NoteChat: A Dataset of Synthetic Doctor-Patient Conversations Conditioned on Clinical Notes

The detailed clinical records drafted by doctors after each patient's visit are crucial for medical practitioners and researchers. Automating the creation of these notes with language models can reduce the workload of doctors. However, training such models can be difficult due to the limited public availability of conversations between patients and doctors. In this paper, we introduce NoteChat, a cooperative multi-agent framework leveraging Large Language Models (LLMs) for generating synthetic doctor-patient conversations conditioned on clinical notes. NoteChat consists of Planning, Roleplay, and Polish modules. We provide a comprehensive automatic and human evaluation of NoteChat, comparing it with state-of-the-art models, including OpenAI's ChatGPT and GPT-4. Results demonstrate that NoteChat facilitates high-quality synthetic doctor-patient conversations, underscoring the untapped potential of LLMs in healthcare. This work represents the first instance of multiple LLMs cooperating to complete a doctor-patient conversation conditioned on clinical notes, offering promising avenues for the intersection of AI and healthcare

Robust Visual Imitation Learning with Inverse Dynamics Representations

Imitation learning (IL) has achieved considerable success in solving complex sequential decision-making problems. However, current IL methods mainly assume that the environment for learning policies is the same as the environment for collecting expert datasets. Therefore, these methods may fail to work when there are slight differences between the learning and expert environments, especially for challenging problems with high-dimensional image observations. However, in real-world scenarios, it is rare to have the chance to collect expert trajectories precisely in the target learning environment. To address this challenge, we propose a novel robust imitation learning approach, where we develop an inverse dynamics state representation learning objective to align the expert environment and the learning environment. With the abstract state representation, we design an effective reward function, which thoroughly measures the similarity between behavior data and expert data not only element-wise, but also from the trajectory level. We conduct extensive experiments to evaluate the proposed approach under various visual perturbations and in diverse visual control tasks. Our approach can achieve a near-expert performance in most environments, and significantly outperforms the state-of-the-art visual IL methods and robust IL methods.

SCALE: Synergized Collaboration of Asymmetric Language Translation Engines

In this paper, we introduce SCALE, a collaborative framework that connects compact Specialized Translation Models (STMs) and general-purpose Large Language Models (LLMs) as one unified translation engine. By introducing translation from STM into the triplet in-context demonstrations, SCALE unlocks refinement and pivoting ability of LLM, thus mitigating language bias of LLM and parallel data bias of STM, enhancing LLM speciality without sacrificing generality, and facilitating continual learning without expensive LLM fine-tuning. Our comprehensive experiments show that SCALE significantly outperforms both few-shot LLMs (GPT-4) and specialized models (NLLB) in challenging low-resource settings. Moreover, in Xhosa to English translation, SCALE experiences consistent improvement by a 4 BLEURT score without tuning LLM and surpasses few-shot GPT-4 by 2.5 COMET score and 3.8 BLEURT score when equipped with a compact model consisting of merely 600M parameters. SCALE could also effectively exploit the existing language bias of LLMs by using an English-centric STM as a pivot for translation between any language pairs, outperforming few-shot GPT-4 by an average of 6 COMET points across eight translation directions. Furthermore we provide an in-depth analysis of SCALE's robustness, translation characteristics, and latency costs, providing solid foundation for future studies exploring the potential synergy between LLMs and more specialized, task-specific models.

Dual-view Curricular Optimal Transport for Cross-lingual Cross-modal Retrieval

Current research on cross-modal retrieval is mostly English-oriented, as the availability of a large number of English-oriented human-labeled vision-language corpora. In order to break the limit of non-English labeled data, cross-lingual cross-modal retrieval (CCR) has attracted increasing attention. Most CCR methods construct pseudo-parallel vision-language corpora via Machine Translation (MT) to achieve cross-lingual transfer. However, the translated sentences from MT are generally imperfect in describing the corresponding visual contents. Improperly assuming the pseudo-parallel data are correctly correlated will make the networks overfit to the noisy correspondence. Therefore, we propose Dual-view Curricular Optimal Transport (DCOT) to learn with noisy correspondence in CCR. In particular, we quantify the confidence of the sample pair correlation with optimal transport theory from both the cross-lingual and cross-modal views, and design dual-view curriculum learning to dynamically model the transportation costs according to the learning stage of the two views. Extensive experiments are conducted on two multilingual image-text datasets and one video-text dataset, and the results demonstrate the effectiveness and robustness of the proposed method. Besides, our proposed method also shows a good expansibility to cross-lingual image-text baselines and a decent generalization on out-of-domain data.

ODD: A Benchmark Dataset for the NLP-based Opioid Related Aberrant Behavior Detection

Opioid related aberrant behaviors (ORAB) present novel risk factors for opioid overdose. Previously, ORAB have been mainly assessed by survey results and by monitoring drug administrations. Such methods however, cannot scale up and do not cover the entire spectrum of aberrant behaviors. On the other hand, ORAB are widely documented in electronic health record notes. This paper introduces a novel biomedical natural language processing benchmark dataset named ODD, for ORAB Detection Dataset. ODD is an expert-annotated dataset comprising of more than 750 publicly available EHR notes. ODD has been designed to identify ORAB from patients' EHR notes and classify them into nine categories; 1) Confirmed Aberrant Behavior, 2) Suggested Aberrant Behavior, 3) Opioids, 4) Indication, 5) Diagnosed opioid dependency, 6) Benzodiapines, 7) Medication Changes, 8) Central Nervous System-related, and 9) Social Determinants of Health. We explored two state-of-the-art natural language processing (NLP) models (finetuning pretrained language models and prompt-tuning approaches) to identify ORAB. Experimental results show that the prompt-tuning models outperformed the finetuning models in most cateogories and the gains were especially higher among uncommon categories (Suggested aberrant behavior, Diagnosed opioid dependency and Medication change). Although the best model achieved the highest 83.92% on area under precision recall curve, uncommon classes (Suggested Aberrant Behavior, Diagnosed Opioid Dependence, and Medication Change) still have a large room for performance improvement.

Early Prediction of Alzheimers Disease Leveraging Symptom Occurrences from Longitudinal Electronic Health Records of US Military Veterans

Early prediction of Alzheimer's disease (AD) is crucial for timely intervention and treatment. This study aims to use machine learning approaches to analyze longitudinal electronic health records (EHRs) of patients with AD and identify signs and symptoms that can predict AD onset earlier. We used a case-control design with longitudinal EHRs from the U.S. Department of Veterans Affairs Veterans Health Administration (VHA) from 2004 to 2021. Cases were VHA patients with AD diagnosed after 1/1/2016 based on ICD-10-CM codes, matched 1:9 with controls by age, sex and clinical utilization with replacement. We used a panel of AD-related keywords and their occurrences over time in a patient's longitudinal EHRs as predictors for AD prediction with four machine learning models. We performed subgroup analyses by age, sex, and race/ethnicity, and validated the model in a hold-out and "unseen" VHA stations group. Model discrimination, calibration, and other relevant metrics were reported for predictions up to ten years before ICD-based diagnosis. The study population included 16,701 cases and 39,097 matched controls. The average number of AD-related keywords (e.g., "concentration", "speaking") per year increased rapidly for cases as diagnosis approached, from around 10 to over 40, while remaining flat at 10 for controls. The best model achieved high discriminative accuracy (ROCAUC 0.997) for predictions using data from at least ten years before ICD-based diagnoses. The model was well-calibrated (Hosmer-Lemeshow goodness-of-fit p-value = 0.99) and consistent across subgroups of age, sex and race/ethnicity, except for patients younger than 65 (ROCAUC 0.746). Machine learning models using AD-related keywords identified from EHR notes can predict future AD diagnoses, suggesting its potential use for identifying AD risk using EHR notes, offering an affordable way for early screening on large population.

In-context Autoencoder for Context Compression in a Large Language Model

We propose the In-context Autoencoder (ICAE) for context compression in a large language model (LLM). The ICAE has two modules: a learnable encoder adapted with LoRA from an LLM for compressing a long context into a limited number of memory slots, and a fixed decoder which is the target LLM that can condition on the memory slots for various purposes. We first pretrain the ICAE using both autoencoding and language modeling objectives on massive text data, enabling it to generate memory slots that accurately and comprehensively represent the original context. Then, we fine-tune the pretrained ICAE on a small amount of instruct data to enhance its interaction with various prompts for producing desirable responses. Our experimental results demonstrate that the ICAE learned with our proposed pretraining and fine-tuning paradigm can effectively produce memory slots with $4\times$ context compression, which can be well conditioned on by the target LLM to respond to various prompts. The promising results demonstrate significant implications of the ICAE for its novel approach to the long context problem and its potential to reduce computation and memory overheads for LLM inference in practice, suggesting further research effort in context management for an LLM. Our code and data will be released shortly.

End-to-End Out-of-distribution Detection with Self-supervised Sampling

Out-of-distribution (OOD) detection empowers the model trained on the closed set to identify unknown data in the open world. Though many prior techniques have yielded considerable improvements, two crucial obstacles still remain. Firstly, a unified perspective has yet to be presented to view the developed arts with individual designs, which is vital for providing insights into the related directions. Secondly, most research focuses on the post-processing schemes of the pre-trained features while disregarding the superiority of end-to-end training, dramatically limiting the upper bound of OOD detection. To tackle these issues, we propose a general probabilistic framework to interpret many existing methods and an OOD-data-free model, namely Self-supervised Sampling for OOD Detection (SSOD), to unfold the potential of end-to-end learning. SSOD efficiently exploits natural OOD signals from the in-distribution (ID) data based on the local property of convolution. With these supervisions, it jointly optimizes the OOD detection and conventional ID classification. Extensive experiments reveal that SSOD establishes competitive state-of-the-art performance on many large-scale benchmarks, where it outperforms the most recent approaches, such as KNN, by a large margin, e.g., 48.99% to 35.52% on SUN at FPR95.

Interactive Editing for Text Summarization

Summarizing lengthy documents is a common and essential task in our daily lives. Although recent advancements in neural summarization models can assist in crafting general-purpose summaries, human writers often have specific requirements that call for a more customized approach. To address this need, we introduce REVISE (Refinement and Editing via Iterative Summarization Enhancement), an innovative framework designed to facilitate iterative editing and refinement of draft summaries by human writers. Within our framework, writers can effortlessly modify unsatisfactory segments at any location or length and provide optional starting phrases -- our system will generate coherent alternatives that seamlessly integrate with the existing summary. At its core, REVISE incorporates a modified fill-in-the-middle model with the encoder-decoder architecture while developing novel evaluation metrics tailored for the summarization task. In essence, our framework empowers users to create high-quality, personalized summaries by effectively harnessing both human expertise and AI capabilities, ultimately transforming the summarization process into a truly collaborative and adaptive experience.