Predicting Diabetic Macular Edema Treatment Responses Using OCT: Dataset and Methods of APTOS Competition

Diabetic macular edema (DME) significantly contributes to visual impairment in diabetic patients. Treatment responses to intravitreal therapies vary, highlighting the need for patient stratification to predict therapeutic benefits and enable personalized strategies. To our knowledge, this study is the first to explore pre-treatment stratification for predicting DME treatment responses. To advance this research, we organized the 2nd Asia-Pacific Tele-Ophthalmology Society (APTOS) Big Data Competition in 2021. The competition focused on improving predictive accuracy for anti-VEGF therapy responses using ophthalmic OCT images. We provided a dataset containing tens of thousands of OCT images from 2,000 patients with labels across four sub-tasks. This paper details the competition's structure, dataset, leading methods, and evaluation metrics. The competition attracted strong scientific community participation, with 170 teams initially registering and 41 reaching the final round. The top-performing team achieved an AUC of 80.06%, highlighting the potential of AI in personalized DME treatment and clinical decision-making.

S3MOT: Monocular 3D Object Tracking with Selective State Space Model

Accurate and reliable multi-object tracking (MOT) in 3D space is essential for advancing robotics and computer vision applications. However, it remains a significant challenge in monocular setups due to the difficulty of mining 3D spatiotemporal associations from 2D video streams. In this work, we present three innovative techniques to enhance the fusion and exploitation of heterogeneous cues for monocular 3D MOT: (1) we introduce the Hungarian State Space Model (HSSM), a novel data association mechanism that compresses contextual tracking cues across multiple paths, enabling efficient and comprehensive assignment decisions with linear complexity. HSSM features a global receptive field and dynamic weights, in contrast to traditional linear assignment algorithms that rely on hand-crafted association costs. (2) We propose Fully Convolutional One-stage Embedding (FCOE), which eliminates ROI pooling by directly using dense feature maps for contrastive learning, thus improving object re-identification accuracy under challenging conditions such as varying viewpoints and lighting. (3) We enhance 6-DoF pose estimation through VeloSSM, an encoder-decoder architecture that models temporal dependencies in velocity to capture motion dynamics, overcoming the limitations of frame-based 3D inference. Experiments on the KITTI public test benchmark demonstrate the effectiveness of our method, achieving a new state-of-the-art performance of 76.86~HOTA at 31~FPS. Our approach outperforms the previous best by significant margins of +2.63~HOTA and +3.62~AssA, showcasing its robustness and efficiency for monocular 3D MOT tasks. The code and models are available at https://github.com/bytepioneerX/s3mot.

Secure Transfer Learning: Training Clean Models Against Backdoor in (Both) Pre-trained Encoders and Downstream Datasets

Transfer learning from pre-trained encoders has become essential in modern machine learning, enabling efficient model adaptation across diverse tasks. However, this combination of pre-training and downstream adaptation creates an expanded attack surface, exposing models to sophisticated backdoor embeddings at both the encoder and dataset levels--an area often overlooked in prior research. Additionally, the limited computational resources typically available to users of pre-trained encoders constrain the effectiveness of generic backdoor defenses compared to end-to-end training from scratch. In this work, we investigate how to mitigate potential backdoor risks in resource-constrained transfer learning scenarios. Specifically, we conduct an exhaustive analysis of existing defense strategies, revealing that many follow a reactive workflow based on assumptions that do not scale to unknown threats, novel attack types, or different training paradigms. In response, we introduce a proactive mindset focused on identifying clean elements and propose the Trusted Core (T-Core) Bootstrapping framework, which emphasizes the importance of pinpointing trustworthy data and neurons to enhance model security. Our empirical evaluations demonstrate the effectiveness and superiority of T-Core, specifically assessing 5 encoder poisoning attacks, 7 dataset poisoning attacks, and 14 baseline defenses across five benchmark datasets, addressing four scenarios of 3 potential backdoor threats.

HA-VLN: A Benchmark for Human-Aware Navigation in Discrete-Continuous Environments with Dynamic Multi-Human Interactions, Real-World Validation, and an Open Leaderboard

Vision-and-Language Navigation (VLN) systems often focus on either discrete (panoramic) or continuous (free-motion) paradigms alone, overlooking the complexities of human-populated, dynamic environments. We introduce a unified Human-Aware VLN (HA-VLN) benchmark that merges these paradigms under explicit social-awareness constraints. Our contributions include: 1. A standardized task definition that balances discrete-continuous navigation with personal-space requirements; 2. An enhanced human motion dataset (HAPS 2.0) and upgraded simulators capturing realistic multi-human interactions, outdoor contexts, and refined motion-language alignment; 3. Extensive benchmarking on 16,844 human-centric instructions, revealing how multi-human dynamics and partial observability pose substantial challenges for leading VLN agents; 4. Real-world robot tests validating sim-to-real transfer in crowded indoor spaces; and 5. A public leaderboard supporting transparent comparisons across discrete and continuous tasks. Empirical results show improved navigation success and fewer collisions when social context is integrated, underscoring the need for human-centric design. By releasing all datasets, simulators, agent code, and evaluation tools, we aim to advance safer, more capable, and socially responsible VLN research.

MaxSup: Overcoming Representation Collapse in Label Smoothing

Label Smoothing (LS) is widely adopted to curb overconfidence in neural network predictions and enhance generalization. However, previous research shows that LS can force feature representations into excessively tight clusters, eroding intra-class distinctions. More recent findings suggest that LS also induces overconfidence in misclassifications, yet the precise mechanism remained unclear. In this work, we decompose the loss term introduced by LS, revealing two key components: (i) a regularization term that functions only when the prediction is correct, and (ii) an error-enhancement term that emerges under misclassifications. This latter term compels the model to reinforce incorrect predictions with exaggerated certainty, further collapsing the feature space. To address these issues, we propose Max Suppression (MaxSup), which uniformly applies the intended regularization to both correct and incorrect predictions by penalizing the top-1 logit instead of the ground-truth logit. Through feature analyses, we show that MaxSup restores intra-class variation and sharpens inter-class boundaries. Extensive experiments on image classification and downstream tasks confirm that MaxSup is a more robust alternative to LS. Code is available at: https://github.com/ZhouYuxuanYX/Maximum-Suppression-Regularization.

SF-Loc: A Visual Mapping and Geo-Localization System based on Sparse Visual Structure Frames

For high-level geo-spatial applications and intelligent robotics, accurate global pose information is of crucial importance. Map-aided localization is an important and universal approach to overcome the limitations of global navigation satellite system (GNSS) in challenging environments. However, current solutions face challenges in terms of mapping flexibility, storage burden and re-localization performance. In this work, we present SF-Loc, a lightweight visual mapping and map-aided localization system, whose core idea is the map representation based on sparse frames with dense (though downsampled) depth, termed as visual structure frames. In the mapping phase, multi-sensor dense bundle adjustment (MS-DBA) is applied to construct geo-referenced visual structure frames. The local co-visbility is checked to keep the map sparsity and achieve incremental mapping. In the localization phase, coarse-to-fine vision-based localization is performed, in which multi-frame information and the map distribution are fully integrated. To be specific, the concept of spatially smoothed similarity (SSS) is proposed to overcome the place ambiguity, and pairwise frame matching is applied for efficient and robust pose estimation. Experimental results on both public and self-made datasets verify the effectiveness of the system. In complex urban road scenarios, the map size is down to 3 MB per kilometer and stable decimeter-level re-localization can be achieved. The code will be made open-source soon (https://github.com/GREAT-WHU/SF-Loc).

PretextTrans: Investigating Medical Factual Knowledge Mastery of LLMs with Predicate-text Dual Transformation

In the study, we aim to investigate current LLMs' mastery of medical factual knowledge with a dynamic evaluation schema, which can automatically generate multiple test samples for each medical factual knowledge point. Test samples produced directly by LLMs always introduce factual errors and lack diversity in the manner of knowledge expression. To overcome the drawbacks, here we propose a novel evaluation method, Predicate-text Dual Transformation (PretextTrans), by introducing predicate transformations into the dynamic evaluation schema. Specifically, each medical knowledge point is firstly transformed into a predicate expression; then, the predicate expression derives a series of variants through predicate transformations; lastly, the produced predicate variants are transformed back into textual expressions, resulting in a series of test samples with both factual reliability and expression diversity. Using the proposed PretextTrans method, we systematically investigate 12 well-known LLMs' mastery of medical factual knowledge based on two medical datasets. The comparison results show that current LLMs still have significant deficiencies in fully mastering medical knowledge, which may illustrate why current LLMs still perform unsatisfactorily in real-world medical scenarios despite having achieved considerable performance on public benchmarks. Our proposed method serves as an effective solution for evaluation of LLMs in medical domain and offers valuable insights for developing medical-specific LLMs.

iKalibr-RGBD: Partially-Specialized Target-Free Visual-Inertial Spatiotemporal Calibration For RGBDs via Continuous-Time Velocity Estimation

Visual-inertial systems have been widely studied and applied in the last two decades, mainly due to their low cost and power consumption, small footprint, and high availability. Such a trend simultaneously leads to a large amount of visual-inertial calibration methods being presented, as accurate spatiotemporal parameters between sensors are a prerequisite for visual-inertial fusion. In our previous work, i.e., iKalibr, a continuous-time-based visual-inertial calibration method was proposed as a part of one-shot multi-sensor resilient spatiotemporal calibration. While requiring no artificial target brings considerable convenience, computationally expensive pose estimation is demanded in initialization and batch optimization, limiting its availability. Fortunately, this could be vastly improved for the RGBDs with additional depth information, by employing mapping-free ego-velocity estimation instead of mapping-based pose estimation. In this paper, we present the continuous-time ego-velocity estimation-based RGBD-inertial spatiotemporal calibration, termed as iKalibr-RGBD, which is also targetless but computationally efficient. The general pipeline of iKalibr-RGBD is inherited from iKalibr, composed of a rigorous initialization procedure and several continuous-time batch optimizations. The implementation of iKalibr-RGBD is open-sourced at (https://github.com/Unsigned-Long/iKalibr) to benefit the research community.

Balancing Diversity and Risk in LLM Sampling: How to Select Your Method and Parameter for Open-Ended Text Generation

Sampling-based decoding strategies have been widely adopted for Large Language Models (LLMs) in numerous applications, which target a balance between diversity and quality via temperature tuning and tail truncation (e.g., top-k and top-p sampling). Considering the high dynamic range of the candidate next-token given different prefixes, recent studies propose to adaptively truncate the tail of LLM's predicted distribution. Although improved results haven been reported with these methods on open-ended text generation tasks, the results are highly dependent on the curated truncation parameters and exemplar text. In this paper, we propose a systematic way to estimate the intrinsic capacity of a truncation sampling method by considering the trade-off between diversity and risk at each decoding step, based on our collected prefix tree which preserves the context of a full sentence. Our work provides a comprehensive comparison between existing truncation sampling methods, as well as their recommended parameters as a guideline for users.

RIs-Calib: An Open-Source Spatiotemporal Calibrator for Multiple 3D Radars and IMUs Based on Continuous-Time Estimation

Aided inertial navigation system (INS), typically consisting of an inertial measurement unit (IMU) and an exteroceptive sensor, has been widely accepted as a feasible solution for navigation. Compared with vision-aided and LiDAR-aided INS, radar-aided INS could achieve better performance in adverse weather conditions since the radar utilizes low-frequency measuring signals with less attenuation effect in atmospheric gases and rain. For such a radar-aided INS, accurate spatiotemporal transformation is a fundamental prerequisite to achieving optimal information fusion. In this work, we present RIs-Calib: a spatiotemporal calibrator for multiple 3D radars and IMUs based on continuous-time estimation, which enables accurate spatiotemporal calibration and does not require any additional artificial infrastructure or prior knowledge. Our approach starts with a rigorous and robust procedure for state initialization, followed by batch optimizations, where all parameters can be refined to global optimal states steadily. We validate and evaluate RIs-Calib on both simulated and real-world experiments, and the results demonstrate that RIs-Calib is capable of accurate and consistent calibration. We open-source our implementations at (https://github.com/Unsigned-Long/RIs-Calib) to benefit the research community.