Dual Meta-Learning with Longitudinally Generalized Regularization for One-Shot Brain Tissue Segmentation Across the Human Lifespan

Brain tissue segmentation is essential for neuroscience and clinical studies. However, segmentation on longitudinal data is challenging due to dynamic brain changes across the lifespan. Previous researches mainly focus on self-supervision with regularizations and will lose longitudinal generalization when fine-tuning on a specific age group. In this paper, we propose a dual meta-learning paradigm to learn longitudinally consistent representations and persist when fine-tuning. Specifically, we learn a plug-and-play feature extractor to extract longitudinal-consistent anatomical representations by meta-feature learning and a well-initialized task head for fine-tuning by meta-initialization learning. Besides, two class-aware regularizations are proposed to encourage longitudinal consistency. Experimental results on the iSeg2019 and ADNI datasets demonstrate the effectiveness of our method. Our code is available at https://github.com/ladderlab-xjtu/DuMeta.

Investigating the Factual Knowledge Boundary of Large Language Models with Retrieval Augmentation

Knowledge-intensive tasks (e.g., open-domain question answering (QA)) require a substantial amount of factual knowledge and often rely on external information for assistance. Recently, large language models (LLMs) (e.g., ChatGPT), have demonstrated impressive prowess in solving a wide range of tasks with world knowledge, including knowledge-intensive tasks. However, it remains unclear how well LLMs are able to perceive their factual knowledge boundaries, particularly how they behave when incorporating retrieval augmentation. In this study, we present an initial analysis of the factual knowledge boundaries of LLMs and how retrieval augmentation affects LLMs on open-domain QA. Specially, we focus on three primary research questions and analyze them by examining QA performance, priori judgement and posteriori judgement of LLMs. We show evidence that LLMs possess unwavering confidence in their capabilities to respond to questions and the accuracy of their responses. Furthermore, retrieval augmentation proves to be an effective approach in enhancing LLMs' awareness of knowledge boundaries, thereby improving their judgemental abilities. Additionally, we also find that LLMs have a propensity to rely on the provided retrieval results when formulating answers, while the quality of these results significantly impacts their reliance. The code to reproduce this work is available at https://github.com/RUCAIBox/LLM-Knowledge-Boundary.

Learning Multilingual Sentence Representations with Cross-lingual Consistency Regularization

Multilingual sentence representations are the foundation for similarity-based bitext mining, which is crucial for scaling multilingual neural machine translation (NMT) system to more languages. In this paper, we introduce MuSR: a one-for-all Multilingual Sentence Representation model that supports more than 220 languages. Leveraging billions of English-centric parallel corpora, we train a multilingual Transformer encoder, coupled with an auxiliary Transformer decoder, by adopting a multilingual NMT framework with CrossConST, a cross-lingual consistency regularization technique proposed in Gao et al. (2023). Experimental results on multilingual similarity search and bitext mining tasks show the effectiveness of our approach. Specifically, MuSR achieves superior performance over LASER3 (Heffernan et al., 2022) which consists of 148 independent multilingual sentence encoders.

TOME: A Two-stage Approach for Model-based Retrieval

Recently, model-based retrieval has emerged as a new paradigm in text retrieval that discards the index in the traditional retrieval model and instead memorizes the candidate corpora using model parameters. This design employs a sequence-to-sequence paradigm to generate document identifiers, which enables the complete capture of the relevance between queries and documents and simplifies the classic indexretrieval-rerank pipeline. Despite its attractive qualities, there remain several major challenges in model-based retrieval, including the discrepancy between pre-training and fine-tuning, and the discrepancy between training and inference. To deal with the above challenges, we propose a novel two-stage model-based retrieval approach called TOME, which makes two major technical contributions, including the utilization of tokenized URLs as identifiers and the design of a two-stage generation architecture. We also propose a number of training strategies to deal with the training difficulty as the corpus size increases. Extensive experiments and analysis on MS MARCO and Natural Questions demonstrate the effectiveness of our proposed approach, and we investigate the scaling laws of TOME by examining various influencing factors.

Improving Zero-shot Multilingual Neural Machine Translation by Leveraging Cross-lingual Consistency Regularization

The multilingual neural machine translation (NMT) model has a promising capability of zero-shot translation, where it could directly translate between language pairs unseen during training. For good transfer performance from supervised directions to zero-shot directions, the multilingual NMT model is expected to learn universal representations across different languages. This paper introduces a cross-lingual consistency regularization, CrossConST, to bridge the representation gap among different languages and boost zero-shot translation performance. The theoretical analysis shows that CrossConST implicitly maximizes the probability distribution for zero-shot translation, and the experimental results on both low-resource and high-resource benchmarks show that CrossConST consistently improves the translation performance. The experimental analysis also proves that CrossConST could close the sentence representation gap and better align the representation space. Given the universality and simplicity of CrossConST, we believe it can serve as a strong baseline for future multilingual NMT research.

Synthesizing PET images from High-field and Ultra-high-field MR images Using Joint Diffusion Attention Model

MRI and PET are crucial diagnostic tools for brain diseases, as they provide complementary information on brain structure and function. However, PET scanning is costly and involves radioactive exposure, resulting in a lack of PET. Moreover, simultaneous PET and MRI at ultra-high-field are currently hardly infeasible. Ultra-high-field imaging has unquestionably proven valuable in both clinical and academic settings, especially in the field of cognitive neuroimaging. These motivate us to propose a method for synthetic PET from high-filed MRI and ultra-high-field MRI. From a statistical perspective, the joint probability distribution (JPD) is the most direct and fundamental means of portraying the correlation between PET and MRI. This paper proposes a novel joint diffusion attention model which has the joint probability distribution and attention strategy, named JDAM. JDAM has a diffusion process and a sampling process. The diffusion process involves the gradual diffusion of PET to Gaussian noise by adding Gaussian noise, while MRI remains fixed. JPD of MRI and noise-added PET was learned in the diffusion process. The sampling process is a predictor-corrector. PET images were generated from MRI by JPD of MRI and noise-added PET. The predictor is a reverse diffusion process and the corrector is Langevin dynamics. Experimental results on the public Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset demonstrate that the proposed method outperforms state-of-the-art CycleGAN for high-field MRI (3T MRI). Finally, synthetic PET images from the ultra-high-field (5T MRI and 7T MRI) be attempted, providing a possibility for ultra-high-field PET-MRI imaging.

Meta-Learning Enabled Score-Based Generative Model for 1.5T-Like Image Reconstruction from 0.5T MRI

Magnetic resonance imaging (MRI) is known to have reduced signal-to-noise ratios (SNR) at lower field strengths, leading to signal degradation when producing a low-field MRI image from a high-field one. Therefore, reconstructing a high-field-like image from a low-field MRI is a complex problem due to the ill-posed nature of the task. Additionally, obtaining paired low-field and high-field MR images is often not practical. We theoretically uncovered that the combination of these challenges renders conventional deep learning methods that directly learn the mapping from a low-field MR image to a high-field MR image unsuitable. To overcome these challenges, we introduce a novel meta-learning approach that employs a teacher-student mechanism. Firstly, an optimal-transport-driven teacher learns the degradation process from high-field to low-field MR images and generates pseudo-paired high-field and low-field MRI images. Then, a score-based student solves the inverse problem of reconstructing a high-field-like MR image from a low-field MRI within the framework of iterative regularization, by learning the joint distribution of pseudo-paired images to act as a regularizer. Experimental results on real low-field MRI data demonstrate that our proposed method outperforms state-of-the-art unpaired learning methods.

ERNIE-UniX2: A Unified Cross-lingual Cross-modal Framework for Understanding and Generation

Recent cross-lingual cross-modal works attempt to extend Vision-Language Pre-training (VLP) models to non-English inputs and achieve impressive performance. However, these models focus only on understanding tasks utilizing encoder-only architecture. In this paper, we propose ERNIE-UniX2, a unified cross-lingual cross-modal pre-training framework for both generation and understanding tasks. ERNIE-UniX2 integrates multiple pre-training paradigms (e.g., contrastive learning and language modeling) based on encoder-decoder architecture and attempts to learn a better joint representation across languages and modalities. Furthermore, ERNIE-UniX2 can be seamlessly fine-tuned for varieties of generation and understanding downstream tasks. Pre-trained on both multilingual text-only and image-text datasets, ERNIE-UniX2 achieves SOTA results on various cross-lingual cross-modal generation and understanding tasks such as multimodal machine translation and multilingual visual question answering.

CLOP: Video-and-Language Pre-Training with Knowledge Regularizations

Video-and-language pre-training has shown promising results for learning generalizable representations. Most existing approaches usually model video and text in an implicit manner, without considering explicit structural representations of the multi-modal content. We denote such form of representations as structural knowledge, which express rich semantics of multiple granularities. There are related works that propose object-aware approaches to inject similar knowledge as inputs. However, the existing methods usually fail to effectively utilize such knowledge as regularizations to shape a superior cross-modal representation space. To this end, we propose a Cross-modaL knOwledge-enhanced Pre-training (CLOP) method with Knowledge Regularizations. There are two key designs of ours: 1) a simple yet effective Structural Knowledge Prediction (SKP) task to pull together the latent representations of similar videos; and 2) a novel Knowledge-guided sampling approach for Contrastive Learning (KCL) to push apart cross-modal hard negative samples. We evaluate our method on four text-video retrieval tasks and one multi-choice QA task. The experiments show clear improvements, outperforming prior works by a substantial margin. Besides, we provide ablations and insights of how our methods affect the latent representation space, demonstrating the value of incorporating knowledge regularizations into video-and-language pre-training.

PLATO-K: Internal and External Knowledge Enhanced Dialogue Generation

Recently, the practical deployment of open-domain dialogue systems has been plagued by the knowledge issue of information deficiency and factual inaccuracy. To this end, we introduce PLATO-K based on two-stage dialogic learning to strengthen internal knowledge memorization and external knowledge exploitation. In the first stage, PLATO-K learns through massive dialogue corpora and memorizes essential knowledge into model parameters. In the second stage, PLATO-K mimics human beings to search for external information and to leverage the knowledge in response generation. Extensive experiments reveal that the knowledge issue is alleviated significantly in PLATO-K with such comprehensive internal and external knowledge enhancement. Compared to the existing state-of-the-art Chinese dialogue model, the overall engagingness of PLATO-K is improved remarkably by 36.2% and 49.2% on chit-chat and knowledge-intensive conversations.