CPathAgent: An Agent-based Foundation Model for Interpretable High-Resolution Pathology Image Analysis Mimicking Pathologists' Diagnostic Logic

Recent advances in computational pathology have led to the emergence of numerous foundation models. However, these approaches fail to replicate the diagnostic process of pathologists, as they either simply rely on general-purpose encoders with multi-instance learning for classification or directly apply multimodal models to generate reports from images. A significant limitation is their inability to emulate the diagnostic logic employed by pathologists, who systematically examine slides at low magnification for overview before progressively zooming in on suspicious regions to formulate comprehensive diagnoses. To address this gap, we introduce CPathAgent, an innovative agent-based model that mimics pathologists' reasoning processes by autonomously executing zoom-in/out and navigation operations across pathology images based on observed visual features. To achieve this, we develop a multi-stage training strategy unifying patch-level, region-level, and whole-slide capabilities within a single model, which is essential for mimicking pathologists, who require understanding and reasoning capabilities across all three scales. This approach generates substantially more detailed and interpretable diagnostic reports compared to existing methods, particularly for huge region understanding. Additionally, we construct an expert-validated PathMMU-HR$^{2}$, the first benchmark for huge region analysis, a critical intermediate scale between patches and whole slides, as diagnosticians typically examine several key regions rather than entire slides at once. Extensive experiments demonstrate that CPathAgent consistently outperforms existing approaches across three scales of benchmarks, validating the effectiveness of our agent-based diagnostic approach and highlighting a promising direction for the future development of computational pathology.

PiFlow: Principle-aware Scientific Discovery with Multi-Agent Collaboration

Large Language Model (LLM)-based multi-agent systems (MAS) demonstrate remarkable potential for scientific discovery. Existing approaches, however, often automate scientific discovery using predefined workflows that lack rationality constraints. This often leads to aimless hypothesizing and a failure to consistently link hypotheses with evidence, thereby hindering systematic uncertainty reduction. Overcoming these limitations fundamentally requires systematic uncertainty reduction. We introduce \texttt{PiFlow}, an information-theoretical framework, treating automated scientific discovery as a structured uncertainty reduction problem guided by principles (e.g., scientific laws). In evaluations across three distinct scientific domains -- discovering nanomaterial structures, bio-molecules, and superconductor candidates with targeted properties -- our method significantly improves discovery efficiency, reflected by a 73.55\% increase in the Area Under the Curve (AUC) of property values versus exploration steps, and enhances solution quality by 94.06\% compared to a vanilla agent system. Overall, \texttt{PiFlow} serves as a Plug-and-Play method, establishing a novel paradigm shift in highly efficient automated scientific discovery, paving the way for more robust and accelerated AI-driven research. Code is publicly available at our \href{https://github.com/amair-lab/PiFlow}{GitHub}.

Collaborative Unlabeled Data Optimization

This paper pioneers a novel data-centric paradigm to maximize the utility of unlabeled data, tackling a critical question: How can we enhance the efficiency and sustainability of deep learning training by optimizing the data itself? We begin by identifying three key limitations in existing model-centric approaches, all rooted in a shared bottleneck: knowledge extracted from data is locked to model parameters, hindering its reusability and scalability. To this end, we propose CoOpt, a highly efficient, parallelized framework for collaborative unlabeled data optimization, thereby effectively encoding knowledge into the data itself. By distributing unlabeled data and leveraging publicly available task-agnostic models, CoOpt facilitates scalable, reusable, and sustainable training pipelines. Extensive experiments across diverse datasets and architectures demonstrate its efficacy and efficiency, achieving 13.6% and 6.8% improvements on Tiny-ImageNet and ImageNet-1K, respectively, with training speedups of $1.94 \times $ and $1.2 \times$.

Unified Continuous Generative Models

Recent advances in continuous generative models, including multi-step approaches like diffusion and flow-matching (typically requiring 8-1000 sampling steps) and few-step methods such as consistency models (typically 1-8 steps), have demonstrated impressive generative performance. However, existing work often treats these approaches as distinct paradigms, resulting in separate training and sampling methodologies. We introduce a unified framework for training, sampling, and analyzing these models. Our implementation, the Unified Continuous Generative Models Trainer and Sampler (UCGM-{T,S}), achieves state-of-the-art (SOTA) performance. For example, on ImageNet 256x256 using a 675M diffusion transformer, UCGM-T trains a multi-step model achieving 1.30 FID in 20 steps and a few-step model reaching 1.42 FID in just 2 steps. Additionally, applying UCGM-S to a pre-trained model (previously 1.26 FID at 250 steps) improves performance to 1.06 FID in only 40 steps. Code is available at: https://github.com/LINs-lab/UCGM.

Efficient Generative Model Training via Embedded Representation Warmup

Diffusion models excel at generating high-dimensional data but fall short in training efficiency and representation quality compared to self-supervised methods. We identify a key bottleneck: the underutilization of high-quality, semantically rich representations during training notably slows down convergence. Our systematic analysis reveals a critical representation processing region -- primarily in the early layers -- where semantic and structural pattern learning takes place before generation can occur. To address this, we propose Embedded Representation Warmup (ERW), a plug-and-play framework where in the first stage we get the ERW module serves as a warmup that initializes the early layers of the diffusion model with high-quality, pretrained representations. This warmup minimizes the burden of learning representations from scratch, thereby accelerating convergence and boosting performance. Our theoretical analysis demonstrates that ERW's efficacy depends on its precise integration into specific neural network layers -- termed the representation processing region -- where the model primarily processes and transforms feature representations for later generation. We further establish that ERW not only accelerates training convergence but also enhances representation quality: empirically, our method achieves a 40$\times$ acceleration in training speed compared to REPA, the current state-of-the-art methods. Code is available at https://github.com/LINs-lab/ERW.

FASR-Net: Unsupervised Shadow Removal Leveraging Inherent Frequency Priors

Shadow removal is challenging due to the complex interaction of geometry, lighting, and environmental factors. Existing unsupervised methods often overlook shadow-specific priors, leading to incomplete shadow recovery. To address this issue, we propose a novel unsupervised Frequency Aware Shadow Removal Network (FASR-Net), which leverages the inherent frequency characteristics of shadow regions. Specifically, the proposed Wavelet Attention Downsampling Module (WADM) integrates wavelet-based image decomposition and deformable attention, effectively breaking down the image into frequency components to enhance shadow details within specific frequency bands. We also introduce several new loss functions for precise shadow-free image reproduction: a frequency loss to capture image component details, a brightness-chromaticity loss that references the chromaticity of shadow-free regions, and an alignment loss to ensure smooth transitions between shadowed and shadow-free regions. Experimental results on the AISTD and SRD datasets demonstrate that our method achieves superior shadow removal performance.

STI-Bench: Are MLLMs Ready for Precise Spatial-Temporal World Understanding?

The use of Multimodal Large Language Models (MLLMs) as an end-to-end solution for Embodied AI and Autonomous Driving has become a prevailing trend. While MLLMs have been extensively studied for visual semantic understanding tasks, their ability to perform precise and quantitative spatial-temporal understanding in real-world applications remains largely unexamined, leading to uncertain prospects. To evaluate models' Spatial-Temporal Intelligence, we introduce STI-Bench, a benchmark designed to evaluate MLLMs' spatial-temporal understanding through challenging tasks such as estimating and predicting the appearance, pose, displacement, and motion of objects. Our benchmark encompasses a wide range of robot and vehicle operations across desktop, indoor, and outdoor scenarios. The extensive experiments reveals that the state-of-the-art MLLMs still struggle in real-world spatial-temporal understanding, especially in tasks requiring precise distance estimation and motion analysis.

Measuring AI Ability to Complete Long Tasks

Despite rapid progress on AI benchmarks, the real-world meaning of benchmark performance remains unclear. To quantify the capabilities of AI systems in terms of human capabilities, we propose a new metric: 50%-task-completion time horizon. This is the time humans typically take to complete tasks that AI models can complete with 50% success rate. We first timed humans with relevant domain expertise on a combination of RE-Bench, HCAST, and 66 novel shorter tasks. On these tasks, current frontier AI models such as Claude 3.7 Sonnet have a 50% time horizon of around 50 minutes. Furthermore, frontier AI time horizon has been doubling approximately every seven months since 2019, though the trend may have accelerated in 2024. The increase in AI models' time horizons seems to be primarily driven by greater reliability and ability to adapt to mistakes, combined with better logical reasoning and tool use capabilities. We discuss the limitations of our results -- including their degree of external validity -- and the implications of increased autonomy for dangerous capabilities. If these results generalize to real-world software tasks, extrapolation of this trend predicts that within 5 years, AI systems will be capable of automating many software tasks that currently take humans a month.

CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathology

The emergence of large multimodal models (LMMs) has brought significant advancements to pathology. Previous research has primarily focused on separately training patch-level and whole-slide image (WSI)-level models, limiting the integration of learned knowledge across patches and WSIs, and resulting in redundant models. In this work, we introduce CPath-Omni, the first 15-billion-parameter LMM designed to unify both patch and WSI level image analysis, consolidating a variety of tasks at both levels, including classification, visual question answering, captioning, and visual referring prompting. Extensive experiments demonstrate that CPath-Omni achieves state-of-the-art (SOTA) performance across seven diverse tasks on 39 out of 42 datasets, outperforming or matching task-specific models trained for individual tasks. Additionally, we develop a specialized pathology CLIP-based visual processor for CPath-Omni, CPath-CLIP, which, for the first time, integrates different vision models and incorporates a large language model as a text encoder to build a more powerful CLIP model, which achieves SOTA performance on nine zero-shot and four few-shot datasets. Our findings highlight CPath-Omni's ability to unify diverse pathology tasks, demonstrating its potential to streamline and advance the field of foundation model in pathology.

Learn How to Query from Unlabeled Data Streams in Federated Learning

Federated learning (FL) enables collaborative learning among decentralized clients while safeguarding the privacy of their local data. Existing studies on FL typically assume offline labeled data available at each client when the training starts. Nevertheless, the training data in practice often arrive at clients in a streaming fashion without ground-truth labels. Given the expensive annotation cost, it is critical to identify a subset of informative samples for labeling on clients. However, selecting samples locally while accommodating the global training objective presents a challenge unique to FL. In this work, we tackle this conundrum by framing the data querying process in FL as a collaborative decentralized decision-making problem and proposing an effective solution named LeaDQ, which leverages multi-agent reinforcement learning algorithms. In particular, under the implicit guidance from global information, LeaDQ effectively learns the local policies for distributed clients and steers them towards selecting samples that can enhance the global model's accuracy. Extensive simulations on image and text tasks show that LeaDQ advances the model performance in various FL scenarios, outperforming the benchmarking algorithms.