GenKI: Enhancing Open-Domain Question Answering with Knowledge Integration and Controllable Generation in Large Language Models

Open-domain question answering (OpenQA) represents a cornerstone in natural language processing (NLP), primarily focused on extracting answers from unstructured textual data. With the rapid advancements in Large Language Models (LLMs), LLM-based OpenQA methods have reaped the benefits of emergent understanding and answering capabilities enabled by massive parameters compared to traditional methods. However, most of these methods encounter two critical challenges: how to integrate knowledge into LLMs effectively and how to adaptively generate results with specific answer formats for various task situations. To address these challenges, we propose a novel framework named GenKI, which aims to improve the OpenQA performance by exploring Knowledge Integration and controllable Generation on LLMs simultaneously. Specifically, we first train a dense passage retrieval model to retrieve associated knowledge from a given knowledge base. Subsequently, we introduce a novel knowledge integration model that incorporates the retrieval knowledge into instructions during fine-tuning to intensify the model. Furthermore, to enable controllable generation in LLMs, we leverage a certain fine-tuned LLM and an ensemble based on text consistency incorporating all coherence, fluency, and answer format assurance. Finally, extensive experiments conducted on the TriviaQA, MSMARCO, and CMRC2018 datasets, featuring diverse answer formats, have demonstrated the effectiveness of GenKI with comparison of state-of-the-art baselines. Moreover, ablation studies have disclosed a linear relationship between the frequency of retrieved knowledge and the model's ability to recall knowledge accurately against the ground truth. Our code of GenKI is available at https://github.com/USTC-StarTeam/GenKI

Hypergraph Tversky-Aware Domain Incremental Learning for Brain Tumor Segmentation with Missing Modalities

Existing methods for multimodal MRI segmentation with missing modalities typically assume that all MRI modalities are available during training. However, in clinical practice, some modalities may be missing due to the sequential nature of MRI acquisition, leading to performance degradation. Furthermore, retraining models to accommodate newly available modalities can be inefficient and may cause overfitting, potentially compromising previously learned knowledge. To address these challenges, we propose Replay-based Hypergraph Domain Incremental Learning (ReHyDIL) for brain tumor segmentation with missing modalities. ReHyDIL leverages Domain Incremental Learning (DIL) to enable the segmentation model to learn from newly acquired MRI modalities without forgetting previously learned information. To enhance segmentation performance across diverse patient scenarios, we introduce the Cross-Patient Hypergraph Segmentation Network (CHSNet), which utilizes hypergraphs to capture high-order associations between patients. Additionally, we incorporate Tversky-Aware Contrastive (TAC) loss to effectively mitigate information imbalance both across and within different modalities. Extensive experiments on the BraTS2019 dataset demonstrate that ReHyDIL outperforms state-of-the-art methods, achieving an improvement of over 2\% in the Dice Similarity Coefficient across various tumor regions. Our code is available at ReHyDIL.

Temporal Alignment of Time Sensitive Facts with Activation Engineering

Large Language Models (LLMs) are trained on diverse and often conflicting knowledge spanning multiple domains and time periods. Some of this knowledge is only valid within specific temporal contexts, such as answering the question, "Who is the President of the United States in 2022?" Ensuring LLMs generate time appropriate responses is crucial for maintaining relevance and accuracy. In this work we explore activation engineering as a method for temporally aligning LLMs to improve factual recall without any training or dataset creation. In this research we explore an activation engineering technique to ground three versions of LLaMA 2 to specific points in time and examine the effects of varying injection layers and prompting strategies. Our experiments demonstrate up to a 44% and 16% improvement in relative and explicit prompting respectively, achieving comparable performance to the fine-tuning method proposed by Zhao et al. (2024) . Notably, our approach achieves similar results to the fine-tuning baseline while being significantly more computationally efficient and requiring no pre-aligned datasets.

Multimodal Cancer Survival Analysis via Hypergraph Learning with Cross-Modality Rebalance

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of contextual and hierarchical details within pathology images. Furthermore, the disparity in data granularity and dimensionality between pathology and genomics leads to a significant modality imbalance. The high spatial resolution inherent in pathology data renders it a dominant role while overshadowing genomics in multimodal integration. In this paper, we propose a multimodal survival prediction framework that incorporates hypergraph learning to effectively capture both contextual and hierarchical details from pathology images. Moreover, it employs a modality rebalance mechanism and an interactive alignment fusion strategy to dynamically reweight the contributions of the two modalities, thereby mitigating the pathology-genomics imbalance. Quantitative and qualitative experiments are conducted on five TCGA datasets, demonstrating that our model outperforms advanced methods by over 3.4\% in C-Index performance.

GVPO: Group Variance Policy Optimization for Large Language Model Post-Training

Post-training plays a crucial role in refining and aligning large language models to meet specific tasks and human preferences. While recent advancements in post-training techniques, such as Group Relative Policy Optimization (GRPO), leverage increased sampling with relative reward scoring to achieve superior performance, these methods often suffer from training instability that limits their practical adoption. To address this challenge, we present Group Variance Policy Optimization (GVPO). GVPO incorporates the analytical solution to KL-constrained reward maximization directly into its gradient weights, ensuring alignment with the optimal policy. The method provides intuitive physical interpretations: its gradient mirrors the mean squared error between the central distance of implicit rewards and that of actual rewards. GVPO offers two key advantages: (1) it guarantees a unique optimal solution, exactly the KL-constrained reward maximization objective, (2) it supports flexible sampling distributions that avoids on-policy and importance sampling limitations. By unifying theoretical guarantees with practical adaptability, GVPO establishes a new paradigm for reliable and versatile LLM post-training.

Bearing-Only Tracking and Circumnavigation of a Fast Time-Varied Velocity Target Utilising an LSTM

Bearing-only tracking, localisation, and circumnavigation is a problem in which a single or a group of agents attempts to track a target while circumnavigating it at a fixed distance using only bearing measurements. While previous studies have addressed scenarios involving stationary targets or those moving with an unknown constant velocity, the challenge of accurately tracking a target moving with a time-varying velocity remains open. This paper presents an approach utilising a Long Short-Term Memory (LSTM) based estimator for predicting the target's position and velocity. We also introduce a corresponding control strategy. When evaluated against previously proposed estimation and circumnavigation approaches, our approach demonstrates significantly lower control and estimation errors across various time-varying velocity scenarios. Additionally, we illustrate the effectiveness of the proposed method in tracking targets with a double integrator nonholonomic system dynamics that mimic real-world systems.

STeP: A General and Scalable Framework for Solving Video Inverse Problems with Spatiotemporal Diffusion Priors

We study how to solve general Bayesian inverse problems involving videos using diffusion model priors. While it is desirable to use a video diffusion prior to effectively capture complex temporal relationships, due to the computational and data requirements of training such a model, prior work has instead relied on image diffusion priors on single frames combined with heuristics to enforce temporal consistency. However, these approaches struggle with faithfully recovering the underlying temporal relationships, particularly for tasks with high temporal uncertainty. In this paper, we demonstrate the feasibility of practical and accessible spatiotemporal diffusion priors by fine-tuning latent video diffusion models from pretrained image diffusion models using limited videos in specific domains. Leveraging this plug-and-play spatiotemporal diffusion prior, we introduce a general and scalable framework for solving video inverse problems. We then apply our framework to two challenging scientific video inverse problems--black hole imaging and dynamic MRI. Our framework enables the generation of diverse, high-fidelity video reconstructions that not only fit observations but also recover multi-modal solutions. By incorporating a spatiotemporal diffusion prior, we significantly improve our ability to capture complex temporal relationships in the data while also enhancing spatial fidelity.

Unified Generative Search and Recommendation

Modern commercial platforms typically offer both search and recommendation functionalities to serve diverse user needs, making joint modeling of these tasks an appealing direction. While prior work has shown that integrating search and recommendation can be mutually beneficial, it also reveals a performance trade-off: enhancements in one task often come at the expense of the other. This challenge arises from their distinct information requirements: search emphasizes semantic relevance between queries and items, whereas recommendation depends more on collaborative signals among users and items. Effectively addressing this trade-off requires tackling two key problems: (1) integrating both semantic and collaborative signals into item representations, and (2) guiding the model to distinguish and adapt to the unique demands of search and recommendation. The emergence of generative retrieval with Large Language Models (LLMs) presents new possibilities. This paradigm encodes items as identifiers and frames both search and recommendation as sequential generation tasks, offering the flexibility to leverage multiple identifiers and task-specific prompts. In light of this, we introduce GenSAR, a unified generative framework for balanced search and recommendation. Our approach designs dual-purpose identifiers and tailored training strategies to incorporate complementary signals and align with task-specific objectives. Experiments on both public and commercial datasets demonstrate that GenSAR effectively reduces the trade-off and achieves state-of-the-art performance on both tasks.

QE-RAG: A Robust Retrieval-Augmented Generation Benchmark for Query Entry Errors

Retriever-augmented generation (RAG) has become a widely adopted approach for enhancing the factual accuracy of large language models (LLMs). While current benchmarks evaluate the performance of RAG methods from various perspectives, they share a common assumption that user queries used for retrieval are error-free. However, in real-world interactions between users and LLMs, query entry errors such as keyboard proximity errors, visual similarity errors, and spelling errors are frequent. The impact of these errors on current RAG methods against such errors remains largely unexplored. To bridge this gap, we propose QE-RAG, the first robust RAG benchmark designed specifically to evaluate performance against query entry errors. We augment six widely used datasets by injecting three common types of query entry errors into randomly selected user queries at rates of 20\% and 40\%, simulating typical user behavior in real-world scenarios. We analyze the impact of these errors on LLM outputs and find that corrupted queries degrade model performance, which can be mitigated through query correction and training a robust retriever for retrieving relevant documents. Based on these insights, we propose a contrastive learning-based robust retriever training method and a retrieval-augmented query correction method. Extensive in-domain and cross-domain experiments reveal that: (1) state-of-the-art RAG methods including sequential, branching, and iterative methods, exhibit poor robustness to query entry errors; (2) our method significantly enhances the robustness of RAG when handling query entry errors and it's compatible with existing RAG methods, further improving their robustness.

Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentation

Weakly supervised image segmentation with image-level labels has drawn attention due to the high cost of pixel-level annotations. Traditional methods using Class Activation Maps (CAMs) often highlight only the most discriminative regions, leading to incomplete masks. Recent approaches that introduce textual information struggle with histopathological images due to inter-class homogeneity and intra-class heterogeneity. In this paper, we propose a prototype-based image prompting framework for histopathological image segmentation. It constructs an image bank from the training set using clustering, extracting multiple prototype features per class to capture intra-class heterogeneity. By designing a matching loss between input features and class-specific prototypes using contrastive learning, our method addresses inter-class homogeneity and guides the model to generate more accurate CAMs. Experiments on four datasets (LUAD-HistoSeg, BCSS-WSSS, GCSS, and BCSS) show that our method outperforms existing weakly supervised segmentation approaches, setting new benchmarks in histopathological image segmentation.