IDER: IDempotent Experience Replay for Reliable Continual Learning

Catastrophic forgetting, the tendency of neural networks to forget previously learned knowledge when learning new tasks, has been a major challenge in continual learning (CL). To tackle this challenge, CL methods have been proposed and shown to reduce forgetting. Furthermore, CL models deployed in mission-critical settings can benefit from uncertainty awareness by calibrating their predictions to reliably assess their confidences. However, existing uncertainty-aware continual learning methods suffer from high computational overhead and incompatibility with mainstream replay methods. To address this, we propose idempotent experience replay (IDER), a novel approach based on the idempotent property where repeated function applications yield the same output. Specifically, we first adapt the training loss to make model idempotent on current data streams. In addition, we introduce an idempotence distillation loss. We feed the output of the current model back into the old checkpoint and then minimize the distance between this reprocessed output and the original output of the current model. This yields a simple and effective new baseline for building reliable continual learners, which can be seamlessly integrated with other CL approaches. Extensive experiments on different CL benchmarks demonstrate that IDER consistently improves prediction reliability while simultaneously boosting accuracy and reducing forgetting. Our results suggest the potential of idempotence as a promising principle for deploying efficient and trustworthy continual learning systems in real-world applications.Our code is available at https://github.com/YutingLi0606/Idempotent-Continual-Learning.

MedGPT-oss: Training a General-Purpose Vision-Language Model for Biomedicine

Biomedical multimodal assistants have the potential to unify radiology, pathology, and clinical-text reasoning, yet a critical deployment gap remains: top-performing systems are either closed-source or computationally prohibitive, precluding the on-premises deployment required for patient privacy and PHI compliance. We introduce MEDGPT-OSS, an open-weight, 20B-parameter generalist vision-language model designed to facilitate open research in clinical AI. Rather than relying on architectural complexity, MEDGPT-OSS pairs the GPT-oss language backbone with a visual front-end via a optimized, three-stage training curriculum. By progressively domain-adapting these modules through rigorous data curation and long-context multimodal alignment, we demonstrate that a 20B model can bridge the capacity gap. It successfully outperforms larger open medical models on out-of-distribution (OOD) multimodal reasoning and complex text-only clinical tasks. By unifying diverse modalities under a single instruction-following interface, MEDGPT-OSS maintains a parameter-efficient footprint fully compatible with commodity GPUs. We release the complete training recipe, open-weight checkpoints, and a rigorous evaluation harness to serve as a verifiable foundation for privacy-preserving, institution-specific clinical AI research.

RankLLM: Weighted Ranking of LLMs by Quantifying Question Difficulty

Benchmarks establish a standardized evaluation framework to systematically assess the performance of large language models (LLMs), facilitating objective comparisons and driving advancements in the field. However, existing benchmarks fail to differentiate question difficulty, limiting their ability to effectively distinguish models' capabilities. To address this limitation, we propose RankLLM, a novel framework designed to quantify both question difficulty and model competency. RankLLM introduces difficulty as the primary criterion for differentiation, enabling a more fine-grained evaluation of LLM capabilities. RankLLM's core mechanism facilitates bidirectional score propagation between models and questions. The core intuition of RankLLM is that a model earns a competency score when it correctly answers a question, while a question's difficulty score increases when it challenges a model. Using this framework, we evaluate 30 models on 35,550 questions across multiple domains. RankLLM achieves 90% agreement with human judgments and consistently outperforms strong baselines such as IRT. It also exhibits strong stability, fast convergence, and high computational efficiency, making it a practical solution for large-scale, difficulty-aware LLM evaluation.

LiveMedBench: A Contamination-Free Medical Benchmark for LLMs with Automated Rubric Evaluation

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination, where test sets inadvertently leak into training corpora, leading to inflated performance estimates; and (2) temporal misalignment, failing to capture the rapid evolution of medical knowledge. Furthermore, current evaluation metrics for open-ended clinical reasoning often rely on either shallow lexical overlap (e.g., ROUGE) or subjective LLM-as-a-Judge scoring, both inadequate for verifying clinical correctness. To bridge these gaps, we introduce LiveMedBench, a continuously updated, contamination-free, and rubric-based benchmark that weekly harvests real-world clinical cases from online medical communities, ensuring strict temporal separation from model training data. We propose a Multi-Agent Clinical Curation Framework that filters raw data noise and validates clinical integrity against evidence-based medical principles. For evaluation, we develop an Automated Rubric-based Evaluation Framework that decomposes physician responses into granular, case-specific criteria, achieving substantially stronger alignment with expert physicians than LLM-as-a-Judge. To date, LiveMedBench comprises 2,756 real-world cases spanning 38 medical specialties and multiple languages, paired with 16,702 unique evaluation criteria. Extensive evaluation of 38 LLMs reveals that even the best-performing model achieves only 39.2%, and 84% of models exhibit performance degradation on post-cutoff cases, confirming pervasive data contamination risks. Error analysis further identifies contextual application-not factual knowledge-as the dominant bottleneck, with 35-48% of failures stemming from the inability to tailor medical knowledge to patient-specific constraints.

Horizon-LM: A RAM-Centric Architecture for LLM Training

The rapid growth of large language models (LLMs) has outpaced the evolution of single-GPU hardware, making model scale increasingly constrained by memory capacity rather than computation. While modern training systems extend GPU memory through distributed parallelism and offloading across CPU and storage tiers, they fundamentally retain a GPU-centric execution paradigm in which GPUs host persistent model replicas and full autograd graphs. As a result, scaling large models remains tightly coupled to multi-GPU clusters, complex distributed runtimes, and unpredictable host memory consumption, creating substantial barriers for node-scale post-training workloads such as instruction tuning, alignment, and domain adaptation. We present Horizon-LM, a memory-centric training system that redefines the roles of CPU and GPU for large-model optimization. Horizon-LM treats host memory as the authoritative parameter store and uses GPUs solely as transient compute engines through a CPU-master, GPU-template execution model. By eliminating persistent GPU-resident modules and autograd graphs, employing explicit recomputation with manual gradient propagation, and introducing a pipelined double-buffered execution engine, Horizon-LM decouples model scale from GPU count and bounds memory usage to the theoretical parameter footprint. On a single H200 GPU with 1.5\,TB host RAM, Horizon-LM reliably trains models up to 120B parameters. On a standard single A100 machine, Horizon-LM achieves up to 12.2$\times$ higher training throughput than DeepSpeed ZeRO-3 with CPU offloading while preserving numerical correctness. Across platforms and scales, Horizon-LM sustains high device utilization and predictable memory growth, demonstrating that host memory, not GPU memory, defines the true feasibility boundary for node-scale large-model training.

Beyond Affinity: A Benchmark of 1D, 2D, and 3D Methods Reveals Critical Trade-offs in Structure-Based Drug Design

Currently, the field of structure-based drug design is dominated by three main types of algorithms: search-based algorithms, deep generative models, and reinforcement learning. While existing works have typically focused on comparing models within a single algorithmic category, cross-algorithm comparisons remain scarce. In this paper, to fill the gap, we establish a benchmark to evaluate the performance of fifteen models across these different algorithmic foundations by assessing the pharmaceutical properties of the generated molecules and their docking affinities and poses with specified target proteins. We highlight the unique advantages of each algorithmic approach and offer recommendations for the design of future SBDD models. We emphasize that 1D/2D ligand-centric drug design methods can be used in SBDD by treating the docking function as a black-box oracle, which is typically neglected. Our evaluation reveals distinct patterns across model categories. 3D structure-based models excel in binding affinities but show inconsistencies in chemical validity and pose quality. 1D models demonstrate reliable performance in standard molecular metrics but rarely achieve optimal binding affinities. 2D models offer balanced performance, maintaining high chemical validity while achieving moderate binding scores. Through detailed analysis across multiple protein targets, we identify key improvement areas for each model category, providing insights for researchers to combine strengths of different approaches while addressing their limitations. All the code that are used for benchmarking is available in https://github.com/zkysfls/2025-sbdd-benchmark

Digital Twin AI: Opportunities and Challenges from Large Language Models to World Models

Digital twins, as precise digital representations of physical systems, have evolved from passive simulation tools into intelligent and autonomous entities through the integration of artificial intelligence technologies. This paper presents a unified four-stage framework that systematically characterizes AI integration across the digital twin lifecycle, spanning modeling, mirroring, intervention, and autonomous management. By synthesizing existing technologies and practices, we distill a unified four-stage framework that systematically characterizes how AI methodologies are embedded across the digital twin lifecycle: (1) modeling the physical twin through physics-based and physics-informed AI approaches, (2) mirroring the physical system into a digital twin with real-time synchronization, (3) intervening in the physical twin through predictive modeling, anomaly detection, and optimization strategies, and (4) achieving autonomous management through large language models, foundation models, and intelligent agents. We analyze the synergy between physics-based modeling and data-driven learning, highlighting the shift from traditional numerical solvers to physics-informed and foundation models for physical systems. Furthermore, we examine how generative AI technologies, including large language models and generative world models, transform digital twins into proactive and self-improving cognitive systems capable of reasoning, communication, and creative scenario generation. Through a cross-domain review spanning eleven application domains, including healthcare, aerospace, smart manufacturing, robotics, and smart cities, we identify common challenges related to scalability, explainability, and trustworthiness, and outline directions for responsible AI-driven digital twin systems.

BLURR: A Boosted Low-Resource Inference for Vision-Language-Action Models

Vision-language-action (VLA) models enable impressive zero shot manipulation, but their inference stacks are often too heavy for responsive web demos or high frequency robot control on commodity GPUs. We present BLURR, a lightweight inference wrapper that can be plugged into existing VLA controllers without retraining or changing model checkpoints. Instantiated on the pi-zero VLA controller, BLURR keeps the original observation interfaces and accelerates control by combining an instruction prefix key value cache, mixed precision execution, and a single step rollout schedule that reduces per step computation. In our SimplerEnv based evaluation, BLURR maintains task success rates comparable to the original controller while significantly lowering effective FLOPs and wall clock latency. We also build an interactive web demo that allows users to switch between controllers and toggle inference options in real time while watching manipulation episodes. This highlights BLURR as a practical approach for deploying modern VLA policies under tight compute budgets.

3D4D: An Interactive, Editable, 4D World Model via 3D Video Generation

We introduce 3D4D, an interactive 4D visualization framework that integrates WebGL with Supersplat rendering. It transforms static images and text into coherent 4D scenes through four core modules and employs a foveated rendering strategy for efficient, real-time multi-modal interaction. This framework enables adaptive, user-driven exploration of complex 4D environments. The project page and code are available at https://yunhonghe1021.github.io/NOVA/.

A Survey of AI Scientists: Surveying the automatic Scientists and Research

Artificial intelligence is undergoing a profound transition from a computational instrument to an autonomous originator of scientific knowledge. This emerging paradigm, the AI scientist, is architected to emulate the complete scientific workflow-from initial hypothesis generation to the final synthesis of publishable findings-thereby promising to fundamentally reshape the pace and scale of discovery. However, the rapid and unstructured proliferation of these systems has created a fragmented research landscape, obscuring overarching methodological principles and developmental trends. This survey provides a systematic and comprehensive synthesis of this domain by introducing a unified, six-stage methodological framework that deconstructs the end-to-end scientific process into: Literature Review, Idea Generation, Experimental Preparation, Experimental Execution, Scientific Writing, and Paper Generation. Through this analytical lens, we chart the field's evolution from early Foundational Modules (2022-2023) to integrated Closed-Loop Systems (2024), and finally to the current frontier of Scalability, Impact, and Human-AI Collaboration (2025-present). By rigorously synthesizing these developments, this survey not only clarifies the current state of autonomous science but also provides a critical roadmap for overcoming remaining challenges in robustness and governance, ultimately guiding the next generation of systems toward becoming trustworthy and indispensable partners in human scientific inquiry.