MetaTPT: Meta Test-time Prompt Tuning for Vision-Language Models

Vision-language models (VLMs) such as CLIP exhibit strong zero-shot generalization but remain sensitive to domain shifts at test time. Test-time prompt tuning (TPT) mitigates this issue by adapting prompts with fixed augmentations, which may falter in more challenging settings. In this work, we propose Meta Test-Time Prompt Tuning (MetaTPT), a meta-learning framework that learns a self-supervised auxiliary task to guide test-time prompt tuning. The auxiliary task dynamically learns parameterized augmentations for each sample, enabling more expressive transformations that capture essential features in target domains. MetaTPT adopts a dual-loop optimization paradigm: an inner loop learns a self-supervised task that generates informative views, while the outer loop performs prompt tuning by enforcing consistency across these views. By coupling augmentation learning with prompt tuning, MetaTPT improves test-time adaptation under domain shifts. Extensive experiments demonstrate that MetaTPT achieves state-of-the-art performance on domain generalization and cross-dataset benchmarks.

Empowering Clinical Trial Design through AI: A Randomized Evaluation of PowerGPT

Sample size calculations for power analysis are critical for clinical research and trial design, yet their complexity and reliance on statistical expertise create barriers for many researchers. We introduce PowerGPT, an AI-powered system integrating large language models (LLMs) with statistical engines to automate test selection and sample size estimation in trial design. In a randomized trial to evaluate its effectiveness, PowerGPT significantly improved task completion rates (99.3% vs. 88.9% for test selection, 99.3% vs. 77.8% for sample size calculation) and accuracy (94.1% vs. 55.4% in sample size estimation, p < 0.001), while reducing average completion time (4.0 vs. 9.3 minutes, p < 0.001). These gains were consistent across various statistical tests and benefited both statisticians and non-statisticians as well as bridging expertise gaps. Already under deployment across multiple institutions, PowerGPT represents a scalable AI-driven approach that enhances accessibility, efficiency, and accuracy in statistical power analysis for clinical research.