FAFE: Immune Complex Modeling with Geodesic Distance Loss on Noisy Group Frames

Despite the striking success of general protein folding models such as AlphaFold2(AF2, Jumper et al. (2021)), the accurate computational modeling of antibody-antigen complexes remains a challenging task. In this paper, we first analyze AF2's primary loss function, known as the Frame Aligned Point Error (FAPE), and raise a previously overlooked issue that FAPE tends to face gradient vanishing problem on high-rotational-error targets. To address this fundamental limitation, we propose a novel geodesic loss called Frame Aligned Frame Error (FAFE, denoted as F2E to distinguish from FAPE), which enables the model to better optimize both the rotational and translational errors between two frames. We then prove that F2E can be reformulated as a group-aware geodesic loss, which translates the optimization of the residue-to-residue error to optimizing group-to-group geodesic frame distance. By fine-tuning AF2 with our proposed new loss function, we attain a correct rate of 52.3\% (DockQ $>$ 0.23) on an evaluation set and 43.8\% correct rate on a subset with low homology, with substantial improvement over AF2 by 182\% and 100\% respectively.

Unsupervised Monocular Depth Estimation Based on Hierarchical Feature-Guided Diffusion

Unsupervised monocular depth estimation has received widespread attention because of its capability to train without ground truth. In real-world scenarios, the images may be blurry or noisy due to the influence of weather conditions and inherent limitations of the camera. Therefore, it is particularly important to develop a robust depth estimation model. Benefiting from the training strategies of generative networks, generative-based methods often exhibit enhanced robustness. In light of this, we employ a well-converging diffusion model among generative networks for unsupervised monocular depth estimation. Additionally, we propose a hierarchical feature-guided denoising module. This model significantly enriches the model's capacity for learning and interpreting depth distribution by fully leveraging image features to guide the denoising process. Furthermore, we explore the implicit depth within reprojection and design an implicit depth consistency loss. This loss function serves to enhance the performance of the model and ensure the scale consistency of depth within a video sequence. We conduct experiments on the KITTI, Make3D, and our self-collected SIMIT datasets. The results indicate that our approach stands out among generative-based models, while also showcasing remarkable robustness.

Dual Attribute-Spatial Relation Alignment for 3D Visual Grounding

3D visual grounding is an emerging research area dedicated to making connections between the 3D physical world and natural language, which is crucial for achieving embodied intelligence. In this paper, we propose DASANet, a Dual Attribute-Spatial relation Alignment Network that separately models and aligns object attributes and spatial relation features between language and 3D vision modalities. We decompose both the language and 3D point cloud input into two separate parts and design a dual-branch attention module to separately model the decomposed inputs while preserving global context in attribute-spatial feature fusion by cross attentions. Our DASANet achieves the highest grounding accuracy 65.1% on the Nr3D dataset, 1.3% higher than the best competitor. Besides, the visualization of the two branches proves that our method is efficient and highly interpretable.

CARES: A Comprehensive Benchmark of Trustworthiness in Medical Vision Language Models

Artificial intelligence has significantly impacted medical applications, particularly with the advent of Medical Large Vision Language Models (Med-LVLMs), sparking optimism for the future of automated and personalized healthcare. However, the trustworthiness of Med-LVLMs remains unverified, posing significant risks for future model deployment. In this paper, we introduce CARES and aim to comprehensively evaluate the Trustworthiness of Med-LVLMs across the medical domain. We assess the trustworthiness of Med-LVLMs across five dimensions, including trustfulness, fairness, safety, privacy, and robustness. CARES comprises about 41K question-answer pairs in both closed and open-ended formats, covering 16 medical image modalities and 27 anatomical regions. Our analysis reveals that the models consistently exhibit concerns regarding trustworthiness, often displaying factual inaccuracies and failing to maintain fairness across different demographic groups. Furthermore, they are vulnerable to attacks and demonstrate a lack of privacy awareness. We publicly release our benchmark and code in https://github.com/richard-peng-xia/CARES.

Low-Rank Similarity Mining for Multimodal Dataset Distillation

Though dataset distillation has witnessed rapid development in recent years, the distillation of multimodal data, e.g., image-text pairs, poses unique and under-explored challenges. Unlike unimodal data, image-text contrastive learning (ITC) data lack inherent categorization and should instead place greater emphasis on modality correspondence. In this work, we propose Low-Rank Similarity Mining (LoRS) for multimodal dataset distillation, that concurrently distills a ground truth similarity matrix with image-text pairs, and leverages low-rank factorization for efficiency and scalability. The proposed approach brings significant improvement to the existing algorithms, marking a significant contribution to the field of visual-language dataset distillation. We advocate adopting LoRS as a foundational synthetic data setup for image-text dataset distillation. Our code is available at https://github.com/silicx/LoRS_Distill.

SimAD: A Simple Dissimilarity-based Approach for Time Series Anomaly Detection

Despite the prevalence of reconstruction-based deep learning methods, time series anomaly detection remains challenging. Existing approaches often struggle with limited temporal contexts, inadequate representation of normal patterns, and flawed evaluation metrics, hindering their effectiveness in identifying aberrant behavior. To address these issues, we introduce $\textbf{{SimAD}}$, a $\textbf{{Sim}}$ple dissimilarity-based approach for time series $\textbf{{A}}$nomaly $\textbf{{D}}$etection. SimAD incorporates an advanced feature extractor adept at processing extended temporal windows, utilizes the EmbedPatch encoder to integrate normal behavioral patterns comprehensively, and introduces an innovative ContrastFusion module designed to accentuate distributional divergences between normal and abnormal data, thereby enhancing the robustness of anomaly discrimination. Additionally, we propose two robust evaluation metrics, UAff and NAff, addressing the limitations of existing metrics and demonstrating their reliability through theoretical and experimental analyses. Experiments across $\textbf{seven}$ diverse time series datasets demonstrate SimAD's superior performance compared to state-of-the-art methods, achieving relative improvements of $\textbf{19.85%}$ on F1, $\textbf{4.44%}$ on Aff-F1, $\textbf{77.79%}$ on NAff-F1, and $\textbf{9.69%}$ on AUC on six multivariate datasets. Code and pre-trained models are available at https://github.com/EmorZz1G/SimAD.

$\textit{LinkPrompt}$: Natural and Universal Adversarial Attacks on Prompt-based Language Models

Prompt-based learning is a new language model training paradigm that adapts the Pre-trained Language Models (PLMs) to downstream tasks, which revitalizes the performance benchmarks across various natural language processing (NLP) tasks. Instead of using a fixed prompt template to fine-tune the model, some research demonstrates the effectiveness of searching for the prompt via optimization. Such prompt optimization process of prompt-based learning on PLMs also gives insight into generating adversarial prompts to mislead the model, raising concerns about the adversarial vulnerability of this paradigm. Recent studies have shown that universal adversarial triggers (UATs) can be generated to alter not only the predictions of the target PLMs but also the prediction of corresponding Prompt-based Fine-tuning Models (PFMs) under the prompt-based learning paradigm. However, UATs found in previous works are often unreadable tokens or characters and can be easily distinguished from natural texts with adaptive defenses. In this work, we consider the naturalness of the UATs and develop $\textit{LinkPrompt}$, an adversarial attack algorithm to generate UATs by a gradient-based beam search algorithm that not only effectively attacks the target PLMs and PFMs but also maintains the naturalness among the trigger tokens. Extensive results demonstrate the effectiveness of $\textit{LinkPrompt}$, as well as the transferability of UATs generated by $\textit{LinkPrompt}$ to open-sourced Large Language Model (LLM) Llama2 and API-accessed LLM GPT-3.5-turbo. The resource is available at $\href{https://github.com/SavannahXu79/LinkPrompt}{https://github.com/SavannahXu79/LinkPrompt}$.

Macro Graph Neural Networks for Online Billion-Scale Recommender Systems

Predicting Click-Through Rate (CTR) in billion-scale recommender systems poses a long-standing challenge for Graph Neural Networks (GNNs) due to the overwhelming computational complexity involved in aggregating billions of neighbors. To tackle this, GNN-based CTR models usually sample hundreds of neighbors out of the billions to facilitate efficient online recommendations. However, sampling only a small portion of neighbors results in a severe sampling bias and the failure to encompass the full spectrum of user or item behavioral patterns. To address this challenge, we name the conventional user-item recommendation graph as "micro recommendation graph" and introduce a more suitable MAcro Recommendation Graph (MAG) for billion-scale recommendations. MAG resolves the computational complexity problems in the infrastructure by reducing the node count from billions to hundreds. Specifically, MAG groups micro nodes (users and items) with similar behavior patterns to form macro nodes. Subsequently, we introduce tailored Macro Graph Neural Networks (MacGNN) to aggregate information on a macro level and revise the embeddings of macro nodes. MacGNN has already served Taobao's homepage feed for two months, providing recommendations for over one billion users. Extensive offline experiments on three public benchmark datasets and an industrial dataset present that MacGNN significantly outperforms twelve CTR baselines while remaining computationally efficient. Besides, online A/B tests confirm MacGNN's superiority in billion-scale recommender systems.

Dancing with Images: Video Distillation via Static-Dynamic Disentanglement

Recently, dataset distillation has paved the way towards efficient machine learning, especially for image datasets. However, the distillation for videos, characterized by an exclusive temporal dimension, remains an underexplored domain. In this work, we provide the first systematic study of video distillation and introduce a taxonomy to categorize temporal compression. Our investigation reveals that the temporal information is usually not well learned during distillation , and the temporal dimension of synthetic data contributes little. The observations motivate our unified framework of disentangling the dynamic and static information in the videos. It first distills the videos into still images as static memory and then compensates the dynamic and motion information with a learnable dynamic memory block. Our method achieves state-of-the-art on video datasets at different scales, with notably smaller storage expenditure. Our code will be publicly available.

EgoPCA: A New Framework for Egocentric Hand-Object Interaction Understanding

With the surge in attention to Egocentric Hand-Object Interaction (Ego-HOI), large-scale datasets such as Ego4D and EPIC-KITCHENS have been proposed. However, most current research is built on resources derived from third-person video action recognition. This inherent domain gap between first- and third-person action videos, which have not been adequately addressed before, makes current Ego-HOI suboptimal. This paper rethinks and proposes a new framework as an infrastructure to advance Ego-HOI recognition by Probing, Curation and Adaption (EgoPCA). We contribute comprehensive pre-train sets, balanced test sets and a new baseline, which are complete with a training-finetuning strategy. With our new framework, we not only achieve state-of-the-art performance on Ego-HOI benchmarks but also build several new and effective mechanisms and settings to advance further research. We believe our data and the findings will pave a new way for Ego-HOI understanding. Code and data are available at https://mvig-rhos.com/ego_pca