Enabling Ultra-Fast Cardiovascular Imaging Across Heterogeneous Clinical Environments with a Generalist Foundation Model and Multimodal Database

Multimodal cardiovascular magnetic resonance (CMR) imaging provides comprehensive and non-invasive insights into cardiovascular disease (CVD) diagnosis and underlying mechanisms. Despite decades of advancements, its widespread clinical adoption remains constrained by prolonged scan times and heterogeneity across medical environments. This underscores the urgent need for a generalist reconstruction foundation model for ultra-fast CMR imaging, one capable of adapting across diverse imaging scenarios and serving as the essential substrate for all downstream analyses. To enable this goal, we curate MMCMR-427K, the largest and most comprehensive multimodal CMR k-space database to date, comprising 427,465 multi-coil k-space data paired with structured metadata across 13 international centers, 12 CMR modalities, 15 scanners, and 17 CVD categories in populations across three continents. Building on this unprecedented resource, we introduce CardioMM, a generalist reconstruction foundation model capable of dynamically adapting to heterogeneous fast CMR imaging scenarios. CardioMM unifies semantic contextual understanding with physics-informed data consistency to deliver robust reconstructions across varied scanners, protocols, and patient presentations. Comprehensive evaluations demonstrate that CardioMM achieves state-of-the-art performance in the internal centers and exhibits strong zero-shot generalization to unseen external settings. Even at imaging acceleration up to 24x, CardioMM reliably preserves key cardiac phenotypes, quantitative myocardial biomarkers, and diagnostic image quality, enabling a substantial increase in CMR examination throughput without compromising clinical integrity. Together, our open-access MMCMR-427K database and CardioMM framework establish a scalable pathway toward high-throughput, high-quality, and clinically accessible cardiovascular imaging.

Multi-Grained Text-Guided Image Fusion for Multi-Exposure and Multi-Focus Scenarios

Image fusion aims to synthesize a single high-quality image from a pair of inputs captured under challenging conditions, such as differing exposure levels or focal depths. A core challenge lies in effectively handling disparities in dynamic range and focus depth between the inputs. With the advent of vision-language models, recent methods incorporate textual descriptions as auxiliary guidance to enhance fusion quality. However, simply incorporating coarse-grained descriptions hampers the understanding of fine-grained details and poses challenges for precise cross-modal alignment. To address these limitations, we propose Multi-grained Text-guided Image Fusion (MTIF), a novel fusion paradigm with three key designs. First, it introduces multi-grained textual descriptions that separately capture fine details, structural cues, and semantic content, guiding image fusion through a hierarchical cross-modal modulation module. Second, it involves supervision signals at each granularity to facilitate alignment between visual and textual features and enhance the utility of auxiliary text. Third, it adopts a saliency-driven enrichment module to augment training data with dense semantic content, further strengthening the cross-modal modulation and alignment. Extensive experiments show that MTIF consistently outperforms previous methods on both multi-exposure and multi-focus image fusion tasks.

Grad: Guided Relation Diffusion Generation for Graph Augmentation in Graph Fraud Detection

Nowadays, Graph Fraud Detection (GFD) in financial scenarios has become an urgent research topic to protect online payment security. However, as organized crime groups are becoming more professional in real-world scenarios, fraudsters are employing more sophisticated camouflage strategies. Specifically, fraudsters disguise themselves by mimicking the behavioral data collected by platforms, ensuring that their key characteristics are consistent with those of benign users to a high degree, which we call Adaptive Camouflage. Consequently, this narrows the differences in behavioral traits between them and benign users within the platform's database, thereby making current GFD models lose efficiency. To address this problem, we propose a relation diffusion-based graph augmentation model Grad. In detail, Grad leverages a supervised graph contrastive learning module to enhance the fraud-benign difference and employs a guided relation diffusion generator to generate auxiliary homophilic relations from scratch. Based on these, weak fraudulent signals would be enhanced during the aggregation process, thus being obvious enough to be captured. Extensive experiments have been conducted on two real-world datasets provided by WeChat Pay, one of the largest online payment platforms with billions of users, and three public datasets. The results show that our proposed model Grad outperforms SOTA methods in both various scenarios, achieving at most 11.10% and 43.95% increases in AUC and AP, respectively. Our code is released at https://github.com/AI4Risk/antifraud and https://github.com/Muyiiiii/WWW25-Grad.

Faithful Contouring: Near-Lossless 3D Voxel Representation Free from Iso-surface

Accurate and efficient voxelized representations of 3D meshes are the foundation of 3D reconstruction and generation. However, existing representations based on iso-surface heavily rely on water-tightening or rendering optimization, which inevitably compromise geometric fidelity. We propose Faithful Contouring, a sparse voxelized representation that supports 2048+ resolutions for arbitrary meshes, requiring neither converting meshes to field functions nor extracting the isosurface during remeshing. It achieves near-lossless fidelity by preserving sharpness and internal structures, even for challenging cases with complex geometry and topology. The proposed method also shows flexibility for texturing, manipulation, and editing. Beyond representation, we design a dual-mode autoencoder for Faithful Contouring, enabling scalable and detail-preserving shape reconstruction. Extensive experiments show that Faithful Contouring surpasses existing methods in accuracy and efficiency for both representation and reconstruction. For direct representation, it achieves distance errors at the $10^{-5}$ level; for mesh reconstruction, it yields a 93\% reduction in Chamfer Distance and a 35\% improvement in F-score over strong baselines, confirming superior fidelity as a representation for 3D learning tasks.

Breaking Privacy in Federated Clustering: Perfect Input Reconstruction via Temporal Correlations

Federated clustering allows multiple parties to discover patterns in distributed data without sharing raw samples. To reduce overhead, many protocols disclose intermediate centroids during training. While often treated as harmless for efficiency, whether such disclosure compromises privacy remains an open question. Prior analyses modeled the problem as a so-called Hidden Subset Sum Problem (HSSP) and argued that centroid release may be safe, since classical HSSP attacks fail to recover inputs. We revisit this question and uncover a new leakage mechanism: temporal regularities in $k$-means iterations create exploitable structure that enables perfect input reconstruction. Building on this insight, we propose Trajectory-Aware Reconstruction (TAR), an attack that combines temporal assignment information with algebraic analysis to recover exact original inputs. Our findings provide the first rigorous evidence, supported by a practical attack, that centroid disclosure in federated clustering significantly compromises privacy, exposing a fundamental tension between privacy and efficiency.

MoE-GraphSAGE-Based Integrated Evaluation of Transient Rotor Angle and Voltage Stability in Power Systems

The large-scale integration of renewable energy and power electronic devices has increased the complexity of power system stability, making transient stability assessment more challenging. Conventional methods are limited in both accuracy and computational efficiency. To address these challenges, this paper proposes MoE-GraphSAGE, a graph neural network framework based on the MoE for unified TAS and TVS assessment. The framework leverages GraphSAGE to capture the power grid's spatiotemporal topological features and employs multi-expert networks with a gating mechanism to model distinct instability modes jointly. Experimental results on the IEEE 39-bus system demonstrate that MoE-GraphSAGE achieves superior accuracy and efficiency, offering an effective solution for online multi-task transient stability assessment in complex power systems.

Large Language Models Meet Virtual Cell: A Survey

Large language models (LLMs) are transforming cellular biology by enabling the development of "virtual cells"--computational systems that represent, predict, and reason about cellular states and behaviors. This work provides a comprehensive review of LLMs for virtual cell modeling. We propose a unified taxonomy that organizes existing methods into two paradigms: LLMs as Oracles, for direct cellular modeling, and LLMs as Agents, for orchestrating complex scientific tasks. We identify three core tasks--cellular representation, perturbation prediction, and gene regulation inference--and review their associated models, datasets, evaluation benchmarks, as well as the critical challenges in scalability, generalizability, and interpretability.

First-order State Space Model for Lightweight Image Super-resolution

State space models (SSMs), particularly Mamba, have shown promise in NLP tasks and are increasingly applied to vision tasks. However, most Mamba-based vision models focus on network architecture and scan paths, with little attention to the SSM module. In order to explore the potential of SSMs, we modified the calculation process of SSM without increasing the number of parameters to improve the performance on lightweight super-resolution tasks. In this paper, we introduce the First-order State Space Model (FSSM) to improve the original Mamba module, enhancing performance by incorporating token correlations. We apply a first-order hold condition in SSMs, derive the new discretized form, and analyzed cumulative error. Extensive experimental results demonstrate that FSSM improves the performance of MambaIR on five benchmark datasets without additionally increasing the number of parameters, and surpasses current lightweight SR methods, achieving state-of-the-art results.

Forewarned is Forearmed: Pre-Synthesizing Jailbreak-like Instructions to Enhance LLM Safety Guardrail to Potential Attacks

Despite advances in improving large language model (LLM) to refuse to answer malicious instructions, widely used LLMs remain vulnerable to jailbreak attacks where attackers generate instructions with distributions differing from safety alignment corpora. New attacks expose LLMs' inability to recognize unseen malicious instructions, highlighting a critical distributional mismatch between training data and real-world attacks that forces developers into reactive patching cycles. To tackle this challenge, we propose IMAGINE, a synthesis framework that leverages embedding space distribution analysis to generate jailbreak-like instructions. This approach effectively fills the distributional gap between authentic jailbreak patterns and safety alignment corpora. IMAGINE follows an iterative optimization process that dynamically evolves text generation distributions across iterations, thereby augmenting the coverage of safety alignment data distributions through synthesized data examples. Based on the safety-aligned corpus enhanced through IMAGINE, our framework demonstrates significant decreases in attack success rate on Qwen2.5, Llama3.1, and Llama3.2 without compromising their utility.

A Physics-Driven Neural Network with Parameter Embedding for Generating Quantitative MR Maps from Weighted Images

We propose a deep learning-based approach that integrates MRI sequence parameters to improve the accuracy and generalizability of quantitative image synthesis from clinical weighted MRI. Our physics-driven neural network embeds MRI sequence parameters -- repetition time (TR), echo time (TE), and inversion time (TI) -- directly into the model via parameter embedding, enabling the network to learn the underlying physical principles of MRI signal formation. The model takes conventional T1-weighted, T2-weighted, and T2-FLAIR images as input and synthesizes T1, T2, and proton density (PD) quantitative maps. Trained on healthy brain MR images, it was evaluated on both internal and external test datasets. The proposed method achieved high performance with PSNR values exceeding 34 dB and SSIM values above 0.92 for all synthesized parameter maps. It outperformed conventional deep learning models in accuracy and robustness, including data with previously unseen brain structures and lesions. Notably, our model accurately synthesized quantitative maps for these unseen pathological regions, highlighting its superior generalization capability. Incorporating MRI sequence parameters via parameter embedding allows the neural network to better learn the physical characteristics of MR signals, significantly enhancing the performance and reliability of quantitative MRI synthesis. This method shows great potential for accelerating qMRI and improving its clinical utility.