CAPSUL: A Comprehensive Human Protein Benchmark for Subcellular Localization

Subcellular localization is a crucial biological task for drug target identification and function annotation. Although it has been biologically realized that subcellular localization is closely associated with protein structure, no existing dataset offers comprehensive 3D structural information with detailed subcellular localization annotations, thus severely hindering the application of promising structure-based models on this task. To address this gap, we introduce a new benchmark called $\mathbf{CAPSUL}$, a $\mathbf{C}$omprehensive hum$\mathbf{A}$n $\mathbf{P}$rotein benchmark for $\mathbf{SU}$bcellular $\mathbf{L}$ocalization. It features a dataset that integrates diverse 3D structural representations with fine-grained subcellular localization annotations carefully curated by domain experts. We evaluate this benchmark using a variety of state-of-the-art sequence-based and structure-based models, showcasing the importance of involving structural features in this task. Furthermore, we explore reweighting and single-label classification strategies to facilitate future investigation on structure-based methods for this task. Lastly, we showcase the powerful interpretability of structure-based methods through a case study on the Golgi apparatus, where we discover a decisive localization pattern $α$-helix from attention mechanisms, demonstrating the potential for bridging the gap with intuitive biological interpretability and paving the way for data-driven discoveries in cell biology.

Breaking User-Centric Agency: A Tri-Party Framework for Agent-Based Recommendation

Recent advances in large language models (LLMs) have stimulated growing interest in agent-based recommender systems, enabling language-driven interaction and reasoning for more expressive preference modeling. However, most existing agentic approaches remain predominantly user-centric, treating items as passive entities and neglecting the interests of other critical stakeholders. This limitation exacerbates exposure concentration and long-tail under-representation, threatening long-term system sustainability. In this work, we identify this fundamental limitation and propose the first Tri-party LLM-agent Recommendation framework (TriRec) that explicitly coordinates user utility, item exposure, and platform-level fairness. The framework employs a two-stage architecture: Stage~1 empowers item agents with personalized self-promotion to improve matching quality and alleviate cold-start barriers, while Stage~2 uses a platform agent for sequential multi-objective re-ranking, balancing user relevance, item utility, and exposure fairness. Experiments on multiple benchmarks show consistent gains in accuracy, fairness, and item-level utility. Moreover, we find that item self-promotion can simultaneously enhance fairness and effectiveness, challenging the conventional trade-off assumption between relevance and fairness. Our code is available at https://github.com/Marfekey/TriRec.

Verifiable Reasoning for LLM-based Generative Recommendation

Reasoning in Large Language Models (LLMs) has recently shown strong potential in enhancing generative recommendation through deep understanding of complex user preference. Existing approaches follow a {reason-then-recommend} paradigm, where LLMs perform step-by-step reasoning before item generation. However, this paradigm inevitably suffers from reasoning degradation (i.e., homogeneous or error-accumulated reasoning) due to the lack of intermediate verification, thus undermining the recommendation. To bridge this gap, we propose a novel \textbf{\textit{reason-verify-recommend}} paradigm, which interleaves reasoning with verification to provide reliable feedback, guiding the reasoning process toward more faithful user preference understanding. To enable effective verification, we establish two key principles for verifier design: 1) reliability ensures accurate evaluation of reasoning correctness and informative guidance generation; and 2) multi-dimensionality emphasizes comprehensive verification across multi-dimensional user preferences. Accordingly, we propose an effective implementation called VRec. It employs a mixture of verifiers to ensure multi-dimensionality, while leveraging a proxy prediction objective to pursue reliability. Experiments on four real-world datasets demonstrate that VRec substantially enhances recommendation effectiveness and scalability without compromising efficiency. The codes can be found at https://github.com/Linxyhaha/Verifiable-Rec.

LiveAgentBench: Comprehensive Benchmarking of Agentic Systems Across 104 Real-World Challenges

As large language models grow more capable, general AI agents have become increasingly prevalent in practical applications. However, existing benchmarks face significant limitations, failing to represent real-world user tasks accurately. To address this gap, we present LiveAgentBench, a comprehensive benchmark with 104 scenarios that reflect real user requirements. It is constructed from publicly sourced questions on social media and real-world products. Central to our approach is the Social Perception-Driven Data Generation (SPDG) method, a novel process we developed to ensure each question's real-world relevance, task complexity, and result verifiability. We evaluate various models, frameworks, and commercial products using LiveAgentBench, revealing their practical performance and identifying areas for improvement. This release includes 374 tasks, with 125 for validation and 249 for testing. The SPDG process enables continuous updates with fresh queries from real-world interactions.

NextAds: Towards Next-generation Personalized Video Advertising

With the rapid growth of online video consumption, video advertising has become increasingly dominant in the digital advertising landscape. Yet diverse users and viewing contexts makes one-size-fits-all ad creatives insufficient for consistent effectiveness, underlining the importance of personalization. In practice, most personalized video advertising systems follow a retrieval-based paradigm, selecting the optimal one from a small set of professionally pre-produced creatives for each user. Such static and finite inventories limits both the granularity and the timeliness of personalization, and prevents the creatives from being continuously refined based on online user feedback. Recent advances in generative AI make it possible to move beyond retrieval toward optimizing video creatives in a continuous space at serving time. In this light, we propose NextAds, a generation-based paradigm for next-generation personalized video advertising, and conceptualize NextAds with four core components. To enable comparable research progress, we formulate two representative tasks: personalized creative generation and personalized creative integration, and introduce corresponding lightweight benchmarks. To assess feasibility, we instantiate end-to-end pipelines for both tasks and conduct initial exploratory experiments, demonstrating that GenAI can generate and integrate personalized creatives with encouraging performance. Moreover, we discuss the key challenges and opportunities under this paradigm, aiming to provide actionable insights for both researchers and practitioners and to catalyze progress in personalized video advertising.

Silent Sabotage During Fine-Tuning: Few-Shot Rationale Poisoning of Compact Medical LLMs

Supervised fine-tuning (SFT) is essential for the development of medical large language models (LLMs), yet prior poisoning studies have mainly focused on the detectable backdoor attacks. We propose a novel poisoning attack targeting the reasoning process of medical LLMs during SFT. Unlike backdoor attacks, our method injects poisoned rationales into few-shot training data, leading to stealthy degradation of model performance on targeted medical topics. Results showed that knowledge overwriting was ineffective, while rationale poisoning caused significant decline on the accuracy of the target subject, as long as no correct samples of the same subject appear in the dataset. A minimum number and ratio of poisoned samples was needed to carry out an effective and stealthy attack, which was more efficient and accurate than catastrophic forgetting. We demonstrate though this study the risk of SFT-stage poisoning, hoping to spur more studies of defense in the sensitive medical domain.

Toward Personalized LLM-Powered Agents: Foundations, Evaluation, and Future Directions

Large language models have enabled agents that reason, plan, and interact with tools and environments to accomplish complex tasks. As these agents operate over extended interaction horizons, their effectiveness increasingly depends on adapting behavior to individual users and maintaining continuity across time, giving rise to personalized LLM-powered agents. In such long-term, user-dependent settings, personalization permeates the entire decision pipeline rather than remaining confined to surface-level generation. This survey provides a capability-oriented review of personalized LLM-powered agents. We organize the literature around four interdependent components: profile modeling, memory, planning, and action execution. Using this taxonomy, we synthesize representative methods and analyze how user signals are represented, propagated, and utilized, highlighting cross-component interactions and recurring design trade-offs. We further examine evaluation metrics and benchmarks tailored to personalized agents, summarize application scenarios spanning general assistance to specialized domains, and outline future directions for research and deployment. By offering a structured framework for understanding and designing personalized LLM-powered agents, this survey charts a roadmap toward more user-aligned, adaptive, robust, and deployable agentic systems, accelerating progress from prototype personalization to scalable real-world assistants.

A Trajectory-Based Safety Audit of Clawdbot (OpenClaw)

Clawdbot is a self-hosted, tool-using personal AI agent with a broad action space spanning local execution and web-mediated workflows, which raises heightened safety and security concerns under ambiguity and adversarial steering. We present a trajectory-centric evaluation of Clawdbot across six risk dimensions. Our test suite samples and lightly adapts scenarios from prior agent-safety benchmarks (including ATBench and LPS-Bench) and supplements them with hand-designed cases tailored to Clawdbot's tool surface. We log complete interaction trajectories (messages, actions, tool-call arguments/outputs) and assess safety using both an automated trajectory judge (AgentDoG-Qwen3-4B) and human review. Across 34 canonical cases, we find a non-uniform safety profile: performance is generally consistent on reliability-focused tasks, while most failures arise under underspecified intent, open-ended goals, or benign-seeming jailbreak prompts, where minor misinterpretations can escalate into higher-impact tool actions. We supplemented the overall results with representative case studies and summarized the commonalities of these cases, analyzing the security vulnerabilities and typical failure modes that Clawdbot is prone to trigger in practice.

DeepGen 1.0: A Lightweight Unified Multimodal Model for Advancing Image Generation and Editing

Current unified multimodal models for image generation and editing typically rely on massive parameter scales (e.g., >10B), entailing prohibitive training costs and deployment footprints. In this work, we present DeepGen 1.0, a lightweight 5B unified model that achieves comprehensive capabilities competitive with or surpassing much larger counterparts. To overcome the limitations of compact models in semantic understanding and fine-grained control, we introduce Stacked Channel Bridging (SCB), a deep alignment framework that extracts hierarchical features from multiple VLM layers and fuses them with learnable 'think tokens' to provide the generative backbone with structured, reasoning-rich guidance. We further design a data-centric training strategy spanning three progressive stages: (1) Alignment Pre-training on large-scale image-text pairs and editing triplets to synchronize VLM and DiT representations, (2) Joint Supervised Fine-tuning on a high-quality mixture of generation, editing, and reasoning tasks to foster omni-capabilities, and (3) Reinforcement Learning with MR-GRPO, which leverages a mixture of reward functions and supervision signals, resulting in substantial gains in generation quality and alignment with human preferences, while maintaining stable training progress and avoiding visual artifacts. Despite being trained on only ~50M samples, DeepGen 1.0 achieves leading performance across diverse benchmarks, surpassing the 80B HunyuanImage by 28% on WISE and the 27B Qwen-Image-Edit by 37% on UniREditBench. By open-sourcing our training code, weights, and datasets, we provide an efficient, high-performance alternative to democratize unified multimodal research.

Synthetic Interaction Data for Scalable Personalization in Large Language Models

Personalized prompting offers large opportunities for deploying large language models (LLMs) to diverse users, yet existing prompt optimization methods primarily focus on task-level optimization while largely overlooking user-specific preferences and latent constraints of individual users. This gap is primarily due to (i) the absence of high-quality, privacy-sensitive data that capture personalized user-LLM interactions at scale, and (ii) the lack of robust reward signals for individual preferences. To overcome existing data limitations, we introduce a high-fidelity synthetic data generation framework called PersonaGym. Unlike prior work that treats personalization as static persona-preference pairs, PersonaGym models a dynamic preference process via an agentic LLM system to simulate realistic preference behaviors and semantic-aware noise in order to generate personalized multi-turn interaction trajectories. Using PersonaGym, we release PersonaAtlas, a large-scale, high-quality, and diverse synthetic dataset of high-fidelity multi-turn personalized interaction trajectories that closely mirror real-world preference expression and noise patterns. We further propose Personalized Prompt Optimization (PPOpt), a scalable and model-agnostic framework that optimizes user prompts based on interaction histories without modifying the deployed LLM. PPOpt adopts a reason-then-optimize paradigm that infers an explicit user profile and conditions prompt rewriting on the user profile to avoid reward hacking. Our training procedure for PPOpt integrates a cold-start supervised prior with outcome-driven multi-objective reinforcement learning. We present extensive experiments to demonstrate consistent improvements over state-of-the-art baselines in terms of task performance, personalization quality, and robustness to noisy as well as to sparse preference signals.