CAPSUL: A Comprehensive Human Protein Benchmark for Subcellular Localization

Subcellular localization is a crucial biological task for drug target identification and function annotation. Although it has been biologically realized that subcellular localization is closely associated with protein structure, no existing dataset offers comprehensive 3D structural information with detailed subcellular localization annotations, thus severely hindering the application of promising structure-based models on this task. To address this gap, we introduce a new benchmark called $\mathbf{CAPSUL}$, a $\mathbf{C}$omprehensive hum$\mathbf{A}$n $\mathbf{P}$rotein benchmark for $\mathbf{SU}$bcellular $\mathbf{L}$ocalization. It features a dataset that integrates diverse 3D structural representations with fine-grained subcellular localization annotations carefully curated by domain experts. We evaluate this benchmark using a variety of state-of-the-art sequence-based and structure-based models, showcasing the importance of involving structural features in this task. Furthermore, we explore reweighting and single-label classification strategies to facilitate future investigation on structure-based methods for this task. Lastly, we showcase the powerful interpretability of structure-based methods through a case study on the Golgi apparatus, where we discover a decisive localization pattern $α$-helix from attention mechanisms, demonstrating the potential for bridging the gap with intuitive biological interpretability and paving the way for data-driven discoveries in cell biology.

Breaking User-Centric Agency: A Tri-Party Framework for Agent-Based Recommendation

Recent advances in large language models (LLMs) have stimulated growing interest in agent-based recommender systems, enabling language-driven interaction and reasoning for more expressive preference modeling. However, most existing agentic approaches remain predominantly user-centric, treating items as passive entities and neglecting the interests of other critical stakeholders. This limitation exacerbates exposure concentration and long-tail under-representation, threatening long-term system sustainability. In this work, we identify this fundamental limitation and propose the first Tri-party LLM-agent Recommendation framework (TriRec) that explicitly coordinates user utility, item exposure, and platform-level fairness. The framework employs a two-stage architecture: Stage~1 empowers item agents with personalized self-promotion to improve matching quality and alleviate cold-start barriers, while Stage~2 uses a platform agent for sequential multi-objective re-ranking, balancing user relevance, item utility, and exposure fairness. Experiments on multiple benchmarks show consistent gains in accuracy, fairness, and item-level utility. Moreover, we find that item self-promotion can simultaneously enhance fairness and effectiveness, challenging the conventional trade-off assumption between relevance and fairness. Our code is available at https://github.com/Marfekey/TriRec.

Verifiable Reasoning for LLM-based Generative Recommendation

Reasoning in Large Language Models (LLMs) has recently shown strong potential in enhancing generative recommendation through deep understanding of complex user preference. Existing approaches follow a {reason-then-recommend} paradigm, where LLMs perform step-by-step reasoning before item generation. However, this paradigm inevitably suffers from reasoning degradation (i.e., homogeneous or error-accumulated reasoning) due to the lack of intermediate verification, thus undermining the recommendation. To bridge this gap, we propose a novel \textbf{\textit{reason-verify-recommend}} paradigm, which interleaves reasoning with verification to provide reliable feedback, guiding the reasoning process toward more faithful user preference understanding. To enable effective verification, we establish two key principles for verifier design: 1) reliability ensures accurate evaluation of reasoning correctness and informative guidance generation; and 2) multi-dimensionality emphasizes comprehensive verification across multi-dimensional user preferences. Accordingly, we propose an effective implementation called VRec. It employs a mixture of verifiers to ensure multi-dimensionality, while leveraging a proxy prediction objective to pursue reliability. Experiments on four real-world datasets demonstrate that VRec substantially enhances recommendation effectiveness and scalability without compromising efficiency. The codes can be found at https://github.com/Linxyhaha/Verifiable-Rec.

NextAds: Towards Next-generation Personalized Video Advertising

With the rapid growth of online video consumption, video advertising has become increasingly dominant in the digital advertising landscape. Yet diverse users and viewing contexts makes one-size-fits-all ad creatives insufficient for consistent effectiveness, underlining the importance of personalization. In practice, most personalized video advertising systems follow a retrieval-based paradigm, selecting the optimal one from a small set of professionally pre-produced creatives for each user. Such static and finite inventories limits both the granularity and the timeliness of personalization, and prevents the creatives from being continuously refined based on online user feedback. Recent advances in generative AI make it possible to move beyond retrieval toward optimizing video creatives in a continuous space at serving time. In this light, we propose NextAds, a generation-based paradigm for next-generation personalized video advertising, and conceptualize NextAds with four core components. To enable comparable research progress, we formulate two representative tasks: personalized creative generation and personalized creative integration, and introduce corresponding lightweight benchmarks. To assess feasibility, we instantiate end-to-end pipelines for both tasks and conduct initial exploratory experiments, demonstrating that GenAI can generate and integrate personalized creatives with encouraging performance. Moreover, we discuss the key challenges and opportunities under this paradigm, aiming to provide actionable insights for both researchers and practitioners and to catalyze progress in personalized video advertising.

Uncertainty-aware Generative Recommendation

Generative Recommendation has emerged as a transformative paradigm, reformulating recommendation as an end-to-end autoregressive sequence generation task. Despite its promise, existing preference optimization methods typically rely on binary outcome correctness, suffering from a systemic limitation we term uncertainty blindness. This issue manifests in the neglect of the model's intrinsic generation confidence, the variation in sample learning difficulty, and the lack of explicit confidence expression, directly leading to unstable training dynamics and unquantifiable decision risks. In this paper, we propose Uncertainty-aware Generative Recommendation (UGR), a unified framework that leverages uncertainty as a critical signal for adaptive optimization. UGR synergizes three mechanisms: (1) an uncertainty-weighted reward to penalize confident errors; (2) difficulty-aware optimization dynamics to prevent premature convergence; and (3) explicit confidence alignment to empower the model with confidence expression capabilities. Extensive experiments demonstrate that UGR not only yields superior recommendation performance but also fundamentally stabilizes training, preventing the performance degradation often observed in standard methods. Furthermore, the learned confidence enables reliable downstream risk-aware applications.

Bringing Reasoning to Generative Recommendation Through the Lens of Cascaded Ranking

Generative Recommendation (GR) has become a promising end-to-end approach with high FLOPS utilization for resource-efficient recommendation. Despite the effectiveness, we show that current GR models suffer from a critical \textbf{bias amplification} issue, where token-level bias escalates as token generation progresses, ultimately limiting the recommendation diversity and hurting the user experience. By comparing against the key factor behind the success of traditional multi-stage pipelines, we reveal two limitations in GR that can amplify the bias: homogeneous reliance on the encoded history, and fixed computational budgets that prevent deeper user preference understanding. To combat the bias amplification issue, it is crucial for GR to 1) incorporate more heterogeneous information, and 2) allocate greater computational resources at each token generation step. To this end, we propose CARE, a simple yet effective cascaded reasoning framework for debiased GR. To incorporate heterogeneous information, we introduce a progressive history encoding mechanism, which progressively incorporates increasingly fine-grained history information as the generation process advances. To allocate more computations, we propose a query-anchored reasoning mechanism, which seeks to perform a deeper understanding of historical information through parallel reasoning steps. We instantiate CARE on three GR backbones. Empirical results on four datasets show the superiority of CARE in recommendation accuracy, diversity, efficiency, and promising scalability. The codes and datasets are available at https://github.com/Linxyhaha/CARE.

Towards Sample-Efficient and Stable Reinforcement Learning for LLM-based Recommendation

While Long Chain-of-Thought (Long CoT) reasoning has shown promise in Large Language Models (LLMs), its adoption for enhancing recommendation quality is growing rapidly. In this work, we critically examine this trend and argue that Long CoT is inherently ill-suited for the sequential recommendation domain. We attribute this misalignment to two primary factors: excessive inference latency and the lack of explicit cognitive reasoning patterns in user behavioral data. Driven by these observations, we propose pivoting away from the CoT structure to directly leverage its underlying mechanism: Reinforcement Learning (RL), to explore the item space. However, applying RL directly faces significant obstacles, notably low sample efficiency-where most actions fail to provide learning signals-and training instability. To overcome these limitations, we propose RISER, a novel Reinforced Item Space Exploration framework for Recommendation. RISER is designed to transform non-learnable trajectories into effective pairwise preference data for optimization. Furthermore, it incorporates specific strategies to ensure stability, including the prevention of redundant rollouts and the constraint of token-level update magnitudes. Extensive experiments on three real-world datasets show that RISER significantly outperforms competitive baselines, establishing a robust paradigm for RL-enhanced LLM recommendation. Our code will be available at https://anonymous.4open.science/r/RISER/.

One Adapts to Any: Meta Reward Modeling for Personalized LLM Alignment

Alignment of Large Language Models (LLMs) aims to align outputs with human preferences, and personalized alignment further adapts models to individual users. This relies on personalized reward models that capture user-specific preferences and automatically provide individualized feedback. However, developing these models faces two critical challenges: the scarcity of feedback from individual users and the need for efficient adaptation to unseen users. We argue that addressing these constraints requires a paradigm shift from fitting data to learn user preferences to learn the process of preference adaptation. To realize this, we propose Meta Reward Modeling (MRM), which reformulates personalized reward modeling as a meta-learning problem. Specifically, we represent each user's reward model as a weighted combination of base reward functions, and optimize the initialization of these weights using a Model-Agnostic Meta-Learning (MAML)-style framework to support fast adaptation under limited feedback. To ensure robustness, we introduce the Robust Personalization Objective (RPO), which places greater emphasis on hard-to-learn users during meta optimization. Extensive experiments on personalized preference datasets validate that MRM enhances few-shot personalization, improves user robustness, and consistently outperforms baselines.

Don't Start Over: A Cost-Effective Framework for Migrating Personalized Prompts Between LLMs

Personalization in Large Language Models (LLMs) often relies on user-specific soft prompts. However, these prompts become obsolete when the foundation model is upgraded, necessitating costly, full-scale retraining. To overcome this limitation, we propose the Prompt-level User Migration Adapter (PUMA), a lightweight framework to efficiently migrate personalized prompts across incompatible models. PUMA utilizes a parameter-efficient adapter to bridge the semantic gap, combined with a group-based user selection strategy to significantly reduce training costs. Experiments on three large-scale datasets show our method matches or even surpasses the performance of retraining from scratch, reducing computational cost by up to 98%. The framework demonstrates strong generalization across diverse model architectures and robustness in advanced scenarios like chained and aggregated migrations, offering a practical path for the sustainable evolution of personalized AI by decoupling user assets from the underlying models.

PERM: Psychology-grounded Empathetic Reward Modeling for Large Language Models

Large Language Models (LLMs) are increasingly deployed in human-centric applications, yet they often fail to provide substantive emotional support. While Reinforcement Learning (RL) has been utilized to enhance empathy of LLMs, existing reward models typically evaluate empathy from a single perspective, overlooking the inherently bidirectional interaction nature of empathy between the supporter and seeker as defined by Empathy Cycle theory. To address this limitation, we propose Psychology-grounded Empathetic Reward Modeling (PERM). PERM operationalizes empathy evaluation through a bidirectional decomposition: 1) Supporter perspective, assessing internal resonation and communicative expression; 2) Seeker perspective, evaluating emotional reception. Additionally, it incorporates a bystander perspective to monitor overall interaction quality. Extensive experiments on a widely-used emotional intelligence benchmark and an industrial daily conversation dataset demonstrate that PERM outperforms state-of-the-art baselines by over 10\%. Furthermore, a blinded user study reveals a 70\% preference for our approach, highlighting its efficacy in generating more empathetic responses. Our code, dataset, and models are available at https://github.com/ZhengWwwq/PERM.