Trustworthy Contrast-enhanced Brain MRI Synthesis

Contrast-enhanced brain MRI (CE-MRI) is a valuable diagnostic technique but may pose health risks and incur high costs. To create safer alternatives, multi-modality medical image translation aims to synthesize CE-MRI images from other available modalities. Although existing methods can generate promising predictions, they still face two challenges, i.e., exhibiting over-confidence and lacking interpretability on predictions. To address the above challenges, this paper introduces TrustI2I, a novel trustworthy method that reformulates multi-to-one medical image translation problem as a multimodal regression problem, aiming to build an uncertainty-aware and reliable system. Specifically, our method leverages deep evidential regression to estimate prediction uncertainties and employs an explicit intermediate and late fusion strategy based on the Mixture of Normal Inverse Gamma (MoNIG) distribution, enhancing both synthesis quality and interpretability. Additionally, we incorporate uncertainty calibration to improve the reliability of uncertainty. Validation on the BraTS2018 dataset demonstrates that our approach surpasses current methods, producing higher-quality images with rational uncertainty estimation.

MBA-Net: SAM-driven Bidirectional Aggregation Network for Ovarian Tumor Segmentation

Accurate segmentation of ovarian tumors from medical images is crucial for early diagnosis, treatment planning, and patient management. However, the diverse morphological characteristics and heterogeneous appearances of ovarian tumors pose significant challenges to automated segmentation methods. In this paper, we propose MBA-Net, a novel architecture that integrates the powerful segmentation capabilities of the Segment Anything Model (SAM) with domain-specific knowledge for accurate and robust ovarian tumor segmentation. MBA-Net employs a hybrid encoder architecture, where the encoder consists of a prior branch, which inherits the SAM encoder to capture robust segmentation priors, and a domain branch, specifically designed to extract domain-specific features. The bidirectional flow of information between the two branches is facilitated by the robust feature injection network (RFIN) and the domain knowledge integration network (DKIN), enabling MBA-Net to leverage the complementary strengths of both branches. We extensively evaluate MBA-Net on the public multi-modality ovarian tumor ultrasound dataset and the in-house multi-site ovarian tumor MRI dataset. Our proposed method consistently outperforms state-of-the-art segmentation approaches. Moreover, MBA-Net demonstrates superior generalization capability across different imaging modalities and clinical sites.

Personalized Federated Continual Learning via Multi-granularity Prompt

Personalized Federated Continual Learning (PFCL) is a new practical scenario that poses greater challenges in sharing and personalizing knowledge. PFCL not only relies on knowledge fusion for server aggregation at the global spatial-temporal perspective but also needs model improvement for each client according to the local requirements. Existing methods, whether in Personalized Federated Learning (PFL) or Federated Continual Learning (FCL), have overlooked the multi-granularity representation of knowledge, which can be utilized to overcome Spatial-Temporal Catastrophic Forgetting (STCF) and adopt generalized knowledge to itself by coarse-to-fine human cognitive mechanisms. Moreover, it allows more effectively to personalized shared knowledge, thus serving its own purpose. To this end, we propose a novel concept called multi-granularity prompt, i.e., coarse-grained global prompt acquired through the common model learning process, and fine-grained local prompt used to personalize the generalized representation. The former focuses on efficiently transferring shared global knowledge without spatial forgetting, and the latter emphasizes specific learning of personalized local knowledge to overcome temporal forgetting. In addition, we design a selective prompt fusion mechanism for aggregating knowledge of global prompts distilled from different clients. By the exclusive fusion of coarse-grained knowledge, we achieve the transmission and refinement of common knowledge among clients, further enhancing the performance of personalization. Extensive experiments demonstrate the effectiveness of the proposed method in addressing STCF as well as improving personalized performance. Our code now is available at https://github.com/SkyOfBeginning/FedMGP.

Evidential Concept Embedding Models: Towards Reliable Concept Explanations for Skin Disease Diagnosis

Due to the high stakes in medical decision-making, there is a compelling demand for interpretable deep learning methods in medical image analysis. Concept Bottleneck Models (CBM) have emerged as an active interpretable framework incorporating human-interpretable concepts into decision-making. However, their concept predictions may lack reliability when applied to clinical diagnosis, impeding concept explanations' quality. To address this, we propose an evidential Concept Embedding Model (evi-CEM), which employs evidential learning to model the concept uncertainty. Additionally, we offer to leverage the concept uncertainty to rectify concept misalignments that arise when training CBMs using vision-language models without complete concept supervision. With the proposed methods, we can enhance concept explanations' reliability for both supervised and label-efficient settings. Furthermore, we introduce concept uncertainty for effective test-time intervention. Our evaluation demonstrates that evi-CEM achieves superior performance in terms of concept prediction, and the proposed concept rectification effectively mitigates concept misalignments for label-efficient training. Our code is available at https://github.com/obiyoag/evi-CEM.

Flexible and Adaptable Summarization via Expertise Separation

A proficient summarization model should exhibit both flexibility -- the capacity to handle a range of in-domain summarization tasks, and adaptability -- the competence to acquire new knowledge and adjust to unseen out-of-domain tasks. Unlike large language models (LLMs) that achieve this through parameter scaling, we propose a more parameter-efficient approach in this study. Our motivation rests on the principle that the general summarization ability to capture salient information can be shared across different tasks, while the domain-specific summarization abilities need to be distinct and tailored. Concretely, we propose MoeSumm, a Mixture-of-Expert Summarization architecture, which utilizes a main expert for gaining the general summarization capability and deputy experts that selectively collaborate to meet specific summarization task requirements. We further propose a max-margin loss to stimulate the separation of these abilities. Our model's distinct separation of general and domain-specific summarization abilities grants it with notable flexibility and adaptability, all while maintaining parameter efficiency. MoeSumm achieves flexibility by managing summarization across multiple domains with a single model, utilizing a shared main expert and selected deputy experts. It exhibits adaptability by tailoring deputy experts to cater to out-of-domain few-shot and zero-shot scenarios. Experimental results on 11 datasets show the superiority of our model compared with recent baselines and LLMs. We also provide statistical and visual evidence of the distinct separation of the two abilities in MoeSumm (https://github.com/iriscxy/MoE_Summ).

Write Summary Step-by-Step: A Pilot Study of Stepwise Summarization

Nowadays, neural text generation has made tremendous progress in abstractive summarization tasks. However, most of the existing summarization models take in the whole document all at once, which sometimes cannot meet the needs in practice. Practically, social text streams such as news events and tweets keep growing from time to time, and can only be fed to the summarization system step by step. Hence, in this paper, we propose the task of Stepwise Summarization, which aims to generate a new appended summary each time a new document is proposed. The appended summary should not only summarize the newly added content but also be coherent with the previous summary, to form an up-to-date complete summary. To tackle this challenge, we design an adversarial learning model, named Stepwise Summary Generator (SSG). First, SSG selectively processes the new document under the guidance of the previous summary, obtaining polished document representation. Next, SSG generates the summary considering both the previous summary and the document. Finally, a convolutional-based discriminator is employed to determine whether the newly generated summary is coherent with the previous summary. For the experiment, we extend the traditional two-step update summarization setting to a multi-step stepwise setting, and re-propose a large-scale stepwise summarization dataset based on a public story generation dataset. Extensive experiments on this dataset show that SSG achieves state-of-the-art performance in terms of both automatic metrics and human evaluations. Ablation studies demonstrate the effectiveness of each module in our framework. We also discuss the benefits and limitations of recent large language models on this task.

Facilitating Multi-Role and Multi-Behavior Collaboration of Large Language Models for Online Job Seeking and Recruiting

The emergence of online recruitment services has revolutionized the traditional landscape of job seeking and recruitment, necessitating the development of high-quality industrial applications to improve person-job fitting. Existing methods generally rely on modeling the latent semantics of resumes and job descriptions and learning a matching function between them. Inspired by the powerful role-playing capabilities of Large Language Models (LLMs), we propose to introduce a mock interview process between LLM-played interviewers and candidates. The mock interview conversations can provide additional evidence for candidate evaluation, thereby augmenting traditional person-job fitting based solely on resumes and job descriptions. However, characterizing these two roles in online recruitment still presents several challenges, such as developing the skills to raise interview questions, formulating appropriate answers, and evaluating two-sided fitness. To this end, we propose MockLLM, a novel applicable framework that divides the person-job matching process into two modules: mock interview generation and two-sided evaluation in handshake protocol, jointly enhancing their performance through collaborative behaviors between interviewers and candidates. We design a role-playing framework as a multi-role and multi-behavior paradigm to enable a single LLM agent to effectively behave with multiple functions for both parties. Moreover, we propose reflection memory generation and dynamic prompt modification techniques to refine the behaviors of both sides, enabling continuous optimization of the augmented additional evidence. Extensive experimental results show that MockLLM can achieve the best performance on person-job matching accompanied by high mock interview quality, envisioning its emerging application in real online recruitment in the future.

SkinCAP: A Multi-modal Dermatology Dataset Annotated with Rich Medical Captions

With the widespread application of artificial intelligence (AI), particularly deep learning (DL) and vision-based large language models (VLLMs), in skin disease diagnosis, the need for interpretability becomes crucial. However, existing dermatology datasets are limited in their inclusion of concept-level meta-labels, and none offer rich medical descriptions in natural language. This deficiency impedes the advancement of LLM-based methods in dermatological diagnosis. To address this gap and provide a meticulously annotated dermatology dataset with comprehensive natural language descriptions, we introduce SkinCAP: a multi-modal dermatology dataset annotated with rich medical captions. SkinCAP comprises 4,000 images sourced from the Fitzpatrick 17k skin disease dataset and the Diverse Dermatology Images dataset, annotated by board-certified dermatologists to provide extensive medical descriptions and captions. Notably, SkinCAP represents the world's first such dataset and is publicly available at https://huggingface.co/datasets/joshuachou/SkinCAP.

Can We Treat Noisy Labels as Accurate?

Noisy labels significantly hinder the accuracy and generalization of machine learning models, particularly due to ambiguous instance features. Traditional techniques that attempt to correct noisy labels directly, such as those using transition matrices, often fail to address the inherent complexities of the problem sufficiently. In this paper, we introduce EchoAlign, a transformative paradigm shift in learning from noisy labels. Instead of focusing on label correction, EchoAlign treats noisy labels ($\tilde{Y}$) as accurate and modifies corresponding instance features ($X$) to achieve better alignment with $\tilde{Y}$. EchoAlign's core components are (1) EchoMod: Employing controllable generative models, EchoMod precisely modifies instances while maintaining their intrinsic characteristics and ensuring alignment with the noisy labels. (2) EchoSelect: Instance modification inevitably introduces distribution shifts between training and test sets. EchoSelect maintains a significant portion of clean original instances to mitigate these shifts. It leverages the distinct feature similarity distributions between original and modified instances as a robust tool for accurate sample selection. This integrated approach yields remarkable results. In environments with 30% instance-dependent noise, even at 99% selection accuracy, EchoSelect retains nearly twice the number of samples compared to the previous best method. Notably, on three datasets, EchoAlign surpasses previous state-of-the-art techniques with a substantial improvement.

Adapting Large Multimodal Models to Distribution Shifts: The Role of In-Context Learning

Recent studies indicate that large multimodal models (LMMs) are highly robust against natural distribution shifts, often surpassing previous baselines. Despite this, domain-specific adaptation is still necessary, particularly in specialized areas like healthcare. Due to the impracticality of fine-tuning LMMs given their vast parameter space, this work investigates in-context learning (ICL) as an effective alternative for enhancing LMMs' adaptability. We find that the success of ICL heavily relies on the choice of demonstration, mirroring challenges seen in large language models but introducing unique complexities for LMMs facing distribution shifts. Our study addresses this by evaluating an unsupervised ICL method, TopKNearestPR, which selects in-context examples through a nearest example search based on feature similarity. We uncover that its effectiveness is limited by the deficiencies of pre-trained vision encoders under distribution shift scenarios. To address these challenges, we propose InvariantSelectPR, a novel method leveraging Class-conditioned Contrastive Invariance (CCI) for more robust demonstration selection. Specifically, CCI enhances pre-trained vision encoders by improving their discriminative capabilities across different classes and ensuring invariance to domain-specific variations. This enhancement allows the encoders to effectively identify and retrieve the most informative examples, which are then used to guide LMMs in adapting to new query samples under varying distributions. Our experiments show that InvariantSelectPR substantially improves the adaptability of LMMs, achieving significant performance gains on benchmark datasets, with a 34.2%$\uparrow$ accuracy increase in 7-shot on Camelyon17 and 16.9%$\uparrow$ increase in 7-shot on HAM10000 compared to the baseline zero-shot performance.