Abstract:Recent advances in Multimodal Large Language Models (MLLMs) have significantly advanced video understanding tasks, yet challenges remain in efficiently compressing visual tokens while preserving spatiotemporal interactions. Existing methods, such as LLaVA family, utilize simplistic pooling or interpolation techniques that overlook the intricate dynamics of visual tokens. To bridge this gap, we propose ST-GridPool, a novel training-free visual token enhancement method designed specifically for Video LLMs. Our approach integrates Pyramid Temporal Gridding (PTG), which captures multi-grained spatiotemporal interactions through hierarchical temporal gridding, and Norm-based Spatial Pooling (NSP), which preserves high-information visual regions by leveraging the correlation between token norms and semantic richness. Extensive experiments on various benchmarks demonstrate that ST-GridPool consistently enhances performance of Video LLMs without requiring costly retraining. Our method offers an efficient and plug-and-play solution for improving visual token representations. Our code is available in https://github.com/bingjunluo/ST-GridPool.
Abstract:Multimodal Large Language Models (MLLMs) face significant computational overhead when processing long videos due to the massive number of visual tokens required. To improve efficiency, existing methods primarily reduce redundancy by pruning or merging tokens based on importance or similarity. However, these approaches largely overlook a critical dimension of video content, i.e., changes and turning points, and they lack a collaborative model for spatio-temporal relationships. To address this, we propose a new perspective: similarity is for identifying redundancy, while difference is for capturing key events. Based on this, we designed a training-free framework named ST-SimDiff. We first construct a spatio-temporal graph from the visual tokens to uniformly model their complex associations. Subsequently, we employ a parallel dual-selection strategy: 1) similarity-based selection uses community detection to retain representative tokens, compressing static information; 2) temporal difference-based selection precisely locates content-changing points to preserve tokens that capture key dynamic shifts. This allows it to preserve both static and dynamic content with a minimal number of tokens. Extensive experiments show our method significantly outperforms state-of-the-art approaches while substantially reducing computational costs. Our code is available in https://github.com/bingjunluo/ST-SimDiff.
Abstract:Medical multimodal large language models (MLLMs) have advanced image understanding and short-video analysis, but real clinical review often requires full-procedure video understanding. Unlike general long videos, medical procedures contain highly redundant anatomical views, while decisive evidence is temporally sparse, spatially subtle, and context dependent. Existing benchmarks often assume this evidence has already been localized through images, short clips, or pre-segmented videos, leaving the retrieval-before-reasoning problem under-tested. We introduce MedHorizon, an in-the-wild benchmark for long-context medical video understanding. MedHorizon preserves 759 hours of full-length clinical procedures and provides 1,253 evidence-grounded multiple-choice questionsthat jointly evaluate sparse evidence understanding and multi-hop clinical reasoning. Its evidence is extremely sparse, with only 0.166% evidence frames on average, requiring models to search noisy procedural streams before interpreting and aggregating findings. We evaluate representative general-domain, medical-domain, and long-video MLLMs. The best model reaches only 41.1% accuracy, showing that current systems remain far from robust full-procedure understanding. Further analysis yields four key findings: performance does not scale reliably with more frames, evidence retrieval and clinical interpretation remain primary bottlenecks; these bottlenecks are rooted in weak procedural reasoning and attention drift under redundancy, and generic sampling methods only partially balances local detail with global coverage. MedHorizon provides a rigorous testbed for MLLMs that retrieve sparse evidence and reason over complete clinical workflows.
Abstract:Multimodal Large Language Models (MLLMs) have demonstrated exceptional capabilities in high-level visual understanding. However, extending these models to fine-grained dense prediction tasks, such as semantic segmentation and depth estimation, typically necessitates the incorporation of complex, task-specific decoders and other customizations. This architectural fragmentation increases model complexity and deviates from the generalist design of MLLMs, ultimately limiting their practicality. In this work, we challenge this paradigm by accommodating standard MLLMs to perform dense predictions without requiring additional task-specific decoders. The proposed model is called DenseMLLM, grounded in the standard architecture with a novel vision token supervision strategy for multiple labels and tasks. Despite its minimalist design, our model achieves highly competitive performance across a wide range of dense prediction and vision-language benchmarks, demonstrating that a standard, general-purpose MLLM can effectively support dense perception without architectural specialization.
Abstract:Generalist Medical AI (GMAI) systems have demonstrated expert-level performance in biomedical perception tasks, yet their clinical utility remains limited by inadequate multi-modal explainability and suboptimal prognostic capabilities. Here, we present XMedGPT, a clinician-centric, multi-modal AI assistant that integrates textual and visual interpretability to support transparent and trustworthy medical decision-making. XMedGPT not only produces accurate diagnostic and descriptive outputs, but also grounds referenced anatomical sites within medical images, bridging critical gaps in interpretability and enhancing clinician usability. To support real-world deployment, we introduce a reliability indexing mechanism that quantifies uncertainty through consistency-based assessment via interactive question-answering. We validate XMedGPT across four pillars: multi-modal interpretability, uncertainty quantification, and prognostic modeling, and rigorous benchmarking. The model achieves an IoU of 0.703 across 141 anatomical regions, and a Kendall's tau-b of 0.479, demonstrating strong alignment between visual rationales and clinical outcomes. For uncertainty estimation, it attains an AUC of 0.862 on visual question answering and 0.764 on radiology report generation. In survival and recurrence prediction for lung and glioma cancers, it surpasses prior leading models by 26.9%, and outperforms GPT-4o by 25.0%. Rigorous benchmarking across 347 datasets covers 40 imaging modalities and external validation spans 4 anatomical systems confirming exceptional generalizability, with performance gains surpassing existing GMAI by 20.7% for in-domain evaluation and 16.7% on 11,530 in-house data evaluation. Together, XMedGPT represents a significant leap forward in clinician-centric AI integration, offering trustworthy and scalable support for diverse healthcare applications.




Abstract:Direct Preference Optimization (DPO) helps reduce hallucinations in Video Multimodal Large Language Models (VLLMs), but its reliance on offline preference data limits adaptability and fails to capture true video-response misalignment. We propose Video Direct Preference Optimization (VDPO), an online preference learning framework that eliminates the need for preference annotation by leveraging video augmentations to generate rejected samples while keeping responses fixed. However, selecting effective augmentations is non-trivial, as some clips may be semantically identical to the original under specific prompts, leading to false rejections and disrupting alignment. To address this, we introduce Prompt-aware Multi-instance Learning VDPO (PaMi-VDPO), which selects augmentations based on prompt context. Instead of a single rejection, we construct a candidate set of augmented clips and apply a close-to-far selection strategy, initially ensuring all clips are semantically relevant while then prioritizing the most prompt-aware distinct clip. This allows the model to better capture meaningful visual differences, mitigating hallucinations, while avoiding false rejections, and improving alignment. PaMi-VDPOseamlessly integrates into existing VLLMs without additional parameters, GPT-4/human supervision. With only 10k SFT data, it improves the base model by 5.3% on VideoHallucer, surpassing GPT-4o, while maintaining stable performance on general video benchmarks.
Abstract:General networks for 3D medical image segmentation have recently undergone extensive exploration. Behind the exceptional performance of these networks lies a significant demand for a large volume of pixel-level annotated data, which is time-consuming and labor-intensive. The emergence of the Segment Anything Model (SAM) has enabled this model to achieve superior performance in 2D medical image segmentation tasks via parameter- and data-efficient feature adaptation. However, the introduction of additional depth channels in 3D medical images not only prevents the sharing of 2D pre-trained features but also results in a quadratic increase in the computational cost for adapting SAM. To overcome these challenges, we present the Tri-Plane Mamba (TP-Mamba) adapters tailored for the SAM, featuring two major innovations: 1) multi-scale 3D convolutional adapters, optimized for efficiently processing local depth-level information, 2) a tri-plane mamba module, engineered to capture long-range depth-level representation without significantly increasing computational costs. This approach achieves state-of-the-art performance in 3D CT organ segmentation tasks. Remarkably, this superior performance is maintained even with scarce training data. Specifically using only three CT training samples from the BTCV dataset, it surpasses conventional 3D segmentation networks, attaining a Dice score that is up to 12% higher.




Abstract:High-resolution inputs enable Large Vision-Language Models (LVLMs) to discern finer visual details, enhancing their comprehension capabilities. To reduce the training and computation costs caused by high-resolution input, one promising direction is to use sliding windows to slice the input into uniform patches, each matching the input size of the well-trained vision encoder. Although efficient, this slicing strategy leads to the fragmentation of original input, i.e., the continuity of contextual information and spatial geometry is lost across patches, adversely affecting performance in cross-patch context perception and position-specific tasks. To overcome these shortcomings, we introduce HiRes-LLaVA, a novel framework designed to efficiently process any size of high-resolution input without altering the original contextual and geometric information. HiRes-LLaVA comprises two innovative components: (i) a SliceRestore adapter that reconstructs sliced patches into their original form, efficiently extracting both global and local features via down-up-sampling and convolution layers, and (ii) a Self-Mining Sampler to compresses the vision tokens based on themselves, preserving the original context and positional information while reducing training overhead. To assess the ability of handling context fragmentation, we construct a new benchmark, EntityGrid-QA, consisting of edge-related and position-related tasks. Our comprehensive experiments demonstrate the superiority of HiRes-LLaVA on both existing public benchmarks and on EntityGrid-QA, particularly on document-oriented tasks, establishing new standards for handling high-resolution inputs.
Abstract:Cone beam computed tomography (CBCT) is an important imaging technology widely used in medical scenarios, such as diagnosis and preoperative planning. Using fewer projection views to reconstruct CT, also known as sparse-view reconstruction, can reduce ionizing radiation and further benefit interventional radiology. Compared with sparse-view reconstruction for traditional parallel/fan-beam CT, CBCT reconstruction is more challenging due to the increased dimensionality caused by the measurement process based on cone-shaped X-ray beams. As a 2D-to-3D reconstruction problem, although implicit neural representations have been introduced to enable efficient training, only local features are considered and different views are processed equally in previous works, resulting in spatial inconsistency and poor performance on complicated anatomies. To this end, we propose C^2RV by leveraging explicit multi-scale volumetric representations to enable cross-regional learning in the 3D space. Additionally, the scale-view cross-attention module is introduced to adaptively aggregate multi-scale and multi-view features. Extensive experiments demonstrate that our C^2RV achieves consistent and significant improvement over previous state-of-the-art methods on datasets with diverse anatomy.




Abstract:The rise of multimodal large language models (MLLMs) has spurred interest in language-based driving tasks. However, existing research typically focuses on limited tasks and often omits key multi-view and temporal information which is crucial for robust autonomous driving. To bridge these gaps, we introduce NuInstruct, a novel dataset with 91K multi-view video-QA pairs across 17 subtasks, where each task demands holistic information (e.g., temporal, multi-view, and spatial), significantly elevating the challenge level. To obtain NuInstruct, we propose a novel SQL-based method to generate instruction-response pairs automatically, which is inspired by the driving logical progression of humans. We further present BEV-InMLLM, an end-to-end method for efficiently deriving instruction-aware Bird's-Eye-View (BEV) features, language-aligned for large language models. BEV-InMLLM integrates multi-view, spatial awareness, and temporal semantics to enhance MLLMs' capabilities on NuInstruct tasks. Moreover, our proposed BEV injection module is a plug-and-play method for existing MLLMs. Our experiments on NuInstruct demonstrate that BEV-InMLLM significantly outperforms existing MLLMs, e.g. around 9% improvement on various tasks. We plan to release our NuInstruct for future research development.