SAM2-PATH: A better segment anything model for semantic segmentation in digital pathology

The semantic segmentation task in pathology plays an indispensable role in assisting physicians in determining the condition of tissue lesions. Foundation models, such as the SAM (Segment Anything Model) and SAM2, exhibit exceptional performance in instance segmentation within everyday natural scenes. SAM-PATH has also achieved impressive results in semantic segmentation within the field of pathology. However, in computational pathology, the models mentioned above still have the following limitations. The pre-trained encoder models suffer from a scarcity of pathology image data; SAM and SAM2 are not suitable for semantic segmentation. In this paper, we have designed a trainable Kolmogorov-Arnold Networks(KAN) classification module within the SAM2 workflow, and we have introduced the largest pretrained vision encoder for histopathology (UNI) to date. Our proposed framework, SAM2-PATH, augments SAM2's capability to perform semantic segmentation in digital pathology autonomously, eliminating the need for human provided input prompts. The experimental results demonstrate that, after fine-tuning the KAN classification module and decoder, Our dataset has achieved competitive results on publicly available pathology data. The code has been open-sourced and can be found at the following address: https://github.com/simzhangbest/SAM2PATH.

Quantum Long Short-Term Memory for Drug Discovery

Quantum computing combined with machine learning (ML) is an extremely promising research area, with numerous studies demonstrating that quantum machine learning (QML) is expected to solve scientific problems more effectively than classical ML. In this work, we successfully apply QML to drug discovery, showing that QML can significantly improve model performance and achieve faster convergence compared to classical ML. Moreover, we demonstrate that the model accuracy of the QML improves as the number of qubits increases. We also introduce noise to the QML model and find that it has little effect on our experimental conclusions, illustrating the high robustness of the QML model. This work highlights the potential application of quantum computing to yield significant benefits for scientific advancement as the qubit quantity increase and quality improvement in the future.

Navigating the Noisy Crowd: Finding Key Information for Claim Verification

Claim verification is a task that involves assessing the truthfulness of a given claim based on multiple evidence pieces. Using large language models (LLMs) for claim verification is a promising way. However, simply feeding all the evidence pieces to an LLM and asking if the claim is factual does not yield good results. The challenge lies in the noisy nature of both the evidence and the claim: evidence passages typically contain irrelevant information, with the key facts hidden within the context, while claims often convey multiple aspects simultaneously. To navigate this "noisy crowd" of information, we propose EACon (Evidence Abstraction and Claim Deconstruction), a framework designed to find key information within evidence and verify each aspect of a claim separately. EACon first finds keywords from the claim and employs fuzzy matching to select relevant keywords for each raw evidence piece. These keywords serve as a guide to extract and summarize critical information into abstracted evidence. Subsequently, EACon deconstructs the original claim into subclaims, which are then verified against both abstracted and raw evidence individually. We evaluate EACon using two open-source LLMs on two challenging datasets. Results demonstrate that EACon consistently and substantially improve LLMs' performance in claim verification.

SliceMamba for Medical Image Segmentation

Despite the progress made in Mamba-based medical image segmentation models, current methods utilizing unidirectional or multi-directional feature scanning mechanisms fail to well model dependencies between neighboring positions in the image, hindering the effective modeling of local features. However, local features are crucial for medical image segmentation as they provide vital information about lesions and tissue structures. To address this limitation, we propose a simple yet effective method named SliceMamba, a locally sensitive pure Mamba medical image segmentation model. The proposed SliceMamba includes an efffcient Bidirectional Slice Scan module (BSS), which performs bidirectional feature segmentation while employing varied scanning mechanisms for distinct features. This ensures that spatially adjacent features maintain proximity in the scanning sequence, thereby enhancing segmentation performance. Extensive experiments on skin lesion and polyp segmentation datasets validate the effectiveness of our method.

Parametric Primitive Analysis of CAD Sketches with Vision Transformer

The design and analysis of Computer-Aided Design (CAD) sketches play a crucial role in industrial product design, primarily involving CAD primitives and their inter-primitive constraints. To address challenges related to error accumulation in autoregressive models and the complexities associated with self-supervised model design for this task, we propose a two-stage network framework. This framework consists of a primitive network and a constraint network, transforming the sketch analysis task into a set prediction problem to enhance the effective handling of primitives and constraints. By decoupling target types from parameters, the model gains increased flexibility and optimization while reducing complexity. Additionally, the constraint network incorporates a pointer module to explicitly indicate the relationship between constraint parameters and primitive indices, enhancing interpretability and performance. Qualitative and quantitative analyses on two publicly available datasets demonstrate the superiority of this method.

Beyond LLaVA-HD: Diving into High-Resolution Large Multimodal Models

Seeing clearly with high resolution is a foundation of Large Multimodal Models (LMMs), which has been proven to be vital for visual perception and reasoning. Existing works usually employ a straightforward resolution upscaling method, where the image consists of global and local branches, with the latter being the sliced image patches but resized to the same resolution as the former. This means that higher resolution requires more local patches, resulting in exorbitant computational expenses, and meanwhile, the dominance of local image tokens may diminish the global context. In this paper, we dive into the problems and propose a new framework as well as an elaborate optimization strategy. Specifically, we extract contextual information from the global view using a mixture of adapters, based on the observation that different adapters excel at different tasks. With regard to local patches, learnable query embeddings are introduced to reduce image tokens, the most important tokens accounting for the user question will be further selected by a similarity-based selector. Our empirical results demonstrate a `less is more' pattern, where \textit{utilizing fewer but more informative local image tokens leads to improved performance}. Besides, a significant challenge lies in the training strategy, as simultaneous end-to-end training of the global mining block and local compression block does not yield optimal results. We thus advocate for an alternating training way, ensuring balanced learning between global and local aspects. Finally, we also introduce a challenging dataset with high requirements for image detail, enhancing the training of the local compression layer. The proposed method, termed LMM with Sophisticated Tasks, Local image compression, and Mixture of global Experts (SliME), achieves leading performance across various benchmarks with only 2 million training data.

Interpretable Multimodal Out-of-context Detection with Soft Logic Regularization

The rapid spread of information through mobile devices and media has led to the widespread of false or deceptive news, causing significant concerns in society. Among different types of misinformation, image repurposing, also known as out-of-context misinformation, remains highly prevalent and effective. However, current approaches for detecting out-of-context misinformation often lack interpretability and offer limited explanations. In this study, we propose a logic regularization approach for out-of-context detection called LOGRAN (LOGic Regularization for out-of-context ANalysis). The primary objective of LOGRAN is to decompose the out-of-context detection at the phrase level. By employing latent variables for phrase-level predictions, the final prediction of the image-caption pair can be aggregated using logical rules. The latent variables also provide an explanation for how the final result is derived, making this fine-grained detection method inherently explanatory. We evaluate the performance of LOGRAN on the NewsCLIPpings dataset, showcasing competitive overall results. Visualized examples also reveal faithful phrase-level predictions of out-of-context images, accompanied by explanations. This highlights the effectiveness of our approach in addressing out-of-context detection and enhancing interpretability.

Less is More: Pseudo-Label Filtering for Continual Test-Time Adaptation

Continual Test-Time Adaptation (CTTA) aims to adapt a pre-trained model to a sequence of target domains during the test phase without accessing the source data. To adapt to unlabeled data from unknown domains, existing methods rely on constructing pseudo-labels for all samples and updating the model through self-training. However, these pseudo-labels often involve noise, leading to insufficient adaptation. To improve the quality of pseudo-labels, we propose a pseudo-label selection method for CTTA, called Pseudo Labeling Filter (PLF). The key idea of PLF is to keep selecting appropriate thresholds for pseudo-labels and identify reliable ones for self-training. Specifically, we present three principles for setting thresholds during continuous domain learning, including initialization, growth and diversity. Based on these principles, we design Self-Adaptive Thresholding to filter pseudo-labels. Additionally, we introduce a Class Prior Alignment (CPA) method to encourage the model to make diverse predictions for unknown domain samples. Through extensive experiments, PLF outperforms current state-of-the-art methods, proving its effectiveness in CTTA.

Controllable Continual Test-Time Adaptation

Continual Test-Time Adaptation (CTTA) is an emerging and challenging task where a model trained in a source domain must adapt to continuously changing conditions during testing, without access to the original source data. CTTA is prone to error accumulation due to uncontrollable domain shifts, leading to blurred decision boundaries between categories. Existing CTTA methods primarily focus on suppressing domain shifts, which proves inadequate during the unsupervised test phase. In contrast, we introduce a novel approach that guides rather than suppresses these shifts. Specifically, we propose $\textbf{C}$ontrollable $\textbf{Co}$ntinual $\textbf{T}$est-$\textbf{T}$ime $\textbf{A}$daptation (C-CoTTA), which explicitly prevents any single category from encroaching on others, thereby mitigating the mutual influence between categories caused by uncontrollable shifts. Moreover, our method reduces the sensitivity of model to domain transformations, thereby minimizing the magnitude of category shifts. Extensive quantitative experiments demonstrate the effectiveness of our method, while qualitative analyses, such as t-SNE plots, confirm the theoretical validity of our approach.

Overcoming Domain Drift in Online Continual Learning

Online Continual Learning (OCL) empowers machine learning models to acquire new knowledge online across a sequence of tasks. However, OCL faces a significant challenge: catastrophic forgetting, wherein the model learned in previous tasks is substantially overwritten upon encountering new tasks, leading to a biased forgetting of prior knowledge. Moreover, the continual doman drift in sequential learning tasks may entail the gradual displacement of the decision boundaries in the learned feature space, rendering the learned knowledge susceptible to forgetting. To address the above problem, in this paper, we propose a novel rehearsal strategy, termed Drift-Reducing Rehearsal (DRR), to anchor the domain of old tasks and reduce the negative transfer effects. First, we propose to select memory for more representative samples guided by constructed centroids in a data stream. Then, to keep the model from domain chaos in drifting, a two-level angular cross-task Contrastive Margin Loss (CML) is proposed, to encourage the intra-class and intra-task compactness, and increase the inter-class and inter-task discrepancy. Finally, to further suppress the continual domain drift, we present an optional Centorid Distillation Loss (CDL) on the rehearsal memory to anchor the knowledge in feature space for each previous old task. Extensive experimental results on four benchmark datasets validate that the proposed DRR can effectively mitigate the continual domain drift and achieve the state-of-the-art (SOTA) performance in OCL.