PHASOR: Anatomy- and Phase-Consistent Volumetric Diffusion for CT Virtual Contrast Enhancement

Contrast-enhanced computed tomography (CECT) is pivotal for highlighting tissue perfusion and vascularity, yet its clinical ubiquity is impeded by the invasive nature of contrast agents and radiation risks. While virtual contrast enhancement (VCE) offers an alternative to synthesizing CECT from non-contrast CT (NCCT), existing methods struggle with anatomical heterogeneity and spatial misalignment, leading to inconsistent enhancement patterns and incorrect details. This paper introduces PHASOR, a volumetric diffusion framework for high-fidelity CT VCE. By treating CT volumes as coherent sequences, we leverage a video diffusion model to enhance structural coherence and volumetric accuracy. To ensure anatomy-phase consistent synthesis, we introduce two complementary modules. First, anatomy-routed mixture-of-experts (AR-MoE) anchors distinct enhancement patterns to anatomical semantics, with organ-specific memory to capture salient details. Second, intensity-phase aware representation alignment (IP-REPA) highlights intricate contrast signals while mitigating the impact of imperfect spatial alignment. Extensive experiments across three datasets demonstrate that PHASOR significantly outperforms state-of-the-art methods in both synthesis quality and enhancement accuracy.

Project Imaging-X: A Survey of 1000+ Open-Access Medical Imaging Datasets for Foundation Model Development

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.

One CT Unified Model Training Framework to Rule All Scanning Protocols

Non-ideal measurement computed tomography (NICT), which lowers radiation at the cost of image quality, is expanding the clinical use of CT. Although unified models have shown promise in NICT enhancement, most methods require paired data, which is an impractical demand due to inevitable organ motion. Unsupervised approaches attempt to overcome this limitation, but their assumption of homogeneous noise neglects the variability of scanning protocols, leading to poor generalization and potential model collapse. We further observe that distinct scanning protocols, which correspond to different physical imaging processes, produce discrete sub-manifolds in the feature space, contradicting these assumptions and limiting their effectiveness. To address this, we propose an Uncertainty-Guided Manifold Smoothing (UMS) framework to bridge the gaps between sub-manifolds. A classifier in UMS identifies sub-manifolds and predicts uncertainty scores, which guide the generation of diverse samples across the entire manifold. By leveraging the classifier's capability, UMS effectively fills the gaps between discrete sub-manifolds, and promotes a continuous and dense feature space. Due to the complexity of the global manifold, it's hard to directly model it. Therefore, we propose to dynamically incorporate the global- and sub-manifold-specific features. Specifically, we design a global- and sub-manifold-driven architecture guided by the classifier, which enables dynamic adaptation to subdomain variations. This dynamic mechanism improves the network's capacity to capture both shared and domain-specific features, thereby improving reconstruction performance. Extensive experiments on public datasets are conducted to validate the effectiveness of our method across different generation paradigms.

TheraAgent: Multi-Agent Framework with Self-Evolving Memory and Evidence-Calibrated Reasoning for PET Theranostics

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond, demanding reliable pre-therapy prediction. While LLM-based agents have shown remarkable potential in complex medical diagnosis, their application to PET theranostic outcome prediction remains unexplored, which faces three key challenges: (1) data and knowledge scarcity: RLT was only FDA-approved in 2022, yielding few training cases and insufficient domain knowledge in general LLMs; (2) heterogeneous information integration: robust prediction hinges on structured knowledge extraction from PET/CT, laboratory tests, and free-text clinical documentation; (3) evidence-grounded reasoning: clinical decisions must be anchored in trial evidence rather than LLM hallucinations. In this paper, we present TheraAgent, to our knowledge, the first agentic framework for PET theranostics, with three core innovations: (1) Multi-Expert Feature Extraction with Confidence-Weighted Consensus, where three specialized experts process heterogeneous inputs with uncertainty quantification; (2) Self-Evolving Agentic Memory (SEA-Mem), which learns prognostic patterns from accumulated cases, enabling case-based reasoning from limited data; (3) Evidence-Calibrated Reasoning, integrating a curated theranostics knowledge base to ground predictions in VISION/TheraP trial evidence. Evaluated on 35 real patients and 400 synthetic cases, TheraAgent achieves 75.7% overall accuracy on real patients and 87.0% on synthetic cases, outperforming MDAgents and MedAgent-Pro by over 20%. These results highlight a promising blueprint for trustworthy AI agents in PET theranostics, enabling trial-calibrated, multi-source decision support. Code will be released upon acceptance.

DreamVideo-Omni: Omni-Motion Controlled Multi-Subject Video Customization with Latent Identity Reinforcement Learning

While large-scale diffusion models have revolutionized video synthesis, achieving precise control over both multi-subject identity and multi-granularity motion remains a significant challenge. Recent attempts to bridge this gap often suffer from limited motion granularity, control ambiguity, and identity degradation, leading to suboptimal performance on identity preservation and motion control. In this work, we present DreamVideo-Omni, a unified framework enabling harmonious multi-subject customization with omni-motion control via a progressive two-stage training paradigm. In the first stage, we integrate comprehensive control signals for joint training, encompassing subject appearances, global motion, local dynamics, and camera movements. To ensure robust and precise controllability, we introduce a condition-aware 3D rotary positional embedding to coordinate heterogeneous inputs and a hierarchical motion injection strategy to enhance global motion guidance. Furthermore, to resolve multi-subject ambiguity, we introduce group and role embeddings to explicitly anchor motion signals to specific identities, effectively disentangling complex scenes into independent controllable instances. In the second stage, to mitigate identity degradation, we design a latent identity reward feedback learning paradigm by training a latent identity reward model upon a pretrained video diffusion backbone. This provides motion-aware identity rewards in the latent space, prioritizing identity preservation aligned with human preferences. Supported by our curated large-scale dataset and the comprehensive DreamOmni Bench for multi-subject and omni-motion control evaluation, DreamVideo-Omni demonstrates superior performance in generating high-quality videos with precise controllability.

Skill-Evolving Grounded Reasoning for Free-Text Promptable 3D Medical Image Segmentation

Free-text promptable 3D medical image segmentation offers an intuitive and clinically flexible interaction paradigm. However, current methods are highly sensitive to linguistic variability: minor changes in phrasing can cause substantial performance degradation despite identical clinical intent. Existing approaches attempt to improve robustness through stronger vision-language fusion or larger vocabularies, yet they lack mechanisms to consistently align ambiguous free-form expressions with anatomically grounded representations. We propose Skill-Evolving grounded Reasoning (SEER), a novel framework for free-text promptable 3D medical image segmentation that explicitly bridges linguistic variability and anatomical precision through a reasoning-driven design. First, we curate the SEER-Trace dataset, which pairs raw clinical requests with image-grounded, skill-tagged reasoning traces, establishing a reproducible benchmark. Second, SEER constructs an evidence-aligned target representation via a vision-language reasoning chain that verifies clinical intent against image-derived anatomical evidence, thereby enforcing semantic consistency before voxel-level decoding. Third, we introduce SEER-Loop, a dynamic skill-evolving strategy that distills high-reward reasoning trajectories into reusable skill artifacts and progressively integrates them into subsequent inference, enabling structured self-refinement and improved robustness to diverse linguistic expressions. Extensive experiments demonstrate superior performance of SEER over state-of-the-art baselines. Under linguistic perturbations, SEER reduces performance variance by 81.94% and improves worst-case Dice by 18.60%.

MedQ-Deg: A Multidimensional Benchmark for Evaluating MLLMs Across Medical Image Quality Degradations

Despite impressive performance on standard benchmarks, multimodal large language models (MLLMs) face critical challenges in real-world clinical environments where medical images inevitably suffer various quality degradations. Existing benchmarks exhibit two key limitations: (1) absence of large-scale, multidimensional assessment across medical image quality gradients and (2) no systematic confidence calibration analysis. To address these gaps, we present MedQ-Deg, a comprehensive benchmark for evaluating medical MLLMs under image quality degradations. MedQ-Deg provides multi-dimensional evaluation spanning 18 distinct degradation types, 30 fine-grained capability dimensions, and 7 imaging modalities, with 24,894 question-answer pairs. Each degradation is implemented at 3 severity degrees, calibrated by expert radiologists. We further introduce Calibration Shift metric, which quantifies the gap between a model's perceived confidence and actual performance to assess metacognitive reliability under degradation. Our comprehensive evaluation of 40 mainstream MLLMs reveals several critical findings: (1) overall model performance degrades systematically as degradation severity increases, (2) models universally exhibit the AI Dunning-Kruger Effect, maintaining inappropriately high confidence despite severe accuracy collapse, and (3) models display markedly differentiated behavioral patterns across capability dimensions, imaging modalities, and degradation types. We hope MedQ-Deg drives progress toward medical MLLMs that are robust and trustworthy in real clinical practice.

Brain-WM: Brain Glioblastoma World Model

Precise prognostic modeling of glioblastoma (GBM) under varying treatment interventions is essential for optimizing clinical outcomes. While generative AI has shown promise in simulating GBM evolution, existing methods typically treat interventions as static conditional inputs rather than dynamic decision variables. Consequently, they fail to capture the complex, reciprocal interplay between tumor evolution and treatment response. To bridge this gap, we present Brain-WM, a pioneering brain GBM world model that unifies next-step treatment prediction and future MRI generation, thereby capturing the co-evolutionary dynamics between tumor and treatment. Specifically, Brain-WM encodes spatiotemporal dynamics into a shared latent space for joint autoregressive treatment prediction and flow-based future MRI generation. Then, instead of a conventional monolithic framework, Brain-WM adopts a novel Y-shaped Mixture-of-Transformers (MoT) architecture. This design structurally disentangles heterogeneous objectives, successfully leveraging cross-task synergies while preventing feature collapse. Finally, a synergistic multi-timepoint mask alignment objective explicitly anchors latent representations to anatomically grounded tumor structures and progression-aware semantics. Extensive validation on internal and external multi-institutional cohorts demonstrates the superiority of Brain-WM, achieving 91.5% accuracy in treatment planning and SSIMs of 0.8524, 0.8581, and 0.8404 for FLAIR, T1CE, and T2W sequences, respectively. Ultimately, Brain-WM offers a robust clinical sandbox for optimizing patient healthcare. The source code is made available at https://github.com/thibault-wch/Brain-GBM-world-model.

Dynamic Differential Linear Attention: Enhancing Linear Diffusion Transformer for High-Quality Image Generation

Diffusion transformers (DiTs) have emerged as a powerful architecture for high-fidelity image generation, yet the quadratic cost of self-attention poses a major scalability bottleneck. To address this, linear attention mechanisms have been adopted to reduce computational cost; unfortunately, the resulting linear diffusion transformers (LiTs) models often come at the expense of generative performance, frequently producing over-smoothed attention weights that limit expressiveness. In this work, we introduce Dynamic Differential Linear Attention (DyDiLA), a novel linear attention formulation that enhances the effectiveness of LiTs by mitigating the oversmoothing issue and improving generation quality. Specifically, the novelty of DyDiLA lies in three key designs: (i) dynamic projection module, which facilitates the decoupling of token representations by learning with dynamically assigned knowledge; (ii) dynamic measure kernel, which provides a better similarity measurement to capture fine-grained semantic distinctions between tokens by dynamically assigning kernel functions for token processing; and (iii) token differential operator, which enables more robust query-to-key retrieval by calculating the differences between the tokens and their corresponding information redundancy produced by dynamic measure kernel. To capitalize on DyDiLA, we introduce a refined LiT, termed DyDi-LiT, that systematically incorporates our advancements. Extensive experiments show that DyDi-LiT consistently outperforms current state-of-the-art (SOTA) models across multiple metrics, underscoring its strong practical potential.

A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.