ADAM: A Systematic Data Extraction Attack on Agent Memory via Adaptive Querying

Large Language Model (LLM) agents have achieved rapid adoption and demonstrated remarkable capabilities across a wide range of applications. To improve reasoning and task execution, modern LLM agents would incorporate memory modules or retrieval-augmented generation (RAG) mechanisms, enabling them to further leverage prior interactions or external knowledge. However, such a design also introduces a group of critical privacy vulnerabilities: sensitive information stored in memory can be leaked through query-based attacks. Although feasible, existing attacks often achieve only limited performance, with low attack success rates (ASR). In this paper, we propose ADAM, a novel privacy attack that features data distribution estimation of a victim agent's memory and employs an entropy-guided query strategy for maximizing privacy leakage. Extensive experiments demonstrate that our attack substantially outperforms state-of-the-art ones, achieving up to 100% ASRs. These results thus underscore the urgent need for robust privacy-preserving methods for current LLM agents.

Reinforcement Learning with LLM-Guided Action Spaces for Synthesizable Lead Optimization

Lead optimization in drug discovery requires improving therapeutic properties while ensuring that proposed molecular modifications correspond to feasible synthetic routes. Existing approaches either prioritize property scores without enforcing synthesizability, or rely on expensive enumeration over large reaction networks, while direct application of Large Language Models (LLMs) frequently produces chemically invalid structures. We introduce MolReAct, a framework that formulates lead optimization as a Markov Decision Process over a synthesis-constrained action space defined by validated reaction templates. A tool-augmented LLM agent serves as a dynamic reaction environment that invokes specialized chemical analysis tools to identify reactive sites and propose chemically grounded transformations from matched templates. A policy model trained via Group Relative Policy Optimization (GRPO) selects among these constrained actions to maximize long-term oracle reward across multi-step reaction trajectories. A SMILES-based caching mechanism further reduces end-to-end optimization time by approximately 43%. Across 13 property optimization tasks from the Therapeutic Data Commons and one structure-based docking task, MolReAct achieves an average Top-10 score of 0.563, outperforming the strongest synthesizable baseline by 10.4% in relative improvement, and attains the best sample efficiency on 10 of 14 tasks. Ablations confirm that both tool-augmented reaction proposals and trajectory-level policy optimization contribute complementary gains. By grounding every step in validated reaction templates, MolReAct produces molecules that are property-improved and each accompanied by an explicit synthetic pathway.

Big2Small: A Unifying Neural Network Framework for Model Compression

With the development of foundational models, model compression has become a critical requirement. Various model compression approaches have been proposed such as low-rank decomposition, pruning, quantization, ergodic dynamic systems, and knowledge distillation, which are based on different heuristics. To elevate the field from fragmentation to a principled discipline, we construct a unifying mathematical framework for model compression grounded in measure theory. We further demonstrate that each model compression technique is mathematically equivalent to a neural network subject to a regularization. Building upon this mathematical and structural equivalence, we propose an experimentally-verified data-free model compression framework, termed \textit{Big2Small}, which translates Implicit Neural Representations (INRs) from data domain to the domain of network parameters. \textit{Big2Small} trains compact INRs to encode the weights of larger models and reconstruct the weights during inference. To enhance reconstruction fidelity, we introduce Outlier-Aware Preprocessing to handle extreme weight values and a Frequency-Aware Loss function to preserve high-frequency details. Experiments on image classification and segmentation demonstrate that \textit{Big2Small} achieves competitive accuracy and compression ratios compared to state-of-the-art baselines.

A Blueprint for Self-Evolving Coding Agents in Vehicle Aerodynamic Drag Prediction

High-fidelity vehicle drag evaluation is constrained less by solver runtime than by workflow friction: geometry cleanup, meshing retries, queue contention, and reproducibility failures across teams. We present a contract-centric blueprint for self-evolving coding agents that discover executable surrogate pipelines for predicting drag coefficient $C_d$ under industrial constraints. The method formulates surrogate discovery as constrained optimization over programs, not static model instances, and combines Famou-Agent-style evaluator feedback with population-based island evolution, structured mutations (data, model, loss, and split policies), and multi-objective selection balancing ranking quality, stability, and cost. A hard evaluation contract enforces leakage prevention, deterministic replay, multi-seed robustness, and resource budgets before any candidate is admitted. Across eight anonymized evolutionary operators, the best system reaches a Combined Score of 0.9335 with sign-accuracy 0.9180, while trajectory and ablation analyses show that adaptive sampling and island migration are primary drivers of convergence quality. The deployment model is explicitly ``screen-and-escalate'': surrogates provide high-throughput ranking for design exploration, but low-confidence or out-of-distribution cases are automatically escalated to high-fidelity CFD. The resulting contribution is an auditable, reusable workflow for accelerating aerodynamic design iteration while preserving decision-grade reliability, governance traceability, and safety boundaries.

RAIN-Merging: A Gradient-Free Method to Enhance Instruction Following in Large Reasoning Models with Preserved Thinking Format

Large reasoning models (LRMs) excel at a long chain of reasoning but often fail to faithfully follow instructions regarding output format, constraints, or specific requirements. We investigate whether this gap can be closed by integrating an instruction-tuned model (ITM) into an LRM. Analyzing their differences in parameter space, namely task vectors, we find that their principal subspaces are nearly orthogonal across key modules, suggesting a lightweight merging with minimal interference. However, we also demonstrate that naive merges are fragile because they overlook the output format mismatch between LRMs (with explicit thinking and response segments) and ITMs (answers-only). We introduce RAIN-Merging (Reasoning-Aware Instruction-attention guided Null-space projection Merging), a gradient-free method that integrates instruction following while preserving thinking format and reasoning performance. First, with a small reasoning calibration set, we project the ITM task vector onto the null space of forward features at thinking special tokens, which preserves the LRM's structured reasoning mechanisms. Second, using a small instruction calibration set, we estimate instruction attention to derive module-specific scaling that amplifies instruction-relevant components and suppresses leakage. Across four instruction-following benchmarks and nine reasoning & general capability benchmarks, RAIN-Merging substantially improves instruction adherence while maintaining reasoning quality. The gains are consistent across model scales and architectures, translating to improved performance in agent settings.

Multi-Probe Zero Collision Hash (MPZCH): Mitigating Embedding Collisions and Enhancing Model Freshness in Large-Scale Recommenders

Embedding tables are critical components of large-scale recommendation systems, facilitating the efficient mapping of high-cardinality categorical features into dense vector representations. However, as the volume of unique IDs expands, traditional hash-based indexing methods suffer from collisions that degrade model performance and personalization quality. We present Multi-Probe Zero Collision Hash (MPZCH), a novel indexing mechanism based on linear probing that effectively mitigates embedding collisions. With reasonable table sizing, it often eliminates these collisions entirely while maintaining production-scale efficiency. MPZCH utilizes auxiliary tensors and high-performance CUDA kernels to implement configurable probing and active eviction policies. By retiring obsolete IDs and resetting reassigned slots, MPZCH prevents the stale embedding inheritance typical of hash-based methods, ensuring new features learn effectively from scratch. Despite its collision-mitigation overhead, the system maintains training QPS and inference latency comparable to existing methods. Rigorous online experiments demonstrate that MPZCH achieves zero collisions for user embeddings and significantly improves item embedding freshness and quality. The solution has been released within the open-source TorchRec library for the broader community.

In-Context Autonomous Network Incident Response: An End-to-End Large Language Model Agent Approach

Rapidly evolving cyberattacks demand incident response systems that can autonomously learn and adapt to changing threats. Prior work has extensively explored the reinforcement learning approach, which involves learning response strategies through extensive simulation of the incident. While this approach can be effective, it requires handcrafted modeling of the simulator and suppresses useful semantics from raw system logs and alerts. To address these limitations, we propose to leverage large language models' (LLM) pre-trained security knowledge and in-context learning to create an end-to-end agentic solution for incident response planning. Specifically, our agent integrates four functionalities, perception, reasoning, planning, and action, into one lightweight LLM (14b model). Through fine-tuning and chain-of-thought reasoning, our LLM agent is capable of processing system logs and inferring the underlying network state (perception), updating its conjecture of attack models (reasoning), simulating consequences under different response strategies (planning), and generating an effective response (action). By comparing LLM-simulated outcomes with actual observations, the LLM agent repeatedly refines its attack conjecture and corresponding response, thereby demonstrating in-context adaptation. Our agentic approach is free of modeling and can run on commodity hardware. When evaluated on incident logs reported in the literature, our agent achieves recovery up to 23% faster than those of frontier LLMs.

OneVoice: One Model, Triple Scenarios-Towards Unified Zero-shot Voice Conversion

Recent progress of voice conversion~(VC) has achieved a new milestone in speaker cloning and linguistic preservation. But the field remains fragmented, relying on specialized models for linguistic-preserving, expressive, and singing scenarios. We propose OneVoice, a unified zero-shot framework capable of handling all three scenarios within a single model. OneVoice is built upon a continuous language model trained with VAE-free next-patch diffusion, ensuring high fidelity and efficient sequence modeling. Its core design for unification lies in a Mixture-of-Experts (MoE) designed to explicitly model shared conversion knowledge and scenario-specific expressivity. Expert selection is coordinated by a dual-path routing mechanism, including shared expert isolation and scenario-aware domain expert assignment with global-local cues. For precise conditioning, scenario-specific prosodic features are fused into each layer via a gated mechanism, allowing adaptive usage of prosody information. Furthermore, to enable the core idea and alleviate the imbalanced issue (abundant speech vs. scarce singing), we adopt a two-stage progressive training that includes foundational pre-training and scenario enhancement with LoRA-based domain experts. Experiments show that OneVoice matches or surpasses specialized models across all three scenarios, while verifying flexible control over scenarios and offering a fast decoding version as few as 2 steps. Code and model will be released soon.

Imaging-anchored Multiomics in Cardiovascular Disease: Integrating Cardiac Imaging, Bulk, Single-cell, and Spatial Transcriptomics

Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT and echocardiography together with bulk, single-cell and spatial transcriptomics, yet these data are still analysed in separate pipelines. This review examines joint representations that link cardiac imaging phenotypes to transcriptomic and spatially resolved molecular states. An imaging-anchored perspective is adopted in which echocardiography, cardiac MRI and CT define a spatial phenotype of the heart, and bulk, single-cell and spatial transcriptomics provide cell-type- and location-specific molecular context. The biological and technical characteristics of these modalities are first summarised, and representation-learning strategies for each are outlined. Multimodal fusion approaches are reviewed, with emphasis on handling missing data, limited sample size, and batch effects. Finally, integrative pipelines for radiogenomics, spatial molecular alignment, and image-based prediction of gene expression are discussed, together with common failure modes, practical considerations, and open challenges. Spatial multiomics of human myocardium and atherosclerotic plaque, single-cell and spatial foundation models, and multimodal medical foundation models are collectively bringing imaging-anchored multiomics closer to large-scale cardiovascular translation.

DiffKD-DCIS: Predicting Upgrade of Ductal Carcinoma In Situ with Diffusion Augmentation and Knowledge Distillation

Accurately predicting the upgrade of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is crucial for surgical planning. However, traditional deep learning methods face challenges due to limited ultrasound data and poor generalization ability. This study proposes the DiffKD-DCIS framework, integrating conditional diffusion modeling with teacher-student knowledge distillation. The framework operates in three stages: First, a conditional diffusion model generates high-fidelity ultrasound images using multimodal conditions for data augmentation. Then, a deep teacher network extracts robust features from both original and synthetic data. Finally, a compact student network learns from the teacher via knowledge distillation, balancing generalization and computational efficiency. Evaluated on a multi-center dataset of 1,435 cases, the synthetic images were of good quality. The student network had fewer parameters and faster inference. On external test sets, it outperformed partial combinations, and its accuracy was comparable to senior radiologists and superior to junior ones, showing significant clinical potential.