Mixture-of-Depths Attention

Scaling depth is a key driver for large language models (LLMs). Yet, as LLMs become deeper, they often suffer from signal degradation: informative features formed in shallow layers are gradually diluted by repeated residual updates, making them harder to recover in deeper layers. We introduce mixture-of-depths attention (MoDA), a mechanism that allows each attention head to attend to sequence KV pairs at the current layer and depth KV pairs from preceding layers. We further describe a hardware-efficient algorithm for MoDA that resolves non-contiguous memory-access patterns, achieving 97.3% of FlashAttention-2's efficiency at a sequence length of 64K. Experiments on 1.5B-parameter models demonstrate that MoDA consistently outperforms strong baselines. Notably, it improves average perplexity by 0.2 across 10 validation benchmarks and increases average performance by 2.11% on 10 downstream tasks, with a negligible 3.7% FLOPs computational overhead. We also find that combining MoDA with post-norm yields better performance than using it with pre-norm. These results suggest that MoDA is a promising primitive for depth scaling. Code is released at https://github.com/hustvl/MoDA .

GloPath: An Entity-Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Glomerular pathology is central to the diagnosis and prognosis of renal diseases, yet the heterogeneity of glomerular morphology and fine-grained lesion patterns remain challenging for current AI approaches. We present GloPath, an entity-centric foundation model trained on over one million glomeruli extracted from 14,049 renal biopsy specimens using multi-scale and multi-view self-supervised learning. GloPath addresses two major challenges in nephropathology: glomerular lesion assessment and clinicopathological insights discovery. For lesion assessment, GloPath was benchmarked across three independent cohorts on 52 tasks, including lesion recognition, grading, few-shot classification, and cross-modality diagnosis-outperforming state-of-the-art methods in 42 tasks (80.8%). In the large-scale real-world study, it achieved an ROC-AUC of 91.51% for lesion recognition, demonstrating strong robustness in routine clinical settings. For clinicopathological insights, GloPath systematically revealed statistically significant associations between glomerular morphological parameters and clinical indicators across 224 morphology-clinical variable pairs, demonstrating its capacity to connect tissue-level pathology with patient-level outcomes. Together, these results position GloPath as a scalable and interpretable platform for glomerular lesion assessment and clinicopathological discovery, representing a step toward clinically translatable AI in renal pathology.

Pixel-Perfect Depth with Semantics-Prompted Diffusion Transformers

This paper presents Pixel-Perfect Depth, a monocular depth estimation model based on pixel-space diffusion generation that produces high-quality, flying-pixel-free point clouds from estimated depth maps. Current generative depth estimation models fine-tune Stable Diffusion and achieve impressive performance. However, they require a VAE to compress depth maps into latent space, which inevitably introduces \textit{flying pixels} at edges and details. Our model addresses this challenge by directly performing diffusion generation in the pixel space, avoiding VAE-induced artifacts. To overcome the high complexity associated with pixel-space generation, we introduce two novel designs: 1) Semantics-Prompted Diffusion Transformers (SP-DiT), which incorporate semantic representations from vision foundation models into DiT to prompt the diffusion process, thereby preserving global semantic consistency while enhancing fine-grained visual details; and 2) Cascade DiT Design that progressively increases the number of tokens to further enhance efficiency and accuracy. Our model achieves the best performance among all published generative models across five benchmarks, and significantly outperforms all other models in edge-aware point cloud evaluation.

Multimodal Prototype Alignment for Semi-supervised Pathology Image Segmentation

Pathological image segmentation faces numerous challenges, particularly due to ambiguous semantic boundaries and the high cost of pixel-level annotations. Although recent semi-supervised methods based on consistency regularization (e.g., UniMatch) have made notable progress, they mainly rely on perturbation-based consistency within the image modality, making it difficult to capture high-level semantic priors, especially in structurally complex pathology images. To address these limitations, we propose MPAMatch - a novel segmentation framework that performs pixel-level contrastive learning under a multimodal prototype-guided supervision paradigm. The core innovation of MPAMatch lies in the dual contrastive learning scheme between image prototypes and pixel labels, and between text prototypes and pixel labels, providing supervision at both structural and semantic levels. This coarse-to-fine supervisory strategy not only enhances the discriminative capability on unlabeled samples but also introduces the text prototype supervision into segmentation for the first time, significantly improving semantic boundary modeling. In addition, we reconstruct the classic segmentation architecture (TransUNet) by replacing its ViT backbone with a pathology-pretrained foundation model (Uni), enabling more effective extraction of pathology-relevant features. Extensive experiments on GLAS, EBHI-SEG-GLAND, EBHI-SEG-CANCER, and KPI show MPAMatch's superiority over state-of-the-art methods, validating its dual advantages in structural and semantic modeling.

TransLight: Image-Guided Customized Lighting Control with Generative Decoupling

Most existing illumination-editing approaches fail to simultaneously provide customized control of light effects and preserve content integrity. This makes them less effective for practical lighting stylization requirements, especially in the challenging task of transferring complex light effects from a reference image to a user-specified target image. To address this problem, we propose TransLight, a novel framework that enables high-fidelity and high-freedom transfer of light effects. Extracting the light effect from the reference image is the most critical and challenging step in our method. The difficulty lies in the complex geometric structure features embedded in light effects that are highly coupled with content in real-world scenarios. To achieve this, we first present Generative Decoupling, where two fine-tuned diffusion models are used to accurately separate image content and light effects, generating a newly curated, million-scale dataset of image-content-light triplets. Then, we employ IC-Light as the generative model and train our model with our triplets, injecting the reference lighting image as an additional conditioning signal. The resulting TransLight model enables customized and natural transfer of diverse light effects. Notably, by thoroughly disentangling light effects from reference images, our generative decoupling strategy endows TransLight with highly flexible illumination control. Experimental results establish TransLight as the first method to successfully transfer light effects across disparate images, delivering more customized illumination control than existing techniques and charting new directions for research in illumination harmonization and editing.

LENS: Learning to Segment Anything with Unified Reinforced Reasoning

Text-prompted image segmentation enables fine-grained visual understanding and is critical for applications such as human-computer interaction and robotics. However, existing supervised fine-tuning methods typically ignore explicit chain-of-thought (CoT) reasoning at test time, which limits their ability to generalize to unseen prompts and domains. To address this issue, we introduce LENS, a scalable reinforcement-learning framework that jointly optimizes the reasoning process and segmentation in an end-to-end manner. We propose unified reinforcement-learning rewards that span sentence-, box-, and segment-level cues, encouraging the model to generate informative CoT rationales while refining mask quality. Using a publicly available 3-billion-parameter vision-language model, i.e., Qwen2.5-VL-3B-Instruct, LENS achieves an average cIoU of 81.2% on the RefCOCO, RefCOCO+, and RefCOCOg benchmarks, outperforming the strong fine-tuned method, i.e., GLaMM, by up to 5.6%. These results demonstrate that RL-driven CoT reasoning serves as a robust prior for text-prompted segmentation and offers a practical path toward more generalizable Segment Anything models. Code is available at https://github.com/hustvl/LENS.

Deformable Attention Graph Representation Learning for Histopathology Whole Slide Image Analysis

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture the spatial dependencies among tissue structures. Graph Neural Networks (GNNs) have emerged as a solution to model inter-instance relationships, yet most rely on static graph topologies and overlook the physical spatial positions of tissue patches. Moreover, conventional attention mechanisms lack specificity, limiting their ability to focus on structurally relevant regions. In this work, we propose a novel GNN framework with deformable attention for pathology image analysis. We construct a dynamic weighted directed graph based on patch features, where each node aggregates contextual information from its neighbors via attention-weighted edges. Specifically, we incorporate learnable spatial offsets informed by the real coordinates of each patch, enabling the model to adaptively attend to morphologically relevant regions across the slide. This design significantly enhances the contextual field while preserving spatial specificity. Our framework achieves state-of-the-art performance on four benchmark datasets (TCGA-COAD, BRACS, gastric intestinal metaplasia grading, and intestinal ROI classification), demonstrating the power of deformable attention in capturing complex spatial structures in WSIs and ROIs.

Subspecialty-Specific Foundation Model for Intelligent Gastrointestinal Pathology

Gastrointestinal (GI) diseases represent a clinically significant burden, necessitating precise diagnostic approaches to optimize patient outcomes. Conventional histopathological diagnosis, heavily reliant on the subjective interpretation of pathologists, suffers from limited reproducibility and diagnostic variability. To overcome these limitations and address the lack of pathology-specific foundation models for GI diseases, we develop Digepath, a specialized foundation model for GI pathology. Our framework introduces a dual-phase iterative optimization strategy combining pretraining with fine-screening, specifically designed to address the detection of sparsely distributed lesion areas in whole-slide images. Digepath is pretrained on more than 353 million image patches from over 200,000 hematoxylin and eosin-stained slides of GI diseases. It attains state-of-the-art performance on 33 out of 34 tasks related to GI pathology, including pathological diagnosis, molecular prediction, gene mutation prediction, and prognosis evaluation, particularly in diagnostically ambiguous cases and resolution-agnostic tissue classification.We further translate the intelligent screening module for early GI cancer and achieve near-perfect 99.6% sensitivity across 9 independent medical institutions nationwide. The outstanding performance of Digepath highlights its potential to bridge critical gaps in histopathological practice. This work not only advances AI-driven precision pathology for GI diseases but also establishes a transferable paradigm for other pathology subspecialties.

GroundingSuite: Measuring Complex Multi-Granular Pixel Grounding

Pixel grounding, encompassing tasks such as Referring Expression Segmentation (RES), has garnered considerable attention due to its immense potential for bridging the gap between vision and language modalities. However, advancements in this domain are currently constrained by limitations inherent in existing datasets, including limited object categories, insufficient textual diversity, and a scarcity of high-quality annotations. To mitigate these limitations, we introduce GroundingSuite, which comprises: (1) an automated data annotation framework leveraging multiple Vision-Language Model (VLM) agents; (2) a large-scale training dataset encompassing 9.56 million diverse referring expressions and their corresponding segmentations; and (3) a meticulously curated evaluation benchmark consisting of 3,800 images. The GroundingSuite training dataset facilitates substantial performance improvements, enabling models trained on it to achieve state-of-the-art results. Specifically, a cIoU of 68.9 on gRefCOCO and a gIoU of 55.3 on RefCOCOm. Moreover, the GroundingSuite annotation framework demonstrates superior efficiency compared to the current leading data annotation method, i.e., $4.5 \times$ faster than the GLaMM.

Multimodal Distillation-Driven Ensemble Learning for Long-Tailed Histopathology Whole Slide Images Analysis

Multiple Instance Learning (MIL) plays a significant role in computational pathology, enabling weakly supervised analysis of Whole Slide Image (WSI) datasets. The field of WSI analysis is confronted with a severe long-tailed distribution problem, which significantly impacts the performance of classifiers. Long-tailed distributions lead to class imbalance, where some classes have sparse samples while others are abundant, making it difficult for classifiers to accurately identify minority class samples. To address this issue, we propose an ensemble learning method based on MIL, which employs expert decoders with shared aggregators and consistency constraints to learn diverse distributions and reduce the impact of class imbalance on classifier performance. Moreover, we introduce a multimodal distillation framework that leverages text encoders pre-trained on pathology-text pairs to distill knowledge and guide the MIL aggregator in capturing stronger semantic features relevant to class information. To ensure flexibility, we use learnable prompts to guide the distillation process of the pre-trained text encoder, avoiding limitations imposed by specific prompts. Our method, MDE-MIL, integrates multiple expert branches focusing on specific data distributions to address long-tailed issues. Consistency control ensures generalization across classes. Multimodal distillation enhances feature extraction. Experiments on Camelyon+-LT and PANDA-LT datasets show it outperforms state-of-the-art methods.