Sub-diffraction terahertz backpropagation compressive imaging

Terahertz single-pixel imaging (TSPI) has garnered significant attention due to its simplicity and cost-effectiveness. However, the relatively long wavelength of THz waves limits sub-diffraction-scale imaging resolution. Although TSPI technique can achieve sub-wavelength resolution, it requires harsh experimental conditions and time-consuming processes. Here, we propose a sub-diffraction THz backpropagation compressive imaging technique. We illuminate the object with monochromatic continuous-wave THz radiation. The transmitted THz wave is modulated by prearranged patterns generated on the back surface of a 500-{\mu}m-thick silicon wafer, realized through photoexcited carriers using a 532-nm laser. The modulated THz wave is then recorded by a single-element detector. An untrained neural network is employed to iteratively reconstruct the object image with an ultralow compression ratio of 1.5625% under a physical model constraint, thus reducing the long sampling times. To further suppress the diffraction-field effects, embedded with the angular spectrum propagation (ASP) theory to model the diffraction of THz waves during propagation, the network retrieves near-field information from the object, enabling sub-diffraction imaging with a spatial resolution of ~{\lambda}0/7 ({\lambda}0 = 833.3 {\mu}m at 0.36 THz) and eliminating the need for ultrathin photomodulators. This approach provides an efficient solution for advancing THz microscopic imaging and addressing other inverse imaging challenges.

Trustworthy Contrast-enhanced Brain MRI Synthesis

Contrast-enhanced brain MRI (CE-MRI) is a valuable diagnostic technique but may pose health risks and incur high costs. To create safer alternatives, multi-modality medical image translation aims to synthesize CE-MRI images from other available modalities. Although existing methods can generate promising predictions, they still face two challenges, i.e., exhibiting over-confidence and lacking interpretability on predictions. To address the above challenges, this paper introduces TrustI2I, a novel trustworthy method that reformulates multi-to-one medical image translation problem as a multimodal regression problem, aiming to build an uncertainty-aware and reliable system. Specifically, our method leverages deep evidential regression to estimate prediction uncertainties and employs an explicit intermediate and late fusion strategy based on the Mixture of Normal Inverse Gamma (MoNIG) distribution, enhancing both synthesis quality and interpretability. Additionally, we incorporate uncertainty calibration to improve the reliability of uncertainty. Validation on the BraTS2018 dataset demonstrates that our approach surpasses current methods, producing higher-quality images with rational uncertainty estimation.

Digital Twin Brain: a simulation and assimilation platform for whole human brain

In this work, we present a computing platform named digital twin brain (DTB) that can simulate spiking neuronal networks of the whole human brain scale and more importantly, a personalized biological brain structure. In comparison to most brain simulations with a homogeneous global structure, we highlight that the sparseness, couplingness and heterogeneity in the sMRI, DTI and PET data of the brain has an essential impact on the efficiency of brain simulation, which is proved from the scaling experiments that the DTB of human brain simulation is communication-intensive and memory-access intensive computing systems rather than computation-intensive. We utilize a number of optimization techniques to balance and integrate the computation loads and communication traffics from the heterogeneous biological structure to the general GPU-based HPC and achieve leading simulation performance for the whole human brain-scaled spiking neuronal networks. On the other hand, the biological structure, equipped with a mesoscopic data assimilation, enables the DTB to investigate brain cognitive function by a reverse-engineering method, which is demonstrated by a digital experiment of visual evaluation on the DTB. Furthermore, we believe that the developing DTB will be a promising powerful platform for a large of research orients including brain-inspiredintelligence, rain disease medicine and brain-machine interface.