TauGenNet: Plasma-Driven Tau PET Image Synthesis via Text-Guided 3D Diffusion Models

Accurate quantification of tau pathology via tau positron emission tomography (PET) scan is crucial for diagnosing and monitoring Alzheimer's disease (AD). However, the high cost and limited availability of tau PET restrict its widespread use. In contrast, structural magnetic resonance imaging (MRI) and plasma-based biomarkers provide non-invasive and widely available complementary information related to brain anatomy and disease progression. In this work, we propose a text-guided 3D diffusion model for 3D tau PET image synthesis, leveraging multimodal conditions from both structural MRI and plasma measurement. Specifically, the textual prompt is from the plasma p-tau217 measurement, which is a key indicator of AD progression, while MRI provides anatomical structure constraints. The proposed framework is trained and evaluated using clinical AV1451 tau PET data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Experimental results demonstrate that our approach can generate realistic, clinically meaningful 3D tau PET across a range of disease stages. The proposed framework can help perform tau PET data augmentation under different settings, provide a non-invasive, cost-effective alternative for visualizing tau pathology, and support the simulation of disease progression under varying plasma biomarker levels and cognitive conditions.

OneRec-V2 Technical Report

Recent breakthroughs in generative AI have transformed recommender systems through end-to-end generation. OneRec reformulates recommendation as an autoregressive generation task, achieving high Model FLOPs Utilization. While OneRec-V1 has shown significant empirical success in real-world deployment, two critical challenges hinder its scalability and performance: (1) inefficient computational allocation where 97.66% of resources are consumed by sequence encoding rather than generation, and (2) limitations in reinforcement learning relying solely on reward models. To address these challenges, we propose OneRec-V2, featuring: (1) Lazy Decoder-Only Architecture: Eliminates encoder bottlenecks, reducing total computation by 94% and training resources by 90%, enabling successful scaling to 8B parameters. (2) Preference Alignment with Real-World User Interactions: Incorporates Duration-Aware Reward Shaping and Adaptive Ratio Clipping to better align with user preferences using real-world feedback. Extensive A/B tests on Kuaishou demonstrate OneRec-V2's effectiveness, improving App Stay Time by 0.467%/0.741% while balancing multi-objective recommendations. This work advances generative recommendation scalability and alignment with real-world feedback, representing a step forward in the development of end-to-end recommender systems.

Understanding How Value Neurons Shape the Generation of Specified Values in LLMs

Rapid integration of large language models (LLMs) into societal applications has intensified concerns about their alignment with universal ethical principles, as their internal value representations remain opaque despite behavioral alignment advancements. Current approaches struggle to systematically interpret how values are encoded in neural architectures, limited by datasets that prioritize superficial judgments over mechanistic analysis. We introduce ValueLocate, a mechanistic interpretability framework grounded in the Schwartz Values Survey, to address this gap. Our method first constructs ValueInsight, a dataset that operationalizes four dimensions of universal value through behavioral contexts in the real world. Leveraging this dataset, we develop a neuron identification method that calculates activation differences between opposing value aspects, enabling precise localization of value-critical neurons without relying on computationally intensive attribution methods. Our proposed validation method demonstrates that targeted manipulation of these neurons effectively alters model value orientations, establishing causal relationships between neurons and value representations. This work advances the foundation for value alignment by bridging psychological value frameworks with neuron analysis in LLMs.

Toward Effective Reinforcement Learning Fine-Tuning for Medical VQA in Vision-Language Models

Recently, reinforcement learning (RL)-based tuning has shifted the trajectory of Multimodal Large Language Models (MLLMs), particularly following the introduction of Group Relative Policy Optimization (GRPO). However, directly applying it to medical tasks remains challenging for achieving clinically grounded model behavior. Motivated by the need to align model response with clinical expectations, we investigate four critical dimensions that affect the effectiveness of RL-based tuning in medical visual question answering (VQA): base model initialization strategy, the role of medical semantic alignment, the impact of length-based rewards on long-chain reasoning, and the influence of bias. We conduct extensive experiments to analyze these factors for medical MLLMs, providing new insights into how models are domain-specifically fine-tuned. Additionally, our results also demonstrate that GRPO-based RL tuning consistently outperforms standard supervised fine-tuning (SFT) in both accuracy and reasoning quality.

Accurate KV Cache Quantization with Outlier Tokens Tracing

The impressive capabilities of Large Language Models (LLMs) come at the cost of substantial computational resources during deployment. While KV Cache can significantly reduce recomputation during inference, it also introduces additional memory overhead. KV Cache quantization presents a promising solution, striking a good balance between memory usage and accuracy. Previous research has shown that the Keys are distributed by channel, while the Values are distributed by token. Consequently, the common practice is to apply channel-wise quantization to the Keys and token-wise quantization to the Values. However, our further investigation reveals that a small subset of unusual tokens exhibit unique characteristics that deviate from this pattern, which can substantially impact quantization accuracy. To address this, we develop a simple yet effective method to identify these tokens accurately during the decoding process and exclude them from quantization as outlier tokens, significantly improving overall accuracy. Extensive experiments show that our method achieves significant accuracy improvements under 2-bit quantization and can deliver a 6.4 times reduction in memory usage and a 2.3 times increase in throughput.

Talk Before You Retrieve: Agent-Led Discussions for Better RAG in Medical QA

Medical question answering (QA) is a reasoning-intensive task that remains challenging for large language models (LLMs) due to hallucinations and outdated domain knowledge. Retrieval-Augmented Generation (RAG) provides a promising post-training solution by leveraging external knowledge. However, existing medical RAG systems suffer from two key limitations: (1) a lack of modeling for human-like reasoning behaviors during information retrieval, and (2) reliance on suboptimal medical corpora, which often results in the retrieval of irrelevant or noisy snippets. To overcome these challenges, we propose Discuss-RAG, a plug-and-play module designed to enhance the medical QA RAG system through collaborative agent-based reasoning. Our method introduces a summarizer agent that orchestrates a team of medical experts to emulate multi-turn brainstorming, thereby improving the relevance of retrieved content. Additionally, a decision-making agent evaluates the retrieved snippets before their final integration. Experimental results on four benchmark medical QA datasets show that Discuss-RAG consistently outperforms MedRAG, especially significantly improving answer accuracy by up to 16.67% on BioASQ and 12.20% on PubMedQA. The code is available at: https://github.com/LLM-VLM-GSL/Discuss-RAG.

Crossing the Reward Bridge: Expanding RL with Verifiable Rewards Across Diverse Domains

Reinforcement learning with verifiable rewards (RLVR) has demonstrated significant success in enhancing mathematical reasoning and coding performance of large language models (LLMs), especially when structured reference answers are accessible for verification. However, its extension to broader, less structured domains remains unexplored. In this work, we investigate the effectiveness and scalability of RLVR across diverse real-world domains including medicine, chemistry, psychology, economics, and education, where structured reference answers are typically unavailable. We reveal that binary verification judgments on broad-domain tasks exhibit high consistency across various LLMs provided expert-written reference answers exist. Motivated by this finding, we utilize a generative scoring technique that yields soft, model-based reward signals to overcome limitations posed by binary verifications, especially in free-form, unstructured answer scenarios. We further demonstrate the feasibility of training cross-domain generative reward models using relatively small (7B) LLMs without the need for extensive domain-specific annotation. Through comprehensive experiments, our RLVR framework establishes clear performance gains, significantly outperforming state-of-the-art open-source aligned models such as Qwen2.5-72B and DeepSeek-R1-Distill-Qwen-32B across domains in free-form settings. Our approach notably enhances the robustness, flexibility, and scalability of RLVR, representing a substantial step towards practical reinforcement learning applications in complex, noisy-label scenarios.

Enhancing Alzheimer's Diagnosis: Leveraging Anatomical Landmarks in Graph Convolutional Neural Networks on Tetrahedral Meshes

Alzheimer's disease (AD) is a major neurodegenerative condition that affects millions around the world. As one of the main biomarkers in the AD diagnosis procedure, brain amyloid positivity is typically identified by positron emission tomography (PET), which is costly and invasive. Brain structural magnetic resonance imaging (sMRI) may provide a safer and more convenient solution for the AD diagnosis. Recent advances in geometric deep learning have facilitated sMRI analysis and early diagnosis of AD. However, determining AD pathology, such as brain amyloid deposition, in preclinical stage remains challenging, as less significant morphological changes can be observed. As a result, few AD classification models are generalizable to the brain amyloid positivity classification task. Blood-based biomarkers (BBBMs), on the other hand, have recently achieved remarkable success in predicting brain amyloid positivity and identifying individuals with high risk of being brain amyloid positive. However, individuals in medium risk group still require gold standard tests such as Amyloid PET for further evaluation. Inspired by the recent success of transformer architectures, we propose a geometric deep learning model based on transformer that is both scalable and robust to variations in input volumetric mesh size. Our work introduced a novel tokenization scheme for tetrahedral meshes, incorporating anatomical landmarks generated by a pre-trained Gaussian process model. Our model achieved superior classification performance in AD classification task. In addition, we showed that the model was also generalizable to the brain amyloid positivity prediction with individuals in the medium risk class, where BM alone cannot achieve a clear classification. Our work may enrich geometric deep learning research and improve AD diagnosis accuracy without using expensive and invasive PET scans.

RetinalGPT: A Retinal Clinical Preference Conversational Assistant Powered by Large Vision-Language Models

Recently, Multimodal Large Language Models (MLLMs) have gained significant attention for their remarkable ability to process and analyze non-textual data, such as images, videos, and audio. Notably, several adaptations of general-domain MLLMs to the medical field have been explored, including LLaVA-Med. However, these medical adaptations remain insufficiently advanced in understanding and interpreting retinal images. In contrast, medical experts emphasize the importance of quantitative analyses for disease detection and interpretation. This underscores a gap between general-domain and medical-domain MLLMs: while general-domain MLLMs excel in broad applications, they lack the specialized knowledge necessary for precise diagnostic and interpretative tasks in the medical field. To address these challenges, we introduce \textit{RetinalGPT}, a multimodal conversational assistant for clinically preferred quantitative analysis of retinal images. Specifically, we achieve this by compiling a large retinal image dataset, developing a novel data pipeline, and employing customized visual instruction tuning to enhance both retinal analysis and enrich medical knowledge. In particular, RetinalGPT outperforms MLLM in the generic domain by a large margin in the diagnosis of retinal diseases in 8 benchmark retinal datasets. Beyond disease diagnosis, RetinalGPT features quantitative analyses and lesion localization, representing a pioneering step in leveraging LLMs for an interpretable and end-to-end clinical research framework. The code is available at https://github.com/Retinal-Research/RetinalGPT

EyeBench: A Call for More Rigorous Evaluation of Retinal Image Enhancement

Over the past decade, generative models have achieved significant success in enhancement fundus images.However, the evaluation of these models still presents a considerable challenge. A comprehensive evaluation benchmark for fundus image enhancement is indispensable for three main reasons: 1) The existing denoising metrics (e.g., PSNR, SSIM) are hardly to extend to downstream real-world clinical research (e.g., Vessel morphology consistency). 2) There is a lack of comprehensive evaluation for both paired and unpaired enhancement methods, along with the need for expert protocols to accurately assess clinical value. 3) An ideal evaluation system should provide insights to inform future developments of fundus image enhancement. To this end, we propose a novel comprehensive benchmark, EyeBench, to provide insights that align enhancement models with clinical needs, offering a foundation for future work to improve the clinical relevance and applicability of generative models for fundus image enhancement. EyeBench has three appealing properties: 1) multi-dimensional clinical alignment downstream evaluation: In addition to evaluating the enhancement task, we provide several clinically significant downstream tasks for fundus images, including vessel segmentation, DR grading, denoising generalization, and lesion segmentation. 2) Medical expert-guided evaluation design: We introduce a novel dataset that promote comprehensive and fair comparisons between paired and unpaired methods and includes a manual evaluation protocol by medical experts. 3) Valuable insights: Our benchmark study provides a comprehensive and rigorous evaluation of existing methods across different downstream tasks, assisting medical experts in making informed choices. Additionally, we offer further analysis of the challenges faced by existing methods. The code is available at \url{https://github.com/Retinal-Research/EyeBench}