The Second Monocular Depth Estimation Challenge

This paper discusses the results for the second edition of the Monocular Depth Estimation Challenge (MDEC). This edition was open to methods using any form of supervision, including fully-supervised, self-supervised, multi-task or proxy depth. The challenge was based around the SYNS-Patches dataset, which features a wide diversity of environments with high-quality dense ground-truth. This includes complex natural environments, e.g. forests or fields, which are greatly underrepresented in current benchmarks. The challenge received eight unique submissions that outperformed the provided SotA baseline on any of the pointcloud- or image-based metrics. The top supervised submission improved relative F-Score by 27.62%, while the top self-supervised improved it by 16.61%. Supervised submissions generally leveraged large collections of datasets to improve data diversity. Self-supervised submissions instead updated the network architecture and pretrained backbones. These results represent a significant progress in the field, while highlighting avenues for future research, such as reducing interpolation artifacts at depth boundaries, improving self-supervised indoor performance and overall natural image accuracy.

Interpretability is a Kind of Safety: An Interpreter-based Ensemble for Adversary Defense

While having achieved great success in rich real-life applications, deep neural network (DNN) models have long been criticized for their vulnerability to adversarial attacks. Tremendous research efforts have been dedicated to mitigating the threats of adversarial attacks, but the essential trait of adversarial examples is not yet clear, and most existing methods are yet vulnerable to hybrid attacks and suffer from counterattacks. In light of this, in this paper, we first reveal a gradient-based correlation between sensitivity analysis-based DNN interpreters and the generation process of adversarial examples, which indicates the Achilles's heel of adversarial attacks and sheds light on linking together the two long-standing challenges of DNN: fragility and unexplainability. We then propose an interpreter-based ensemble framework called X-Ensemble for robust adversary defense. X-Ensemble adopts a novel detection-rectification process and features in building multiple sub-detectors and a rectifier upon various types of interpretation information toward target classifiers. Moreover, X-Ensemble employs the Random Forests (RF) model to combine sub-detectors into an ensemble detector for adversarial hybrid attacks defense. The non-differentiable property of RF further makes it a precious choice against the counterattack of adversaries. Extensive experiments under various types of state-of-the-art attacks and diverse attack scenarios demonstrate the advantages of X-Ensemble to competitive baseline methods.

mcLARO: Multi-Contrast Learned Acquisition and Reconstruction Optimization for simultaneous quantitative multi-parametric mapping

Purpose: To develop a method for rapid sub-millimeter T1, T2, T2* and QSM mapping in a single scan using multi-contrast Learned Acquisition and Reconstruction Optimization (mcLARO). Methods: A pulse sequence was developed by interleaving inversion recovery and T2 magnetization preparations and single-echo and multi-echo gradient echo acquisitions, which sensitized k-space data to T1, T2, T2* and magnetic susceptibility. The proposed mcLARO used a deep learning framework to optimize both the multi-contrast k-space under-sampling pattern and the image reconstruction based on image feature fusion. The proposed mcLARO method with R=8 under-sampling was validated in a retrospective ablation study using fully sampled data as reference and evaluated in a prospective study using separately acquired conventionally sampled quantitative maps as reference standard. Results: The retrospective ablation study showed improved image sharpness of mcLARO compared to the baseline network without multi-contrast sampling pattern optimization or image feature fusion, and negligible bias and narrow 95% limits of agreement on regional T1, T2, T2* and QSM values were obtained by the under-sampled reconstructions compared to the fully sampled reconstruction. The prospective study showed small or negligible bias and narrow 95% limits of agreement on regional T1, T2, T2* and QSM values by mcLARO (5:39 mins) compared to reference scans (40:03 mins in total). Conclusion: mcLARO enabled fast sub-millimeter T1, T2, T2* and QSM mapping in a single scan.

Multi-task Learning of Histology and Molecular Markers for Classifying Diffuse Glioma

Most recently, the pathology diagnosis of cancer is shifting to integrating molecular makers with histology features. It is a urgent need for digital pathology methods to effectively integrate molecular markers with histology, which could lead to more accurate diagnosis in the real world scenarios. This paper presents a first attempt to jointly predict molecular markers and histology features and model their interactions for classifying diffuse glioma bases on whole slide images. Specifically, we propose a hierarchical multi-task multi-instance learning framework to jointly predict histology and molecular markers. Moreover, we propose a co-occurrence probability-based label correction graph network to model the co-occurrence of molecular markers. Lastly, we design an inter-omic interaction strategy with the dynamical confidence constraint loss to model the interactions of histology and molecular markers. Our experiments show that our method outperforms other state-of-the-art methods in classifying diffuse glioma,as well as related histology and molecular markers on a multi-institutional dataset.

CoLa-Diff: Conditional Latent Diffusion Model for Multi-Modal MRI Synthesis

MRI synthesis promises to mitigate the challenge of missing MRI modality in clinical practice. Diffusion model has emerged as an effective technique for image synthesis by modelling complex and variable data distributions. However, most diffusion-based MRI synthesis models are using a single modality. As they operate in the original image domain, they are memory-intensive and less feasible for multi-modal synthesis. Moreover, they often fail to preserve the anatomical structure in MRI. Further, balancing the multiple conditions from multi-modal MRI inputs is crucial for multi-modal synthesis. Here, we propose the first diffusion-based multi-modality MRI synthesis model, namely Conditioned Latent Diffusion Model (CoLa-Diff). To reduce memory consumption, we design CoLa-Diff to operate in the latent space. We propose a novel network architecture, e.g., similar cooperative filtering, to solve the possible compression and noise in latent space. To better maintain the anatomical structure, brain region masks are introduced as the priors of density distributions to guide diffusion process. We further present auto-weight adaptation to employ multi-modal information effectively. Our experiments demonstrate that CoLa-Diff outperforms other state-of-the-art MRI synthesis methods, promising to serve as an effective tool for multi-modal MRI synthesis.

DisC-Diff: Disentangled Conditional Diffusion Model for Multi-Contrast MRI Super-Resolution

Multi-contrast magnetic resonance imaging (MRI) is the most common management tool used to characterize neurological disorders based on brain tissue contrasts. However, acquiring high-resolution MRI scans is time-consuming and infeasible under specific conditions. Hence, multi-contrast super-resolution methods have been developed to improve the quality of low-resolution contrasts by leveraging complementary information from multi-contrast MRI. Current deep learning-based super-resolution methods have limitations in estimating restoration uncertainty and avoiding mode collapse. Although the diffusion model has emerged as a promising approach for image enhancement, capturing complex interactions between multiple conditions introduced by multi-contrast MRI super-resolution remains a challenge for clinical applications. In this paper, we propose a disentangled conditional diffusion model, DisC-Diff, for multi-contrast brain MRI super-resolution. It utilizes the sampling-based generation and simple objective function of diffusion models to estimate uncertainty in restorations effectively and ensure a stable optimization process. Moreover, DisC-Diff leverages a disentangled multi-stream network to fully exploit complementary information from multi-contrast MRI, improving model interpretation under multiple conditions of multi-contrast inputs. We validated the effectiveness of DisC-Diff on two datasets: the IXI dataset, which contains 578 normal brains, and a clinical dataset with 316 pathological brains. Our experimental results demonstrate that DisC-Diff outperforms other state-of-the-art methods both quantitatively and visually.

Transformed Low-Rank Parameterization Can Help Robust Generalization for Tensor Neural Networks

Achieving efficient and robust multi-channel data learning is a challenging task in data science. By exploiting low-rankness in the transformed domain, i.e., transformed low-rankness, tensor Singular Value Decomposition (t-SVD) has achieved extensive success in multi-channel data representation and has recently been extended to function representation such as Neural Networks with t-product layers (t-NNs). However, it still remains unclear how t-SVD theoretically affects the learning behavior of t-NNs. This paper is the first to answer this question by deriving the upper bounds of the generalization error of both standard and adversarially trained t-NNs. It reveals that the t-NNs compressed by exact transformed low-rank parameterization can achieve a sharper adversarial generalization bound. In practice, although t-NNs rarely have exactly transformed low-rank weights, our analysis further shows that by adversarial training with gradient flow (GF), the over-parameterized t-NNs with ReLU activations are trained with implicit regularization towards transformed low-rank parameterization under certain conditions. We also establish adversarial generalization bounds for t-NNs with approximately transformed low-rank weights. Our analysis indicates that the transformed low-rank parameterization can promisingly enhance robust generalization for t-NNs.

Gaussian Mask Convolution for Convolutional Neural Networks

Square convolution is a default unit in convolutional neural networks as it fits well on the tensor computation for convolution operation, which usually has a fixed N x N receptive field (RF). However, what matters most to the network is the effective receptive field (ERF), which indicates the extent each pixel contributes to the output. ERF shows a Gaussian distribution and can not be modeled by simply sampling pixels with offsets. To simulate ERF, we propose a Gaussian Mask convolutional kernel (GMConv) in this work. Specifically, GMConv utilizes the Gaussian function to generate a concentric symmetry mask and put the mask over the kernel to refine the RF. Our GMConv can directly replace the standard convolutions in existing CNNs and can be easily trained end-to-end by standard backpropagation. Extensive experiments on multiple image classification benchmark datasets show that our method is comparable to, and outperforms in many cases, the standard convolution. For instance, using GMConv for AlexNet and ResNet-50, the top-1 accuracy on ImageNet classification is boosted by 0.98% and 0.85%, respectively.

Improved Differential-neural Cryptanalysis for Round-reduced Simeck32/64

In CRYPTO 2019, Gohr presented differential-neural cryptanalysis by building the differential distinguisher with a neural network, achieving practical 11-, and 12-round key recovery attack for Speck32/64. Inspired by this framework, we develop the Inception neural network that is compatible with the round function of Simeck to improve the accuracy of the neural distinguishers, thus improving the accuracy of (9-12)-round neural distinguishers for Simeck32/64. To provide solid baselines for neural distinguishers, we compute the full distribution of differences induced by one specific input difference up to 13-round Simeck32/64. Moreover, the performance of the DDT-based distinguishers in multiple ciphertext pairs is evaluated. Compared with the DDT-based distinguishers, the 9-, and 10-round neural distinguishers achieve better accuracy. Also, an in-depth analysis of the wrong key response profile revealed that the 12-th and 13-th bits of the subkey have little effect on the score of the neural distinguisher, thereby accelerating key recovery attacks. Finally, an enhanced 15-round and the first practical 16-, and 17-round attacks are implemented for Simeck32/64, and the success rate of both the 15-, and 16-round attacks is almost 100%.

Spatially Covariant Lesion Segmentation

Compared to natural images, medical images usually show stronger visual patterns and therefore this adds flexibility and elasticity to resource-limited clinical applications by injecting proper priors into neural networks. In this paper, we propose spatially covariant pixel-aligned classifier (SCP) to improve the computational efficiency and meantime maintain or increase accuracy for lesion segmentation. SCP relaxes the spatial invariance constraint imposed by convolutional operations and optimizes an underlying implicit function that maps image coordinates to network weights, the parameters of which are obtained along with the backbone network training and later used for generating network weights to capture spatially covariant contextual information. We demonstrate the effectiveness and efficiency of the proposed SCP using two lesion segmentation tasks from different imaging modalities: white matter hyperintensity segmentation in magnetic resonance imaging and liver tumor segmentation in contrast-enhanced abdominal computerized tomography. The network using SCP has achieved 23.8%, 64.9% and 74.7% reduction in GPU memory usage, FLOPs, and network size with similar or better accuracy for lesion segmentation.