Department of Biomedical Engineering, School of Basic Medical Sciences, Central South University, 172 Tongzipo Road, Changsha, 410013, China
Abstract:Large language models (LLMs) achieve remarkable performance, yet further gains often require costly training. This has motivated growing interest in post-training techniques-especially training-free approaches that improve models at inference time without updating weights. Most training-free methods treat the model as a black box and improve outputs via input/output-level interventions, such as prompt design and test-time scaling through repeated sampling, reranking/verification, or search. In contrast, they rarely offer a plug-and-play mechanism to intervene in a model's internal computation. We propose ARACH(Attention Reallocation via an Adaptive Context Hub), a training-free inference-time plug-in that augments LLMs with an adaptive context hub to aggregate context and reallocate attention. Extensive experiments across multiple language modeling tasks show consistent improvements with modest inference overhead and no parameter updates. Attention analyses further suggest that ARACH mitigates the attention sink phenomenon. These results indicate that engineering a model's internal computation offers a distinct inference-time strategy, fundamentally different from both prompt-based test-time methods and training-based post-training approaches.
Abstract:Tooth image segmentation is a cornerstone of dental digitization. However, traditional image encoders relying on fixed-resolution feature maps often lead to discontinuous segmentation and poor discrimination between target regions and background, due to insufficient modeling of environmental and global context. Moreover, transformer-based self-attention introduces substantial computational overhead because of its quadratic complexity (O(n^2)), making it inefficient for high-resolution dental images. To address these challenges, we introduce a three-stage encoder with hierarchical feature representation to capture scale-adaptive information in dental images. By jointly leveraging low-level details and high-level semantics through cross-scale feature fusion, the model effectively preserves fine structural information while maintaining strong contextual awareness. Furthermore, a bidirectional sequence modeling strategy is incorporated to enhance global spatial context understanding without incurring high computational cost. We validate our method on two dental datasets, with experimental results demonstrating its superiority over existing approaches. On the OralVision dataset, our model achieves a 1.1% improvement in mean intersection over union (mIoU).
Abstract:Cellular identity and function are linked to both their intrinsic genomic makeup and extrinsic spatial context within the tissue microenvironment. Spatial transcriptomics (ST) offers an unprecedented opportunity to study this, providing in situ gene expression profiles at single-cell resolution and illuminating the spatial and functional organization of cells within tissues. However, a significant hurdle remains: ST data is inherently noisy, large, and structurally complex. This complexity makes it intractable for existing computational methods to effectively capture the interplay between spatial interactions and intrinsic genomic relationships, thus limiting our ability to discern critical biological patterns. Here, we present CellScape, a deep learning framework designed to overcome these limitations for high-performance ST data analysis and pattern discovery. CellScape jointly models cellular interactions in tissue space and genomic relationships among cells, producing comprehensive representations that seamlessly integrate spatial signals with underlying gene regulatory mechanisms. This technique uncovers biologically informative patterns that improve spatial domain segmentation and supports comprehensive spatial cellular analyses across diverse transcriptomics datasets, offering an accurate and versatile framework for deep analysis and interpretation of ST data.w
Abstract:AI agents are increasingly used to solve real-world tasks by reasoning over multi-turn user interactions and invoking external tools. However, applying reinforcement learning to such settings remains difficult: realistic objectives often lack verifiable rewards and instead emphasize open-ended behaviors; moreover, RL for multi-turn, multi-step agentic tool use is still underexplored; and building and maintaining executable tool environments is costly, limiting scale and coverage. We propose CM2, an RL framework that replaces verifiable outcome rewards with checklist rewards. CM2 decomposes each turn's intended behavior into fine-grained binary criteria with explicit evidence grounding and structured metadata, turning open-ended judging into more stable classification-style decisions. To balance stability and informativeness, our method adopts a strategy of sparse reward assignment but dense evaluation criteria. Training is performed in a scalable LLM-simulated tool environment, avoiding heavy engineering for large tool sets. Experiments show that CM2 consistently improves over supervised fine-tuning. Starting from an 8B Base model and training on an 8k-example RL dataset, CM2 improves over the SFT counterpart by 8 points on tau^-Bench, by 10 points on BFCL-V4, and by 12 points on ToolSandbox. The results match or even outperform similarly sized open-source baselines, including the judging model. CM2 thus provides a scalable recipe for optimizing multi-turn, multi-step tool-using agents without relying on verifiable rewards. Code provided by the open-source community: https://github.com/namezhenzhang/CM2-RLCR-Tool-Agent.
Abstract:Reparameterization Policy Gradient (RPG) has emerged as a powerful paradigm for model-based reinforcement learning, enabling high sample efficiency by backpropagating gradients through differentiable dynamics. However, prior RPG approaches have been predominantly restricted to Gaussian policies, limiting their performance and failing to leverage recent advances in generative models. In this work, we identify that flow policies, which generate actions via differentiable ODE integration, naturally align with the RPG framework, a connection not established in prior work. However, naively exploiting this synergy proves ineffective, often suffering from training instability and a lack of exploration. We propose Reparameterization Flow Policy Optimization (RFO). RFO computes policy gradients by backpropagating jointly through the flow generation process and system dynamics, unlocking high sample efficiency without requiring intractable log-likelihood calculations. RFO includes two tailored regularization terms for stability and exploration. We also propose a variant of RFO with action chunking. Extensive experiments on diverse locomotion and manipulation tasks, involving both rigid and soft bodies with state or visual inputs, demonstrate the effectiveness of RFO. Notably, on a challenging locomotion task controlling a soft-body quadruped, RFO achieves almost $2\times$ the reward of the state-of-the-art baseline.
Abstract:With the continued scaling of advanced technology nodes, the design-technology co-optimization (DTCO) paradigm has become increasingly critical, rendering efficient device design and optimization essential. In the domain of TCAD simulation, however, the scarcity of open-source resources hinders language models from generating valid TCAD code. To overcome this limitation, we construct an open-source TCAD dataset curated by experts and fine-tune a domain-specific model for TCAD code generation. Building on this foundation, we propose AgenticTCAD, a natural language - driven multi-agent framework that enables end-to-end automated device design and optimization. Validation on a 2 nm nanosheet FET (NS-FET) design shows that AgenticTCAD achieves the International Roadmap for Devices and Systems (IRDS)-2024 device specifications within 4.2 hours, whereas human experts required 7.1 days with commercial tools.




Abstract:Garment-centric fashion image generation aims to synthesize realistic and controllable human models dressing a given garment, which has attracted growing interest due to its practical applications in e-commerce. The key challenges of the task lie in two aspects: (1) faithfully preserving the garment details, and (2) gaining fine-grained controllability over the model's appearance. Existing methods typically require performing garment deformation in the generation process, which often leads to garment texture distortions. Also, they fail to control the fine-grained attributes of the generated models, due to the lack of specifically designed mechanisms. To address these issues, we propose FashionMAC, a novel diffusion-based deformation-free framework that achieves high-quality and controllable fashion showcase image generation. The core idea of our framework is to eliminate the need for performing garment deformation and directly outpaint the garment segmented from a dressed person, which enables faithful preservation of the intricate garment details. Moreover, we propose a novel region-adaptive decoupled attention (RADA) mechanism along with a chained mask injection strategy to achieve fine-grained appearance controllability over the synthesized human models. Specifically, RADA adaptively predicts the generated regions for each fine-grained text attribute and enforces the text attribute to focus on the predicted regions by a chained mask injection strategy, significantly enhancing the visual fidelity and the controllability. Extensive experiments validate the superior performance of our framework compared to existing state-of-the-art methods.
Abstract:Existing multi-person video pose estimation methods typically adopt a two-stage pipeline: detecting individuals in each frame, followed by temporal modeling for single-person pose estimation. This design relies on heuristic operations such as detection, RoI cropping, and non-maximum suppression (NMS), limiting both accuracy and efficiency. In this paper, we present a fully end-to-end framework for multi-person 2D pose estimation in videos, effectively eliminating heuristic operations. A key challenge is to associate individuals across frames under complex and overlapping temporal trajectories. To address this, we introduce a novel Pose-Aware Video transformEr Network (PAVE-Net), which features a spatial encoder to model intra-frame relations and a spatiotemporal pose decoder to capture global dependencies across frames. To achieve accurate temporal association, we propose a pose-aware attention mechanism that enables each pose query to selectively aggregate features corresponding to the same individual across consecutive frames.Additionally, we explicitly model spatiotemporal dependencies among pose keypoints to improve accuracy. Notably, our approach is the first end-to-end method for multi-frame 2D human pose estimation.Extensive experiments show that PAVE-Net substantially outperforms prior image-based end-to-end methods, achieving a \textbf{6.0} mAP improvement on PoseTrack2017, and delivers accuracy competitive with state-of-the-art two-stage video-based approaches, while offering significant gains in efficiency.Project page: https://github.com/zgspose/PAVENet
Abstract:Instruction following has catalyzed the recent era of Large Language Models (LLMs) and is the foundational skill underpinning more advanced capabilities such as reasoning and agentic behaviors. As tasks grow more challenging, the logic structures embedded in natural language instructions becomes increasingly intricate. However, how well LLMs perform on such logic-rich instructions remains under-explored. We propose LogicIFGen and LogicIFEval. LogicIFGen is a scalable, automated framework for generating verifiable instructions from code functions, which can naturally express rich logic such as conditionals, nesting, recursion, and function calls. We further curate a collection of complex code functions and use LogicIFGen to construct LogicIFEval, a benchmark comprising 426 verifiable logic-rich instructions. Our experiments demonstrate that current state-of-the-art LLMs still struggle to correctly follow the instructions in LogicIFEval. Most LLMs can only follow fewer than 60% of the instructions, revealing significant deficiencies in the instruction-following ability. Code and Benchmark: https://github.com/mianzhang/LogicIF
Abstract:Generative models, especially diffusion and flow-based models, have been promising in offline multi-agent reinforcement learning. However, integrating powerful generative models into this framework poses unique challenges. In particular, diffusion and flow-based policies suffer from low sampling efficiency due to their iterative generation processes, making them impractical in time-sensitive or resource-constrained settings. To tackle these difficulties, we propose OM2P (Offline Multi-Agent Mean-Flow Policy), a novel offline MARL algorithm to achieve efficient one-step action sampling. To address the misalignment between generative objectives and reward maximization, we introduce a reward-aware optimization scheme that integrates a carefully-designed mean-flow matching loss with Q-function supervision. Additionally, we design a generalized timestep distribution and a derivative-free estimation strategy to reduce memory overhead and improve training stability. Empirical evaluations on Multi-Agent Particle and MuJoCo benchmarks demonstrate that OM2P achieves superior performance, with up to a 3.8x reduction in GPU memory usage and up to a 10.8x speed-up in training time. Our approach represents the first to successfully integrate mean-flow model into offline MARL, paving the way for practical and scalable generative policies in cooperative multi-agent settings.