DRL-STAF: A Deep Reinforcement Learning Framework for State-Aware Forecasting of Complex Multivariate Hidden Markov Processes

Forecasting multivariate hidden Markov processes is challenging due to nonlinear and nonstationary observations, latent state transitions, and cross-sequence dependencies. While deep learning methods achieve strong predictive accuracy, they typically lack explicit state modeling, whereas Hidden Markov Models (HMMs) provide interpretable latent states but struggle with complex nonlinear emissions and scalability. To address these limitations, we propose DRL-STAF, a Deep Reinforcement Learning based STate-Aware Forecasting framework that jointly predicts next-step observations and estimates the corresponding hidden states for complex multivariate hidden Markov processes. Specifically, DRL-STAF models complex nonlinear emissions using deep neural networks and estimates discrete hidden states using reinforcement learning, reducing the reliance on predefined transition structures and enabling flexible adaptation to diverse temporal dynamics. In particular, DRL-STAF mitigates the state-space explosion encountered by typical multivariate HMM-based methods. Extensive experiments demonstrate that DRL-STAF outperforms HMM variants, standalone deep learning models, and existing DL-HMM hybrids in most cases, while also providing reliable hidden-state estimates.

Foundation Models to Unlock Real-World Evidence from Nationwide Medical Claims

Evidence derived from large-scale real-world data (RWD) is increasingly informing regulatory evaluation and healthcare decision-making. Administrative claims provide population-scale, longitudinal records of healthcare utilization, expenditure, and detailed coding of diagnoses, procedures, and medications, yet their potential as a substrate for healthcare foundation models remains largely unexplored. Here we present ReClaim, a generative transformer trained from scratch on 43.8 billion medical events from more than 200 million enrollees in the MarketScan claims data spanning 2008-2022. ReClaim models longitudinal trajectories across diagnoses, procedures, medications, and expenditure, and was scaled to 140 million, 700 million, and 1.7 billion parameters. Across over 1,000 disease-onset prediction tasks, ReClaim achieved a mean AUC of 75.6%, substantially outperforming disease-specific LightGBM (66.3%) and the transformer-based Delphi model (69.4%), with the largest gains for rare diseases. These advantages held across retrospective and prospective evaluations and in external validation on two independent datasets. Performance improved monotonically with scale, and post-training added 13.8 percentage points over pre-training alone. Beyond disease prediction, ReClaim captured financial outcomes and improved real-world evidence (RWE) analyses: for healthcare expenditure forecasting it increased explained variance from 0.28 to 0.37 relative to LightGBM, and in a target trial emulation it reduced systematic bias by 72% on average relative to Delphi. Together, these results establish administrative claims as a scalable substrate for healthcare foundation models and show that learned representations generalize across time periods and data sources, supporting disease surveillance, expenditure forecasting, and RWE generation.

Disentangling Shared and Task-Specific Representations from Multi-Modal Clinical Data

Real-world clinical data is inherently multimodal, providing complementary evidence that mirrors the practical necessity of jointly assessing multiple related outcomes. Although multi-task learning can improve efficiency by sharing information across outcomes, existing approaches often fail to balance shared representation learning with outcome-specific modeling. Hard parameter sharing can trigger negative transfer when task gradients conflict, while flexible sharing may still entangle shared and task-specific signals. To address this, we propose a multi-task framework built on a unified Transformer for multimodal fusion, augmented with Orthogonal Task Decomposition (OrthTD) to split patient representations into shared and task-specific subspaces and impose a geometric orthogonality constraint to reduce redundancy and isolate task-specific signals. We evaluated OrthTD on a real-world cohort of 12,430 surgical patients for predicting four outcomes. OrthTD achieved average AUC (area under the receiver operating characteristic curve) of 87.5% and average AUPRC (area under the precision-recall curve) of 37.2%, consistently outperformed advanced tabular and multi-task methods. Notably, OrthTD achieves substantial gains in AUPRC, indicating superior performance in identifying rare events within imbalanced clinical data. These results suggest that enforcing non-redundant shared and task-specific representations can improve multi-outcome prediction from multimodal clinical data.

Memory-Augmented LLM-based Multi-Agent System for Automated Feature Generation on Tabular Data

Automated feature generation extracts informative features from raw tabular data without manual intervention and is crucial for accurate, generalizable machine learning. Traditional methods rely on predefined operator libraries and cannot leverage task semantics, limiting their ability to produce diverse, high-value features for complex tasks. Recent Large Language Model (LLM)-based approaches introduce richer semantic signals, but still suffer from a restricted feature space due to fixed generation patterns and from the absence of feedback from the learning objective. To address these challenges, we propose a Memory-Augmented LLM-based Multi-Agent System (\textbf{MALMAS}) for automated feature generation. MALMAS decomposes the generation process into agents with distinct responsibilities, and a Router Agent activates an appropriate subset of agents per iteration, further broadening exploration of the feature space. We further integrate a memory module comprising procedural memory, feedback memory, and conceptual memory, enabling iterative refinement that adaptively guides subsequent feature generation and improves feature quality and diversity. Extensive experiments on multiple public datasets against state-of-the-art baselines demonstrate the effectiveness of our approach. The code is available at https://github.com/fxdong24/MALMAS

TP-Seg: Task-Prototype Framework for Unified Medical Lesion Segmentation

Building a unified model with a single set of parameters to efficiently handle diverse types of medical lesion segmentation has become a crucial objective for AI-assisted diagnosis. Existing unified segmentation approaches typically rely on shared encoders across heterogeneous tasks and modalities, which often leads to feature entanglement, gradient interference, and suboptimal lesion discrimination. In this work, we propose TP-Seg, a task-prototype framework for unified medical lesion segmentation. On one hand, the task-conditioned adapter effectively balances shared and task-specific representations through a dual-path expert structure, enabling adaptive feature extraction across diverse medical imaging modalities and lesion types. On the other hand, the prototype-guided task decoder introduces learnable task prototypes as semantic anchors and employs a cross-attention mechanism to achieve fine-grained modeling of task-specific foreground and background semantics. Without bells and whistles, TP-Seg consistently outperforms specialized, general and unified segmentation methods across 8 different medical lesion segmentation tasks covering multiple imaging modalities, demonstrating strong generalization, scalability and clinical applicability.

SDE-Driven Spatio-Temporal Hypergraph Neural Networks for Irregular Longitudinal fMRI Connectome Modeling in Alzheimer's Disease

Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations. To address this challenge, we propose SDE-HGNN, a stochastic differential equation (SDE)-driven spatio-temporal hypergraph neural network for irregular longitudinal fMRI connectome modeling. The framework first employs an SDE-based reconstruction module to recover continuous latent trajectories from irregular observations. Based on these reconstructed representations, dynamic hypergraphs are constructed to capture higher-order interactions among brain regions over time. To further model temporal evolution, hypergraph convolution parameters evolve through SDE-controlled recurrent dynamics conditioned on inter-scan intervals, enabling disease-stage-adaptive connectivity modeling. We also incorporate a sparsity-based importance learning mechanism to identify salient brain regions and discriminative connectivity patterns. Extensive experiments on the OASIS-3 and ADNI cohorts demonstrate consistent improvements over state-of-the-art graph and hypergraph baselines in AD progression prediction. The source code is available at https://anonymous.4open.science/r/SDE-HGNN-017F.

HAMMER: Harnessing MLLM via Cross-Modal Integration for Intention-Driven 3D Affordance Grounding

Humans commonly identify 3D object affordance through observed interactions in images or videos, and once formed, such knowledge can be generically generalized to novel objects. Inspired by this principle, we advocate for a novel framework that leverages emerging multimodal large language models (MLLMs) for interaction intention-driven 3D affordance grounding, namely HAMMER. Instead of generating explicit object attribute descriptions or relying on off-the-shelf 2D segmenters, we alternatively aggregate the interaction intention depicted in the image into a contact-aware embedding and guide the model to infer textual affordance labels, ensuring it thoroughly excavates object semantics and contextual cues. We further devise a hierarchical cross-modal integration mechanism to fully exploit the complementary information from the MLLM for 3D representation refinement and introduce a multi-granular geometry lifting module that infuses spatial characteristics into the extracted intention embedding, thus facilitating accurate 3D affordance localization. Extensive experiments on public datasets and our newly constructed corrupted benchmark demonstrate the superiority and robustness of HAMMER compared to existing approaches. All code and weights are publicly available.

RTLocating: Intent-aware RTL Localization for Hardware Design Iteration

Industrial chip development is inherently iterative, favoring localized, intent-driven updates over rewriting RTL from scratch. Yet most LLM-Aided Hardware Design (LAD) work focuses on one-shot synthesis, leaving this workflow underexplored. To bridge this gap, we for the first time formalize $Δ$Spec-to-RTL localization, a multi-positive problem mapping natural language change requests ($Δ$Spec) to the affected Register Transfer Level (RTL) syntactic blocks. We propose RTLocating, an intent-aware RTL localization framework, featuring a dynamic router that adaptively fuses complementary views from a textual semantic encoder, a local structural encoder, and a global interaction and dependency encoder (GLIDE). To enable scalable supervision, we introduce EvoRTL-Bench, the first industrial-scale benchmark for intent-code alignment derived from OpenTitan's Git history, comprising 1,905 validated requests and 13,583 $Δ$Spec-RTL block pairs. On EvoRTL-Bench, RTLocating achieves 0.568 MRR and 15.08% R@1, outperforming the strongest baseline by +22.9% and +67.0%, respectively, establishing a new state-of-the-art for intent-driven localization in evolving hardware designs.

Unlearning Noise in PINNs: A Selective Pruning Framework for PDE Inverse Problems

Physics-informed neural networks (PINNs) provide a promising framework for solving inverse problems governed by partial differential equations (PDEs) by integrating observational data and physical constraints in a unified optimization objective. However, the ill-posed nature of PDE inverse problems makes them highly sensitive to noise. Even a small fraction of corrupted observations can distort internal neural representations, severely impairing accuracy and destabilizing training. Motivated by recent advances in machine unlearning and structured network pruning, we propose P-PINN, a selective pruning framework designed to unlearn the influence of corrupted data in a pretrained PINN. Specifically, starting from a PINN trained on the full dataset, P-PINN evaluates a joint residual--data fidelity indicator, a weighted combination of data misfit and PDE residuals, to partition the training set into reliable and corrupted subsets. Next, we introduce a bias-based neuron importance measure that quantifies directional activation discrepancies between the two subsets, identifying neurons whose representations are predominantly driven by corrupted samples. Building on this, an iterative pruning strategy then removes noise-sensitive neurons layer by layer. The resulting pruned network is fine-tuned on the reliable data subject to the original PDE constraints, acting as a lightweight post-processing stage rather than a complete retraining. Numerical experiments on extensive PDE inverse-problem benchmarks demonstrate that P-PINN substantially improves robustness, accuracy, and training stability under noisy conditions, achieving up to a 96.6\% reduction in relative error compared with baseline PINNs. These results indicate that activation-level post hoc pruning is a promising mechanism for enhancing the reliability of physics-informed learning in noise-contaminated settings.

SoulX-Singer: Towards High-Quality Zero-Shot Singing Voice Synthesis

While recent years have witnessed rapid progress in speech synthesis, open-source singing voice synthesis (SVS) systems still face significant barriers to industrial deployment, particularly in terms of robustness and zero-shot generalization. In this report, we introduce SoulX-Singer, a high-quality open-source SVS system designed with practical deployment considerations in mind. SoulX-Singer supports controllable singing generation conditioned on either symbolic musical scores (MIDI) or melodic representations, enabling flexible and expressive control in real-world production workflows. Trained on more than 42,000 hours of vocal data, the system supports Mandarin Chinese, English, and Cantonese and consistently achieves state-of-the-art synthesis quality across languages under diverse musical conditions. Furthermore, to enable reliable evaluation of zero-shot SVS performance in practical scenarios, we construct SoulX-Singer-Eval, a dedicated benchmark with strict training-test disentanglement, facilitating systematic assessment in zero-shot settings.