Subspecialty-Specific Foundation Model for Intelligent Gastrointestinal Pathology

Gastrointestinal (GI) diseases represent a clinically significant burden, necessitating precise diagnostic approaches to optimize patient outcomes. Conventional histopathological diagnosis, heavily reliant on the subjective interpretation of pathologists, suffers from limited reproducibility and diagnostic variability. To overcome these limitations and address the lack of pathology-specific foundation models for GI diseases, we develop Digepath, a specialized foundation model for GI pathology. Our framework introduces a dual-phase iterative optimization strategy combining pretraining with fine-screening, specifically designed to address the detection of sparsely distributed lesion areas in whole-slide images. Digepath is pretrained on more than 353 million image patches from over 200,000 hematoxylin and eosin-stained slides of GI diseases. It attains state-of-the-art performance on 33 out of 34 tasks related to GI pathology, including pathological diagnosis, molecular prediction, gene mutation prediction, and prognosis evaluation, particularly in diagnostically ambiguous cases and resolution-agnostic tissue classification.We further translate the intelligent screening module for early GI cancer and achieve near-perfect 99.6% sensitivity across 9 independent medical institutions nationwide. The outstanding performance of Digepath highlights its potential to bridge critical gaps in histopathological practice. This work not only advances AI-driven precision pathology for GI diseases but also establishes a transferable paradigm for other pathology subspecialties.

Deep Video Discovery: Agentic Search with Tool Use for Long-form Video Understanding

Long-form video understanding presents significant challenges due to extensive temporal-spatial complexity and the difficulty of question answering under such extended contexts. While Large Language Models (LLMs) have demonstrated considerable advancements in video analysis capabilities and long context handling, they continue to exhibit limitations when processing information-dense hour-long videos. To overcome such limitations, we propose the Deep Video Discovery agent to leverage an agentic search strategy over segmented video clips. Different from previous video agents manually designing a rigid workflow, our approach emphasizes the autonomous nature of agents. By providing a set of search-centric tools on multi-granular video database, our DVD agent leverages the advanced reasoning capability of LLM to plan on its current observation state, strategically selects tools, formulates appropriate parameters for actions, and iteratively refines its internal reasoning in light of the gathered information. We perform comprehensive evaluation on multiple long video understanding benchmarks that demonstrates the advantage of the entire system design. Our DVD agent achieves SOTA performance, significantly surpassing prior works by a large margin on the challenging LVBench dataset. Comprehensive ablation studies and in-depth tool analyses are also provided, yielding insights to further advance intelligent agents tailored for long-form video understanding tasks. The code will be released later.

MOOSE-Chem3: Toward Experiment-Guided Hypothesis Ranking via Simulated Experimental Feedback

Hypothesis ranking is a crucial component of automated scientific discovery, particularly in natural sciences where wet-lab experiments are costly and throughput-limited. Existing approaches focus on pre-experiment ranking, relying solely on large language model's internal reasoning without incorporating empirical outcomes from experiments. We introduce the task of experiment-guided ranking, which aims to prioritize candidate hypotheses based on the results of previously tested ones. However, developing such strategies is challenging due to the impracticality of repeatedly conducting real experiments in natural science domains. To address this, we propose a simulator grounded in three domain-informed assumptions, modeling hypothesis performance as a function of similarity to a known ground truth hypothesis, perturbed by noise. We curate a dataset of 124 chemistry hypotheses with experimentally reported outcomes to validate the simulator. Building on this simulator, we develop a pseudo experiment-guided ranking method that clusters hypotheses by shared functional characteristics and prioritizes candidates based on insights derived from simulated experimental feedback. Experiments show that our method outperforms pre-experiment baselines and strong ablations.

Self-Classification Enhancement and Correction for Weakly Supervised Object Detection

In recent years, weakly supervised object detection (WSOD) has attracted much attention due to its low labeling cost. The success of recent WSOD models is often ascribed to the two-stage multi-class classification (MCC) task, i.e., multiple instance learning and online classification refinement. Despite achieving non-trivial progresses, these methods overlook potential classification ambiguities between these two MCC tasks and fail to leverage their unique strengths. In this work, we introduce a novel WSOD framework to ameliorate these two issues. For one thing, we propose a self-classification enhancement module that integrates intra-class binary classification (ICBC) to bridge the gap between the two distinct MCC tasks. The ICBC task enhances the network's discrimination between positive and mis-located samples in a class-wise manner and forges a mutually reinforcing relationship with the MCC task. For another, we propose a self-classification correction algorithm during inference, which combines the results of both MCC tasks to effectively reduce the mis-classified predictions. Extensive experiments on the prevalent VOC 2007 & 2012 datasets demonstrate the superior performance of our framework.

Generative Latent Coding for Ultra-Low Bitrate Image and Video Compression

Most existing approaches for image and video compression perform transform coding in the pixel space to reduce redundancy. However, due to the misalignment between the pixel-space distortion and human perception, such schemes often face the difficulties in achieving both high-realism and high-fidelity at ultra-low bitrate. To solve this problem, we propose \textbf{G}enerative \textbf{L}atent \textbf{C}oding (\textbf{GLC}) models for image and video compression, termed GLC-image and GLC-Video. The transform coding of GLC is conducted in the latent space of a generative vector-quantized variational auto-encoder (VQ-VAE). Compared to the pixel-space, such a latent space offers greater sparsity, richer semantics and better alignment with human perception, and show its advantages in achieving high-realism and high-fidelity compression. To further enhance performance, we improve the hyper prior by introducing a spatial categorical hyper module in GLC-image and a spatio-temporal categorical hyper module in GLC-video. Additionally, the code-prediction-based loss function is proposed to enhance the semantic consistency. Experiments demonstrate that our scheme shows high visual quality at ultra-low bitrate for both image and video compression. For image compression, GLC-image achieves an impressive bitrate of less than $0.04$ bpp, achieving the same FID as previous SOTA model MS-ILLM while using $45\%$ fewer bitrate on the CLIC 2020 test set. For video compression, GLC-video achieves 65.3\% bitrate saving over PLVC in terms of DISTS.

Multi-Level Aware Preference Learning: Enhancing RLHF for Complex Multi-Instruction Tasks

RLHF has emerged as a predominant approach for aligning artificial intelligence systems with human preferences, demonstrating exceptional and measurable efficacy in instruction following tasks; however, it exhibits insufficient compliance capabilities when confronted with complex multi-instruction tasks. Conventional approaches rely heavily on human annotation or more sophisticated large language models, thereby introducing substantial resource expenditure or potential bias concerns. Meanwhile, alternative synthetic methods that augment standard preference datasets often compromise the model's semantic quality. Our research identifies a critical oversight in existing techniques, which predominantly focus on comparing responses while neglecting valuable latent signals embedded within prompt inputs, and which only focus on preference disparities at the intra-sample level, while neglecting to account for the inter-sample level preference differentials that exist among preference data. To leverage these previously neglected indicators, we propose a novel Multi-level Aware Preference Learning (MAPL) framework, capable of enhancing multi-instruction capabilities. Specifically, for any given response in original preference data pairs, we construct varied prompts with a preference relation under different conditions, in order to learn intra-sample level preference disparities. Furthermore, for any given original preference pair, we synthesize multi-instruction preference pairs to capture preference discrepancies at the inter-sample level. Building on the two datasets constructed above, we consequently devise two sophisticated training objective functions. Subsequently, our framework integrates seamlessly into both Reward Modeling and Direct Preference Optimization paradigms. Through rigorous evaluation across multiple benchmarks, we empirically validate the efficacy of our framework.

Mitigating Hallucination in VideoLLMs via Temporal-Aware Activation Engineering

Multimodal large language models (MLLMs) have achieved remarkable progress in video understanding.However, hallucination, where the model generates plausible yet incorrect outputs, persists as a significant and under-addressed challenge in the video domain. Among existing solutions, activation engineering has proven successful in mitigating hallucinations in LLMs and ImageLLMs, yet its applicability to VideoLLMs remains largely unexplored. In this work, we are the first to systematically investigate the effectiveness and underlying mechanisms of activation engineering for mitigating hallucinations in VideoLLMs. We initially conduct an investigation of the key factors affecting the performance of activation engineering and find that a model's sensitivity to hallucination depends on $\textbf{temporal variation}$ rather than task type. Moreover, selecting appropriate internal modules and dataset for activation engineering is critical for reducing hallucination. Guided by these findings, we propose a temporal-aware activation engineering framework for VideoLLMs, which adaptively identifies and manipulates hallucination-sensitive modules based on the temporal variation characteristic, substantially mitigating hallucinations without additional LLM fine-tuning. Experiments across multiple models and benchmarks demonstrate that our method markedly reduces hallucination in VideoLLMs, thereby validating the robustness of our findings.

Bias Fitting to Mitigate Length Bias of Reward Model in RLHF

Reinforcement Learning from Human Feedback relies on reward models to align large language models with human preferences. However, RLHF often suffers from reward hacking, wherein policy learning exploits flaws in the trained reward model to maximize reward scores without genuinely aligning with human preferences. A significant example of such reward hacking is length bias, where reward models usually favor longer responses irrespective of actual response quality. Previous works on length bias have notable limitations, these approaches either mitigate bias without characterizing the bias form, or simply assume a linear length-reward relation. To accurately model the intricate nature of length bias and facilitate more effective bias mitigation, we propose FiMi-RM (Bias Fitting to Mitigate Length Bias of Reward Model in RLHF), a framework that autonomously learns and corrects underlying bias patterns. Our approach consists of three stages: First, we train a standard reward model which inherently contains length bias. Next, we deploy a lightweight fitting model to explicitly capture the non-linear relation between length and reward. Finally, we incorporate this learned relation into the reward model to debias. Experimental results demonstrate that FiMi-RM achieves a more balanced length-reward distribution. Furthermore, when applied to alignment algorithms, our debiased reward model improves length-controlled win rate and reduces verbosity without compromising its performance.

VisuLogic: A Benchmark for Evaluating Visual Reasoning in Multi-modal Large Language Models

Visual reasoning is a core component of human intelligence and a critical capability for advanced multimodal models. Yet current reasoning evaluations of multimodal large language models (MLLMs) often rely on text descriptions and allow language-based reasoning shortcuts, failing to measure genuine vision-centric reasoning. To address this, we introduce VisuLogic: a benchmark of 1,000 human-verified problems across six categories (e.g., quantitative shifts, spatial relations, attribute comparisons). These various types of questions can be evaluated to assess the visual reasoning capabilities of MLLMs from multiple perspectives. We evaluate leading MLLMs on this benchmark and analyze their results to identify common failure modes. Most models score below 30% accuracy-only slightly above the 25% random baseline and far below the 51.4% achieved by humans-revealing significant gaps in visual reasoning. Furthermore, we provide a supplementary training dataset and a reinforcement-learning baseline to support further progress.

Multi-Scale Invertible Neural Network for Wide-Range Variable-Rate Learned Image Compression

Autoencoder-based structures have dominated recent learned image compression methods. However, the inherent information loss associated with autoencoders limits their rate-distortion performance at high bit rates and restricts their flexibility of rate adaptation. In this paper, we present a variable-rate image compression model based on invertible transform to overcome these limitations. Specifically, we design a lightweight multi-scale invertible neural network, which bijectively maps the input image into multi-scale latent representations. To improve the compression efficiency, a multi-scale spatial-channel context model with extended gain units is devised to estimate the entropy of the latent representation from high to low levels. Experimental results demonstrate that the proposed method achieves state-of-the-art performance compared to existing variable-rate methods, and remains competitive with recent multi-model approaches. Notably, our method is the first learned image compression solution that outperforms VVC across a very wide range of bit rates using a single model, especially at high bit rates.The source code is available at \href{https://github.com/hytu99/MSINN-VRLIC}{https://github.com/hytu99/MSINN-VRLIC}.