Early Risk Stratification of Dosing Errors in Clinical Trials Using Machine Learning

Objective: The objective of this study is to develop a machine learning (ML)-based framework for early risk stratification of clinical trials (CTs) according to their likelihood of exhibiting a high rate of dosing errors, using information available prior to trial initiation. Materials and Methods: We constructed a dataset from ClinicalTrials.gov comprising 42,112 CTs. Structured, semi-structured trial data, and unstructured protocol-related free-text data were extracted. CTs were assigned binary labels indicating elevated dosing error rate, derived from adverse event reports, MedDRA terminology, and Wilson confidence intervals. We evaluated an XGBoost model trained on structured features, a ClinicalModernBERT model using textual data, and a simple late-fusion model combining both modalities. Post-hoc probability calibration was applied to enable interpretable, trial-level risk stratification. Results: The late-fusion model achieved the highest AUC-ROC (0.862). Beyond discrimination, calibrated outputs enabled robust stratification of CTs into predefined risk categories. The proportion of trials labeled as having an excessively high dosing error rate increased monotonically across higher predicted risk groups and aligned with the corresponding predicted probability ranges. Discussion: These findings indicate that dosing error risk can be anticipated at the trial level using pre-initiation information. Probability calibration was essential for translating model outputs into reliable and interpretable risk categories, while simple multimodal integration yielded performance gains without requiring complex architectures. Conclusion: This study introduces a reproducible and scalable ML framework for early, trial-level risk stratification of CTs at risk of high dosing error rates, supporting proactive, risk-based quality management in clinical research.

Fine-grained Semantics Integration for Large Language Model-based Recommendation

Recent advances in Large Language Models (LLMs) have shifted in recommendation systems from the discriminative paradigm to the LLM-based generative paradigm, where the recommender autoregressively generates sequences of semantic identifiers (SIDs) for target items conditioned on historical interaction. While prevalent LLM-based recommenders have demonstrated performance gains by aligning pretrained LLMs between the language space and the SID space, modeling the SID space still faces two fundamental challenges: (1) Semantically Meaningless Initialization: SID tokens are randomly initialized, severing the semantic linkage between the SID space and the pretrained language space at start point, and (2) Coarse-grained Alignment: existing SFT-based alignment tasks primarily focus on item-level optimization, while overlooking the semantics of individual tokens within SID sequences.To address these challenges, we propose TS-Rec, which can integrate Token-level Semantics into LLM-based Recommenders. Specifically, TS-Rec comprises two key components: (1) Semantic-Aware embedding Initialization (SA-Init), which initializes SID token embeddings by applying mean pooling to the pretrained embeddings of keywords extracted by a teacher model; and (2) Token-level Semantic Alignment (TS-Align), which aligns individual tokens within the SID sequence with the shared semantics of the corresponding item clusters. Extensive experiments on two real-world benchmarks demonstrate that TS-Rec consistently outperforms traditional and generative baselines across all standard metrics. The results demonstrate that integrating fine-grained semantic information significantly enhances the performance of LLM-based generative recommenders.

Human-Guided Agentic AI for Multimodal Clinical Prediction: Lessons from the AgentDS Healthcare Benchmark

Agentic AI systems are increasingly capable of autonomous data science workflows, yet clinical prediction tasks demand domain expertise that purely automated approaches struggle to provide. We investigate how human guidance of agentic AI can improve multimodal clinical prediction, presenting our approach to all three AgentDS Healthcare benchmark challenges: 30-day hospital readmission prediction (Macro-F1 = 0.8986), emergency department cost forecasting (MAE = $465.13), and discharge readiness assessment (Macro-F1 = 0.7939). Across these tasks, human analysts directed the agentic workflow at key decision points, multimodal feature engineering from clinical notes, scanned PDF billing receipts, and time-series vital signs; task-appropriate model selection; and clinically informed validation strategies. Our approach ranked 5th overall in the healthcare domain, with a 3rd-place finish on the discharge readiness task. Ablation studies reveal that human-guided decisions compounded to a cumulative gain of +0.065 F1 over automated baselines, with multimodal feature extraction contributing the largest single improvement (+0.041 F1). We distill three generalizable lessons: (1) domain-informed feature engineering at each pipeline stage yields compounding gains that outperform extensive automated search; (2) multimodal data integration requires task-specific human judgment that no single extraction strategy generalizes across clinical text, PDFs, and time-series; and (3) deliberate ensemble diversity with clinically motivated model configurations outperforms random hyperparameter search. These findings offer practical guidance for teams deploying agentic AI in healthcare settings where interpretability, reproducibility, and clinical validity are essential.

Powering Up Zeroth-Order Training via Subspace Gradient Orthogonalization

Zeroth-order (ZO) optimization provides a gradient-free alternative to first-order (FO) methods by estimating gradients via finite differences of function evaluations, and has recently emerged as a memory-efficient paradigm for fine-tuning large-scale models by avoiding backpropagation. However, ZO optimization has a fundamental tension between accuracy and query efficiency. In this work, we show that ZO optimization can be substantially improved by unifying two complementary principles: (i) a projection-based subspace view that reduces gradient estimation variance by exploiting the intrinsic low-rank structure of model updates, and (ii) Muon-style spectral optimization that applies gradient orthogonalization to extract informative spectral structure from noisy ZO gradients. These findings form a unified framework of subspace gradient orthogonalization, which we instantiate in a new method, ZO-Muon, admitting a natural interpretation as a low-rank Muon optimizer in the ZO setting. Extensive experiments on large language models (LLMs) and vision transformers (ViTs) demonstrate that ZO-Muon significantly accelerates convergence and achieves a win-win improvement in accuracy and query/runtime efficiency. Notably, compared to the popular MeZO baseline, ZO-Muon requires only 24.7% of the queries to reach the same SST-2 performance for LLM fine-tuning, and improves accuracy by 25.1% on ViT-B fine-tuning on CIFAR-100.

Revolutionizing Long-Term Memory in AI: New Horizons with High-Capacity and High-Speed Storage

Driven by our mission of "uplifting the world with memory," this paper explores the design concept of "memory" that is essential for achieving artificial superintelligence (ASI). Rather than proposing novel methods, we focus on several alternative approaches whose potential benefits are widely imaginable, yet have remained largely unexplored. The currently dominant paradigm, which can be termed "extract then store," involves extracting information judged to be useful from experiences and saving only the extracted content. However, this approach inherently risks the loss of information, as some valuable knowledge particularly for different tasks may be discarded in the extraction process. In contrast, we emphasize the "store then on-demand extract" approach, which seeks to retain raw experiences and flexibly apply them to various tasks as needed, thus avoiding such information loss. In addition, we highlight two further approaches: discovering deeper insights from large collections of probabilistic experiences, and improving experience collection efficiency by sharing stored experiences. While these approaches seem intuitively effective, our simple experiments demonstrate that this is indeed the case. Finally, we discuss major challenges that have limited investigation into these promising directions and propose research topics to address them.

RADE-Net: Robust Attention Network for Radar-Only Object Detection in Adverse Weather

Automotive perception systems are obligated to meet high requirements. While optical sensors such as Camera and Lidar struggle in adverse weather conditions, Radar provides a more robust perception performance, effectively penetrating fog, rain, and snow. Since full Radar tensors have large data sizes and very few datasets provide them, most Radar-based approaches work with sparse point clouds or 2D projections, which can result in information loss. Additionally, deep learning methods show potential to extract richer and more dense features from low level Radar data and therefore significantly increase the perception performance. Therefore, we propose a 3D projection method for fast-Fourier-transformed 4D Range-Azimuth-Doppler-Elevation (RADE) tensors. Our method preserves rich Doppler and Elevation features while reducing the required data size for a single frame by 91.9% compared to a full tensor, thus achieving higher training and inference speed as well as lower model complexity. We introduce RADE-Net, a lightweight model tailored to 3D projections of the RADE tensor. The backbone enables exploitation of low-level and high-level cues of Radar tensors with spatial and channel-attention. The decoupled detection heads predict object center-points directly in the Range-Azimuth domain and regress rotated 3D bounding boxes from rich feature maps in the cartesian scene. We evaluate the model on scenes with multiple different road users and under various weather conditions on the large-scale K-Radar dataset and achieve a 16.7% improvement compared to their baseline, as well as 6.5% improvement over current Radar-only models. Additionally, we outperform several Lidar approaches in scenarios with adverse weather conditions. The code is available under https://github.com/chr-is-tof/RADE-Net.

ScrapeGraphAI-100k: A Large-Scale Dataset for LLM-Based Web Information Extraction

The use of large language models for web information extraction is becoming increasingly fundamental to modern web information retrieval pipelines. However, existing datasets tend to be small, synthetic or text-only, failing to capture the structural context of the web. We introduce ScrapeGraphAI-100k, a large-scale dataset comprising real-world LLM extraction events, collected via opt-in ScrapeGraphAI telemetry during Q2 and Q3 of 2025. Starting from 9M events, we deduplicate and balance by schema to produce 93,695 examples spanning diverse domains and languages. Each instance includes Markdown content, a prompt, a JSON schema, the LLM response, and complexity/validation metadata. We characterize the datasets structural diversity and its failure modes as schema complexity increases. We also provide a fine-tuning experiment showing that a small language model (1.7B) trained on a subset narrows the gap to larger baselines (30B), underscoring the datasets utility for efficient extraction. ScrapeGraphAI-100k enables fine-tuning small models, benchmarking structured extraction, and studying schema induction for web IR indexing, and is publicly available on HuggingFace.

GrIT: Group Informed Transformer for Sequential Recommendation

Sequential recommender systems aim to predict a user's future interests by extracting temporal patterns from their behavioral history. Existing approaches typically employ transformer-based architectures to process long sequences of user interactions, capturing preference shifts by modeling temporal relationships between items. However, these methods often overlook the influence of group-level features that capture the collective behavior of similar users. We hypothesize that explicitly modeling temporally evolving group features alongside individual user histories can significantly enhance next-item recommendation. Our approach introduces latent group representations, where each user's affiliation to these groups is modeled through learnable, time-varying membership weights. The membership weights at each timestep are computed by modeling shifts in user preferences through their interaction history, where we incorporate both short-term and long-term user preferences. We extract a set of statistical features that capture the dynamics of user behavior and further refine them through a series of transformations to produce the final drift-aware membership weights. A group-based representation is derived by weighting latent group embeddings with the learned membership scores. This representation is integrated with the user's sequential representation within the transformer block to jointly capture personal and group-level temporal dynamics, producing richer embeddings that lead to more accurate, context-aware recommendations. We validate the effectiveness of our approach through extensive experiments on five benchmark datasets, where it consistently outperforms state-of-the-art sequential recommendation methods.

Memory-guided Prototypical Co-occurrence Learning for Mixed Emotion Recognition

Emotion recognition from multi-modal physiological and behavioral signals plays a pivotal role in affective computing, yet most existing models remain constrained to the prediction of singular emotions in controlled laboratory settings. Real-world human emotional experiences, by contrast, are often characterized by the simultaneous presence of multiple affective states, spurring recent interest in mixed emotion recognition as an emotion distribution learning problem. Current approaches, however, often neglect the valence consistency and structured correlations inherent among coexisting emotions. To address this limitation, we propose a Memory-guided Prototypical Co-occurrence Learning (MPCL) framework that explicitly models emotion co-occurrence patterns. Specifically, we first fuse multi-modal signals via a multi-scale associative memory mechanism. To capture cross-modal semantic relationships, we construct emotion-specific prototype memory banks, yielding rich physiological and behavioral representations, and employ prototype relation distillation to ensure cross-modal alignment in the latent prototype space. Furthermore, inspired by human cognitive memory systems, we introduce a memory retrieval strategy to extract semantic-level co-occurrence associations across emotion categories. Through this bottom-up hierarchical abstraction process, our model learns affectively informative representations for accurate emotion distribution prediction. Comprehensive experiments on two public datasets demonstrate that MPCL consistently outperforms state-of-the-art methods in mixed emotion recognition, both quantitatively and qualitatively.

CSI-RFF: Leveraging Micro-Signals on CSI for RF Fingerprinting of Commodity WiFi

This paper introduces CSI-RFF, a new framework that leverages micro-signals embedded within Channel State Information (CSI) curves to realize Radio-Frequency Fingerprinting of commodity off-the-shelf (COTS) WiFi devices for open-set authentication. The micro-signals that serve as RF fingerprints are termed ``micro-CSI''. Through experimentation, we have found that the presence of micro-CSI can primarily be attributed to imperfections in the RF circuitry. Furthermore, this characteristic signal is detectable in WiFi 4/5/6 network interface cards (NICs). We have conducted further experiments to determine the most effective CSI collection configurations to stabilize micro-CSI. Yet, extracting micro-CSI for authentication purposes poses a significant challenge. This complexity arises from the fact that CSI measurements inherently include both micro-CSI and the distortions introduced by wireless channels. These two elements are intricately intertwined, making their separation non-trivial. To tackle this challenge, we have developed a signal space-based extraction technique for line-of-sight (LoS) scenarios, which can effectively separate the distortions caused by wireless channels and micro-CSI. Over the course of our comprehensive CSI data collection period extending beyond one year, we found that the extracted micro-CSI displays unique characteristics specific to each WiFi device and remains invariant over time. This establishes micro-CSI as a suitable candidate for device fingerprinting. Finally, we conduct a case study focusing on area access control for mobile robots. Our experimental results demonstrate that the micro-CSI-based authentication algorithm can achieve an average attack detection rate close to 99% with a false alarm rate of 0% in both static and mobile conditions when using 20 CSI measurements to construct one fingerprint.