Latent Distance Guided Alignment Training for Large Language Models

Ensuring alignment with human preferences is a crucial characteristic of large language models (LLMs). Presently, the primary alignment methods, RLHF and DPO, require extensive human annotation, which is expensive despite their efficacy. The significant expenses associated with current alignment techniques motivate researchers to investigate the development of annotation-free alignment training methods. In pursuit of improved alignment without relying on external annotation, we introduce Latent Distance Guided Alignment Training (LD-Align). This approach seeks to align the model with a high-quality supervised fine-tune dataset using guidance from a latent space. The latent space is generated through sample reconstruction, akin to auto-encoding. Consequently, we utilize the distance between sample pairs in the latent space to guide DPO-based alignment training. Extensive experimentation and evaluation show the efficacy of our proposed method in achieving notable alignment.

Multimodal Clinical Trial Outcome Prediction with Large Language Models

The clinical trial is a pivotal and costly process, often spanning multiple years and requiring substantial financial resources. Therefore, the development of clinical trial outcome prediction models aims to exclude drugs likely to fail and holds the potential for significant cost savings. Recent data-driven attempts leverage deep learning methods to integrate multimodal data for predicting clinical trial outcomes. However, these approaches rely on manually designed modal-specific encoders, which limits both the extensibility to adapt new modalities and the ability to discern similar information patterns across different modalities. To address these issues, we propose a multimodal mixture-of-experts (LIFTED) approach for clinical trial outcome prediction. Specifically, LIFTED unifies different modality data by transforming them into natural language descriptions. Then, LIFTED constructs unified noise-resilient encoders to extract information from modal-specific language descriptions. Subsequently, a sparse Mixture-of-Experts framework is employed to further refine the representations, enabling LIFTED to identify similar information patterns across different modalities and extract more consistent representations from those patterns using the same expert model. Finally, a mixture-of-experts module is further employed to dynamically integrate different modality representations for prediction, which gives LIFTED the ability to automatically weigh different modalities and pay more attention to critical information. The experiments demonstrate that LIFTED significantly enhances performance in predicting clinical trial outcomes across all three phases compared to the best baseline, showcasing the effectiveness of our proposed key components.

STAN: Stage-Adaptive Network for Multi-Task Recommendation by Learning User Lifecycle-Based Representation

Recommendation systems play a vital role in many online platforms, with their primary objective being to satisfy and retain users. As directly optimizing user retention is challenging, multiple evaluation metrics are often employed. Existing methods generally formulate the optimization of these evaluation metrics as a multitask learning problem, but often overlook the fact that user preferences for different tasks are personalized and change over time. Identifying and tracking the evolution of user preferences can lead to better user retention. To address this issue, we introduce the concept of "user lifecycle", consisting of multiple stages characterized by users' varying preferences for different tasks. We propose a novel Stage-Adaptive Network (STAN) framework for modeling user lifecycle stages. STAN first identifies latent user lifecycle stages based on learned user preferences, and then employs the stage representation to enhance multi-task learning performance. Our experimental results using both public and industrial datasets demonstrate that the proposed model significantly improves multi-task prediction performance compared to state-of-the-art methods, highlighting the importance of considering user lifecycle stages in recommendation systems. Furthermore, online A/B testing reveals that our model outperforms the existing model, achieving a significant improvement of 3.05% in staytime per user and 0.88% in CVR. These results indicate that our approach effectively improves the overall efficiency of the multi-task recommendation system.

Knowledge Soft Integration for Multimodal Recommendation

One of the main challenges in modern recommendation systems is how to effectively utilize multimodal content to achieve more personalized recommendations. Despite various proposed solutions, most of them overlook the mismatch between the knowledge gained from independent feature extraction processes and downstream recommendation tasks. Specifically, multimodal feature extraction processes do not incorporate prior knowledge relevant to recommendation tasks, while recommendation tasks often directly use these multimodal features as side information. This mismatch can lead to model fitting biases and performance degradation, which this paper refers to as the \textit{curse of knowledge} problem. To address this issue, we propose using knowledge soft integration to balance the utilization of multimodal features and the curse of knowledge problem it brings about. To achieve this, we put forward a Knowledge Soft Integration framework for the multimodal recommendation, abbreviated as KSI, which is composed of the Structure Efficiently Injection (SEI) module and the Semantic Soft Integration (SSI) module. In the SEI module, we model the modality correlation between items using Refined Graph Neural Network (RGNN), and introduce a regularization term to reduce the redundancy of user/item representations. In the SSI module, we design a self-supervised retrieval task to further indirectly integrate the semantic knowledge of multimodal features, and enhance the semantic discrimination of item representations. Extensive experiments on three benchmark datasets demonstrate the superiority of KSI and validate the effectiveness of its two modules.

Robust Image Ordinal Regression with Controllable Image Generation

Image ordinal regression has been mainly studied along the line of exploiting the order of categories. However, the issues of class imbalance and category overlap that are very common in ordinal regression were largely overlooked. As a result, the performance on minority categories is often unsatisfactory. In this paper, we propose a novel framework called CIG based on controllable image generation to directly tackle these two issues. Our main idea is to generate extra training samples with specific labels near category boundaries, and the sample generation is biased toward the less-represented categories. To achieve controllable image generation, we seek to separate structural and categorical information of images based on structural similarity, categorical similarity, and reconstruction constraints. We evaluate the effectiveness of our new CIG approach in three different image ordinal regression scenarios. The results demonstrate that CIG can be flexibly integrated with off-the-shelf image encoders or ordinal regression models to achieve improvement, and further, the improvement is more significant for minority categories.

Click-aware Structure Transfer with Sample Weight Assignment for Post-Click Conversion Rate Estimation

Post-click Conversion Rate (CVR) prediction task plays an essential role in industrial applications, such as recommendation and advertising. Conventional CVR methods typically suffer from the data sparsity problem as they rely only on samples where the user has clicked. To address this problem, researchers have introduced the method of multi-task learning, which utilizes non-clicked samples and shares feature representations of the Click-Through Rate (CTR) task with the CVR task. However, it should be noted that the CVR and CTR tasks are fundamentally different and may even be contradictory. Therefore, introducing a large amount of CTR information without distinction may drown out valuable information related to CVR. This phenomenon is called the curse of knowledge problem in this paper. To tackle this issue, we argue that a trade-off should be achieved between the introduction of large amounts of auxiliary information and the protection of valuable information related to CVR. Hence, we propose a Click-aware Structure Transfer model with sample Weight Assignment, abbreviated as CSTWA. It pays more attention to the latent structure information, which can filter the input information that is related to CVR, instead of directly sharing feature representations. Meanwhile, to capture the representation conflict between CTR and CVR, we calibrate the representation layer and reweight the discriminant layer to excavate the click bias information from the CTR tower. Moreover, it incorporates a sample weight assignment algorithm biased towards CVR modeling, to make the knowledge from CTR would not mislead the CVR. Extensive experiments on industrial and public datasets have demonstrated that CSTWA significantly outperforms widely used and competitive models.

CTT-Net: A Multi-view Cross-token Transformer for Cataract Postoperative Visual Acuity Prediction

Surgery is the only viable treatment for cataract patients with visual acuity (VA) impairment. Clinically, to assess the necessity of cataract surgery, accurately predicting postoperative VA before surgery by analyzing multi-view optical coherence tomography (OCT) images is crucially needed. Unfortunately, due to complicated fundus conditions, determining postoperative VA remains difficult for medical experts. Deep learning methods for this problem were developed in recent years. Although effective, these methods still face several issues, such as not efficiently exploring potential relations between multi-view OCT images, neglecting the key role of clinical prior knowledge (e.g., preoperative VA value), and using only regression-based metrics which are lacking reference. In this paper, we propose a novel Cross-token Transformer Network (CTT-Net) for postoperative VA prediction by analyzing both the multi-view OCT images and preoperative VA. To effectively fuse multi-view features of OCT images, we develop cross-token attention that could restrict redundant/unnecessary attention flow. Further, we utilize the preoperative VA value to provide more information for postoperative VA prediction and facilitate fusion between views. Moreover, we design an auxiliary classification loss to improve model performance and assess VA recovery more sufficiently, avoiding the limitation by only using the regression metrics. To evaluate CTT-Net, we build a multi-view OCT image dataset collected from our collaborative hospital. A set of extensive experiments validate the effectiveness of our model compared to existing methods in various metrics. Code is available at: https://github.com/wjh892521292/Cataract OCT.

PNM: Pixel Null Model for General Image Segmentation

A major challenge in image segmentation is classifying object boundaries. Recent efforts propose to refine the segmentation result with boundary masks. However, models are still prone to misclassifying boundary pixels even when they correctly capture the object contours. In such cases, even a perfect boundary map is unhelpful for segmentation refinement. In this paper, we argue that assigning proper prior weights to error-prone pixels such as object boundaries can significantly improve the segmentation quality. Specifically, we present the \textit{pixel null model} (PNM), a prior model that weights each pixel according to its probability of being correctly classified by a random segmenter. Empirical analysis shows that PNM captures the misclassification distribution of different state-of-the-art (SOTA) segmenters. Extensive experiments on semantic, instance, and panoptic segmentation tasks over three datasets (Cityscapes, ADE20K, MS COCO) confirm that PNM consistently improves the segmentation quality of most SOTA methods (including the vision transformers) and outperforms boundary-based methods by a large margin. We also observe that the widely-used mean IoU (mIoU) metric is insensitive to boundaries of different sharpness. As a byproduct, we propose a new metric, \textit{PNM IoU}, which perceives the boundary sharpness and better reflects the model segmentation performance in error-prone regions.

A Deep Learning Approach to Predicting Ventilator Parameters for Mechanically Ventilated Septic Patients

We develop a deep learning approach to predicting a set of ventilator parameters for a mechanically ventilated septic patient using a long and short term memory (LSTM) recurrent neural network (RNN) model. We focus on short-term predictions of a set of ventilator parameters for the septic patient in emergency intensive care unit (EICU). The short-term predictability of the model provides attending physicians with early warnings to make timely adjustment to the treatment of the patient in the EICU. The patient specific deep learning model can be trained on any given critically ill patient, making it an intelligent aide for physicians to use in emergent medical situations.