One CT Unified Model Training Framework to Rule All Scanning Protocols

Non-ideal measurement computed tomography (NICT), which lowers radiation at the cost of image quality, is expanding the clinical use of CT. Although unified models have shown promise in NICT enhancement, most methods require paired data, which is an impractical demand due to inevitable organ motion. Unsupervised approaches attempt to overcome this limitation, but their assumption of homogeneous noise neglects the variability of scanning protocols, leading to poor generalization and potential model collapse. We further observe that distinct scanning protocols, which correspond to different physical imaging processes, produce discrete sub-manifolds in the feature space, contradicting these assumptions and limiting their effectiveness. To address this, we propose an Uncertainty-Guided Manifold Smoothing (UMS) framework to bridge the gaps between sub-manifolds. A classifier in UMS identifies sub-manifolds and predicts uncertainty scores, which guide the generation of diverse samples across the entire manifold. By leveraging the classifier's capability, UMS effectively fills the gaps between discrete sub-manifolds, and promotes a continuous and dense feature space. Due to the complexity of the global manifold, it's hard to directly model it. Therefore, we propose to dynamically incorporate the global- and sub-manifold-specific features. Specifically, we design a global- and sub-manifold-driven architecture guided by the classifier, which enables dynamic adaptation to subdomain variations. This dynamic mechanism improves the network's capacity to capture both shared and domain-specific features, thereby improving reconstruction performance. Extensive experiments on public datasets are conducted to validate the effectiveness of our method across different generation paradigms.

Low-Level Dataset Distillation for Medical Image Enhancement

Medical image enhancement is clinically valuable, but existing methods require large-scale datasets to learn complex pixel-level mappings. However, the substantial training and storage costs associated with these datasets hinder their practical deployment. While dataset distillation (DD) can alleviate these burdens, existing methods mainly target high-level tasks, where multiple samples share the same label. This many-to-one mapping allows distilled data to capture shared semantics and achieve information compression. In contrast, low-level tasks involve a many-to-many mapping that requires pixel-level fidelity, making low-level DD an underdetermined problem, as a small distilled dataset cannot fully constrain the dense pixel-level mappings. To address this, we propose the first low-level DD method for medical image enhancement. We first leverage anatomical similarities across patients to construct the shared anatomical prior based on a representative patient, which serves as the initialization for the distilled data of different patients. This prior is then personalized for each patient using a Structure-Preserving Personalized Generation (SPG) module, which integrates patient-specific anatomical information into the distilled dataset while preserving pixel-level fidelity. For different low-level tasks, the distilled data is used to construct task-specific high- and low-quality training pairs. Patient-specific knowledge is injected into the distilled data by aligning the gradients computed from networks trained on the distilled pairs with those from the corresponding patient's raw data. Notably, downstream users cannot access raw patient data. Instead, only a distilled dataset containing abstract training information is shared, which excludes patient-specific details and thus preserves privacy.