RAIN-Merging: A Gradient-Free Method to Enhance Instruction Following in Large Reasoning Models with Preserved Thinking Format

Large reasoning models (LRMs) excel at a long chain of reasoning but often fail to faithfully follow instructions regarding output format, constraints, or specific requirements. We investigate whether this gap can be closed by integrating an instruction-tuned model (ITM) into an LRM. Analyzing their differences in parameter space, namely task vectors, we find that their principal subspaces are nearly orthogonal across key modules, suggesting a lightweight merging with minimal interference. However, we also demonstrate that naive merges are fragile because they overlook the output format mismatch between LRMs (with explicit thinking and response segments) and ITMs (answers-only). We introduce RAIN-Merging (Reasoning-Aware Instruction-attention guided Null-space projection Merging), a gradient-free method that integrates instruction following while preserving thinking format and reasoning performance. First, with a small reasoning calibration set, we project the ITM task vector onto the null space of forward features at thinking special tokens, which preserves the LRM's structured reasoning mechanisms. Second, using a small instruction calibration set, we estimate instruction attention to derive module-specific scaling that amplifies instruction-relevant components and suppresses leakage. Across four instruction-following benchmarks and nine reasoning & general capability benchmarks, RAIN-Merging substantially improves instruction adherence while maintaining reasoning quality. The gains are consistent across model scales and architectures, translating to improved performance in agent settings.

Multi-Probe Zero Collision Hash (MPZCH): Mitigating Embedding Collisions and Enhancing Model Freshness in Large-Scale Recommenders

Embedding tables are critical components of large-scale recommendation systems, facilitating the efficient mapping of high-cardinality categorical features into dense vector representations. However, as the volume of unique IDs expands, traditional hash-based indexing methods suffer from collisions that degrade model performance and personalization quality. We present Multi-Probe Zero Collision Hash (MPZCH), a novel indexing mechanism based on linear probing that effectively mitigates embedding collisions. With reasonable table sizing, it often eliminates these collisions entirely while maintaining production-scale efficiency. MPZCH utilizes auxiliary tensors and high-performance CUDA kernels to implement configurable probing and active eviction policies. By retiring obsolete IDs and resetting reassigned slots, MPZCH prevents the stale embedding inheritance typical of hash-based methods, ensuring new features learn effectively from scratch. Despite its collision-mitigation overhead, the system maintains training QPS and inference latency comparable to existing methods. Rigorous online experiments demonstrate that MPZCH achieves zero collisions for user embeddings and significantly improves item embedding freshness and quality. The solution has been released within the open-source TorchRec library for the broader community.

In-Context Autonomous Network Incident Response: An End-to-End Large Language Model Agent Approach

Rapidly evolving cyberattacks demand incident response systems that can autonomously learn and adapt to changing threats. Prior work has extensively explored the reinforcement learning approach, which involves learning response strategies through extensive simulation of the incident. While this approach can be effective, it requires handcrafted modeling of the simulator and suppresses useful semantics from raw system logs and alerts. To address these limitations, we propose to leverage large language models' (LLM) pre-trained security knowledge and in-context learning to create an end-to-end agentic solution for incident response planning. Specifically, our agent integrates four functionalities, perception, reasoning, planning, and action, into one lightweight LLM (14b model). Through fine-tuning and chain-of-thought reasoning, our LLM agent is capable of processing system logs and inferring the underlying network state (perception), updating its conjecture of attack models (reasoning), simulating consequences under different response strategies (planning), and generating an effective response (action). By comparing LLM-simulated outcomes with actual observations, the LLM agent repeatedly refines its attack conjecture and corresponding response, thereby demonstrating in-context adaptation. Our agentic approach is free of modeling and can run on commodity hardware. When evaluated on incident logs reported in the literature, our agent achieves recovery up to 23% faster than those of frontier LLMs.

OneVoice: One Model, Triple Scenarios-Towards Unified Zero-shot Voice Conversion

Recent progress of voice conversion~(VC) has achieved a new milestone in speaker cloning and linguistic preservation. But the field remains fragmented, relying on specialized models for linguistic-preserving, expressive, and singing scenarios. We propose OneVoice, a unified zero-shot framework capable of handling all three scenarios within a single model. OneVoice is built upon a continuous language model trained with VAE-free next-patch diffusion, ensuring high fidelity and efficient sequence modeling. Its core design for unification lies in a Mixture-of-Experts (MoE) designed to explicitly model shared conversion knowledge and scenario-specific expressivity. Expert selection is coordinated by a dual-path routing mechanism, including shared expert isolation and scenario-aware domain expert assignment with global-local cues. For precise conditioning, scenario-specific prosodic features are fused into each layer via a gated mechanism, allowing adaptive usage of prosody information. Furthermore, to enable the core idea and alleviate the imbalanced issue (abundant speech vs. scarce singing), we adopt a two-stage progressive training that includes foundational pre-training and scenario enhancement with LoRA-based domain experts. Experiments show that OneVoice matches or surpasses specialized models across all three scenarios, while verifying flexible control over scenarios and offering a fast decoding version as few as 2 steps. Code and model will be released soon.

Imaging-anchored Multiomics in Cardiovascular Disease: Integrating Cardiac Imaging, Bulk, Single-cell, and Spatial Transcriptomics

Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT and echocardiography together with bulk, single-cell and spatial transcriptomics, yet these data are still analysed in separate pipelines. This review examines joint representations that link cardiac imaging phenotypes to transcriptomic and spatially resolved molecular states. An imaging-anchored perspective is adopted in which echocardiography, cardiac MRI and CT define a spatial phenotype of the heart, and bulk, single-cell and spatial transcriptomics provide cell-type- and location-specific molecular context. The biological and technical characteristics of these modalities are first summarised, and representation-learning strategies for each are outlined. Multimodal fusion approaches are reviewed, with emphasis on handling missing data, limited sample size, and batch effects. Finally, integrative pipelines for radiogenomics, spatial molecular alignment, and image-based prediction of gene expression are discussed, together with common failure modes, practical considerations, and open challenges. Spatial multiomics of human myocardium and atherosclerotic plaque, single-cell and spatial foundation models, and multimodal medical foundation models are collectively bringing imaging-anchored multiomics closer to large-scale cardiovascular translation.

DiffKD-DCIS: Predicting Upgrade of Ductal Carcinoma In Situ with Diffusion Augmentation and Knowledge Distillation

Accurately predicting the upgrade of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is crucial for surgical planning. However, traditional deep learning methods face challenges due to limited ultrasound data and poor generalization ability. This study proposes the DiffKD-DCIS framework, integrating conditional diffusion modeling with teacher-student knowledge distillation. The framework operates in three stages: First, a conditional diffusion model generates high-fidelity ultrasound images using multimodal conditions for data augmentation. Then, a deep teacher network extracts robust features from both original and synthetic data. Finally, a compact student network learns from the teacher via knowledge distillation, balancing generalization and computational efficiency. Evaluated on a multi-center dataset of 1,435 cases, the synthetic images were of good quality. The student network had fewer parameters and faster inference. On external test sets, it outperformed partial combinations, and its accuracy was comparable to senior radiologists and superior to junior ones, showing significant clinical potential.

RoboMIND 2.0: A Multimodal, Bimanual Mobile Manipulation Dataset for Generalizable Embodied Intelligence

While data-driven imitation learning has revolutionized robotic manipulation, current approaches remain constrained by the scarcity of large-scale, diverse real-world demonstrations. Consequently, the ability of existing models to generalize across long-horizon bimanual tasks and mobile manipulation in unstructured environments remains limited. To bridge this gap, we present RoboMIND 2.0, a comprehensive real-world dataset comprising over 310K dual-arm manipulation trajectories collected across six distinct robot embodiments and 739 complex tasks. Crucially, to support research in contact-rich and spatially extended tasks, the dataset incorporates 12K tactile-enhanced episodes and 20K mobile manipulation trajectories. Complementing this physical data, we construct high-fidelity digital twins of our real-world environments, releasing an additional 20K-trajectory simulated dataset to facilitate robust sim-to-real transfer. To fully exploit the potential of RoboMIND 2.0, we propose MIND-2 system, a hierarchical dual-system frame-work optimized via offline reinforcement learning. MIND-2 integrates a high-level semantic planner (MIND-2-VLM) to decompose abstract natural language instructions into grounded subgoals, coupled with a low-level Vision-Language-Action executor (MIND-2-VLA), which generates precise, proprioception-aware motor actions.

VL-RouterBench: A Benchmark for Vision-Language Model Routing

Multi-model routing has evolved from an engineering technique into essential infrastructure, yet existing work lacks a systematic, reproducible benchmark for evaluating vision-language models (VLMs). We present VL-RouterBench to assess the overall capability of VLM routing systems systematically. The benchmark is grounded in raw inference and scoring logs from VLMs and constructs quality and cost matrices over sample-model pairs. In scale, VL-RouterBench covers 14 datasets across 3 task groups, totaling 30,540 samples, and includes 15 open-source models and 2 API models, yielding 519,180 sample-model pairs and a total input-output token volume of 34,494,977. The evaluation protocol jointly measures average accuracy, average cost, and throughput, and builds a ranking score from the harmonic mean of normalized cost and accuracy to enable comparison across router configurations and cost budgets. On this benchmark, we evaluate 10 routing methods and baselines and observe a significant routability gain, while the best current routers still show a clear gap to the ideal Oracle, indicating considerable room for improvement in router architecture through finer visual cues and modeling of textual structure. We will open-source the complete data construction and evaluation toolchain to promote comparability, reproducibility, and practical deployment in multimodal routing research.

PFed-Signal: An ADR Prediction Model based on Federated Learning

The adverse drug reactions (ADRs) predicted based on the biased records in FAERS (U.S. Food and Drug Administration Adverse Event Reporting System) may mislead diagnosis online. Generally, such problems are solved by optimizing reporting odds ratio (ROR) or proportional reporting ratio (PRR). However, these methods that rely on statistical methods cannot eliminate the biased data, leading to inaccurate signal prediction. In this paper, we propose PFed-signal, a federated learning-based signal prediction model of ADR, which utilizes the Euclidean distance to eliminate the biased data from FAERS, thereby improving the accuracy of ADR prediction. Specifically, we first propose Pfed-Split, a method to split the original dataset into a split dataset based on ADR. Then we propose ADR-signal, an ADR prediction model, including a biased data identification method based on federated learning and an ADR prediction model based on Transformer. The former identifies the biased data according to the Euclidean distance and generates a clean dataset by deleting the biased data. The latter is an ADR prediction model based on Transformer trained on the clean data set. The results show that the ROR and PRR on the clean dataset are better than those of the traditional methods. Furthermore, the accuracy rate, F1 score, recall rate and AUC of PFed-Signal are 0.887, 0.890, 0.913 and 0.957 respectively, which are higher than the baselines.

Agentic AI for Cyber Resilience: A New Security Paradigm and Its System-Theoretic Foundations

Cybersecurity is being fundamentally reshaped by foundation-model-based artificial intelligence. Large language models now enable autonomous planning, tool orchestration, and strategic adaptation at scale, challenging security architectures built on static rules, perimeter defenses, and human-centered workflows. This chapter argues for a shift from prevention-centric security toward agentic cyber resilience. Rather than seeking perfect protection, resilient systems must anticipate disruption, maintain critical functions under attack, recover efficiently, and learn continuously. We situate this shift within the historical evolution of cybersecurity paradigms, culminating in an AI-augmented paradigm where autonomous agents participate directly in sensing, reasoning, action, and adaptation across cyber and cyber-physical systems. We then develop a system-level framework for designing agentic AI workflows. A general agentic architecture is introduced, and attacker and defender workflows are analyzed as coupled adaptive processes, and game-theoretic formulations are shown to provide a unifying design language for autonomy allocation, information flow, and temporal composition. Case studies in automated penetration testing, remediation, and cyber deception illustrate how equilibrium-based design enables system-level resiliency design.