MinerU.Chem: A High-Precision System for Optical Chemical Structure and Reaction Recognition

In organic chemistry papers and patents, molecular structures, reaction schemes, and experimental conditions are often presented as molecular structure depictions, reaction diagrams, and complex tables or figures. Such information is difficult for general-purpose document parsing systems to directly convert into machine-readable data. This limits data production for organic chemistry knowledge base construction and for AI for Chemistry tasks such as reaction prediction, retrosynthesis, condition recommendation, molecular property prediction, and drug molecule design. This report introduces MinerU-Chem, a document parsing system for organic chemistry literature integrated into the MinerU online platform. Built on top of MinerU's general document parsing pipeline, MinerU-Chem adds five chemistry-specific modules: chemistry relevance filtering, molecular structure detection, molecule identifier extraction, molecular structure recognition, and reaction scheme parsing. Together, these modules convert organic-chemistry-related image regions in documents into a Molecule Summary List and a Reaction Summary List. For molecular structure recognition, MinerU-Chem uses CARBON (Complex Atomic Representation and Bonding Object Notation) as its core representation. CARBON enables recognition results to preserve both the visual layout of the original image and complex chemical semantics, while supporting the export of standard downstream formats such as MolFile and SMILES. On the SMILES-evaluable subset of MolRecBench-Wild (N=2,392), MinerU-Chem's molecular structure recognition module achieves a SMILES exact-match accuracy of 93.02%, outperforming the best evaluated comparison system, GPT-5.6-Sol (74.87%), by 18.15 percentage points. The system has been integrated into the MinerU online platform and is available at https://mineru.net/OpenSourceTools/Extractor .

SCTA: An Agentic Framework for Stable and Interpretable Target Gene Discovery from Single-Cell RNA Sequencing

Identifying therapeutic target genes from single-cell RNA sequencing (scRNA-seq) data remains a fundamental challenge in translational biology. Unlike bulk assays, scRNA-seq captures heterogeneous cellular states and rare subpopulations, but this same heterogeneity makes target discovery highly sensitive to analytical choices throughout the pipeline, including preprocessing, cell population selection, differential expression analysis, and downstream biological interpretation. As a result, existing workflows and general-purpose analysis agents often produce unstable or difficult-to-interpret target hypotheses, limiting their reliability for disease-focused discovery. We present SCTA (Single-Cell Target Agent), a decision-centric agentic framework for stable and interpretable target gene discovery from scRNA-seq data. Rather than treating analysis as a single general-purpose reasoning task, SCTA decomposes target discovery into specialized agents aligned with key decision points in the single-cell pipeline and constrains downstream reasoning with structured biological evidence. In a representative ablation study on hereditary chronic pancreatitis, we demonstrate that SCTA's full evidence integration yields the most stable target selection across independent runs among the tested configurations, while recovering biologically coherent, disease-relevant mechanisms validated in prior studies. These results suggest that decision-aware agent orchestration tailored to the structure of single-cell analysis can improve the robustness, interpretability, and practical utility of target discovery in precision medicine.

pAI-Econ-claude: A Gated Human-in-the-Loop Multi-Agent Architecture for AI-Assisted Economic Theory Development

In many social-science research tasks, such as economics, LLM-based agents must produce outputs for which no cheap, task-complete, machine-readable correctness signal exists. This creates a distinctive reliability problem for multi-agent systems: how should generation, critique, coordination, and human judgment be organized when no component can certify the final result? We address this problem through pAI-Econ-claude, a gated, human-in-the-loop multi-agent architecture for AI-assisted economic theory development. Agents coordinate through a shared workspace of inspectable intermediate records; specialized gates diagnose targeted failure modes and recommend loopbacks without certifying correctness; and human checkpoints retain authority over decisions that are costly to reverse. We evaluate the architecture on five matched economic-theory tasks against an ungated baseline. Two evaluators blinded to configuration agreed on all five pairwise rankings, preferring the gated architecture in four tasks and the baseline in one. Mean failure severity fell from 1.58 to 1.16, while overall usefulness rose from 2.60 to 3.10. The largest observed gain occurred when a reality check rejected a false market-structure premise and a proof review prompted revision of a false welfare claim. The negative case shows that scaffolding can also compress an economically important mechanism too aggressively. The results support a bounded claim: gated oversight improves the auditability of AI-assisted economic theory without substituting for formal verification, and the allocation of irreversible human judgment is a more informative design variable than pure agent autonomy. The workflow is publicly available at https://github.com/maxwell2732/pAI-Econ-claude.

(Human) Attention Is (Still) All You Need: Human oversight makes AI-assisted social science reliable

Large language models (LLMs) are increasingly used for tasks once reserved for trained researchers, including hypothesis generation, specification choice, and drafting conclusions. We argue that the reliability of AI-assisted research depends not only on model capability, but also on how cognitive labour is structured between humans and machines. We study this problem through Human-in-the-Loop Economic Research (HLER), a decision architecture based on pre-commitment, decision sequencing, accountability, and attention allocation. In a pre-specified 2*4 factorial experiment with 280 complete research runs across four datasets, an unconstrained multi-agent baseline produced critical failures in 72% of runs. Using the same underlying model, the same agent decomposition, and identical prompts for the shared reasoning agents, HLER reduced the failure rate to 16% by imposing three architectural commitments: LLMs reason but do not execute data work, data and estimation are handled deterministically, and three human decision gates bind the workflow. Fisher's exact test rejects equality of failure rates at p<0.001. Reliability gains were largest on the least publicly represented dataset, a Qing-dynasty population register, consistent with a task-based production model with Frechet-distributed output quality. An 80-run ablation suggests that deterministic computation and human gates contribute independently, with exploratory evidence of complementarity. We interpret HLER as a research harness rather than an autonomous AI scientist: it sharply reduces failures, makes residual weaknesses more visible, and prevents unreliable claims from being advanced as publication-ready outputs.

Joint Communication and Computation Design for Mobile Embodied AI Network (MEAN)

This letter investigates the problem of energy efficient collaborative strategy for mobile embodied artificial intelligence network (MEAN) over wireless communication. In the considered model, the agents execute the tasks through collaboration, and they can switch between two operating modes based on the signal-to-noise ratio (SNR) and global collaboration. The dual-mode comprises the base station (BS)-assisted collaborative mode, in which agents make decisions through semantic communication with BS and then collaborate on tasks, and the local computing mode, in which the agents make decisions and execute tasks independently. Due to the dynamic wireless communication and flexible collaboration strategy, we jointly consider computation energy, communication energy, and task-execution energy with specific collaborative gains into a mixed-integer nonlinear programming (MINLP) optimization problem whose goal is to minimize the total system energy consumption. To solve it, we propose a lower-complexity enumeration algorithm: first, we get the optimal closed-form solution for semantic compression ratio and transmit power by proving the strict convexity. Second, we determine the scale of collaboration and the operating mode of each agent by a greedy sorting algorithm based on individual energy-saving potentials. Simulation results show that the proposed algorithm can significantly reduce the total energy consumption compared to benchmark schemes.

MolRecBench-Wild: A Real-World Benchmark for Optical Chemical Structure Recognition

Optical Chemical Structure Recognition (OCSR) aims to translate molecular diagrams in scientific literature into machine-readable formats, but current systems remain unreliable on real-world images due to substantial visual and chemical complexity. We introduce MOSAIC, a dual-dimensional difficulty framework with 37 fine-grained labels that jointly characterize visual interference and chemical semantic challenges in molecular diagrams. Based on this framework, we construct MolRecBench-Wild, a benchmark of 5,029 structures from 820 recent chemistry papers, covering the full difficulty spectrum observed in real publications. To enable faithful semantic evaluation beyond SMILES and MolFile, we propose CARBON, a representation language capable of expressing valence variations, icon-based groups, and other non-standard chemical semantics. We further adopt a dual-track evaluation protocol supporting both CARBON and SMILES outputs for broad model compatibility. Comprehensive experiments over 18 OCSR-capable models reveal severe performance degradation on MolRecBench-Wild, exposing a large gap between previous patent benchmarks and real-world academic scenarios.

Scalable Hyperparameter-Divergent Ensemble Training with Automatic Learning Rate Exploration for Large Models

Training large neural networks with data-parallel stochastic gradient descent allocates N GPU replicas to compute effectively identical updates -- a practice that leaves the rich space of learning rate configurations entirely unexplored during training. We propose Hyperparameter-Divergent Ensemble Training (HDET), a method that repurposes these replicas for simultaneous learning rate exploration at negligible communication overhead. HDET operates in alternating phases: a fan-out stage in which replicas train independently under a structured, symmetric spread of learning rates, and a converge stage in which parameters are averaged across all replicas via AllReduce every T steps. Building on this ensemble substrate, we further propose an automatic learning rate (auto-LR) controller that treats the relative training loss across replicas as a performance signal, updating the shared base schedule toward higher-performing configurations via a momentum-based gradient-free meta-update. The combined method produces a self-adapting learning rate schedule that improves both optimization quality and generalization without additional hyperparameter sweeps or training budget. Crucially, the framework generalizes beyond learning rate: any scalar hyperparameter that does not alter model architecture -- such as dropout rate, attention scale temperature, or weight-decay coefficient -- can be explored across replicas using the same fan-out/converge protocol, with inter-replica loss differences serving as zero-order hypergradients that guide the search direction. HDET is implemented as a drop-in replacement for PyTorch's OneCycleLR scheduler, requiring no changes to model architecture, optimizer, or data pipeline.

Extending One-Step Image Generation from Class Labels to Text via Discriminative Text Representation

Few-step generation has been a long-standing goal, with recent one-step generation methods exemplified by MeanFlow achieving remarkable results. Existing research on MeanFlow primarily focuses on class-to-image generation. However, an intuitive yet unexplored direction is to extend the condition from fixed class labels to flexible text inputs, enabling richer content creation. Compared to the limited class labels, text conditions pose greater challenges to the model's understanding capability, necessitating the effective integration of powerful text encoders into the MeanFlow framework. Surprisingly, although incorporating text conditions appears straightforward, we find that integrating powerful LLM-based text encoders using conventional training strategies results in unsatisfactory performance. To uncover the underlying cause, we conduct detailed analyses and reveal that, due to the extremely limited number of refinement steps in the MeanFlow generation, such as only one step, the text feature representations are required to possess sufficiently high discriminability. This also explains why discrete and easily distinguishable class features perform well within the MeanFlow framework. Guided by these insights, we leverage a powerful LLM-based text encoder validated to possess the required semantic properties and adapt the MeanFlow generation process to this framework, resulting in efficient text-conditioned synthesis for the first time. Furthermore, we validate our approach on the widely used diffusion model, demonstrating significant generation performance improvements. We hope this work provides a general and practical reference for future research on text-conditioned MeanFlow generation. The code is available at https://github.com/AMAP-ML/EMF.

Near-Field Integrated Sensing, Computing and Semantic Communication in Digital Twin-Assisted Vehicular Networks

Digital twin (DT) technology offers transformative potential for vehicular networks, enabling high-fidelity virtual representations for enhanced safety and automation. However, seamless DT synchronization in dynamic environments faces challenges such as massive data transmission, precision sensing, and strict computational constraints. This paper proposes an integrated sensing, computing, and semantic communication (ISCSC) framework tailored for DT-assisted vehicular networks in the near-field (NF) regime. Leveraging a multi-user multiple-input multiple-output (MU-MIMO) configuration, each roadside unit (RSU) employs semantic communication to serve vehicles while simultaneously utilizing millimeter-wave (mmWave) radar for environmental mapping. We implement particle filtering at RSUs to achieve high-precision vehicle tracking. To optimize performance, we formulate a joint optimization problem balancing semantic communication rates and sensing accuracy under limited computational resources and power budget. Our solution includes a hybrid heuristic algorithm for vehicle-to-RSU assignment and an alternating optimization approach for determining semantic extraction ratios and beamforming matrices. Performance is extensively evaluated via the Cramér-Rao bound (CRB) for angle and distance estimation, semantic transmission rates, and resource utilization. Numerical results demonstrate that the proposed ISCSC framework achieves a 20% improvement in transmission rate while maintaining the sensing accuracy of existing integrated sensing and communication (ISAC) schemes under constrained resource conditions.

An Industrial-Scale Sequential Recommender for LinkedIn Feed Ranking

LinkedIn Feed enables professionals worldwide to discover relevant content, build connections, and share knowledge at scale. We present Feed Sequential Recommender (Feed-SR), a transformer-based sequential ranking model for LinkedIn Feed that replaces a DCNv2-based ranker and meets strict production constraints. We detail the modeling choices, training techniques, and serving optimizations that enable deployment at LinkedIn scale. Feed-SR is currently the primary member experience on LinkedIn's Feed and shows significant improvements in member engagement (+2.10% time spent) in online A/B tests compared to the existing production model. We also describe our deployment experience with alternative sequential and LLM-based ranking architectures and why Feed-SR provided the best combination of online metrics and production efficiency.