LncRNA-disease association prediction method based on heterogeneous information completion and convolutional neural network

The emerging research shows that lncRNA has crucial research value in a series of complex human diseases. Therefore, the accurate identification of lncRNA-disease associations (LDAs) is very important for the warning and treatment of diseases. However, most of the existing methods have limitations in identifying nonlinear LDAs, and it remains a huge challenge to predict new LDAs. In this paper, a deep learning model based on a heterogeneous network and convolutional neural network (CNN) is proposed for lncRNA-disease association prediction, named HCNNLDA. The heterogeneous network containing the lncRNA, disease, and miRNA nodes, is constructed firstly. The embedding matrix of a lncRNA-disease node pair is constructed according to various biological premises about lncRNAs, diseases, and miRNAs. Then, the low-dimensional feature representation is fully learned by the convolutional neural network. In the end, the XGBoot classifier model is trained to predict the potential LDAs. HCNNLDA obtains a high AUC value of 0.9752 and AUPR of 0.9740 under the 5-fold cross-validation. The experimental results show that the proposed model has better performance than that of several latest prediction models. Meanwhile, the effectiveness of HCNNLDA in identifying novel LDAs is further demonstrated by case studies of three diseases. To sum up, HCNNLDA is a feasible calculation model to predict LDAs.

PromptIQA: Boosting the Performance and Generalization for No-Reference Image Quality Assessment via Prompts

Due to the diversity of assessment requirements in various application scenarios for the IQA task, existing IQA methods struggle to directly adapt to these varied requirements after training. Thus, when facing new requirements, a typical approach is fine-tuning these models on datasets specifically created for those requirements. However, it is time-consuming to establish IQA datasets. In this work, we propose a Prompt-based IQA (PromptIQA) that can directly adapt to new requirements without fine-tuning after training. On one hand, it utilizes a short sequence of Image-Score Pairs (ISP) as prompts for targeted predictions, which significantly reduces the dependency on the data requirements. On the other hand, PromptIQA is trained on a mixed dataset with two proposed data augmentation strategies to learn diverse requirements, thus enabling it to effectively adapt to new requirements. Experiments indicate that the PromptIQA outperforms SOTA methods with higher performance and better generalization. The code will be available.

GMC-IQA: Exploiting Global-correlation and Mean-opinion Consistency for No-reference Image Quality Assessment

Due to the subjective nature of image quality assessment (IQA), assessing which image has better quality among a sequence of images is more reliable than assigning an absolute mean opinion score for an image. Thus, IQA models are evaluated by global correlation consistency (GCC) metrics like PLCC and SROCC, rather than mean opinion consistency (MOC) metrics like MAE and MSE. However, most existing methods adopt MOC metrics to define their loss functions, due to the infeasible computation of GCC metrics during training. In this work, we construct a novel loss function and network to exploit Global-correlation and Mean-opinion Consistency, forming a GMC-IQA framework. Specifically, we propose a novel GCC loss by defining a pairwise preference-based rank estimation to solve the non-differentiable problem of SROCC and introducing a queue mechanism to reserve previous data to approximate the global results of the whole data. Moreover, we propose a mean-opinion network, which integrates diverse opinion features to alleviate the randomness of weight learning and enhance the model robustness. Experiments indicate that our method outperforms SOTA methods on multiple authentic datasets with higher accuracy and generalization. We also adapt the proposed loss to various networks, which brings better performance and more stable training.

Weakly Supervised Image Segmentation Beyond Tight Bounding Box Annotations

Weakly supervised image segmentation approaches in the literature usually achieve high segmentation performance using tight bounding box supervision and decrease the performance greatly when supervised by loose bounding boxes. However, compared with loose bounding box, it is much more difficult to acquire tight bounding box due to its strict requirements on the precise locations of the four sides of the box. To resolve this issue, this study investigates whether it is possible to maintain good segmentation performance when loose bounding boxes are used as supervision. For this purpose, this work extends our previous parallel transformation based multiple instance learning (MIL) for tight bounding box supervision by integrating an MIL strategy based on polar transformation to assist image segmentation. The proposed polar transformation based MIL formulation works for both tight and loose bounding boxes, in which a positive bag is defined as pixels in a polar line of a bounding box with one endpoint located inside the object enclosed by the box and the other endpoint located at one of the four sides of the box. Moreover, a weighted smooth maximum approximation is introduced to incorporate the observation that pixels closer to the origin of the polar transformation are more likely to belong to the object in the box. The proposed approach was evaluated on two public datasets using dice coefficient when bounding boxes at different precision levels were considered in the experiments. The results demonstrate that the proposed approach achieves state-of-the-art performance for bounding boxes at all precision levels and is robust to mild and moderate errors in the loose bounding box annotations. The codes are available at \url{https://github.com/wangjuan313/wsis-beyond-tightBB}.

Learned Smartphone ISP on Mobile GPUs with Deep Learning, Mobile AI & AIM 2022 Challenge: Report

The role of mobile cameras increased dramatically over the past few years, leading to more and more research in automatic image quality enhancement and RAW photo processing. In this Mobile AI challenge, the target was to develop an efficient end-to-end AI-based image signal processing (ISP) pipeline replacing the standard mobile ISPs that can run on modern smartphone GPUs using TensorFlow Lite. The participants were provided with a large-scale Fujifilm UltraISP dataset consisting of thousands of paired photos captured with a normal mobile camera sensor and a professional 102MP medium-format FujiFilm GFX100 camera. The runtime of the resulting models was evaluated on the Snapdragon's 8 Gen 1 GPU that provides excellent acceleration results for the majority of common deep learning ops. The proposed solutions are compatible with all recent mobile GPUs, being able to process Full HD photos in less than 20-50 milliseconds while achieving high fidelity results. A detailed description of all models developed in this challenge is provided in this paper.

Personalized Execution Time Optimization for the Scheduled Jobs

Scheduled batch jobs have been widely used on the asynchronous computing platforms to execute various enterprise applications, including the scheduled notifications and the candidate computation for the modern recommender systems. It is important to deliver or update the information to the users at the right time to maintain the user experience and the execution impact. However, it is challenging to provide a versatile execution time optimization solution for the user-basis scheduled jobs to satisfy various product scenarios while maintaining reasonable infrastructure resource consumption. In this paper, we describe how we apply a pointwise learning-to-rank approach plus a "best time policy" in the best time selection. In addition, we propose a value model approach to efficiently leverage multiple streams of user activity signals in our scheduling decisions of the execution time. Our optimization approach has been successfully tested with production traffic that serves billions of users per day, with statistically significant improvements in various product metrics, including the notifications and content candidate generation. To the best of our knowledge, our study represents the first ML-based multi-tenant solution to the execution time optimization problem for the scheduled jobs at a large industrial scale.

Polar Transformation Based Multiple Instance Learning Assisting Weakly Supervised Image Segmentation With Loose Bounding Box Annotations

This study investigates weakly supervised image segmentation using loose bounding box supervision. It presents a multiple instance learning strategy based on polar transformation to assist image segmentation when loose bounding boxes are employed as supervision. In this strategy, weighted smooth maximum approximation is introduced to incorporate the observation that pixels closer to the origin of the polar transformation are more likely to belong to the object in the bounding box. The proposed approach was evaluated on a public medical dataset using Dice coefficient. The results demonstrate its superior performance. The codes are available at \url{https://github.com/wangjuan313/wsis-polartransform}.

Accurate Cup-to-Disc Ratio Measurement with Tight Bounding Box Supervision in Fundus Photography

The cup-to-disc ratio (CDR) is one of the most significant indicator for glaucoma diagnosis. Different from the use of costly fully supervised learning formulation with pixel-wise annotations in the literature, this study investigates the feasibility of accurate CDR measurement in fundus images using only tight bounding box supervision. For this purpose, we develop a two-task network for accurate CDR measurement, one for weakly supervised image segmentation, and the other for bounding-box regression. The weakly supervised image segmentation task is implemented based on generalized multiple instance learning formulation and smooth maximum approximation, and the bounding-box regression task outputs class-specific bounding box prediction in a single scale at the original image resolution. To get accurate bounding box prediction, a class-specific bounding-box normalizer and an expected intersection-over-union are proposed. In the experiments, the proposed approach was evaluated by a testing set with 1200 images using CDR error and F1 score for CDR measurement and dice coefficient for image segmentation. A grader study was conducted to compare the performance of the proposed approach with those of individual graders. The results demonstrate that the proposed approach outperforms the state-of-the-art performance obtained from the fully supervised image segmentation (FSIS) approach using pixel-wise annotation for CDR measurement, which is also better than those of individual graders. It also gets performance close to the state-of-the-art obtained from FSIS for optic cup and disc segmentation, similar to those of individual graders. The codes are available at \url{https://github.com/wangjuan313/CDRNet}.

Bounding Box Tightness Prior for Weakly Supervised Image Segmentation

This paper presents a weakly supervised image segmentation method that adopts tight bounding box annotations. It proposes generalized multiple instance learning (MIL) and smooth maximum approximation to integrate the bounding box tightness prior into the deep neural network in an end-to-end manner. In generalized MIL, positive bags are defined by parallel crossing lines with a set of different angles, and negative bags are defined as individual pixels outside of any bounding boxes. Two variants of smooth maximum approximation, i.e., $\alpha$-softmax function and $\alpha$-quasimax function, are exploited to conquer the numeral instability introduced by maximum function of bag prediction. The proposed approach was evaluated on two pubic medical datasets using Dice coefficient. The results demonstrate that it outperforms the state-of-the-art methods. The codes are available at \url{https://github.com/wangjuan313/wsis-boundingbox}.

Reinforcement Learning-based Product Delivery Frequency Control

Frequency control is an important problem in modern recommender systems. It dictates the delivery frequency of recommendations to maintain product quality and efficiency. For example, the frequency of delivering promotional notifications impacts daily metrics as well as the infrastructure resource consumption (e.g. CPU and memory usage). There remain open questions on what objective we should optimize to represent business values in the long term best, and how we should balance between daily metrics and resource consumption in a dynamically fluctuating environment. We propose a personalized methodology for the frequency control problem, which combines long-term value optimization using reinforcement learning (RL) with a robust volume control technique we termed "Effective Factor". We demonstrate statistically significant improvement in daily metrics and resource efficiency by our method in several notification applications at a scale of billions of users. To our best knowledge, our study represents the first deep RL application on the frequency control problem at such an industrial scale.