Generalized Relation Modeling for Transformer Tracking

Compared with previous two-stream trackers, the recent one-stream tracking pipeline, which allows earlier interaction between the template and search region, has achieved a remarkable performance gain. However, existing one-stream trackers always let the template interact with all parts inside the search region throughout all the encoder layers. This could potentially lead to target-background confusion when the extracted feature representations are not sufficiently discriminative. To alleviate this issue, we propose a generalized relation modeling method based on adaptive token division. The proposed method is a generalized formulation of attention-based relation modeling for Transformer tracking, which inherits the merits of both previous two-stream and one-stream pipelines whilst enabling more flexible relation modeling by selecting appropriate search tokens to interact with template tokens. An attention masking strategy and the Gumbel-Softmax technique are introduced to facilitate the parallel computation and end-to-end learning of the token division module. Extensive experiments show that our method is superior to the two-stream and one-stream pipelines and achieves state-of-the-art performance on six challenging benchmarks with a real-time running speed.

When Evolutionary Computation Meets Privacy

Recently, evolutionary computation (EC) has been promoted by machine learning, distributed computing, and big data technologies, resulting in new research directions of EC like distributed EC and surrogate-assisted EC. These advances have significantly improved the performance and the application scope of EC, but also trigger privacy leakages, such as the leakage of optimal results and surrogate model. Accordingly, evolutionary computation combined with privacy protection is becoming an emerging topic. However, privacy concerns in evolutionary computation lack a systematic exploration, especially for the object, motivation, position, and method of privacy protection. To this end, in this paper, we discuss three typical optimization paradigms (i.e., \textit{centralized optimization, distributed optimization, and data-driven optimization}) to characterize optimization modes of evolutionary computation and propose BOOM to sort out privacy concerns in evolutionary computation. Specifically, the centralized optimization paradigm allows clients to outsource optimization problems to the centralized server and obtain optimization solutions from the server. While the distributed optimization paradigm exploits the storage and computational power of distributed devices to solve optimization problems. Also, the data-driven optimization paradigm utilizes data collected in history to tackle optimization problems lacking explicit objective functions. Particularly, this paper adopts BOOM to characterize the object and motivation of privacy protection in three typical optimization paradigms and discusses potential privacy-preserving technologies balancing optimization performance and privacy guarantees in three typical optimization paradigms. Furthermore, this paper attempts to foresee some new research directions of privacy-preserving evolutionary computation.

Low-complexity Deep Video Compression with A Distributed Coding Architecture

Prevalent predictive coding-based video compression methods rely on a heavy encoder to reduce the temporal redundancy, which makes it challenging to deploy them on resource-constrained devices. Meanwhile, as early as the 1970s, distributed source coding theory has indicated that independent encoding and joint decoding with side information (SI) can achieve high-efficient compression of correlated sources. This has inspired a distributed coding architecture aiming at reducing the encoding complexity. However, traditional distributed coding methods suffer from a substantial performance gap to predictive coding ones. Inspired by the great success of learning-based compression, we propose the first end-to-end distributed deep video compression framework to improve the rate-distortion performance. A key ingredient is an effective SI generation module at the decoder, which helps to effectively exploit inter-frame correlations without computation-intensive encoder-side motion estimation and compensation. Experiments show that our method significantly outperforms conventional distributed video coding and H.264. Meanwhile, it enjoys 6-7x encoding speedup against DVC [1] with comparable compression performance. Code is released at https://github.com/Xinjie-Q/Distributed-DVC.

DSDP: A Blind Docking Strategy Accelerated by GPUs

Virtual screening, including molecular docking, plays an essential role in drug discovery. Many traditional and machine-learning based methods are available to fulfil the docking task. The traditional docking methods are normally extensively time-consuming, and their performance in blind docking remains to be improved. Although the runtime of docking based on machine learning is significantly decreased, their accuracy is still limited. In this study, we take the advantage of both traditional and machine-learning based methods, and present a method Deep Site and Docking Pose (DSDP) to improve the performance of blind docking. For the traditional blind docking, the entire protein is covered by a cube, and the initial positions of ligands are randomly generated in the cube. In contract, DSDP can predict the binding site of proteins and provide an accurate searching space and initial positions for the further conformational sampling. The docking task of DSDP makes use of the score function and a similar but modified searching strategy of AutoDock Vina, accelerated by implementation in GPUs. We systematically compare its performance with the state-of-the-art methods, including Autodock Vina, GNINA, QuickVina, SMINA, and DiffDock. DSDP reaches a 29.8% top-1 success rate (RMSD < 2 {\AA}) on an unbiased and challenging test dataset with 1.2 s wall-clock computational time per system. Its performances on DUD-E dataset and the time-split PDBBind dataset used in EquiBind, TankBind, and DiffDock are also effective, presenting a 57.2% and 41.8% top-1 success rate with 0.8 s and 1.0 s per system, respectively.

CoNIC Challenge: Pushing the Frontiers of Nuclear Detection, Segmentation, Classification and Counting

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and survival analysis, where we demonstrated that the challenge's improvement over the previous state-of-the-art led to significant boosts in downstream performance. Our findings also suggest that eosinophils and neutrophils play an important role in the tumour microevironment. We release challenge models and WSI-level results to foster the development of further methods for biomarker discovery.

AC2C: Adaptively Controlled Two-Hop Communication for Multi-Agent Reinforcement Learning

Learning communication strategies in cooperative multi-agent reinforcement learning (MARL) has recently attracted intensive attention. Early studies typically assumed a fully-connected communication topology among agents, which induces high communication costs and may not be feasible. Some recent works have developed adaptive communication strategies to reduce communication overhead, but these methods cannot effectively obtain valuable information from agents that are beyond the communication range. In this paper, we consider a realistic communication model where each agent has a limited communication range, and the communication topology dynamically changes. To facilitate effective agent communication, we propose a novel communication protocol called Adaptively Controlled Two-Hop Communication (AC2C). After an initial local communication round, AC2C employs an adaptive two-hop communication strategy to enable long-range information exchange among agents to boost performance, which is implemented by a communication controller. This controller determines whether each agent should ask for two-hop messages and thus helps to reduce the communication overhead during distributed execution. We evaluate AC2C on three cooperative multi-agent tasks, and the experimental results show that it outperforms relevant baselines with lower communication costs.

Federated contrastive learning models for prostate cancer diagnosis and Gleason grading

The application effect of artificial intelligence (AI) in the field of medical imaging is remarkable. Robust AI model training requires large datasets, but data collection faces communication, ethics, and privacy protection constraints. Fortunately, federated learning can solve the above problems by coordinating multiple clients to train the model without sharing the original data. In this study, we design a federated contrastive learning framework (FCL) for large-scale pathology images and the heterogeneity challenges. It enhances the model's generalization ability by maximizing the attention consistency between the local client and server models. To alleviate the privacy leakage problem when transferring parameters and verify the robustness of FCL, we use differential privacy to further protect the model by adding noise. We evaluate the effectiveness of FCL on the cancer diagnosis task and Gleason grading task on 19,635 prostate cancer WSIs from multiple clients. In the diagnosis task, the average AUC of 7 clients is 95% when the categories are relatively balanced, and our FCL achieves 97%. In the Gleason grading task, the average Kappa of 6 clients is 0.74, and the Kappa of FCL reaches 0.84. Furthermore, we also validate the robustness of the model on external datasets(one public dataset and two private datasets). In addition, to better explain the classification effect of the model, we show whether the model focuses on the lesion area by drawing a heatmap. Finally, FCL brings a robust, accurate, low-cost AI training model to biomedical research, effectively protecting medical data privacy.

Message Passing Meets Graph Neural Networks: A New Paradigm for Massive MIMO Systems

As one of the core technologies for 5G systems, massive multiple-input multiple-output (MIMO) introduces dramatic capacity improvements along with very high beamforming and spatial multiplexing gains. When developing efficient physical layer algorithms for massive MIMO systems, message passing is one promising candidate owing to the superior performance. However, as their computational complexity increases dramatically with the problem size, the state-of-the-art message passing algorithms cannot be directly applied to future 6G systems, where an exceedingly large number of antennas are expected to be deployed. To address this issue, we propose a model-driven deep learning (DL) framework, namely the AMP-GNN for massive MIMO transceiver design, by considering the low complexity of the AMP algorithm and adaptability of GNNs. Specifically, the structure of the AMP-GNN network is customized by unfolding the approximate message passing (AMP) algorithm and introducing a graph neural network (GNN) module into it. The permutation equivariance property of AMP-GNN is proved, which enables the AMP-GNN to learn more efficiently and to adapt to different numbers of users. We also reveal the underlying reason why GNNs improve the AMP algorithm from the perspective of expectation propagation, which motivates us to amalgamate various GNNs with different message passing algorithms. In the simulation, we take the massive MIMO detection to exemplify that the proposed AMP-GNN significantly improves the performance of the AMP detector, achieves comparable performance as the state-of-the-art DL-based MIMO detectors, and presents strong robustness to various mismatches.

Hyperspectral Image Super Resolution with Real Unaligned RGB Guidance

Fusion-based hyperspectral image (HSI) super-resolution has become increasingly prevalent for its capability to integrate high-frequency spatial information from the paired high-resolution (HR) RGB reference image. However, most of the existing methods either heavily rely on the accurate alignment between low-resolution (LR) HSIs and RGB images, or can only deal with simulated unaligned RGB images generated by rigid geometric transformations, which weakens their effectiveness for real scenes. In this paper, we explore the fusion-based HSI super-resolution with real RGB reference images that have both rigid and non-rigid misalignments. To properly address the limitations of existing methods for unaligned reference images, we propose an HSI fusion network with heterogenous feature extractions, multi-stage feature alignments, and attentive feature fusion. Specifically, our network first transforms the input HSI and RGB images into two sets of multi-scale features with an HSI encoder and an RGB encoder, respectively. The features of RGB reference images are then processed by a multi-stage alignment module to explicitly align the features of RGB reference with the LR HSI. Finally, the aligned features of RGB reference are further adjusted by an adaptive attention module to focus more on discriminative regions before sending them to the fusion decoder to generate the reconstructed HR HSI. Additionally, we collect a real-world HSI fusion dataset, consisting of paired HSI and unaligned RGB reference, to support the evaluation of the proposed model for real scenes. Extensive experiments are conducted on both simulated and our real-world datasets, and it shows that our method obtains a clear improvement over existing single-image and fusion-based super-resolution methods on quantitative assessment as well as visual comparison.