Warp-free Cross-view Geo-localization via Feature-space Consensus Mining

Cross-view geo-localization is challenging due to drastic viewpoint changes and large appearance discrepancies between street-level and satellite imagery. Although existing methods often use geometric warping to expose co-visible cues, such transformations rely on restrictive spatial assumptions and inevitably introduce severe visual distortions under view-dependent visibility, yielding noisy supervision and fragile correspondences. To overcome this, we propose a novel joint-view consensus-guided learning framework that entirely bypasses explicit geometric warping. Instead of forcing rigid spatial alignment, we dynamically mine and adaptively strengthen a semantic consensus directly within the feature space. Specifically, an auxiliary joint-view pathway during training enables direct cross-view interaction, allowing each view to selectively aggregate corroborative evidence into a unified consensus representation. To resolve feature heterogeneity among the single- and joint-view streams, we introduce global pattern probes acting as a semantic dictionary to project divergent modalities into a strictly aligned metric space. Guided by a consensus-mediated contrastive objective, single-view embeddings are explicitly pulled toward the joint-view anchor during training, distilling this consensus-mining capability into the single-view encoders for robust retrieval at inference. Extensive experiments demonstrate that our method achieves state-of-the-art performance across four standard benchmarks, underscoring the importance of discovering cross-view semantic consensus for reliable geo-localization.

Kimi K3: Open Frontier Intelligence

We introduce Kimi K3, a 2.8T parameter Mixture-of-Experts model with 104 billion activated parameters, native vision capabilities, and a 1-million-token context window. Kimi K3 is built on Kimi Delta Attention and Attention Residuals, which improve information flow across sequence length and model depth. Together with Stable LatentMoE, which effectively activates 16 of 896 routed experts per token, and refined training and data recipes, these advances yield an approximately 2.5x improvement in overall scaling efficiency over Kimi K2. Post-training highlights reinforcement learning across general, agentic, and coding domains and multiple reasoning-effort levels, enabling compositional generalization and robust long-horizon execution. At 2.8T scale, Kimi K3 is supported by infrastructure advances in multiple areas: algorithm-system co-design for KDA, perfectly balanced expert-parallel training with efficient memory management, million-token agentic RL with persistent rollout and sandbox states, and deployment innovations. Extensive evaluations show that Kimi K3 achieves frontier-level performance across long-horizon coding, agentic, knowledge, reasoning, and vision tasks. While its overall performance still trails the most powerful proprietary models, namely Claude Fable 5 and GPT-5.6 Sol, Kimi K3 consistently outperforms other open and proprietary models evaluated in our suite. We release the full Kimi K3 model weights to facilitate future research and accelerate the broader deployment and adoption of frontier intelligence.

SCTA: An Agentic Framework for Stable and Interpretable Target Gene Discovery from Single-Cell RNA Sequencing

Identifying therapeutic target genes from single-cell RNA sequencing (scRNA-seq) data remains a fundamental challenge in translational biology. Unlike bulk assays, scRNA-seq captures heterogeneous cellular states and rare subpopulations, but this same heterogeneity makes target discovery highly sensitive to analytical choices throughout the pipeline, including preprocessing, cell population selection, differential expression analysis, and downstream biological interpretation. As a result, existing workflows and general-purpose analysis agents often produce unstable or difficult-to-interpret target hypotheses, limiting their reliability for disease-focused discovery. We present SCTA (Single-Cell Target Agent), a decision-centric agentic framework for stable and interpretable target gene discovery from scRNA-seq data. Rather than treating analysis as a single general-purpose reasoning task, SCTA decomposes target discovery into specialized agents aligned with key decision points in the single-cell pipeline and constrains downstream reasoning with structured biological evidence. In a representative ablation study on hereditary chronic pancreatitis, we demonstrate that SCTA's full evidence integration yields the most stable target selection across independent runs among the tested configurations, while recovering biologically coherent, disease-relevant mechanisms validated in prior studies. These results suggest that decision-aware agent orchestration tailored to the structure of single-cell analysis can improve the robustness, interpretability, and practical utility of target discovery in precision medicine.

ScalePredictor: Instance-aware Scale Learning for Accurate Quantization of Vision Transformers

Vision Transformers have achieved remarkable success in many fields, yet their deployment on edge devices remains challenging due to their substantial computational demands. Post-Training Quantization (PTQ) offers an attractive solution by compressing models using a small calibration set with minimal training overhead. However, most existing PTQ works adopt a static quantization paradigm that is uniformly applied to all instances. Given the substantial diversity of natural images, the activation distributions vary significantly across samples, making these methods inherently suboptimal. In this paper, we propose ScalePredictor, a dynamic quantization framework for accurate and efficient quantization scale learning of ViTs. We first reveal a hidden correlation between the distribution range of shallow-layer activations and the optimal scales of deeper layers. Based on this, we develop a scale learning mechanism that integrates an efficient range extraction approach to capture robust range statistics at the shallow stage, which are then fed into a Taylor-motivated polynomial scale projection module to generate all quantization scales simultaneously. With the efficiency of polynomial approximation, ScalePredictor introduces insignificant computational overhead while avoiding costly just-in-time calibration. Extensive experiments on ImageNet demonstrate that ScalePredictor consistently outperforms prior PTQ methods, achieving a more favorable accuracy-efficiency trade-off. Code and additional results are shown in the supplementary materials.

Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

Triple Spectral Fusion for Sensor-based Human Activity Recognition

The field of sensor-based human activity recognition (HAR) mainly uses posture, motion and context data of Inertial Measurement Units (IMUs) to identify daily activities. Despite the advancements in learning-based methods, it is challenging to perform information fusion from the temporal perspective due to the complexities in fusing heterogeneous sensor data and establishing long-term context correlations. This paper proposes a novel triple spectral fusion framework tailored for HAR. First, we develop an adaptive complementary filtering technique for noise suppression and organize each IMU's sensors into posture and motion modality nodes. Given that IMU nodes form a dynamic heterogeneous graph, we then apply adaptive filtering within the graph Fourier domain to merge both homogeneous and heterogeneous node information. Furthermore, an adaptive wavelet frequency selection approach is implemented to suppress context redundancy and shorten the length of features. This approach enhances both timestamp-based graph aggregation and the correlation of long-term contexts. Our framework uses adaptive filtering in the Fourier, graph Fourier, and wavelet domains, enabling effective multi-sensor fusion and context correlation. Extensive experiments on ten benchmark datasets demonstrate the superior performance of our framework. Project page: https://github.com/crocodilegogogo/TSF-TPAMI2026.

DoseRAD2026 Challenge dataset: AI accelerated photon and proton dose calculation for radiotherapy

Purpose: Accurate dose calculation is essential in radiotherapy for precise tumor irradiation while sparing healthy tissue. With the growing adoption of MRI-guided and real-time adaptive radiotherapy, fast and accurate dose calculation on CT and MRI is increasingly needed. The DoseRAD2026 dataset and challenge provide a public benchmark of paired CT and MRI data with beam-level photon and proton Monte Carlo dose distributions for developing and evaluating advanced dose calculation methods. Acquisition and validation methods: The dataset comprises paired CT and MRI from 115 patients (75 training, 40 testing) treated on an MRI-linac for thoracic or abdominal lesions, derived from the SynthRAD2025 dataset. Pre-processing included deformable image registration, air-cavity correction, and resampling. Ground-truth photon (6 MV) and proton dose distributions were computed using open-source Monte Carlo algorithms, yielding 40,500 photon beams and 81,000 proton beamlets. Data format and usage notes: Data are organized into photon and proton subsets with paired CT-MRI images, beam-level dose distributions, and JSON beam configuration files. Files are provided in compressed MetaImage (.mha) format. The dataset is released under CC BY-NC 4.0, with training data available from April 2026 and the test set withheld until March 2030. Potential applications: The dataset supports benchmarking of fast dose calculation methods, including beam-level dose estimation for photon and proton therapy, MRI-based dose calculation in MRI-guided workflows, and real-time adaptive radiotherapy.

LoD Sketch Extraction from Architectural Models Using Generative AI: Dataset Construction for Multi-Level Architectural Design Generation

For architectural design, representation across multiple Levels of Details (LoD) is essential for achieving a smooth transition from conceptual massing to detailed modeling. However, traditional LoD modeling processes rely on manual operations that are time-consuming, labor-intensive, and prone to geometric inconsistencies. While the rapid advancement of generative artificial intelligence (AI) has opened new possibilities for generating multi-level architectural models from sketch inputs, its application remains limited by the lack of high-quality paired LoD training data. To address this issue, we propose an automatic LoD sketch extraction framework using generative AI models, which progressively simplifies high-detail architectural models to automatically generate geometrically consistent and hierarchically coherent multi-LoD representations. The proposed framework integrates computer vision techniques with generative AI methods to establish a progressive extraction pipeline that transitions from detailed representations to volumetric abstractions. Experimental results demonstrate that the method maintains strong geometric consistency across LoD levels, achieving SSIM values of 0.7319 and 0.7532 for the transitions from LoD3 to LoD2 and from LoD2 to LoD1, respectively, with corresponding normalized Hausdorff distances of 25.1% and 61.0% of the image diagonal, reflecting controlled geometric deviation during abstraction. These results verify that the proposed framework effectively preserves global structure while achieving progressive semantic simplification across different LoD levels, providing reliable data and technical support for AI-driven multi-level architectural generation and hierarchical modeling.

AI-generated data contamination erodes pathological variability and diagnostic reliability

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI-generated data. However, the clinical consequences of this AI-generated data contamination remain unexplored. Here, we show that in the absence of mandatory human verification, this self-referential cycle drives a rapid erosion of pathological variability and diagnostic reliability. By analysing more than 800,000 synthetic data points across clinical text generation, vision-language reporting, and medical image synthesis, we find that models progressively converge toward generic phenotypes regardless of the model architecture. Specifically, rare but critical findings, including pneumothorax and effusions, vanish from the synthetic content generated by AI models, while demographic representations skew heavily toward middle-aged male phenotypes. Crucially, this degradation is masked by false diagnostic confidence; models continue to issue reassuring reports while failing to detect life-threatening pathology, with false reassurance rates tripling to 40%. Blinded physician evaluation confirms that this decoupling of confidence and accuracy renders AI-generated documentation clinically useless after just two generations. We systematically evaluate three mitigation strategies, finding that while synthetic volume scaling fails to prevent collapse, mixing real data with quality-aware filtering effectively preserves diversity. Ultimately, our results suggest that without policy-mandated human oversight, the deployment of generative AI threatens to degrade the very healthcare data ecosystems it relies upon.

Sketch-Based Facade Renovation With Generative AI: A Streamlined Framework for Bypassing As-Built Modelling in Industrial Adaptive Reuse

Facade renovation offers a more sustainable alternative to full demolition, yet producing design proposals that preserve existing structures while expressing new intent remains challenging. Current workflows typically require detailed as-built modelling before design, which is time-consuming, labour-intensive, and often involves repeated revisions. To solve this issue, we propose a three-stage framework combining generative artificial intelligence (AI) and vision-language models (VLM) that directly processes rough structural sketch and textual descriptions to produce consistent renovation proposals. First, the input sketch is used by a fine-tuned VLM model to predict bounding boxes specifying where modifications are needed and which components should be added. Next, a stable diffusion model generates detailed sketches of new elements, which are merged with the original outline through a generative inpainting pipeline. Finally, ControlNet is employed to refine the result into a photorealistic image. Experiments on datasets and real industrial buildings indicate that the proposed framework can generate renovation proposals that preserve the original structure while improving facade detail quality. This approach effectively bypasses the need for detailed as-built modelling, enabling architects to rapidly explore design alternatives, iterate on early-stage concepts, and communicate renovation intentions with greater clarity.