A Versatile AI Agent for Rare Disease Diagnosis and Risk Gene Prioritization

Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School of Medicine and Duke-NUS Medical School, we further validated its practical utility by showing (1) Hygieia's superior diagnostic performance compared to physicians with an improvement from 12%-60% and (2) its effectiveness in assisting clinicians with medical records for handling real-world cases. Our findings indicate that Hygieia not only enhances diagnostic accuracy and interpretability but also significantly reduces clinician workload, highlighting its potential as a valuable tool in clinical decision support systems.

The Chameleon's Limit: Investigating Persona Collapse and Homogenization in Large Language Models

Applications based on large language models (LLMs), such as multi-agent simulations, require population diversity among agents. We identify a pervasive failure mode we term \emph{Persona Collapse}: agents each assigned a distinct profile nonetheless converge into a narrow behavioral mode, producing a homogeneous simulated population. To quantify persona collapse, we propose a framework that measures how much of the persona space a population occupies (Coverage), how evenly agents spread across it (Uniformity), and how rich the resulting behavioral patterns are (Complexity). Evaluating ten LLMs on personality simulation (BFI-44), moral reasoning, and self-introduction, we observe persona collapse along two axes: (1) Dimensions: a model can appear diverse on one axis yet structurally degenerate on another, and (2) Domains: the same model may collapse the most in personality yet be the most diverse in moral reasoning. Furthermore, item-level diagnostics reveal that behavioral variation tracks coarse demographic stereotypes rather than the fine-grained individual differences specified in each persona. Counter-intuitively, \textbf{the models achieving the highest per-persona fidelity consistently produce the most stereotyped populations}. We release our toolkit and data to support population-level evaluation of LLMs.

Code-Switching Information Retrieval: Benchmarks, Analysis, and the Limits of Current Retrievers

Code-switching is a pervasive linguistic phenomenon in global communication, yet modern information retrieval systems remain predominantly designed for, and evaluated within, monolingual contexts. To bridge this critical disconnect, we present a holistic study dedicated to code-switching IR. We introduce CSR-L (Code-Switching Retrieval benchmark-Lite), constructing a dataset via human annotation to capture the authentic naturalness of mixed-language queries. Our evaluation across statistical, dense, and late-interaction paradigms reveals that code-switching acts as a fundamental performance bottleneck, degrading the effectiveness of even robust multilingual models. We demonstrate that this failure stems from substantial divergence in the embedding space between pure and code-switched text. Scaling this investigation, we propose CS-MTEB, a comprehensive benchmark covering 11 diverse tasks, where we observe performance declines of up to 27%. Finally, we show that standard multilingual techniques like vocabulary expansion are insufficient to resolve these deficits completely. These findings underscore the fragility of current systems and establish code-switching as a crucial frontier for future IR optimization.

Say Something Else: Rethinking Contextual Privacy as Information Sufficiency

LLM agents increasingly draft messages on behalf of users, yet users routinely overshare sensitive information and disagree on what counts as private. Existing systems support only suppression (omitting sensitive information) and generalization (replacing information with an abstraction), and are typically evaluated on single isolated messages, leaving both the strategy space and evaluation setting incomplete. We formalize privacy-preserving LLM communication as an \textbf{Information Sufficiency (IS)} task, introduce \textbf{free-text pseudonymization} as a third strategy that replaces sensitive attributes with functionally equivalent alternatives, and propose a \textbf{conversational evaluation protocol} that assesses strategies under realistic multi-turn follow-up pressure. Across 792 scenarios spanning three power-relation types (institutional, peer, intimate) and three sensitivity categories (discrimination risk, social cost, boundary), we evaluate seven frontier LLMs on privacy at two granularities, covertness, and utility. Pseudonymization yields the strongest privacy\textendash utility tradeoff overall, and single-message evaluation systematically underestimates leakage, with generalization losing up to 16.3 percentage points of privacy under follow-up.

OpenEarth-Agent: From Tool Calling to Tool Creation for Open-Environment Earth Observation

Earth Observation (EO) is essential for perceiving dynamic land surface changes, yet deploying autonomous EO in open environments is hindered by the immense diversity of multi-source data and heterogeneous tasks. While remote sensing agents have emerged to streamline EO workflows, existing tool-calling agents are confined to closed environments. They rely on pre-defined tools and are restricted to narrow scope, limiting their generalization to the diverse data and tasks. To overcome these limitations, we introduce OpenEarth-Agent, the first tool-creation agent framework tailored for open-environment EO. Rather than calling predefined tools, OpenEarth-Agent employs adaptive workflow planning and tool creation to generalize to unseen data and tasks. This adaptability is bolstered by an open-ended integration of multi-stage tools and cross-domain knowledge bases, enabling robust execution in the entire EO pipeline across multiple application domains. To comprehensively evaluate EO agents in open environments, we propose OpenEarth-Bench, a novel benchmark comprising 596 real-world, full-pipeline cases across seven application domains, explicitly designed to assess agents' adaptive planning and tool creation capabilities. Only essential pre-trained model tools are provided in this benchmark, devoid of any other predefined task-specific tools. Extensive experiments demonstrate that OpenEarth-Agent successfully masters full-pipeline EO across multiple domains in the open environment. Notably, on the cross-benchmark Earth-Bench, our tool-creating agent equipped with 6 essential pre-trained models achieves performance comparable to tool-calling agents relying on 104 specialized tools, and significantly outperforms them when provided with the complete toolset. In several cases, the created tools exhibit superior robustness to data anomalies compared to human-engineered counterparts.

Direction-aware 3D Large Multimodal Models

3D large multimodal models (3D LMMs) rely heavily on ego poses for enabling directional question-answering and spatial reasoning. However, most existing point cloud benchmarks contain rich directional queries but lack the corresponding ego poses, making them inherently ill-posed in 3D large multimodal modelling. In this work, we redefine a new and rigorous paradigm that enables direction-aware 3D LMMs by identifying and supplementing ego poses into point cloud benchmarks and transforming the corresponding point cloud data according to the identified ego poses. We enable direction-aware 3D LMMs with two novel designs. The first is PoseRecover, a fully automatic pose recovery pipeline that matches questions with ego poses from RGB-D video extrinsics via object-frustum intersection and visibility check with Z-buffers. The second is PoseAlign that transforms the point cloud data to be aligned with the identified ego poses instead of either injecting ego poses into textual prompts or introducing pose-encoded features in the projection layers. Extensive experiments show that our designs yield consistent improvements across multiple 3D LMM backbones such as LL3DA, LL3DA-SONATA, Chat-Scene, and 3D-LLAVA, improving ScanRefer mIoU by 30.0% and Scan2Cap LLM-as-judge accuracy by 11.7%. In addition, our approach is simple, generic, and training-efficient, requiring only instruction tuning while establishing a strong baseline for direction-aware 3D-LMMs.

Experience-Driven Multi-Agent Systems Are Training-free Context-aware Earth Observers

Recent advances have enabled large language model (LLM) agents to solve complex tasks by orchestrating external tools. However, these agents often struggle in specialized, tool-intensive domains that demand long-horizon execution, tight coordination across modalities, and strict adherence to implicit tool constraints. Earth Observation (EO) tasks exemplify this challenge due to the multi-modal and multi-temporal data inputs, as well as the requirements of geo-knowledge constraints (spectrum library, spatial reasoning, etc): many high-level plans can be derailed by subtle execution errors that propagate through a pipeline and invalidate final results. A core difficulty is that existing agents lack a mechanism to learn fine-grained, tool-level expertise from interaction. Without such expertise, they cannot reliably configure tool parameters or recover from mid-execution failures, limiting their effectiveness in complex EO workflows. To address this, we introduce \textbf{GeoEvolver}, a self-evolving multi-agent system~(MAS) that enables LLM agents to acquire EO expertise through structured interaction without any parameter updates. GeoEvolver decomposes each query into independent sub-goals via a retrieval-augmented multi-agent orchestrator, then explores diverse tool-parameter configurations at the sub-goal level. Successful patterns and root-cause attribution from failures are then distilled in an evolving memory bank that provides in-context demonstrations for future queries. Experiments on three tool-integrated EO benchmarks show that GeoEvolver consistently improves end-to-end task success, with an average gain of 12\% across multiple LLM backbones, demonstrating that EO expertise can emerge progressively from efficient, fine-grained interactions with the environment.

Sentipolis: Emotion-Aware Agents for Social Simulations

LLM agents are increasingly used for social simulation, yet emotion is often treated as a transient cue, causing emotional amnesia and weak long-horizon continuity. We present Sentipolis, a framework for emotionally stateful agents that integrates continuous Pleasure-Arousal-Dominance (PAD) representation, dual-speed emotion dynamics, and emotion--memory coupling. Across thousands of interactions over multiple base models and evaluators, Sentipolis improves emotionally grounded behavior, boosting communication, and emotional continuity. Gains are model-dependent: believability increases for higher-capacity models but can drop for smaller ones, and emotion-awareness can mildly reduce adherence to social norms, reflecting a human-like tension between emotion-driven behavior and rule compliance in social simulation. Network-level diagnostics show reciprocal, moderately clustered, and temporally stable relationship structures, supporting the study of cumulative social dynamics such as alliance formation and gradual relationship change.

The Confidence Dichotomy: Analyzing and Mitigating Miscalibration in Tool-Use Agents

Autonomous agents based on large language models (LLMs) are rapidly evolving to handle multi-turn tasks, but ensuring their trustworthiness remains a critical challenge. A fundamental pillar of this trustworthiness is calibration, which refers to an agent's ability to express confidence that reliably reflects its actual performance. While calibration is well-established for static models, its dynamics in tool-integrated agentic workflows remain underexplored. In this work, we systematically investigate verbalized calibration in tool-use agents, revealing a fundamental confidence dichotomy driven by tool type. Specifically, our pilot study identifies that evidence tools (e.g., web search) systematically induce severe overconfidence due to inherent noise in retrieved information, while verification tools (e.g., code interpreters) can ground reasoning through deterministic feedback and mitigate miscalibration. To robustly improve calibration across tool types, we propose a reinforcement learning (RL) fine-tuning framework that jointly optimizes task accuracy and calibration, supported by a holistic benchmark of reward designs. We demonstrate that our trained agents not only achieve superior calibration but also exhibit robust generalization from local training environments to noisy web settings and to distinct domains such as mathematical reasoning. Our results highlight the necessity of domain-specific calibration strategies for tool-use agents. More broadly, this work establishes a foundation for building self-aware agents that can reliably communicate uncertainty in high-stakes, real-world deployments.

Toward Global Large Language Models in Medicine

Despite continuous advances in medical technology, the global distribution of health care resources remains uneven. The development of large language models (LLMs) has transformed the landscape of medicine and holds promise for improving health care quality and expanding access to medical information globally. However, existing LLMs are primarily trained on high-resource languages, limiting their applicability in global medical scenarios. To address this gap, we constructed GlobMed, a large multilingual medical dataset, containing over 500,000 entries spanning 12 languages, including four low-resource languages. Building on this, we established GlobMed-Bench, which systematically assesses 56 state-of-the-art proprietary and open-weight LLMs across multiple multilingual medical tasks, revealing significant performance disparities across languages, particularly for low-resource languages. Additionally, we introduced GlobMed-LLMs, a suite of multilingual medical LLMs trained on GlobMed, with parameters ranging from 1.7B to 8B. GlobMed-LLMs achieved an average performance improvement of over 40% relative to baseline models, with a more than threefold increase in performance on low-resource languages. Together, these resources provide an important foundation for advancing the equitable development and application of LLMs globally, enabling broader language communities to benefit from technological advances.