The Butterfly Effect in Pathology: Exploring Security in Pathology Foundation Models

With the widespread adoption of pathology foundation models in both research and clinical decision support systems, exploring their security has become a critical concern. However, despite their growing impact, the vulnerability of these models to adversarial attacks remains largely unexplored. In this work, we present the first systematic investigation into the security of pathology foundation models for whole slide image~(WSI) analysis against adversarial attacks. Specifically, we introduce the principle of \textit{local perturbation with global impact} and propose a label-free attack framework that operates without requiring access to downstream task labels. Under this attack framework, we revise four classical white-box attack methods and redefine the perturbation budget based on the characteristics of WSI. We conduct comprehensive experiments on three representative pathology foundation models across five datasets and six downstream tasks. Despite modifying only 0.1\% of patches per slide with imperceptible noise, our attack leads to downstream accuracy degradation that can reach up to 20\% in the worst cases. Furthermore, we analyze key factors that influence attack success, explore the relationship between patch-level vulnerability and semantic content, and conduct a preliminary investigation into potential defence strategies. These findings lay the groundwork for future research on the adversarial robustness and reliable deployment of pathology foundation models. Our code is publicly available at: https://github.com/Jiashuai-Liu-hmos/Attack-WSI-pathology-foundation-models.

DecompileBench: A Comprehensive Benchmark for Evaluating Decompilers in Real-World Scenarios

Decompilers are fundamental tools for critical security tasks, from vulnerability discovery to malware analysis, yet their evaluation remains fragmented. Existing approaches primarily focus on syntactic correctness through synthetic micro-benchmarks or subjective human ratings, failing to address real-world requirements for semantic fidelity and analyst usability. We present DecompileBench, the first comprehensive framework that enables effective evaluation of decompilers in reverse engineering workflows through three key components: \textit{real-world function extraction} (comprising 23,400 functions from 130 real-world programs), \textit{runtime-aware validation}, and \textit{automated human-centric assessment} using LLM-as-Judge to quantify the effectiveness of decompilers in reverse engineering workflows. Through a systematic comparison between six industrial-strength decompilers and six recent LLM-powered approaches, we demonstrate that LLM-based methods surpass commercial tools in code understandability despite 52.2% lower functionality correctness. These findings highlight the potential of LLM-based approaches to transform human-centric reverse engineering. We open source \href{https://github.com/Jennieett/DecompileBench}{DecompileBench} to provide a framework to advance research on decompilers and assist security experts in making informed tool selections based on their specific requirements.

Generalised Label-free Artefact Cleaning for Real-time Medical Pulsatile Time Series

Artefacts compromise clinical decision-making in the use of medical time series. Pulsatile waveforms offer probabilities for accurate artefact detection, yet most approaches rely on supervised manners and overlook patient-level distribution shifts. To address these issues, we introduce a generalised label-free framework, GenClean, for real-time artefact cleaning and leverage an in-house dataset of 180,000 ten-second arterial blood pressure (ABP) samples for training. We first investigate patient-level generalisation, demonstrating robust performances under both intra- and inter-patient distribution shifts. We further validate its effectiveness through challenging cross-disease cohort experiments on the MIMIC-III database. Additionally, we extend our method to photoplethysmography (PPG), highlighting its applicability to diverse medical pulsatile signals. Finally, its integration into ICM+, a clinical research monitoring software, confirms the real-time feasibility of our framework, emphasising its practical utility in continuous physiological monitoring. This work provides a foundational step toward precision medicine in improving the reliability of high-resolution medical time series analysis

ST-Prompt Guided Histological Hypergraph Learning for Spatial Gene Expression Prediction

Spatial Transcriptomics (ST) reveals the spatial distribution of gene expression in tissues, offering critical insights into biological processes and disease mechanisms. However, predicting ST from H\&E-stained histology images is challenging due to the heterogeneous relationship between histomorphology and gene expression, which arises from substantial variability across different patients and tissue sections. A more practical and valuable approach is to utilize ST data from a few local regions to predict the spatial transcriptomic landscape across the remaining regions in H&E slides. In response, we propose PHG2ST, an ST-prompt guided histological hypergraph learning framework, which leverages sparse ST signals as prompts to guide histological hypergraph learning for global spatial gene expression prediction. Our framework fuses histological hypergraph representations at multiple scales through a masked ST-prompt encoding mechanism, improving robustness and generalizability. Benchmark evaluations on two public ST datasets demonstrate that PHG2ST outperforms the existing state-of-the-art methods and closely aligns with the ground truth. These results underscore the potential of leveraging sparse local ST data for scalable and cost-effective spatial gene expression mapping in real-world biomedical applications.

RoboMIND: Benchmark on Multi-embodiment Intelligence Normative Data for Robot Manipulation

Developing robust and general-purpose robotic manipulation policies is a key goal in the field of robotics. To achieve effective generalization, it is essential to construct comprehensive datasets that encompass a large number of demonstration trajectories and diverse tasks. Unlike vision or language data that can be collected from the Internet, robotic datasets require detailed observations and manipulation actions, necessitating significant investment in hardware-software infrastructure and human labor. While existing works have focused on assembling various individual robot datasets, there remains a lack of a unified data collection standard and insufficient diversity in tasks, scenarios, and robot types. In this paper, we introduce RoboMIND (Multi-embodiment Intelligence Normative Data for Robot manipulation), featuring 55k real-world demonstration trajectories across 279 diverse tasks involving 61 different object classes. RoboMIND is collected through human teleoperation and encompasses comprehensive robotic-related information, including multi-view RGB-D images, proprioceptive robot state information, end effector details, and linguistic task descriptions. To ensure dataset consistency and reliability during policy learning, RoboMIND is built on a unified data collection platform and standardized protocol, covering four distinct robotic embodiments. We provide a thorough quantitative and qualitative analysis of RoboMIND across multiple dimensions, offering detailed insights into the diversity of our datasets. In our experiments, we conduct extensive real-world testing with four state-of-the-art imitation learning methods, demonstrating that training with RoboMIND data results in a high manipulation success rate and strong generalization. Our project is at https://x-humanoid-robomind.github.io/.

CoxKAN: Kolmogorov-Arnold Networks for Interpretable, High-Performance Survival Analysis

Survival analysis is a branch of statistics used for modeling the time until a specific event occurs and is widely used in medicine, engineering, finance, and many other fields. When choosing survival models, there is typically a trade-off between performance and interpretability, where the highest performance is achieved by black-box models based on deep learning. This is a major problem in fields such as medicine where practitioners are reluctant to blindly trust black-box models to make important patient decisions. Kolmogorov-Arnold Networks (KANs) were recently proposed as an interpretable and accurate alternative to multi-layer perceptrons (MLPs). We introduce CoxKAN, a Cox proportional hazards Kolmogorov-Arnold Network for interpretable, high-performance survival analysis. We evaluate the proposed CoxKAN on 4 synthetic datasets and 9 real medical datasets. The synthetic experiments demonstrate that CoxKAN accurately recovers interpretable symbolic formulae for the hazard function, and effectively performs automatic feature selection. Evaluation on the 9 real datasets show that CoxKAN consistently outperforms the Cox proportional hazards model and achieves performance that is superior or comparable to that of tuned MLPs. Furthermore, we find that CoxKAN identifies complex interactions between predictor variables that would be extremely difficult to recognise using existing survival methods, and automatically finds symbolic formulae which uncover the precise effect of important biomarkers on patient risk.

RoboTwin: Dual-Arm Robot Benchmark with Generative Digital Twins (early version)

Effective collaboration of dual-arm robots and their tool use capabilities are increasingly important areas in the advancement of robotics. These skills play a significant role in expanding robots' ability to operate in diverse real-world environments. However, progress is impeded by the scarcity of specialized training data. This paper introduces RoboTwin, a novel benchmark dataset combining real-world teleoperated data with synthetic data from digital twins, designed for dual-arm robotic scenarios. Using the COBOT Magic platform, we have collected diverse data on tool usage and human-robot interaction. We present a innovative approach to creating digital twins using AI-generated content, transforming 2D images into detailed 3D models. Furthermore, we utilize large language models to generate expert-level training data and task-specific pose sequences oriented toward functionality. Our key contributions are: 1) the RoboTwin benchmark dataset, 2) an efficient real-to-simulation pipeline, and 3) the use of language models for automatic expert-level data generation. These advancements are designed to address the shortage of robotic training data, potentially accelerating the development of more capable and versatile robotic systems for a wide range of real-world applications. The project page is available at https://robotwin-benchmark.github.io/early-version/

ViC: Virtual Compiler Is All You Need For Assembly Code Search

Assembly code search is vital for reducing the burden on reverse engineers, allowing them to quickly identify specific functions using natural language within vast binary programs. Despite its significance, this critical task is impeded by the complexities involved in building high-quality datasets. This paper explores training a Large Language Model (LLM) to emulate a general compiler. By leveraging Ubuntu packages to compile a dataset of 20 billion tokens, we further continue pre-train CodeLlama as a Virtual Compiler (ViC), capable of compiling any source code of any language to assembly code. This approach allows for virtual compilation across a wide range of programming languages without the need for a real compiler, preserving semantic equivalency and expanding the possibilities for assembly code dataset construction. Furthermore, we use ViC to construct a sufficiently large dataset for assembly code search. Employing this extensive dataset, we achieve a substantial improvement in assembly code search performance, with our model surpassing the leading baseline by 26%.

A Self-Supervised Image Registration Approach for Measuring Local Response Patterns in Metastatic Ovarian Cancer

High-grade serous ovarian carcinoma (HGSOC) is characterised by significant spatial and temporal heterogeneity, typically manifesting at an advanced metastatic stage. A major challenge in treating advanced HGSOC is effectively monitoring localised change in tumour burden across multiple sites during neoadjuvant chemotherapy (NACT) and predicting long-term pathological response and overall patient survival. In this work, we propose a self-supervised deformable image registration algorithm that utilises a general-purpose image encoder for image feature extraction to co-register contrast-enhanced computerised tomography scan images acquired before and after neoadjuvant chemotherapy. This approach addresses challenges posed by highly complex tumour deformations and longitudinal lesion matching during treatment. Localised tumour changes are calculated using the Jacobian determinant maps of the registration deformation at multiple disease sites and their macroscopic areas, including hypo-dense (i.e., cystic/necrotic), hyper-dense (i.e., calcified), and intermediate density (i.e., soft tissue) portions. A series of experiments is conducted to understand the role of a general-purpose image encoder and its application in quantifying change in tumour burden during neoadjuvant chemotherapy in HGSOC. This work is the first to demonstrate the feasibility of a self-supervised image registration approach in quantifying NACT-induced localised tumour changes across the whole disease burden of patients with complex multi-site HGSOC, which could be used as a potential marker for ovarian cancer patient's long-term pathological response and survival.

DAG-Plan: Generating Directed Acyclic Dependency Graphs for Dual-Arm Cooperative Planning

Dual-arm robots offer enhanced versatility and efficiency over single-arm counterparts by enabling concurrent manipulation of multiple objects or cooperative execution of tasks using both arms. However, effectively coordinating the two arms for complex long-horizon tasks remains a significant challenge. Existing task planning methods predominantly focus on single-arm robots or rely on predefined bimanual operations, failing to fully leverage the capabilities of dual-arm systems. To address this limitation, we introduce DAG-Plan, a structured task planning framework tailored for dual-arm robots. DAG-Plan harnesses large language models (LLMs) to decompose intricate tasks into actionable sub-tasks represented as nodes within a directed acyclic graph (DAG). Critically, DAG-Plan dynamically assigns these sub-tasks to the appropriate arm based on real-time environmental observations, enabling parallel and adaptive execution. We evaluate DAG-Plan on the novel Dual-Arm Kitchen Benchmark, comprising 9 sequential tasks with 78 sub-tasks and 26 objects. Extensive experiments demonstrate the superiority of DAG-Plan over directly using LLM to generate plans, achieving nearly 50% higher efficiency compared to the single-arm task planning baseline and nearly double the success rate of the dual-arm task planning baseline.