatial$\times$Temporal Transformer for Real-World Video Super-Resolution (DualX-VSR), which introduces a novel dual axial spatial$\times$temporal attention mechanism that integrates spatial and temporal information along orthogonal directions. DualX-VSR eliminates the need for motion compensation, offering a simplified structure that provides a cohesive representation of spatiotemporal information. As a result, DualX-VSR achieves high fidelity and superior performance in real-world VSR task.

Synthetic multi-inversion time magnetic resonance images for visualization of subcortical structures

Purpose: Visualization of subcortical gray matter is essential in neuroscience and clinical practice, particularly for disease understanding and surgical planning.While multi-inversion time (multi-TI) T$_1$-weighted (T$_1$-w) magnetic resonance (MR) imaging improves visualization, it is rarely acquired in clinical settings. Approach: We present SyMTIC (Synthetic Multi-TI Contrasts), a deep learning method that generates synthetic multi-TI images using routinely acquired T$_1$-w, T$_2$-weighted (T$_2$-w), and FLAIR images. Our approach combines image translation via deep neural networks with imaging physics to estimate longitudinal relaxation time (T$_1$) and proton density (PD) maps. These maps are then used to compute multi-TI images with arbitrary inversion times. Results: SyMTIC was trained using paired MPRAGE and FGATIR images along with T$_2$-w and FLAIR images. It accurately synthesized multi-TI images from standard clinical inputs, achieving image quality comparable to that from explicitly acquired multi-TI data.The synthetic images, especially for TI values between 400-800 ms, enhanced visualization of subcortical structures and improved segmentation of thalamic nuclei. Conclusion: SyMTIC enables robust generation of high-quality multi-TI images from routine MR contrasts. It generalizes well to varied clinical datasets, including those with missing FLAIR images or unknown parameters, offering a practical solution for improving brain MR image visualization and analysis.

Pretraining Deformable Image Registration Networks with Random Images

Recent advances in deep learning-based medical image registration have shown that training deep neural networks~(DNNs) does not necessarily require medical images. Previous work showed that DNNs trained on randomly generated images with carefully designed noise and contrast properties can still generalize well to unseen medical data. Building on this insight, we propose using registration between random images as a proxy task for pretraining a foundation model for image registration. Empirical results show that our pretraining strategy improves registration accuracy, reduces the amount of domain-specific data needed to achieve competitive performance, and accelerates convergence during downstream training, thereby enhancing computational efficiency.

Beyond the LUMIR challenge: The pathway to foundational registration models

Medical image challenges have played a transformative role in advancing the field, catalyzing algorithmic innovation and establishing new performance standards across diverse clinical applications. Image registration, a foundational task in neuroimaging pipelines, has similarly benefited from the Learn2Reg initiative. Building on this foundation, we introduce the Large-scale Unsupervised Brain MRI Image Registration (LUMIR) challenge, a next-generation benchmark designed to assess and advance unsupervised brain MRI registration. Distinct from prior challenges that leveraged anatomical label maps for supervision, LUMIR removes this dependency by providing over 4,000 preprocessed T1-weighted brain MRIs for training without any label maps, encouraging biologically plausible deformation modeling through self-supervision. In addition to evaluating performance on 590 held-out test subjects, LUMIR introduces a rigorous suite of zero-shot generalization tasks, spanning out-of-domain imaging modalities (e.g., FLAIR, T2-weighted, T2*-weighted), disease populations (e.g., Alzheimer's disease), acquisition protocols (e.g., 9.4T MRI), and species (e.g., macaque brains). A total of 1,158 subjects and over 4,000 image pairs were included for evaluation. Performance was assessed using both segmentation-based metrics (Dice coefficient, 95th percentile Hausdorff distance) and landmark-based registration accuracy (target registration error). Across both in-domain and zero-shot tasks, deep learning-based methods consistently achieved state-of-the-art accuracy while producing anatomically plausible deformation fields. The top-performing deep learning-based models demonstrated diffeomorphic properties and inverse consistency, outperforming several leading optimization-based methods, and showing strong robustness to most domain shifts, the exception being a drop in performance on out-of-domain contrasts.

StyleGuard: Preventing Text-to-Image-Model-based Style Mimicry Attacks by Style Perturbations

Recently, text-to-image diffusion models have been widely used for style mimicry and personalized customization through methods such as DreamBooth and Textual Inversion. This has raised concerns about intellectual property protection and the generation of deceptive content. Recent studies, such as Glaze and Anti-DreamBooth, have proposed using adversarial noise to protect images from these attacks. However, recent purification-based methods, such as DiffPure and Noise Upscaling, have successfully attacked these latest defenses, showing the vulnerabilities of these methods. Moreover, present methods show limited transferability across models, making them less effective against unknown text-to-image models. To address these issues, we propose a novel anti-mimicry method, StyleGuard. We propose a novel style loss that optimizes the style-related features in the latent space to make it deviate from the original image, which improves model-agnostic transferability. Additionally, to enhance the perturbation's ability to bypass diffusion-based purification, we designed a novel upscale loss that involves ensemble purifiers and upscalers during training. Extensive experiments on the WikiArt and CelebA datasets demonstrate that StyleGuard outperforms existing methods in robustness against various transformations and purifications, effectively countering style mimicry in various models. Moreover, StyleGuard is effective on different style mimicry methods, including DreamBooth and Textual Inversion.

Correlation Ratio for Unsupervised Learning of Multi-modal Deformable Registration

In recent years, unsupervised learning for deformable image registration has been a major research focus. This approach involves training a registration network using pairs of moving and fixed images, along with a loss function that combines an image similarity measure and deformation regularization. For multi-modal image registration tasks, the correlation ratio has been a widely-used image similarity measure historically, yet it has been underexplored in current deep learning methods. Here, we propose a differentiable correlation ratio to use as a loss function for learning-based multi-modal deformable image registration. This approach extends the traditionally non-differentiable implementation of the correlation ratio by using the Parzen windowing approximation, enabling backpropagation with deep neural networks. We validated the proposed correlation ratio on a multi-modal neuroimaging dataset. In addition, we established a Bayesian training framework to study how the trade-off between the deformation regularizer and similarity measures, including mutual information and our proposed correlation ratio, affects the registration performance.

Lumina-OmniLV: A Unified Multimodal Framework for General Low-Level Vision

We present Lunima-OmniLV (abbreviated as OmniLV), a universal multimodal multi-task framework for low-level vision that addresses over 100 sub-tasks across four major categories: image restoration, image enhancement, weak-semantic dense prediction, and stylization. OmniLV leverages both textual and visual prompts to offer flexible and user-friendly interactions. Built on Diffusion Transformer (DiT)-based generative priors, our framework supports arbitrary resolutions -- achieving optimal performance at 1K resolution -- while preserving fine-grained details and high fidelity. Through extensive experiments, we demonstrate that separately encoding text and visual instructions, combined with co-training using shallow feature control, is essential to mitigate task ambiguity and enhance multi-task generalization. Our findings also reveal that integrating high-level generative tasks into low-level vision models can compromise detail-sensitive restoration. These insights pave the way for more robust and generalizable low-level vision systems.

EGVD: Event-Guided Video Diffusion Model for Physically Realistic Large-Motion Frame Interpolation

Video frame interpolation (VFI) in scenarios with large motion remains challenging due to motion ambiguity between frames. While event cameras can capture high temporal resolution motion information, existing event-based VFI methods struggle with limited training data and complex motion patterns. In this paper, we introduce Event-Guided Video Diffusion Model (EGVD), a novel framework that leverages the powerful priors of pre-trained stable video diffusion models alongside the precise temporal information from event cameras. Our approach features a Multi-modal Motion Condition Generator (MMCG) that effectively integrates RGB frames and event signals to guide the diffusion process, producing physically realistic intermediate frames. We employ a selective fine-tuning strategy that preserves spatial modeling capabilities while efficiently incorporating event-guided temporal information. We incorporate input-output normalization techniques inspired by recent advances in diffusion modeling to enhance training stability across varying noise levels. To improve generalization, we construct a comprehensive dataset combining both real and simulated event data across diverse scenarios. Extensive experiments on both real and simulated datasets demonstrate that EGVD significantly outperforms existing methods in handling large motion and challenging lighting conditions, achieving substantial improvements in perceptual quality metrics (27.4% better LPIPS on Prophesee and 24.1% on BSRGB) while maintaining competitive fidelity measures. Code and datasets available at: https://github.com/OpenImagingLab/EGVD.

TablePilot; Recommending Human-Preferred Tabular Data Analysis with Large Language Models

Tabular data analysis is crucial in many scenarios, yet efficiently identifying the most relevant data analysis queries and results for a new table remains a significant challenge. The complexity of tabular data, diverse analytical operations, and the demand for high-quality analysis make the process tedious. To address these challenges, we aim to recommend query-code-result triplets tailored for new tables in tabular data analysis workflows. In this paper, we present TablePilot, a pioneering tabular data analysis framework leveraging large language models to autonomously generate comprehensive and superior analytical results without relying on user profiles or prior interactions. The framework incorporates key designs in analysis preparation and analysis optimization to enhance accuracy. Additionally, we propose Rec-Align, a novel method to further improve recommendation quality and better align with human preferences. Experiments on DART, a dataset specifically designed for comprehensive tabular data analysis recommendation, demonstrate the effectiveness of our framework. Based on GPT-4o, the tuned TablePilot achieves 77.0% top-5 recommendation recall. Human evaluations further highlight its effectiveness in optimizing tabular data analysis workflows.