Unsupervised Anomaly Detection in Brain MRI via Disentangled Anatomy Learning

Detection of various lesions in brain MRI is clinically critical, but challenging due to the diversity of lesions and variability in imaging conditions. Current unsupervised learning methods detect anomalies mainly through reconstructing abnormal images into pseudo-healthy images (PHIs) by normal samples learning and then analyzing differences between images. However, these unsupervised models face two significant limitations: restricted generalizability to multi-modality and multi-center MRIs due to their reliance on the specific imaging information in normal training data, and constrained performance due to abnormal residuals propagated from input images to reconstructed PHIs. To address these limitations, two novel modules are proposed, forming a new PHI reconstruction framework. Firstly, the disentangled representation module is proposed to improve generalizability by decoupling brain MRI into imaging information and essential imaging-invariant anatomical images, ensuring that the reconstruction focuses on the anatomy. Specifically, brain anatomical priors and a differentiable one-hot encoding operator are introduced to constrain the disentanglement results and enhance the disentanglement stability. Secondly, the edge-to-image restoration module is designed to reconstruct high-quality PHIs by restoring the anatomical representation from the high-frequency edge information of anatomical images, and then recoupling the disentangled imaging information. This module not only suppresses abnormal residuals in PHI by reducing abnormal pixels input through edge-only input, but also effectively reconstructs normal regions using the preserved structural details in the edges. Evaluated on nine public datasets (4,443 patients' MRIs from multiple centers), our method outperforms 17 SOTA methods, achieving absolute improvements of +18.32% in AP and +13.64% in DSC.

Seedance 1.5 pro: A Native Audio-Visual Joint Generation Foundation Model

Recent strides in video generation have paved the way for unified audio-visual generation. In this work, we present Seedance 1.5 pro, a foundational model engineered specifically for native, joint audio-video generation. Leveraging a dual-branch Diffusion Transformer architecture, the model integrates a cross-modal joint module with a specialized multi-stage data pipeline, achieving exceptional audio-visual synchronization and superior generation quality. To ensure practical utility, we implement meticulous post-training optimizations, including Supervised Fine-Tuning (SFT) on high-quality datasets and Reinforcement Learning from Human Feedback (RLHF) with multi-dimensional reward models. Furthermore, we introduce an acceleration framework that boosts inference speed by over 10X. Seedance 1.5 pro distinguishes itself through precise multilingual and dialect lip-syncing, dynamic cinematic camera control, and enhanced narrative coherence, positioning it as a robust engine for professional-grade content creation. Seedance 1.5 pro is now accessible on Volcano Engine at https://console.volcengine.com/ark/region:ark+cn-beijing/experience/vision?type=GenVideo.

AgentMath: Empowering Mathematical Reasoning for Large Language Models via Tool-Augmented Agent

Large Reasoning Models (LRMs) like o3 and DeepSeek-R1 have achieved remarkable progress in natural language reasoning with long chain-of-thought. However, they remain computationally inefficient and struggle with accuracy when solving problems requiring complex mathematical operations. In this work, we present AgentMath, an agent framework that seamlessly integrates language models' reasoning capabilities with code interpreters' computational precision to efficiently tackle complex mathematical problems. Our approach introduces three key innovations: (1) An automated method that converts natural language chain-of-thought into structured tool-augmented trajectories, generating high-quality supervised fine-tuning (SFT) data to alleviate data scarcity; (2) A novel agentic reinforcement learning (RL) paradigm that dynamically interleaves natural language generation with real-time code execution. This enables models to autonomously learn optimal tool-use strategies through multi-round interactive feedback, while fostering emergent capabilities in code refinement and error correction; (3) An efficient training system incorporating innovative techniques, including request-level asynchronous rollout scheduling, agentic partial rollout, and prefix-aware weighted load balancing, achieving 4-5x speedup and making efficient RL training feasible on ultra-long sequences with scenarios with massive tool calls.Extensive evaluations show that AgentMath achieves state-of-the-art performance on challenging mathematical competition benchmarks including AIME24, AIME25, and HMMT25. Specifically, AgentMath-30B-A3B attains 90.6%, 86.4%, and 73.8% accuracy respectively, achieving advanced capabilities.These results validate the effectiveness of our approach and pave the way for building more sophisticated and scalable mathematical reasoning agents.

A Specialized Large Language Model for Clinical Reasoning and Diagnosis in Rare Diseases

Rare diseases affect hundreds of millions worldwide, yet diagnosis often spans years. Convectional pipelines decouple noisy evidence extraction from downstream inferential diagnosis, and general/medical large language models (LLMs) face scarce real world electronic health records (EHRs), stale domain knowledge, and hallucinations. We assemble a large, domain specialized clinical corpus and a clinician validated reasoning set, and develop RareSeek R1 via staged instruction tuning, chain of thought learning, and graph grounded retrieval. Across multicenter EHR narratives and public benchmarks, RareSeek R1 attains state of the art accuracy, robust generalization, and stability under noisy or overlapping phenotypes. Augmented retrieval yields the largest gains when narratives pair with prioritized variants by resolving ambiguity and aligning candidates to mechanisms. Human studies show performance on par with experienced physicians and consistent gains in assistive use. Notably, transparent reasoning highlights decisive non phenotypic evidence (median 23.1%, such as imaging, interventions, functional tests) underpinning many correct diagnoses. This work advances a narrative first, knowledge integrated reasoning paradigm that shortens the diagnostic odyssey and enables auditable, clinically translatable decision support.

MarsRL: Advancing Multi-Agent Reasoning System via Reinforcement Learning with Agentic Pipeline Parallelism

Recent progress in large language models (LLMs) has been propelled by reinforcement learning with verifiable rewards (RLVR) and test-time scaling. However, the limited output length of LLMs constrains the depth of reasoning attainable in a single inference process. Multi-agent reasoning systems offer a promising alternative by employing multiple agents including Solver, Verifier, and Corrector, to iteratively refine solutions. While effective in closed-source models like Gemini 2.5 Pro, they struggle to generalize to open-source models due to insufficient critic and correction capabilities. To address this, we propose MarsRL, a novel reinforcement learning framework with agentic pipeline parallelism, designed to jointly optimize all agents in the system. MarsRL introduces agent-specific reward mechanisms to mitigate reward noise and employs pipeline-inspired training to enhance efficiency in handling long trajectories. Applied to Qwen3-30B-A3B-Thinking-2507, MarsRL improves AIME2025 accuracy from 86.5% to 93.3% and BeyondAIME from 64.9% to 73.8%, even surpassing Qwen3-235B-A22B-Thinking-2507. These findings highlight the potential of MarsRL to advance multi-agent reasoning systems and broaden their applicability across diverse reasoning tasks.

QUARK: Quantization-Enabled Circuit Sharing for Transformer Acceleration by Exploiting Common Patterns in Nonlinear Operations

Transformer-based models have revolutionized computer vision (CV) and natural language processing (NLP) by achieving state-of-the-art performance across a range of benchmarks. However, nonlinear operations in models significantly contribute to inference latency, presenting unique challenges for efficient hardware acceleration. To this end, we propose QUARK, a quantization-enabled FPGA acceleration framework that leverages common patterns in nonlinear operations to enable efficient circuit sharing, thereby reducing hardware resource requirements. QUARK targets all nonlinear operations within Transformer-based models, achieving high-performance approximation through a novel circuit-sharing design tailored to accelerate these operations. Our evaluation demonstrates that QUARK significantly reduces the computational overhead of nonlinear operators in mainstream Transformer architectures, achieving up to a 1.96 times end-to-end speedup over GPU implementations. Moreover, QUARK lowers the hardware overhead of nonlinear modules by more than 50% compared to prior approaches, all while maintaining high model accuracy -- and even substantially boosting accuracy under ultra-low-bit quantization.

Self-Forcing++: Towards Minute-Scale High-Quality Video Generation

Diffusion models have revolutionized image and video generation, achieving unprecedented visual quality. However, their reliance on transformer architectures incurs prohibitively high computational costs, particularly when extending generation to long videos. Recent work has explored autoregressive formulations for long video generation, typically by distilling from short-horizon bidirectional teachers. Nevertheless, given that teacher models cannot synthesize long videos, the extrapolation of student models beyond their training horizon often leads to pronounced quality degradation, arising from the compounding of errors within the continuous latent space. In this paper, we propose a simple yet effective approach to mitigate quality degradation in long-horizon video generation without requiring supervision from long-video teachers or retraining on long video datasets. Our approach centers on exploiting the rich knowledge of teacher models to provide guidance for the student model through sampled segments drawn from self-generated long videos. Our method maintains temporal consistency while scaling video length by up to 20x beyond teacher's capability, avoiding common issues such as over-exposure and error-accumulation without recomputing overlapping frames like previous methods. When scaling up the computation, our method shows the capability of generating videos up to 4 minutes and 15 seconds, equivalent to 99.9% of the maximum span supported by our base model's position embedding and more than 50x longer than that of our baseline model. Experiments on standard benchmarks and our proposed improved benchmark demonstrate that our approach substantially outperforms baseline methods in both fidelity and consistency. Our long-horizon videos demo can be found at https://self-forcing-plus-plus.github.io/

Learning More with Less: A Dynamic Dual-Level Down-Sampling Framework for Efficient Policy Optimization

Critic-free methods like GRPO reduce memory demands by estimating advantages from multiple rollouts but tend to converge slowly, as critical learning signals are diluted by an abundance of uninformative samples and tokens. To tackle this challenge, we propose the \textbf{Dynamic Dual-Level Down-Sampling (D$^3$S)} framework that prioritizes the most informative samples and tokens across groups to improve the efficient of policy optimization. D$^3$S operates along two levels: (1) the sample-level, which selects a subset of rollouts to maximize advantage variance ($\text{Var}(A)$). We theoretically proven that this selection is positively correlated with the upper bound of the policy gradient norms, yielding higher policy gradients. (2) the token-level, which prioritizes tokens with a high product of advantage magnitude and policy entropy ($|A_{i,t}|\times H_{i,t}$), focusing updates on tokens where the policy is both uncertain and impactful. Moreover, to prevent overfitting to high-signal data, D$^3$S employs a dynamic down-sampling schedule inspired by curriculum learning. This schedule starts with aggressive down-sampling to accelerate early learning and gradually relaxes to promote robust generalization. Extensive experiments on Qwen2.5 and Llama3.1 demonstrate that integrating D$^3$S into advanced RL algorithms achieves state-of-the-art performance and generalization while requiring \textit{fewer} samples and tokens across diverse reasoning benchmarks. Our code is added in the supplementary materials and will be made publicly available.

WeChat-YATT: A Simple, Scalable and Balanced RLHF Trainer

Reinforcement Learning from Human Feedback (RLHF) has emerged as a prominent paradigm for training large language models and multimodal systems. Despite notable advances enabled by existing RLHF training frameworks, significant challenges remain in scaling to complex multimodal workflows and adapting to dynamic workloads. In particular, current systems often encounter limitations related to controller scalability when managing large models, as well as inefficiencies in orchestrating intricate RLHF pipelines, especially in scenarios that require dynamic sampling and resource allocation. In this paper, we introduce WeChat-YATT (Yet Another Transformer Trainer in WeChat), a simple, scalable, and balanced RLHF training framework specifically designed to address these challenges. WeChat-YATT features a parallel controller programming model that enables flexible and efficient orchestration of complex RLHF workflows, effectively mitigating the bottlenecks associated with centralized controller architectures and facilitating scalability in large-scale data scenarios. In addition, we propose a dynamic placement schema that adaptively partitions computational resources and schedules workloads, thereby significantly reducing hardware idle time and improving GPU utilization under variable training conditions. We evaluate WeChat-YATT across a range of experimental scenarios, demonstrating that it achieves substantial improvements in throughput compared to state-of-the-art RLHF training frameworks. Furthermore, WeChat-YATT has been successfully deployed to train models supporting WeChat product features for a large-scale user base, underscoring its effectiveness and robustness in real-world applications.

G-Core: A Simple, Scalable and Balanced RLHF Trainer

Reinforcement Learning from Human Feedback (RLHF) has become an increasingly popular paradigm for training large language models (LLMs) and diffusion models. While existing RLHF training systems have enabled significant progress, they often face challenges in scaling to multi-modal and diffusion workflows and adapting to dynamic workloads. In particular, current approaches may encounter limitations in controller scalability, flexible resource placement, and efficient orchestration when handling complex RLHF pipelines, especially in scenarios involving dynamic sampling or generative reward modeling. In this paper, we present \textbf{G-Core}, a simple, scalable, and balanced RLHF training framework designed to address these challenges. G-Core introduces a parallel controller programming model, enabling flexible and efficient orchestration of complex RLHF workflows without the bottlenecks of a single centralized controller. Furthermore, we propose a dynamic placement schema that adaptively partitions resources and schedules workloads, significantly reducing hardware idle time and improving utilization, even under highly variable training conditions. G-Core has successfully trained models that support WeChat product features serving a large-scale user base, demonstrating its effectiveness and robustness in real-world scenarios. Our results show that G-Core advances the state of the art in RLHF training, providing a solid foundation for future research and deployment of large-scale, human-aligned models.