HookMIL: Revisiting Context Modeling in Multiple Instance Learning for Computational Pathology

Multiple Instance Learning (MIL) has enabled weakly supervised analysis of whole-slide images (WSIs) in computational pathology. However, traditional MIL approaches often lose crucial contextual information, while transformer-based variants, though more expressive, suffer from quadratic complexity and redundant computations. To address these limitations, we propose HookMIL, a context-aware and computationally efficient MIL framework that leverages compact, learnable hook tokens for structured contextual aggregation. These tokens can be initialized from (i) key-patch visual features, (ii) text embeddings from vision-language pathology models, and (iii) spatially grounded features from spatial transcriptomics-vision models. This multimodal initialization enables Hook Tokens to incorporate rich textual and spatial priors, accelerating convergence and enhancing representation quality. During training, Hook tokens interact with instances through bidirectional attention with linear complexity. To further promote specialization, we introduce a Hook Diversity Loss that encourages each token to focus on distinct histopathological patterns. Additionally, a hook-to-hook communication mechanism refines contextual interactions while minimizing redundancy. Extensive experiments on four public pathology datasets demonstrate that HookMIL achieves state-of-the-art performance, with improved computational efficiency and interpretability. Codes are available at https://github.com/lingxitong/HookMIL.

DigiData: Training and Evaluating General-Purpose Mobile Control Agents

AI agents capable of controlling user interfaces have the potential to transform human interaction with digital devices. To accelerate this transformation, two fundamental building blocks are essential: high-quality datasets that enable agents to achieve complex and human-relevant goals, and robust evaluation methods that allow researchers and practitioners to rapidly enhance agent performance. In this paper, we introduce DigiData, a large-scale, high-quality, diverse, multi-modal dataset designed for training mobile control agents. Unlike existing datasets, which derive goals from unstructured interactions, DigiData is meticulously constructed through comprehensive exploration of app features, resulting in greater diversity and higher goal complexity. Additionally, we present DigiData-Bench, a benchmark for evaluating mobile control agents on real-world complex tasks. We demonstrate that the commonly used step-accuracy metric falls short in reliably assessing mobile control agents and, to address this, we propose dynamic evaluation protocols and AI-powered evaluations as rigorous alternatives for agent assessment. Our contributions aim to significantly advance the development of mobile control agents, paving the way for more intuitive and effective human-device interactions.

Age of Information Aided Intelligent Grant-Free Massive Access for Heterogeneous mMTC Traffic

With the arrival of 6G, the Internet of Things (IoT) traffic is becoming more and more complex and diverse. To meet the diverse service requirements of IoT devices, massive machine-type communications (mMTC) becomes a typical scenario, and more recently, grant-free random access (GF-RA) presents a promising direction due to its low signaling overhead. However, existing GF-RA research primarily focuses on improving the accuracy of user detection and data recovery, without considering the heterogeneity of traffic. In this paper, we investigate a non-orthogonal GF-RA scenario where two distinct types of traffic coexist: event-triggered traffic with alarm devices (ADs), and status update traffic with monitor devices (MDs). The goal is to simultaneously achieve high detection success rates for ADs and high information timeliness for MDs. First, we analyze the age-based random access scheme and optimize the access parameters to minimize the average age of information (AoI) of MDs. Then, we design an age-based prior information aided autoencoder (A-PIAAE) to jointly detect active devices, together with learned pilots used in GF-RA to reduce interference between non-orthogonal pilots. In the decoder, an Age-based Learned Iterative Shrinkage Thresholding Algorithm (LISTA-AGE) utilizing the AoI of MDs as the prior information is proposed to enhance active user detection. Theoretical analysis is provided to demonstrate the proposed A-PIAAE has better convergence performance. Experiments demonstrate the advantage of the proposed method in reducing the average AoI of MDs and improving the successful detection rate of ADs.

FedTeddi: Temporal Drift and Divergence Aware Scheduling for Timely Federated Edge Learning

Federated edge learning (FEEL) enables collaborative model training across distributed clients over wireless networks without exposing raw data. While most existing studies assume static datasets, in real-world scenarios clients may continuously collect data with time-varying and non-independent and identically distributed (non-i.i.d.) characteristics. A critical challenge is how to adapt models in a timely yet efficient manner to such evolving data. In this paper, we propose FedTeddi, a temporal-drift-and-divergence-aware scheduling algorithm that facilitates fast convergence of FEEL under dynamic data evolution and communication resource limits. We first quantify the temporal dynamics and non-i.i.d. characteristics of data using temporal drift and collective divergence, respectively, and represent them as the Earth Mover's Distance (EMD) of class distributions for classification tasks. We then propose a novel optimization objective and develop a joint scheduling and bandwidth allocation algorithm, enabling the FEEL system to learn from new data quickly without forgetting previous knowledge. Experimental results show that our algorithm achieves higher test accuracy and faster convergence compared to benchmark methods, improving the rate of convergence by 58.4% on CIFAR-10 and 49.2% on CIFAR-100 compared to random scheduling.

FedCGD: Collective Gradient Divergence Optimized Scheduling for Wireless Federated Learning

Federated learning (FL) is a promising paradigm for multiple devices to cooperatively train a model. When applied in wireless networks, two issues consistently affect the performance of FL, i.e., data heterogeneity of devices and limited bandwidth. Many papers have investigated device scheduling strategies considering the two issues. However, most of them recognize data heterogeneity as a property of individual devices. In this paper, we prove that the convergence speed of FL is affected by the sum of device-level and sample-level collective gradient divergence (CGD). The device-level CGD refers to the gradient divergence of the scheduled device group, instead of the sum of the individual device divergence. The sample-level CGD is statistically upper bounded by sampling variance, which is inversely proportional to the total number of samples scheduled for local update. To derive a tractable form of the device-level CGD, we further consider a classification problem and transform it into the weighted earth moving distance (WEMD) between the group distribution and the global distribution. Then we propose FedCGD algorithm to minimize the sum of multi-level CGDs by balancing WEMD and sampling variance, within polynomial time. Simulation shows that the proposed strategy increases classification accuracy on the CIFAR-10 dataset by up to 4.2\% while scheduling 41.8\% fewer devices, and flexibly switches between reducing WEMD and reducing sampling variance.

Mobility-Aware Asynchronous Federated Learning with Dynamic Sparsification

Asynchronous Federated Learning (AFL) enables distributed model training across multiple mobile devices, allowing each device to independently update its local model without waiting for others. However, device mobility introduces intermittent connectivity, which necessitates gradient sparsification and leads to model staleness, jointly affecting AFL convergence. This paper develops a theoretical model to characterize the interplay among sparsification, model staleness and mobility-induced contact patterns, and their joint impact on AFL convergence. Based on the analysis, we propose a mobility-aware dynamic sparsification (MADS) algorithm that optimizes the sparsification degree based on contact time and model staleness. Closed-form solutions are derived, showing that under low-speed conditions, MADS increases the sparsification degree to enhance convergence, while under high-speed conditions, it reduces the sparsification degree to guarantee reliable uploads within limited contact time. Experimental results validate the theoretical findings. Compared with the state-of-the-art benchmarks, the MADS algorithm increases the image classification accuracy on the CIFAR-10 dataset by 8.76% and reduces the average displacement error in the Argoverse trajectory prediction dataset by 9.46%.

CPathAgent: An Agent-based Foundation Model for Interpretable High-Resolution Pathology Image Analysis Mimicking Pathologists' Diagnostic Logic

Recent advances in computational pathology have led to the emergence of numerous foundation models. However, these approaches fail to replicate the diagnostic process of pathologists, as they either simply rely on general-purpose encoders with multi-instance learning for classification or directly apply multimodal models to generate reports from images. A significant limitation is their inability to emulate the diagnostic logic employed by pathologists, who systematically examine slides at low magnification for overview before progressively zooming in on suspicious regions to formulate comprehensive diagnoses. To address this gap, we introduce CPathAgent, an innovative agent-based model that mimics pathologists' reasoning processes by autonomously executing zoom-in/out and navigation operations across pathology images based on observed visual features. To achieve this, we develop a multi-stage training strategy unifying patch-level, region-level, and whole-slide capabilities within a single model, which is essential for mimicking pathologists, who require understanding and reasoning capabilities across all three scales. This approach generates substantially more detailed and interpretable diagnostic reports compared to existing methods, particularly for huge region understanding. Additionally, we construct an expert-validated PathMMU-HR$^{2}$, the first benchmark for huge region analysis, a critical intermediate scale between patches and whole slides, as diagnosticians typically examine several key regions rather than entire slides at once. Extensive experiments demonstrate that CPathAgent consistently outperforms existing approaches across three scales of benchmarks, validating the effectiveness of our agent-based diagnostic approach and highlighting a promising direction for the future development of computational pathology.

FASR-Net: Unsupervised Shadow Removal Leveraging Inherent Frequency Priors

Shadow removal is challenging due to the complex interaction of geometry, lighting, and environmental factors. Existing unsupervised methods often overlook shadow-specific priors, leading to incomplete shadow recovery. To address this issue, we propose a novel unsupervised Frequency Aware Shadow Removal Network (FASR-Net), which leverages the inherent frequency characteristics of shadow regions. Specifically, the proposed Wavelet Attention Downsampling Module (WADM) integrates wavelet-based image decomposition and deformable attention, effectively breaking down the image into frequency components to enhance shadow details within specific frequency bands. We also introduce several new loss functions for precise shadow-free image reproduction: a frequency loss to capture image component details, a brightness-chromaticity loss that references the chromaticity of shadow-free regions, and an alignment loss to ensure smooth transitions between shadowed and shadow-free regions. Experimental results on the AISTD and SRD datasets demonstrate that our method achieves superior shadow removal performance.

Quantization Hurts Reasoning? An Empirical Study on Quantized Reasoning Models

Recent advancements in reasoning language models have demonstrated remarkable performance in complex tasks, but their extended chain-of-thought reasoning process increases inference overhead. While quantization has been widely adopted to reduce the inference cost of large language models, its impact on reasoning models remains understudied. In this study, we conduct the first systematic study on quantized reasoning models, evaluating the open-sourced DeepSeek-R1-Distilled Qwen and LLaMA families ranging from 1.5B to 70B parameters, and QwQ-32B. Our investigation covers weight, KV cache, and activation quantization using state-of-the-art algorithms at varying bit-widths, with extensive evaluation across mathematical (AIME, MATH-500), scientific (GPQA), and programming (LiveCodeBench) reasoning benchmarks. Our findings reveal that while lossless quantization can be achieved with W8A8 or W4A16 quantization, lower bit-widths introduce significant accuracy risks. We further identify model size, model origin, and task difficulty as critical determinants of performance. Contrary to expectations, quantized models do not exhibit increased output lengths. In addition, strategically scaling the model sizes or reasoning steps can effectively enhance the performance. All quantized models and codes will be open-sourced in https://github.com/ruikangliu/Quantized-Reasoning-Models.

Towards Effective and Efficient Context-aware Nucleus Detection in Histopathology Whole Slide Images

Nucleus detection in histopathology whole slide images (WSIs) is crucial for a broad spectrum of clinical applications. Current approaches for nucleus detection in gigapixel WSIs utilize a sliding window methodology, which overlooks boarder contextual information (eg, tissue structure) and easily leads to inaccurate predictions. To address this problem, recent studies additionally crops a large Filed-of-View (FoV) region around each sliding window to extract contextual features. However, such methods substantially increases the inference latency. In this paper, we propose an effective and efficient context-aware nucleus detection algorithm. Specifically, instead of leveraging large FoV regions, we aggregate contextual clues from off-the-shelf features of historically visited sliding windows. This design greatly reduces computational overhead. Moreover, compared to large FoV regions at a low magnification, the sliding window patches have higher magnification and provide finer-grained tissue details, thereby enhancing the detection accuracy. To further improve the efficiency, we propose a grid pooling technique to compress dense feature maps of each patch into a few contextual tokens. Finally, we craft OCELOT-seg, the first benchmark dedicated to context-aware nucleus instance segmentation. Code, dataset, and model checkpoints will be available at https://github.com/windygoo/PathContext.