CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-ray

The CXR-LT series is a community-driven initiative designed to enhance lung disease classification using chest X-rays (CXR). It tackles challenges in open long-tailed lung disease classification and enhances the measurability of state-of-the-art techniques. The first event, CXR-LT 2023, aimed to achieve these goals by providing high-quality benchmark CXR data for model development and conducting comprehensive evaluations to identify ongoing issues impacting lung disease classification performance. Building on the success of CXR-LT 2023, the CXR-LT 2024 expands the dataset to 377,110 chest X-rays (CXRs) and 45 disease labels, including 19 new rare disease findings. It also introduces a new focus on zero-shot learning to address limitations identified in the previous event. Specifically, CXR-LT 2024 features three tasks: (i) long-tailed classification on a large, noisy test set, (ii) long-tailed classification on a manually annotated "gold standard" subset, and (iii) zero-shot generalization to five previously unseen disease findings. This paper provides an overview of CXR-LT 2024, detailing the data curation process and consolidating state-of-the-art solutions, including the use of multimodal models for rare disease detection, advanced generative approaches to handle noisy labels, and zero-shot learning strategies for unseen diseases. Additionally, the expanded dataset enhances disease coverage to better represent real-world clinical settings, offering a valuable resource for future research. By synthesizing the insights and innovations of participating teams, we aim to advance the development of clinically realistic and generalizable diagnostic models for chest radiography.

Kinetics: Rethinking Test-Time Scaling Laws

We rethink test-time scaling laws from a practical efficiency perspective, revealing that the effectiveness of smaller models is significantly overestimated. Prior work, grounded in compute-optimality, overlooks critical memory access bottlenecks introduced by inference-time strategies (e.g., Best-of-$N$, long CoTs). Our holistic analysis, spanning models from 0.6B to 32B parameters, reveals a new Kinetics Scaling Law that better guides resource allocation by incorporating both computation and memory access costs. Kinetics Scaling Law suggests that test-time compute is more effective when used on models above a threshold than smaller ones. A key reason is that in TTS, attention, rather than parameter count, emerges as the dominant cost factor. Motivated by this, we propose a new scaling paradigm centered on sparse attention, which lowers per-token cost and enables longer generations and more parallel samples within the same resource budget. Empirically, we show that sparse attention models consistently outperform dense counterparts, achieving over 60 points gains in low-cost regimes and over 5 points gains in high-cost regimes for problem-solving accuracy on AIME, encompassing evaluations on state-of-the-art MoEs. These results suggest that sparse attention is essential and increasingly important with more computing invested, for realizing the full potential of test-time scaling where, unlike training, accuracy has yet to saturate as a function of computation, and continues to improve through increased generation. The code is available at https://github.com/Infini-AI-Lab/Kinetics.

Nonlinear Oscillatory Response of Automated Vehicle Car-following: Theoretical Analysis with Traffic State and Control Input Limits

This paper presents a framework grounded in the theory of describing function (DF) and incremental-input DF to theoretically analyze the nonlinear oscillatory response of automated vehicles (AVs) car-following (CF) amidst traffic oscillations, considering the limits of traffic state and control input. While prevailing approaches largely ignore these limits (i.e., saturation of acceleration/deceleration and speed) and focus on linear string stability analysis, this framework establishes a basis for theoretically analyzing the frequency response of AV systems with nonlinearities imposed by these limits. To this end, trajectories of CF pairs are decomposed into nominal and oscillatory trajectories, subsequently, the controlled AV system is repositioned within the oscillatory trajectory coordinates. Built on this base, DFs are employed to approximate the frequency responses of nonlinear saturation components by using their first harmonic output, thereby capturing the associated amplification ratio and phase shift. Considering the closed-loop nature of AV control systems, where system states and control input mutually influence each other, amplification ratios and phase shifts are balanced within the loop to ensure consistency. This balancing process may render multiple solutions, hence the incremental-input DF is further applied to identify the reasonable ones. The proposed method is validated by estimations from Simulink, and further comparisons with prevailing methods are conducted. Results confirm the alignment of our framework with Simulink results and exhibit its superior accuracy in analysis compared to the prevailing methods. Furthermore, the framework proves valuable in string stability analysis, especially when conventional linear methods offer misleading insights.

Simulating the Unseen: Crash Prediction Must Learn from What Did Not Happen

Traffic safety science has long been hindered by a fundamental data paradox: the crashes we most wish to prevent are precisely those events we rarely observe. Existing crash-frequency models and surrogate safety metrics rely heavily on sparse, noisy, and under-reported records, while even sophisticated, high-fidelity simulations undersample the long-tailed situations that trigger catastrophic outcomes such as fatalities. We argue that the path to achieving Vision Zero, i.e., the complete elimination of traffic fatalities and severe injuries, requires a paradigm shift from traditional crash-only learning to a new form of counterfactual safety learning: reasoning not only about what happened, but also about the vast set of plausible yet perilous scenarios that could have happened under slightly different circumstances. To operationalize this shift, our proposed agenda bridges macro to micro. Guided by crash-rate priors, generative scene engines, diverse driver models, and causal learning, near-miss events are synthesized and explained. A crash-focused digital twin testbed links micro scenes to macro patterns, while a multi-objective validator ensures that simulations maintain statistical realism. This pipeline transforms sparse crash data into rich signals for crash prediction, enabling the stress-testing of vehicles, roads, and policies before deployment. By learning from crashes that almost happened, we can shift traffic safety from reactive forensics to proactive prevention, advancing Vision Zero.

SeRL: Self-Play Reinforcement Learning for Large Language Models with Limited Data

Recent advances have demonstrated the effectiveness of Reinforcement Learning (RL) in improving the reasoning capabilities of Large Language Models (LLMs). However, existing works inevitably rely on high-quality instructions and verifiable rewards for effective training, both of which are often difficult to obtain in specialized domains. In this paper, we propose Self-play Reinforcement Learning(SeRL) to bootstrap LLM training with limited initial data. Specifically, SeRL comprises two complementary modules: self-instruction and self-rewarding. The former module generates additional instructions based on the available data at each training step, employing robust online filtering strategies to ensure instruction quality, diversity, and difficulty. The latter module introduces a simple yet effective majority-voting mechanism to estimate response rewards for additional instructions, eliminating the need for external annotations. Finally, SeRL performs conventional RL based on the generated data, facilitating iterative self-play learning. Extensive experiments on various reasoning benchmarks and across different LLM backbones demonstrate that the proposed SeRL yields results superior to its counterparts and achieves performance on par with those obtained by high-quality data with verifiable rewards. Our code is available at https://github.com/wantbook-book/SeRL.

Deployable and Generalizable Motion Prediction: Taxonomy, Open Challenges and Future Directions

Motion prediction, the anticipation of future agent states or scene evolution, is rooted in human cognition, bridging perception and decision-making. It enables intelligent systems, such as robots and self-driving cars, to act safely in dynamic, human-involved environments, and informs broader time-series reasoning challenges. With advances in methods, representations, and datasets, the field has seen rapid progress, reflected in quickly evolving benchmark results. Yet, when state-of-the-art methods are deployed in the real world, they often struggle to generalize to open-world conditions and fall short of deployment standards. This reveals a gap between research benchmarks, which are often idealized or ill-posed, and real-world complexity. To address this gap, this survey revisits the generalization and deployability of motion prediction models, with an emphasis on the applications of robotics, autonomous driving, and human motion. We first offer a comprehensive taxonomy of motion prediction methods, covering representations, modeling strategies, application domains, and evaluation protocols. We then study two key challenges: (1) how to push motion prediction models to be deployable to realistic deployment standards, where motion prediction does not act in a vacuum, but functions as one module of closed-loop autonomy stacks - it takes input from the localization and perception, and informs downstream planning and control. 2) how to generalize motion prediction models from limited seen scenarios/datasets to the open-world settings. Throughout the paper, we highlight critical open challenges to guide future work, aiming to recalibrate the community's efforts, fostering progress that is not only measurable but also meaningful for real-world applications.

Generative AI for Autonomous Driving: Frontiers and Opportunities

Generative Artificial Intelligence (GenAI) constitutes a transformative technological wave that reconfigures industries through its unparalleled capabilities for content creation, reasoning, planning, and multimodal understanding. This revolutionary force offers the most promising path yet toward solving one of engineering's grandest challenges: achieving reliable, fully autonomous driving, particularly the pursuit of Level 5 autonomy. This survey delivers a comprehensive and critical synthesis of the emerging role of GenAI across the autonomous driving stack. We begin by distilling the principles and trade-offs of modern generative modeling, encompassing VAEs, GANs, Diffusion Models, and Large Language Models (LLMs). We then map their frontier applications in image, LiDAR, trajectory, occupancy, video generation as well as LLM-guided reasoning and decision making. We categorize practical applications, such as synthetic data workflows, end-to-end driving strategies, high-fidelity digital twin systems, smart transportation networks, and cross-domain transfer to embodied AI. We identify key obstacles and possibilities such as comprehensive generalization across rare cases, evaluation and safety checks, budget-limited implementation, regulatory compliance, ethical concerns, and environmental effects, while proposing research plans across theoretical assurances, trust metrics, transport integration, and socio-technical influence. By unifying these threads, the survey provides a forward-looking reference for researchers, engineers, and policymakers navigating the convergence of generative AI and advanced autonomous mobility. An actively maintained repository of cited works is available at https://github.com/taco-group/GenAI4AD.

An integrated language-vision foundation model for conversational diagnostics and triaging in primary eye care

Current deep learning models are mostly task specific and lack a user-friendly interface to operate. We present Meta-EyeFM, a multi-function foundation model that integrates a large language model (LLM) with vision foundation models (VFMs) for ocular disease assessment. Meta-EyeFM leverages a routing mechanism to enable accurate task-specific analysis based on text queries. Using Low Rank Adaptation, we fine-tuned our VFMs to detect ocular and systemic diseases, differentiate ocular disease severity, and identify common ocular signs. The model achieved 100% accuracy in routing fundus images to appropriate VFMs, which achieved $\ge$ 82.2% accuracy in disease detection, $\ge$ 89% in severity differentiation, $\ge$ 76% in sign identification. Meta-EyeFM was 11% to 43% more accurate than Gemini-1.5-flash and ChatGPT-4o LMMs in detecting various eye diseases and comparable to an ophthalmologist. This system offers enhanced usability and diagnostic performance, making it a valuable decision support tool for primary eye care or an online LLM for fundus evaluation.

TeDA: Boosting Vision-Lanuage Models for Zero-Shot 3D Object Retrieval via Testing-time Distribution Alignment

Learning discriminative 3D representations that generalize well to unknown testing categories is an emerging requirement for many real-world 3D applications. Existing well-established methods often struggle to attain this goal due to insufficient 3D training data from broader concepts. Meanwhile, pre-trained large vision-language models (e.g., CLIP) have shown remarkable zero-shot generalization capabilities. Yet, they are limited in extracting suitable 3D representations due to substantial gaps between their 2D training and 3D testing distributions. To address these challenges, we propose Testing-time Distribution Alignment (TeDA), a novel framework that adapts a pretrained 2D vision-language model CLIP for unknown 3D object retrieval at test time. To our knowledge, it is the first work that studies the test-time adaptation of a vision-language model for 3D feature learning. TeDA projects 3D objects into multi-view images, extracts features using CLIP, and refines 3D query embeddings with an iterative optimization strategy by confident query-target sample pairs in a self-boosting manner. Additionally, TeDA integrates textual descriptions generated by a multimodal language model (InternVL) to enhance 3D object understanding, leveraging CLIP's aligned feature space to fuse visual and textual cues. Extensive experiments on four open-set 3D object retrieval benchmarks demonstrate that TeDA greatly outperforms state-of-the-art methods, even those requiring extensive training. We also experimented with depth maps on Objaverse-LVIS, further validating its effectiveness. Code is available at https://github.com/wangzhichuan123/TeDA.

AI2-Active Safety: AI-enabled Interaction-aware Active Safety Analysis with Vehicle Dynamics

This paper introduces an AI-enabled, interaction-aware active safety analysis framework that accounts for groupwise vehicle interactions. Specifically, the framework employs a bicycle model-augmented with road gradient considerations-to accurately capture vehicle dynamics. In parallel, a hypergraph-based AI model is developed to predict probabilistic trajectories of ambient traffic. By integrating these two components, the framework derives vehicle intra-spacing over a 3D road surface as the solution of a stochastic ordinary differential equation, yielding high-fidelity surrogate safety measures such as time-to-collision (TTC). To demonstrate its effectiveness, the framework is analyzed using stochastic numerical methods comprising 4th-order Runge-Kutta integration and AI inference, generating probability-weighted high-fidelity TTC (HF-TTC) distributions that reflect complex multi-agent maneuvers and behavioral uncertainties. Evaluated with HF-TTC against traditional constant-velocity TTC and non-interaction-aware approaches on highway datasets, the proposed framework offers a systematic methodology for active safety analysis with enhanced potential for improving safety perception in complex traffic environments.