MTPNet: Multi-Grained Target Perception for Unified Activity Cliff Prediction

Activity cliff prediction is a critical task in drug discovery and material design. Existing computational methods are limited to handling single binding targets, which restricts the applicability of these prediction models. In this paper, we present the Multi-Grained Target Perception network (MTPNet) to incorporate the prior knowledge of interactions between the molecules and their target proteins. Specifically, MTPNet is a unified framework for activity cliff prediction, which consists of two components: Macro-level Target Semantic (MTS) guidance and Micro-level Pocket Semantic (MPS) guidance. By this way, MTPNet dynamically optimizes molecular representations through multi-grained protein semantic conditions. To our knowledge, it is the first time to employ the receptor proteins as guiding information to effectively capture critical interaction details. Extensive experiments on 30 representative activity cliff datasets demonstrate that MTPNet significantly outperforms previous approaches, achieving an average RMSE improvement of 18.95% on top of several mainstream GNN architectures. Overall, MTPNet internalizes interaction patterns through conditional deep learning to achieve unified predictions of activity cliffs, helping to accelerate compound optimization and design. Codes are available at: https://github.com/ZishanShu/MTPNet.

SeMe: Training-Free Language Model Merging via Semantic Alignment

Despite the remarkable capabilities of Language Models (LMs) across diverse tasks, no single model consistently outperforms others, necessitating efficient methods to combine their strengths without expensive retraining. Existing model merging techniques, such as parameter averaging and task-guided fusion, often rely on data-dependent computations or fail to preserve internal knowledge, limiting their robustness and scalability. We introduce SeMe (Semantic-based Merging), a novel, data-free, and training-free approach that leverages latent semantic alignment to merge LMs at a fine-grained, layer-wise level. Unlike prior work, SeMe not only preserves model behaviors but also explicitly stabilizes internal knowledge, addressing a critical gap in LM fusion. Through extensive experiments across diverse architectures and tasks, we demonstrate that SeMe outperforms existing methods in both performance and efficiency while eliminating reliance on external data. Our work establishes a new paradigm for knowledge-aware model merging and provides insights into the semantic structure of LMs, paving the way for more scalable and interpretable model composition.

MHANet: Multi-scale Hybrid Attention Network for Auditory Attention Detection

Auditory attention detection (AAD) aims to detect the target speaker in a multi-talker environment from brain signals, such as electroencephalography (EEG), which has made great progress. However, most AAD methods solely utilize attention mechanisms sequentially and overlook valuable multi-scale contextual information within EEG signals, limiting their ability to capture long-short range spatiotemporal dependencies simultaneously. To address these issues, this paper proposes a multi-scale hybrid attention network (MHANet) for AAD, which consists of the multi-scale hybrid attention (MHA) module and the spatiotemporal convolution (STC) module. Specifically, MHA combines channel attention and multi-scale temporal and global attention mechanisms. This effectively extracts multi-scale temporal patterns within EEG signals and captures long-short range spatiotemporal dependencies simultaneously. To further improve the performance of AAD, STC utilizes temporal and spatial convolutions to aggregate expressive spatiotemporal representations. Experimental results show that the proposed MHANet achieves state-of-the-art performance with fewer trainable parameters across three datasets, 3 times lower than that of the most advanced model. Code is available at: https://github.com/fchest/MHANet.

ListenNet: A Lightweight Spatio-Temporal Enhancement Nested Network for Auditory Attention Detection

Auditory attention detection (AAD) aims to identify the direction of the attended speaker in multi-speaker environments from brain signals, such as Electroencephalography (EEG) signals. However, existing EEG-based AAD methods overlook the spatio-temporal dependencies of EEG signals, limiting their decoding and generalization abilities. To address these issues, this paper proposes a Lightweight Spatio-Temporal Enhancement Nested Network (ListenNet) for AAD. The ListenNet has three key components: Spatio-temporal Dependency Encoder (STDE), Multi-scale Temporal Enhancement (MSTE), and Cross-Nested Attention (CNA). The STDE reconstructs dependencies between consecutive time windows across channels, improving the robustness of dynamic pattern extraction. The MSTE captures temporal features at multiple scales to represent both fine-grained and long-range temporal patterns. In addition, the CNA integrates hierarchical features more effectively through novel dynamic attention mechanisms to capture deep spatio-temporal correlations. Experimental results on three public datasets demonstrate the superiority of ListenNet over state-of-the-art methods in both subject-dependent and challenging subject-independent settings, while reducing the trainable parameter count by approximately 7 times. Code is available at:https://github.com/fchest/ListenNet.

Towards an Understanding of Context Utilization in Code Intelligence

Code intelligence is an emerging domain in software engineering, aiming to improve the effectiveness and efficiency of various code-related tasks. Recent research suggests that incorporating contextual information beyond the basic original task inputs (i.e., source code) can substantially enhance model performance. Such contextual signals may be obtained directly or indirectly from sources such as API documentation or intermediate representations like abstract syntax trees can significantly improve the effectiveness of code intelligence. Despite growing academic interest, there is a lack of systematic analysis of context in code intelligence. To address this gap, we conduct an extensive literature review of 146 relevant studies published between September 2007 and August 2024. Our investigation yields four main contributions. (1) A quantitative analysis of the research landscape, including publication trends, venues, and the explored domains; (2) A novel taxonomy of context types used in code intelligence; (3) A task-oriented analysis investigating context integration strategies across diverse code intelligence tasks; (4) A critical evaluation of evaluation methodologies for context-aware methods. Based on these findings, we identify fundamental challenges in context utilization in current code intelligence systems and propose a research roadmap that outlines key opportunities for future research.

MagicComp: Training-free Dual-Phase Refinement for Compositional Video Generation

Text-to-video (T2V) generation has made significant strides with diffusion models. However, existing methods still struggle with accurately binding attributes, determining spatial relationships, and capturing complex action interactions between multiple subjects. To address these limitations, we propose MagicComp, a training-free method that enhances compositional T2V generation through dual-phase refinement. Specifically, (1) During the Conditioning Stage: We introduce the Semantic Anchor Disambiguation to reinforces subject-specific semantics and resolve inter-subject ambiguity by progressively injecting the directional vectors of semantic anchors into original text embedding; (2) During the Denoising Stage: We propose Dynamic Layout Fusion Attention, which integrates grounding priors and model-adaptive spatial perception to flexibly bind subjects to their spatiotemporal regions through masked attention modulation. Furthermore, MagicComp is a model-agnostic and versatile approach, which can be seamlessly integrated into existing T2V architectures. Extensive experiments on T2V-CompBench and VBench demonstrate that MagicComp outperforms state-of-the-art methods, highlighting its potential for applications such as complex prompt-based and trajectory-controllable video generation. Project page: https://hong-yu-zhang.github.io/MagicComp-Page/.

A Semantic-based Optimization Approach for Repairing LLMs: Case Study on Code Generation

Language Models (LMs) are widely used in software engineering for code generation, but they may produce code with errors. Rather than repairing the generated code, an alternative way is to address the underlying failures of models. LM repair offers a lightweight solution to this challenge: it requires minimal data, reduces computational costs, and reduces the side effects. Unlike retraining, LM repair focuses on applying tailored updates to targeted neurons, making it ideal for scenarios with limited resources, high-performance demands, or strict safety requirements. In this paper, we propose \ul{S}emantic \ul{T}argeting for \ul{A}nalytical \ul{R}epair (\textsc{STAR}), a pioneering and novel semantic-based optimization approach for repairing LLMs. \textsc{STAR} realizes main operations in LM repair methods in an optimization process, including locating ``buggy neurons'', solving ``neuron patches'', and patching ``buggy neurons''. Correspondingly, it computes the deltas of weight matrix as the prior information to guide optimization; and attributes the targeted layers and neurons leveraging statistical insights. The neuron patches are computed with a solid semantic-based analytical formula, which directly bridges the changes to logits with the deltas of neurons, by steering latent representations. Compared to the prior work of LM repair (\textsc{MINT}) and optimization methods (\textsc{SGD}), \textsc{STAR} integrates their strengths while mitigating their limitations. \textsc{STAR} supports solving multiple failures together, significantly improving the usefulness. Evaluated on three code generation tasks using popular code LMs, \textsc{STAR} demonstrates superior effectiveness. Additionally, \textsc{STAR} exhibits better efficiency. In terms of side effects, namely the balance between generalization and specificity, \textsc{STAR} outperforms prior work by a significant margin.

Evaluating the Generalizability of LLMs in Automated Program Repair

LLM-based automated program repair methods have attracted significant attention for their state-of-the-art performance. However, they were primarily evaluated on a few well known datasets like Defects4J, raising questions about their effectiveness on new datasets. In this study, we evaluate 11 top-performing LLMs on DEFECTS4J-TRANS, a new dataset derived from transforming Defects4J while maintaining the original semantics. Results from experiments on both Defects4J and DEFECTS4J-TRANS show that all studied LLMs have limited generalizability in APR tasks, with the average number of correct and plausible patches decreasing by 49.48% and 42.90%, respectively, on DEFECTS4J-TRANS. Further investigation into incorporating additional repair-relevant information in repair prompts reveals that, although this information significantly enhances the LLMs' capabilities (increasing the number of correct and plausible patches by up to 136.67% and 121.82%, respectively), performance still falls short of their original results. This indicates that prompt engineering alone is insufficient to substantially enhance LLMs' repair capabilities. Based on our study, we also offer several recommendations for future research.

nvAgent: Automated Data Visualization from Natural Language via Collaborative Agent Workflow

Natural Language to Visualization (NL2Vis) seeks to convert natural-language descriptions into visual representations of given tables, empowering users to derive insights from large-scale data. Recent advancements in Large Language Models (LLMs) show promise in automating code generation to transform tabular data into accessible visualizations. However, they often struggle with complex queries that require reasoning across multiple tables. To address this limitation, we propose a collaborative agent workflow, termed nvAgent, for NL2Vis. Specifically, nvAgent comprises three agents: a processor agent for database processing and context filtering, a composer agent for planning visualization generation, and a validator agent for code translation and output verification. Comprehensive evaluations on the new VisEval benchmark demonstrate that nvAgent consistently surpasses state-of-the-art baselines, achieving a 7.88% improvement in single-table and a 9.23% improvement in multi-table scenarios. Qualitative analyses further highlight that nvAgent maintains nearly a 20% performance margin over previous models, underscoring its capacity to produce high-quality visual representations from complex, heterogeneous data sources.

Can Large Language Models Understand Intermediate Representations?

Intermediate Representations (IRs) are essential in compiler design and program analysis, yet their comprehension by Large Language Models (LLMs) remains underexplored. This paper presents a pioneering empirical study to investigate the capabilities of LLMs, including GPT-4, GPT-3, Gemma 2, LLaMA 3.1, and Code Llama, in understanding IRs. We analyze their performance across four tasks: Control Flow Graph (CFG) reconstruction, decompilation, code summarization, and execution reasoning. Our results indicate that while LLMs demonstrate competence in parsing IR syntax and recognizing high-level structures, they struggle with control flow reasoning, execution semantics, and loop handling. Specifically, they often misinterpret branching instructions, omit critical IR operations, and rely on heuristic-based reasoning, leading to errors in CFG reconstruction, IR decompilation, and execution reasoning. The study underscores the necessity for IR-specific enhancements in LLMs, recommending fine-tuning on structured IR datasets and integration of explicit control flow models to augment their comprehension and handling of IR-related tasks.