DeepFAN, a transformer-based deep learning model for human-artificial intelligence collaborative assessment of incidental pulmonary nodules in CT scans: a multi-reader, multi-case trial

The widespread adoption of CT has notably increased the number of detected lung nodules. However, current deep learning methods for classifying benign and malignant nodules often fail to comprehensively integrate global and local features, and most of them have not been validated through clinical trials. To address this, we developed DeepFAN, a transformer-based model trained on over 10K pathology-confirmed nodules and further conducted a multi-reader, multi-case clinical trial to evaluate its efficacy in assisting junior radiologists. DeepFAN achieved diagnostic area under the curve (AUC) of 0.939 (95% CI 0.930-0.948) on an internal test set and 0.954 (95% CI 0.934-0.973) on the clinical trial dataset involving 400 cases across three independent medical institutions. Explainability analysis indicated higher contributions from global than local features. Twelve readers' average performance significantly improved by 10.9% (95% CI 8.3%-13.5%) in AUC, 10.0% (95% CI 8.9%-11.1%) in accuracy, 7.6% (95% CI 6.1%-9.2%) in sensitivity, and 12.6% (95% CI 10.9%-14.3%) in specificity (P<0.001 for all). Nodule-level inter-reader diagnostic consistency improved from fair to moderate (overall k: 0.313 vs. 0.421; P=0.019). In conclusion, DeepFAN effectively assisted junior radiologists and may help homogenize diagnostic quality and reduce unnecessary follow-up of indeterminate pulmonary nodules. Chinese Clinical Trial Registry: ChiCTR2400084624.

Deep Learning-Based Airway Segmentation in Systemic Lupus Erythematosus Patients with Interstitial Lung Disease (SLE-ILD): A Comparative High-Resolution CT Analysis

To characterize lobar and segmental airway volume differences between systemic lupus erythematosus (SLE) patients with interstitial lung disease (ILD) and those without ILD (non-ILD) using a deep learning-based approach on non-contrast chest high-resolution CT (HRCT). Methods: A retrospective analysis was conducted on 106 SLE patients (27 SLE-ILD, 79 SLE-non-ILD) who underwent HRCT. A customized deep learning framework based on the U-Net architecture was developed to automatically segment airway structures at the lobar and segmental levels via HRCT. Volumetric measurements of lung lobes and segments derived from the segmentations were statistically compared between the two groups using two-sample t-tests (significance threshold: p < 0.05). Results: At lobar level, significant airway volume enlargement in SLE-ILD patients was observed in the right upper lobe (p=0.009) and left upper lobe (p=0.039) compared to SLE-non-ILD. At the segmental level, significant differences were found in segments including R1 (p=0.016), R3 (p<0.001), and L3 (p=0.038), with the most marked changes in the upper lung zones, while lower zones showed non-significant trends. Conclusion: Our study demonstrates that an automated deep learning-based approach can effectively quantify airway volumes on HRCT scans and reveal significant, region-specific airway dilation in patients with SLE-ILD compared to those without ILD. The pattern of involvement, predominantly affecting the upper lobes and specific segments, highlights a distinct topographic phenotype of SLE-ILD and implicates airway structural alterations as a potential biomarker for disease presence. This AI-powered quantitative imaging biomarker holds promise for enhancing the early detection and monitoring of ILD in the SLE population, ultimately contributing to more personalized patient management.

SWE-Skills-Bench: Do Agent Skills Actually Help in Real-World Software Engineering?

Agent skills, structured procedural knowledge packages injected at inference time, are increasingly used to augment LLM agents on software engineering tasks. However, their real utility in end-to-end development settings remains unclear. We present SWE-Skills-Bench, the first requirement-driven benchmark that isolates the marginal utility of agent skills in real-world software engineering (SWE). It pairs 49 public SWE skills with authentic GitHub repositories pinned at fixed commits and requirement documents with explicit acceptance criteria, yielding approximately 565 task instances across six SWE subdomains. We introduce a deterministic verification framework that maps each task's acceptance criteria to execution-based tests, enabling controlled paired evaluation with and without the skill. Our results show that skill injection benefits are far more limited than rapid adoption suggests: 39 of 49 skills yield zero pass-rate improvement, and the average gain is only +1.2%. Token overhead varies from modest savings to a 451% increase while pass rates remain unchanged. Only seven specialized skills produce meaningful gains (up to +30%), while three degrade performance (up to -10%) due to version-mismatched guidance conflicting with project context. These findings suggest that agent skills are a narrow intervention whose utility depends strongly on domain fit, abstraction level, and contextual compatibility. SWE-Skills-Bench provides a testbed for evaluating the design, selection, and deployment of skills in software engineering agents. SWE-Skills-Bench is available at https://github.com/GeniusHTX/SWE-Skills-Bench.

HALO:Closing Sim-to-Real Gap for Heavy-loaded Humanoid Agile Motion Skills via Differentiable Simulation

Humanoid robots deployed in real-world scenarios often need to carry unknown payloads, which introduce significant mismatch and degrade the effectiveness of simulation-to-reality reinforcement learning methods. To address this challenge, we propose a two-stage gradient-based system identification framework built on the differentiable simulator MuJoCo XLA. The first stage calibrates the nominal robot model using real-world data to reduce intrinsic sim-to-real discrepancies, while the second stage further identifies the mass distribution of the unknown payload. By explicitly reducing structured model bias prior to policy training, our approach enables zero-shot transfer of reinforcement learning policies to hardware under heavy-load conditions. Extensive simulation and real-world experiments demonstrate more precise parameter identification, improved motion tracking accuracy, and substantially enhanced agility and robustness compared to existing baselines. Project Page: https://mwondering.github.io/halo-humanoid/

LLM-Guided Knowledge Distillation for Temporal Knowledge Graph Reasoning

Temporal knowledge graphs (TKGs) support reasoning over time-evolving facts, yet state-of-the-art models are often computationally heavy and costly to deploy. Existing compression and distillation techniques are largely designed for static graphs; directly applying them to temporal settings may overlook time-dependent interactions and lead to performance degradation. We propose an LLM-assisted distillation framework specifically designed for temporal knowledge graph reasoning. Beyond a conventional high-capacity temporal teacher, we incorporate a large language model as an auxiliary instructor to provide enriched supervision. The LLM supplies broad background knowledge and temporally informed signals, enabling a lightweight student to better model event dynamics without increasing inference-time complexity. Training is conducted by jointly optimizing supervised and distillation objectives, using a staged alignment strategy to progressively integrate guidance from both teachers. Extensive experiments on multiple public TKG benchmarks with diverse backbone architectures demonstrate that the proposed approach consistently improves link prediction performance over strong distillation baselines, while maintaining a compact and efficient student model. The results highlight the potential of large language models as effective teachers for transferring temporal reasoning capability to resource-efficient TKG systems.

DeepGen 1.0: A Lightweight Unified Multimodal Model for Advancing Image Generation and Editing

Current unified multimodal models for image generation and editing typically rely on massive parameter scales (e.g., >10B), entailing prohibitive training costs and deployment footprints. In this work, we present DeepGen 1.0, a lightweight 5B unified model that achieves comprehensive capabilities competitive with or surpassing much larger counterparts. To overcome the limitations of compact models in semantic understanding and fine-grained control, we introduce Stacked Channel Bridging (SCB), a deep alignment framework that extracts hierarchical features from multiple VLM layers and fuses them with learnable 'think tokens' to provide the generative backbone with structured, reasoning-rich guidance. We further design a data-centric training strategy spanning three progressive stages: (1) Alignment Pre-training on large-scale image-text pairs and editing triplets to synchronize VLM and DiT representations, (2) Joint Supervised Fine-tuning on a high-quality mixture of generation, editing, and reasoning tasks to foster omni-capabilities, and (3) Reinforcement Learning with MR-GRPO, which leverages a mixture of reward functions and supervision signals, resulting in substantial gains in generation quality and alignment with human preferences, while maintaining stable training progress and avoiding visual artifacts. Despite being trained on only ~50M samples, DeepGen 1.0 achieves leading performance across diverse benchmarks, surpassing the 80B HunyuanImage by 28% on WISE and the 27B Qwen-Image-Edit by 37% on UniREditBench. By open-sourcing our training code, weights, and datasets, we provide an efficient, high-performance alternative to democratize unified multimodal research.

VideoSTF: Stress-Testing Output Repetition in Video Large Language Models

Video Large Language Models (VideoLLMs) have recently achieved strong performance in video understanding tasks. However, we identify a previously underexplored generation failure: severe output repetition, where models degenerate into self-reinforcing loops of repeated phrases or sentences. This failure mode is not captured by existing VideoLLM benchmarks, which focus primarily on task accuracy and factual correctness. We introduce VideoSTF, the first framework for systematically measuring and stress-testing output repetition in VideoLLMs. VideoSTF formalizes repetition using three complementary n-gram-based metrics and provides a standardized testbed of 10,000 diverse videos together with a library of controlled temporal transformations. Using VideoSTF, we conduct pervasive testing, temporal stress testing, and adversarial exploitation across 10 advanced VideoLLMs. We find that output repetition is widespread and, critically, highly sensitive to temporal perturbations of video inputs. Moreover, we show that simple temporal transformations can efficiently induce repetitive degeneration in a black-box setting, exposing output repetition as an exploitable security vulnerability. Our results reveal output repetition as a fundamental stability issue in modern VideoLLMs and motivate stability-aware evaluation for video-language systems. Our evaluation code and scripts are available at: https://github.com/yuxincao22/VideoSTF_benchmark.

UniReason 1.0: A Unified Reasoning Framework for World Knowledge Aligned Image Generation and Editing

Unified multimodal models often struggle with complex synthesis tasks that demand deep reasoning, and typically treat text-to-image generation and image editing as isolated capabilities rather than interconnected reasoning steps. To address this, we propose UniReason, a unified framework that harmonizes these two tasks through a dual reasoning paradigm. We formulate generation as world knowledge-enhanced planning to inject implicit constraints, and leverage editing capabilities for fine-grained visual refinement to further correct visual errors via self-reflection. This approach unifies generation and editing within a shared representation, mirroring the human cognitive process of planning followed by refinement. We support this framework by systematically constructing a large-scale reasoning-centric dataset (~300k samples) covering five major knowledge domains (e.g., cultural commonsense, physics, etc.) for planning, alongside an agent-generated corpus for visual self-correction. Extensive experiments demonstrate that UniReason achieves advanced performance on reasoning-intensive benchmarks such as WISE, KrisBench and UniREditBench, while maintaining superior general synthesis capabilities.

FAIRT2V: Training-Free Debiasing for Text-to-Video Diffusion Models

Text-to-video (T2V) diffusion models have achieved rapid progress, yet their demographic biases, particularly gender bias, remain largely unexplored. We present FairT2V, a training-free debiasing framework for text-to-video generation that mitigates encoder-induced bias without finetuning. We first analyze demographic bias in T2V models and show that it primarily originates from pretrained text encoders, which encode implicit gender associations even for neutral prompts. We quantify this effect with a gender-leaning score that correlates with bias in generated videos. Based on this insight, FairT2V mitigates demographic bias by neutralizing prompt embeddings via anchor-based spherical geodesic transformations while preserving semantics. To maintain temporal coherence, we apply debiasing only during early identity-forming steps through a dynamic denoising schedule. We further propose a video-level fairness evaluation protocol combining VideoLLM-based reasoning with human verification. Experiments on the modern T2V model Open-Sora show that FairT2V substantially reduces demographic bias across occupations with minimal impact on video quality.

DeMark: A Query-Free Black-Box Attack on Deepfake Watermarking Defenses

The rapid proliferation of realistic deepfakes has raised urgent concerns over their misuse, motivating the use of defensive watermarks in synthetic images for reliable detection and provenance tracking. However, this defense paradigm assumes such watermarks are inherently resistant to removal. We challenge this assumption with DeMark, a query-free black-box attack framework that targets defensive image watermarking schemes for deepfakes. DeMark exploits latent-space vulnerabilities in encoder-decoder watermarking models through a compressive sensing based sparsification process, suppressing watermark signals while preserving perceptual and structural realism appropriate for deepfakes. Across eight state-of-the-art watermarking schemes, DeMark reduces watermark detection accuracy from 100% to 32.9% on average while maintaining natural visual quality, outperforming existing attacks. We further evaluate three defense strategies, including image super resolution, sparse watermarking, and adversarial training, and find them largely ineffective. These results demonstrate that current encoder decoder watermarking schemes remain vulnerable to latent-space manipulations, underscoring the need for more robust watermarking methods to safeguard against deepfakes.