A Versatile AI Agent for Rare Disease Diagnosis and Risk Gene Prioritization

Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School of Medicine and Duke-NUS Medical School, we further validated its practical utility by showing (1) Hygieia's superior diagnostic performance compared to physicians with an improvement from 12%-60% and (2) its effectiveness in assisting clinicians with medical records for handling real-world cases. Our findings indicate that Hygieia not only enhances diagnostic accuracy and interpretability but also significantly reduces clinician workload, highlighting its potential as a valuable tool in clinical decision support systems.

Structured 3D Latents Are Surprisingly Powerful: Unleashing Generalizable Style with 2D Diffusion

3D asset generation plays a pivotal role in fields such as gaming and virtual reality, enabling the rapid synthesis of high-fidelity 3D objects from a single or multiple images. Building on this capability, enabling style-controllable generation naturally emerges as an important and desirable direction. However, existing approaches typically rely on style images that lie within or are similar to the training distribution of 3D generation models. When presented with out-of-distribution (OOD) styles, their performance degrades significantly or even fails. To address this limitation, we introduce $\textbf{DiLAST}$: 2D Diffusion-based Latent Awakening for 3D Style Transfer. Specifically, we leverage a pretrained 2D diffusion model as a teacher to provide rich and generalizable style priors. By aligning rendered views with the target style under diffusion-based guidance, our method optimizes the structured 3D latent representation for stylization. We observe that this limitation stems not from insufficient model capacity, but from the underutilization of structured 3D latents, which are inherently expressive. Despite being trained on comparatively limited data, 3D generation models can leverage 2D diffusion guidance to steer denoising toward specific directions in latent space, thereby producing diverse, OOD styles. Extensive experiments across diverse data and multiple 3D generation backbones demonstrate the effectiveness and plug-and-play nature of our approach.

Evaluation-driven Scaling for Scientific Discovery

Language models are increasingly used in scientific discovery to generate hypotheses, propose candidate solutions, implement systems, and iteratively refine them. At the core of these trial-and-error loops lies evaluation: the process of obtaining feedback on candidate solutions via verifiers, simulators, or task-specific scoring functions. While prior work has highlighted the importance of evaluation, it has not explicitly formulated the problem of how evaluation-driven discovery loops can be scaled up in a principled and effective manner to push the boundaries of scientific discovery, a problem this paper seeks to address. We introduce Simple Test-time Evaluation-driven Scaling (SimpleTES), a general framework that strategically combines parallel exploration, feedback-driven refinement, and local selection, revealing substantial gains unlocked by scaling evaluation-driven discovery loops along the right dimensions. Across 21 scientific problems spanning six domains, SimpleTES discovers state-of-the-art solutions using gpt-oss models, consistently outperforming both frontier-model baselines and sophisticated optimization pipelines. Particularly, we sped up the widely used LASSO algorithm by over 2x, designed quantum circuit routing policies that reduce gate overhead by 24.5%, and discovered new Erdos minimum overlap constructions that surpass the best-known results. Beyond novel discoveries, SimpleTES produces trajectory-level histories that naturally supervise feedback-driven learning. When post-trained on successful trajectories, models not only improve efficiency on seen problems but also generalize to unseen problems, discovering solutions that base models fail to uncover. Together, our results establish effective evaluation-driven loop scaling as a central axis for advancing LLM-driven scientific discovery, and provide a simple yet practical framework for realizing these gains.

Framelet-Based Blind Image Restoration with Minimax Concave Regularization

Recovering corrupted images is one of the most challenging problems in image processing. Among various restoration tasks, blind image deblurring has been extensively studied due to its practical importance and inherent difficulty. In this problem, both the point spread function (PSF) and the underlying latent sharp image must be estimated simultaneously. This problem cannot be solved directly due to its ill-posed nature. One powerful tool for solving such problems is total variation (TV) regularization. The $\ell_0$-norm regularization within the TV framework has been widely adopted to promote sparsity in image gradients or transform domains, leading to improved preservation of edges and fine structures. However, the use of the $\ell_0$-norm results in a highly nonconvex and computationally intractable optimization problem, which limits its practical applicability. To overcome these difficulties, we employ the minimax concave penalty (MCP), which promotes enhanced sparsity and provides a closer approximation to the $\ell_0$-norm. In addition, a reweighted $\ell_1$-norm regularization is incorporated to further reduce estimation bias and improve the preservation of fine image details and textures. After introducing the proposed model, a numerical algorithm is developed to solve the resulting optimization problem. The effectiveness of the proposed approach is then demonstrated through experimental evaluations on several test images.

Relax: An Asynchronous Reinforcement Learning Engine for Omni-Modal Post-Training at Scale

Reinforcement learning (RL) post-training has proven effective at unlocking reasoning, self-reflection, and tool-use capabilities in large language models. As models extend to omni-modal inputs and agentic multi-turn workflows, RL training systems face three interdependent challenges: heterogeneous data flows, operational robustness at scale, and the staleness -- throughput tradeoff. We present \textbf{Relax} (Reinforcement Engine Leveraging Agentic X-modality), an open-source RL training engine that addresses these challenges through three co-designed architectural layers. First, an \emph{omni-native architecture} builds multimodal support into the full stack -- from data preprocessing and modality-aware parallelism to inference generation -- rather than retrofitting it onto a text-centric pipeline. Second, each RL role runs as an independent, fault-isolated service that can be scaled, recovered, and upgraded without global coordination. Third, service-level decoupling enables asynchronous training via the TransferQueue data bus, where a single staleness parameter smoothly interpolates among on-policy, near-on-policy, and fully asynchronous execution. Relax achieves a 1.20$\times$ end-to-end speedup over veRL on Qwen3-4B on-policy training. Its fully async mode delivers a 1.76$\times$ speedup over colocate on Qwen3-4B and a 2.00$\times$ speedup on Qwen3-Omni-30B, while all modes converge to the same reward level. Relax supports R3 (Rollout Routing Replay)~\cite{ma2025r3} for MoE models with only 1.9\% overhead, compared to 32\% degradation in veRL under the same configuration. It further demonstrates stable omni-modal RL convergence on Qwen3-Omni across image, text, and audio, sustaining over 2{,}000 steps on video without degradation. Relax is available at https://github.com/rednote-ai/Relax.

Attention Sink in Transformers: A Survey on Utilization, Interpretation, and Mitigation

As the foundational architecture of modern machine learning, Transformers have driven remarkable progress across diverse AI domains. Despite their transformative impact, a persistent challenge across various Transformers is Attention Sink (AS), in which a disproportionate amount of attention is focused on a small subset of specific yet uninformative tokens. AS complicates interpretability, significantly affecting the training and inference dynamics, and exacerbates issues such as hallucinations. In recent years, substantial research has been dedicated to understanding and harnessing AS. However, a comprehensive survey that systematically consolidates AS-related research and offers guidance for future advancements remains lacking. To address this gap, we present the first survey on AS, structured around three key dimensions that define the current research landscape: Fundamental Utilization, Mechanistic Interpretation, and Strategic Mitigation. Our work provides a pivotal contribution by clarifying key concepts and guiding researchers through the evolution and trends of the field. We envision this survey as a definitive resource, empowering researchers and practitioners to effectively manage AS within the current Transformer paradigm, while simultaneously inspiring innovative advancements for the next generation of Transformers. The paper list of this work is available at https://github.com/ZunhaiSu/Awesome-Attention-Sink.

OpenSpatial: A Principled Data Engine for Empowering Spatial Intelligence

Spatial understanding is a fundamental cornerstone of human-level intelligence. Nonetheless, current research predominantly focuses on domain-specific data production, leaving a critical void: the absence of a principled, open-source engine capable of fully unleashing the potential of high-quality spatial data. To bridge this gap, we elucidate the design principles of a robust data generation system and introduce OpenSpatial -- an open-source data engine engineered for high quality, extensive scalability, broad task diversity, and optimized efficiency. OpenSpatial adopts 3D bounding boxes as the fundamental primitive to construct a comprehensive data hierarchy across five foundational tasks: Spatial Measurement (SM), Spatial Relationship (SR), Camera Perception (CP), Multi-view Consistency (MC), and Scene-Aware Reasoning (SAR). Leveraging this scalable infrastructure, we curate OpenSpatial-3M, a large-scale dataset comprising 3 million high-fidelity samples. Extensive evaluations demonstrate that versatile models trained on our dataset achieve state-of-the-art performance across a wide spectrum of spatial reasoning benchmarks. Notably, the best-performing model exhibits a substantial average improvement of 19 percent, relatively. Furthermore, we provide a systematic analysis of how data attributes influence spatial perception. By open-sourcing both the engine and the 3M-scale dataset, we provide a robust foundation to accelerate future research in spatial intelligence.

ViGoR-Bench: How Far Are Visual Generative Models From Zero-Shot Visual Reasoners?

Beneath the stunning visual fidelity of modern AIGC models lies a "logical desert", where systems fail tasks that require physical, causal, or complex spatial reasoning. Current evaluations largely rely on superficial metrics or fragmented benchmarks, creating a ``performance mirage'' that overlooks the generative process. To address this, we introduce ViGoR Vision-G}nerative Reasoning-centric Benchmark), a unified framework designed to dismantle this mirage. ViGoR distinguishes itself through four key innovations: 1) holistic cross-modal coverage bridging Image-to-Image and Video tasks; 2) a dual-track mechanism evaluating both intermediate processes and final results; 3) an evidence-grounded automated judge ensuring high human alignment; and 4) granular diagnostic analysis that decomposes performance into fine-grained cognitive dimensions. Experiments on over 20 leading models reveal that even state-of-the-art systems harbor significant reasoning deficits, establishing ViGoR as a critical ``stress test'' for the next generation of intelligent vision models. The demo have been available at https://vincenthancoder.github.io/ViGoR-Bench/

AdvSplat: Adversarial Attacks on Feed-Forward Gaussian Splatting Models

3D Gaussian Splatting (3DGS) is increasingly recognized as a powerful paradigm for real-time, high-fidelity 3D reconstruction. However, its per-scene optimization pipeline limits scalability and generalization, and prevents efficient inference. Recently emerged feed-forward 3DGS models address these limitations by enabling fast reconstruction from a few input views after large-scale pretraining, without scene-specific optimization. Despite their advantages and strong potential for commercial deployment, the use of neural networks as the backbone also amplifies the risk of adversarial manipulation. In this paper, we introduce AdvSplat, the first systematic study of adversarial attacks on feed-forward 3DGS. We first employ white-box attacks to reveal fundamental vulnerabilities of this model family. We then develop two improved, practically relevant, query-efficient black-box algorithms that optimize pixel-space perturbations via a frequency-domain parameterization: one based on gradient estimation and the other gradient-free, without requiring any access to model internals. Extensive experiments across multiple datasets demonstrate that AdvSplat can significantly disrupt reconstruction results by injecting imperceptible perturbations into the input images. Our findings surface an overlooked yet urgent problem in this domain, and we hope to draw the community's attention to this emerging security and robustness challenge.

CAPTCHA Solving for Native GUI Agents: Automated Reasoning-Action Data Generation and Self-Corrective Training

GUI agents are rapidly shifting from multi-module pipelines to end-to-end, native vision-language models (VLMs) that perceive raw screenshots and directly interact with digital devices. Despite rapid progress on general GUI tasks, CAPTCHA solving remains a major challenge. On the other hand, although specialized CAPTCHA solving pipelines exist, they cannot handle general GUI tasks. To address this gap, we introduce ReCAP: a CAPTCHA-capable native GUI agent that can robustly solve modern, interactive CAPTCHA challenges, while preserving their performance as a general GUI agent. We first develop a dynamic CAPTCHA system spanning seven representative CAPTCHA types, designed to stress primitive and complementary capabilities for CAPTCHA solving (e.g., robust OCR under heavy noise and text stylization, fine-grained visual understanding, and precise control). Then, we develop an automated data collection and curation pipeline that generates large-scale CAPTCHA interaction trajectories paired with reasoning traces. As CAPTCHA solving often requires multi-step interaction and recovery from intermediate mistakes, we further leverage failed trajectories to construct self-correction data, training agents to reflect on errors and correct their actions online. Across held-out test sets, ReCAP improves CAPTCHA-solving success from roughly 30\% to 80\%, while maintaining strong performance on general GUI-agent benchmarks.