iMD4GC: Incomplete Multimodal Data Integration to Advance Precise Treatment Response Prediction and Survival Analysis for Gastric Cancer

Gastric cancer (GC) is a prevalent malignancy worldwide, ranking as the fifth most common cancer with over 1 million new cases and 700 thousand deaths in 2020. Locally advanced gastric cancer (LAGC) accounts for approximately two-thirds of GC diagnoses, and neoadjuvant chemotherapy (NACT) has emerged as the standard treatment for LAGC. However, the effectiveness of NACT varies significantly among patients, with a considerable subset displaying treatment resistance. Ineffective NACT not only leads to adverse effects but also misses the optimal therapeutic window, resulting in lower survival rate. However, existing multimodal learning methods assume the availability of all modalities for each patient, which does not align with the reality of clinical practice. The limited availability of modalities for each patient would cause information loss, adversely affecting predictive accuracy. In this study, we propose an incomplete multimodal data integration framework for GC (iMD4GC) to address the challenges posed by incomplete multimodal data, enabling precise response prediction and survival analysis. Specifically, iMD4GC incorporates unimodal attention layers for each modality to capture intra-modal information. Subsequently, the cross-modal interaction layers explore potential inter-modal interactions and capture complementary information across modalities, thereby enabling information compensation for missing modalities. To evaluate iMD4GC, we collected three multimodal datasets for GC study: GastricRes (698 cases) for response prediction, GastricSur (801 cases) for survival analysis, and TCGA-STAD (400 cases) for survival analysis. The scale of our datasets is significantly larger than previous studies. The iMD4GC achieved impressive performance with an 80.2% AUC on GastricRes, 71.4% C-index on GastricSur, and 66.1% C-index on TCGA-STAD, significantly surpassing other compared methods.

CBLab: Scalable Traffic Simulation with Enriched Data Supporting

Traffic simulation provides interactive data for the optimization of traffic policies. However, existing traffic simulators are limited by their lack of scalability and shortage in input data, which prevents them from generating interactive data from traffic simulation in the scenarios of real large-scale city road networks. In this paper, we present City Brain Lab, a toolkit for scalable traffic simulation. CBLab is consist of three components: CBEngine, CBData, and CBScenario. CBEngine is a highly efficient simulators supporting large scale traffic simulation. CBData includes a traffic dataset with road network data of 100 cities all around the world. We also develop a pipeline to conduct one-click transformation from raw road networks to input data of our traffic simulation. Combining CBEngine and CBData allows researchers to run scalable traffic simulation in the road network of real large-scale cities. Based on that, CBScenario implements an interactive environment and several baseline methods for two scenarios of traffic policies respectively, with which traffic policies adaptable for large-scale urban traffic can be trained and tuned. To the best of our knowledge, CBLab is the first infrastructure supporting traffic policy optimization on large-scale urban scenarios. The code is available on Github: https://github.com/CityBrainLab/CityBrainLab.git.

Boosting Offline Reinforcement Learning with Residual Generative Modeling

Offline reinforcement learning (RL) tries to learn the near-optimal policy with recorded offline experience without online exploration. Current offline RL research includes: 1) generative modeling, i.e., approximating a policy using fixed data; and 2) learning the state-action value function. While most research focuses on the state-action function part through reducing the bootstrapping error in value function approximation induced by the distribution shift of training data, the effects of error propagation in generative modeling have been neglected. In this paper, we analyze the error in generative modeling. We propose AQL (action-conditioned Q-learning), a residual generative model to reduce policy approximation error for offline RL. We show that our method can learn more accurate policy approximations in different benchmark datasets. In addition, we show that the proposed offline RL method can learn more competitive AI agents in complex control tasks under the multiplayer online battle arena (MOBA) game Honor of Kings.

Learning to Route via Theory-Guided Residual Network

The heavy traffic and related issues have always been concerns for modern cities. With the help of deep learning and reinforcement learning, people have proposed various policies to solve these traffic-related problems, such as smart traffic signal control systems and taxi dispatching systems. People usually validate these policies in a city simulator, since directly applying them in the real city introduces real cost. However, these policies validated in the city simulator may fail in the real city if the simulator is significantly different from the real world. To tackle this problem, we need to build a real-like traffic simulation system. Therefore, in this paper, we propose to learn the human routing model, which is one of the most essential part in the traffic simulator. This problem has two major challenges. First, human routing decisions are determined by multiple factors, besides the common time and distance factor. Second, current historical routes data usually covers just a small portion of vehicles, due to privacy and device availability issues. To address these problems, we propose a theory-guided residual network model, where the theoretical part can emphasize the general principles for human routing decisions (e.g., fastest route), and the residual part can capture drivable condition preferences (e.g., local road or highway). Since the theoretical part is composed of traditional shortest path algorithms that do not need data to train, our residual network can learn human routing models from limited data. We have conducted extensive experiments on multiple real-world datasets to show the superior performance of our model, especially with small data. Besides, we have also illustrated why our model is better at recovering real routes through case studies.

Objective-aware Traffic Simulation via Inverse Reinforcement Learning

Traffic simulators act as an essential component in the operating and planning of transportation systems. Conventional traffic simulators usually employ a calibrated physical car-following model to describe vehicles' behaviors and their interactions with traffic environment. However, there is no universal physical model that can accurately predict the pattern of vehicle's behaviors in different situations. A fixed physical model tends to be less effective in a complicated environment given the non-stationary nature of traffic dynamics. In this paper, we formulate traffic simulation as an inverse reinforcement learning problem, and propose a parameter sharing adversarial inverse reinforcement learning model for dynamics-robust simulation learning. Our proposed model is able to imitate a vehicle's trajectories in the real world while simultaneously recovering the reward function that reveals the vehicle's true objective which is invariant to different dynamics. Extensive experiments on synthetic and real-world datasets show the superior performance of our approach compared to state-of-the-art methods and its robustness to variant dynamics of traffic.

Learning to Simulate on Sparse Trajectory Data

Simulation of the real-world traffic can be used to help validate the transportation policies. A good simulator means the simulated traffic is similar to real-world traffic, which often requires dense traffic trajectories (i.e., with a high sampling rate) to cover dynamic situations in the real world. However, in most cases, the real-world trajectories are sparse, which makes simulation challenging. In this paper, we present a novel framework ImInGAIL to address the problem of learning to simulate the driving behavior from sparse real-world data. The proposed architecture incorporates data interpolation with the behavior learning process of imitation learning. To the best of our knowledge, we are the first to tackle the data sparsity issue for behavior learning problems. We investigate our framework on both synthetic and real-world trajectory datasets of driving vehicles, showing that our method outperforms various baselines and state-of-the-art methods.

Automatic Historical Feature Generation through Tree-based Method in Ads Prediction

Historical features are important in ads click-through rate (CTR) prediction, because they account for past engagements between users and ads. In this paper, we study how to efficiently construct historical features through counting features. The key challenge of such problem lies in how to automatically identify counting keys. We propose a tree-based method for counting key selection. The intuition is that a decision tree naturally provides various combinations of features, which could be used as counting key candidate. In order to select personalized counting features, we train one decision tree model per user, and the counting keys are selected across different users with a frequency-based importance measure. To validate the effectiveness of proposed solution, we conduct large scale experiments on Twitter video advertising data. In both online learning and offline training settings, the automatically identified counting features outperform the manually curated counting features.

Online Structured Meta-learning

Learning quickly is of great importance for machine intelligence deployed in online platforms. With the capability of transferring knowledge from learned tasks, meta-learning has shown its effectiveness in online scenarios by continuously updating the model with the learned prior. However, current online meta-learning algorithms are limited to learn a globally-shared meta-learner, which may lead to sub-optimal results when the tasks contain heterogeneous information that are distinct by nature and difficult to share. We overcome this limitation by proposing an online structured meta-learning (OSML) framework. Inspired by the knowledge organization of human and hierarchical feature representation, OSML explicitly disentangles the meta-learner as a meta-hierarchical graph with different knowledge blocks. When a new task is encountered, it constructs a meta-knowledge pathway by either utilizing the most relevant knowledge blocks or exploring new blocks. Through the meta-knowledge pathway, the model is able to quickly adapt to the new task. In addition, new knowledge is further incorporated into the selected blocks. Experiments on three datasets demonstrate the effectiveness and interpretability of our proposed framework in the context of both homogeneous and heterogeneous tasks.

Relation-aware Meta-learning for Market Segment Demand Prediction with Limited Records

Recently, E-commerce platforms have extensive impacts on our human life. To provide an efficient platform, one of the most fundamental problem is how to balance the demand and supply in market segments. While conventional machine learning models have achieved a great success on data-sufficient segments, it may fail in a large-portion of segments in E-commerce platforms, where there are not sufficient records to learn well-trained models. In this paper, we tackle this problem in the context of market segment demand prediction. The goal is to facilitate the learning process in the target segments even facing a shortage of related training data by leveraging the learned knowledge from data-sufficient source segments. Specifically, we propose a novel algorithm, RMLDP, to incorporate a multi-pattern fusion network (MPFN) with a meta-learning paradigm. The multi-pattern fusion network considers both local and global temporal patterns for segment demand prediction. In the meta-learning paradigm, the transferable knowledge is regarded as the model parameter initializations of MPFN, which are learned from diverse source segments. Furthermore, we capture the segment relations by combining data-driven segment representation and segment knowledge graph representation and tailor the segment-specific relations to customize transferable model parameter initializations. Thus, even with limited data, the target segment can quickly find the most relevant transferred knowledge and adapt to the optimal parameters. Extensive experiments are conducted on two large-scale industrial datasets. The results show that our RMLDP outperforms a set of state-of-the-art baselines. In addition, RMLDP has also been deployed in Taobao, a real-world E-commerce platform. The online A/B testing results further demonstrate the practicality of RMLDP.