Extracting Post-Acute Sequelae of SARS-CoV-2 Infection Symptoms from Clinical Notes via Hybrid Natural Language Processing

Accurately and efficiently diagnosing Post-Acute Sequelae of COVID-19 (PASC) remains challenging due to its myriad symptoms that evolve over long- and variable-time intervals. To address this issue, we developed a hybrid natural language processing pipeline that integrates rule-based named entity recognition with BERT-based assertion detection modules for PASC-symptom extraction and assertion detection from clinical notes. We developed a comprehensive PASC lexicon with clinical specialists. From 11 health systems of the RECOVER initiative network across the U.S., we curated 160 intake progress notes for model development and evaluation, and collected 47,654 progress notes for a population-level prevalence study. We achieved an average F1 score of 0.82 in one-site internal validation and 0.76 in 10-site external validation for assertion detection. Our pipeline processed each note at $2.448\pm 0.812$ seconds on average. Spearman correlation tests showed $\rho >0.83$ for positive mentions and $\rho >0.72$ for negative ones, both with $P <0.0001$. These demonstrate the effectiveness and efficiency of our models and their potential for improving PASC diagnosis.

GLM-4.5: Agentic, Reasoning, and Coding (ARC) Foundation Models

We present GLM-4.5, an open-source Mixture-of-Experts (MoE) large language model with 355B total parameters and 32B activated parameters, featuring a hybrid reasoning method that supports both thinking and direct response modes. Through multi-stage training on 23T tokens and comprehensive post-training with expert model iteration and reinforcement learning, GLM-4.5 achieves strong performance across agentic, reasoning, and coding (ARC) tasks, scoring 70.1% on TAU-Bench, 91.0% on AIME 24, and 64.2% on SWE-bench Verified. With much fewer parameters than several competitors, GLM-4.5 ranks 3rd overall among all evaluated models and 2nd on agentic benchmarks. We release both GLM-4.5 (355B parameters) and a compact version, GLM-4.5-Air (106B parameters), to advance research in reasoning and agentic AI systems. Code, models, and more information are available at https://github.com/zai-org/GLM-4.5.

Controllable Pedestrian Video Editing for Multi-View Driving Scenarios via Motion Sequence

Pedestrian detection models in autonomous driving systems often lack robustness due to insufficient representation of dangerous pedestrian scenarios in training datasets. To address this limitation, we present a novel framework for controllable pedestrian video editing in multi-view driving scenarios by integrating video inpainting and human motion control techniques. Our approach begins by identifying pedestrian regions of interest across multiple camera views, expanding detection bounding boxes with a fixed ratio, and resizing and stitching these regions into a unified canvas while preserving cross-view spatial relationships. A binary mask is then applied to designate the editable area, within which pedestrian editing is guided by pose sequence control conditions. This enables flexible editing functionalities, including pedestrian insertion, replacement, and removal. Extensive experiments demonstrate that our framework achieves high-quality pedestrian editing with strong visual realism, spatiotemporal coherence, and cross-view consistency. These results establish the proposed method as a robust and versatile solution for multi-view pedestrian video generation, with broad potential for applications in data augmentation and scenario simulation in autonomous driving.

HOLA: Enhancing Audio-visual Deepfake Detection via Hierarchical Contextual Aggregations and Efficient Pre-training

Advances in Generative AI have made video-level deepfake detection increasingly challenging, exposing the limitations of current detection techniques. In this paper, we present HOLA, our solution to the Video-Level Deepfake Detection track of 2025 1M-Deepfakes Detection Challenge. Inspired by the success of large-scale pre-training in the general domain, we first scale audio-visual self-supervised pre-training in the multimodal video-level deepfake detection, which leverages our self-built dataset of 1.81M samples, thereby leading to a unified two-stage framework. To be specific, HOLA features an iterative-aware cross-modal learning module for selective audio-visual interactions, hierarchical contextual modeling with gated aggregations under the local-global perspective, and a pyramid-like refiner for scale-aware cross-grained semantic enhancements. Moreover, we propose the pseudo supervised singal injection strategy to further boost model performance. Extensive experiments across expert models and MLLMs impressivly demonstrate the effectiveness of our proposed HOLA. We also conduct a series of ablation studies to explore the crucial design factors of our introduced components. Remarkably, our HOLA ranks 1st, outperforming the second by 0.0476 AUC on the TestA set.

Motion Matters: Motion-guided Modulation Network for Skeleton-based Micro-Action Recognition

Micro-Actions (MAs) are an important form of non-verbal communication in social interactions, with potential applications in human emotional analysis. However, existing methods in Micro-Action Recognition often overlook the inherent subtle changes in MAs, which limits the accuracy of distinguishing MAs with subtle changes. To address this issue, we present a novel Motion-guided Modulation Network (MMN) that implicitly captures and modulates subtle motion cues to enhance spatial-temporal representation learning. Specifically, we introduce a Motion-guided Skeletal Modulation module (MSM) to inject motion cues at the skeletal level, acting as a control signal to guide spatial representation modeling. In parallel, we design a Motion-guided Temporal Modulation module (MTM) to incorporate motion information at the frame level, facilitating the modeling of holistic motion patterns in micro-actions. Finally, we propose a motion consistency learning strategy to aggregate the motion cues from multi-scale features for micro-action classification. Experimental results on the Micro-Action 52 and iMiGUE datasets demonstrate that MMN achieves state-of-the-art performance in skeleton-based micro-action recognition, underscoring the importance of explicitly modeling subtle motion cues. The code will be available at https://github.com/momiji-bit/MMN.

An AI-native experimental laboratory for autonomous biomolecular engineering

Autonomous scientific research, capable of independently conducting complex experiments and serving non-specialists, represents a long-held aspiration. Achieving it requires a fundamental paradigm shift driven by artificial intelligence (AI). While autonomous experimental systems are emerging, they remain confined to areas featuring singular objectives and well-defined, simple experimental workflows, such as chemical synthesis and catalysis. We present an AI-native autonomous laboratory, targeting highly complex scientific experiments for applications like autonomous biomolecular engineering. This system autonomously manages instrumentation, formulates experiment-specific procedures and optimization heuristics, and concurrently serves multiple user requests. Founded on a co-design philosophy of models, experiments, and instruments, the platform supports the co-evolution of AI models and the automation system. This establishes an end-to-end, multi-user autonomous laboratory that handles complex, multi-objective experiments across diverse instrumentation. Our autonomous laboratory supports fundamental nucleic acid functions-including synthesis, transcription, amplification, and sequencing. It also enables applications in fields such as disease diagnostics, drug development, and information storage. Without human intervention, it autonomously optimizes experimental performance to match state-of-the-art results achieved by human scientists. In multi-user scenarios, the platform significantly improves instrument utilization and experimental efficiency. This platform paves the way for advanced biomaterials research to overcome dependencies on experts and resource barriers, establishing a blueprint for science-as-a-service at scale.

Hear No Evil: Detecting Gradient Leakage by Malicious Servers in Federated Learning

Recent work has shown that gradient updates in federated learning (FL) can unintentionally reveal sensitive information about a client's local data. This risk becomes significantly greater when a malicious server manipulates the global model to provoke information-rich updates from clients. In this paper, we adopt a defender's perspective to provide the first comprehensive analysis of malicious gradient leakage attacks and the model manipulation techniques that enable them. Our investigation reveals a core trade-off: these attacks cannot be both highly effective in reconstructing private data and sufficiently stealthy to evade detection -- especially in realistic FL settings that incorporate common normalization techniques and federated averaging. Building on this insight, we argue that malicious gradient leakage attacks, while theoretically concerning, are inherently limited in practice and often detectable through basic monitoring. As a complementary contribution, we propose a simple, lightweight, and broadly applicable client-side detection mechanism that flags suspicious model updates before local training begins, despite the fact that such detection may not be strictly necessary in realistic FL settings. This mechanism further underscores the feasibility of defending against these attacks with minimal overhead, offering a deployable safeguard for privacy-conscious federated learning systems.

Leaner Training, Lower Leakage: Revisiting Memorization in LLM Fine-Tuning with LoRA

Memorization in large language models (LLMs) makes them vulnerable to data extraction attacks. While pre-training memorization has been extensively studied, fewer works have explored its impact in fine-tuning, particularly for LoRA fine-tuning, a widely adopted parameter-efficient method. In this work, we re-examine memorization in fine-tuning and uncover a surprising divergence from prior findings across different fine-tuning strategies. Factors such as model scale and data duplication, which strongly influence memorization in pre-training and full fine-tuning, do not follow the same trend in LoRA fine-tuning. Using a more relaxed similarity-based memorization metric, we demonstrate that LoRA significantly reduces memorization risks compared to full fine-tuning, while still maintaining strong task performance.

Merlin: Multi-View Representation Learning for Robust Multivariate Time Series Forecasting with Unfixed Missing Rates

Multivariate Time Series Forecasting (MTSF) involves predicting future values of multiple interrelated time series. Recently, deep learning-based MTSF models have gained significant attention for their promising ability to mine semantics (global and local information) within MTS data. However, these models are pervasively susceptible to missing values caused by malfunctioning data collectors. These missing values not only disrupt the semantics of MTS, but their distribution also changes over time. Nevertheless, existing models lack robustness to such issues, leading to suboptimal forecasting performance. To this end, in this paper, we propose Multi-View Representation Learning (Merlin), which can help existing models achieve semantic alignment between incomplete observations with different missing rates and complete observations in MTS. Specifically, Merlin consists of two key modules: offline knowledge distillation and multi-view contrastive learning. The former utilizes a teacher model to guide a student model in mining semantics from incomplete observations, similar to those obtainable from complete observations. The latter improves the student model's robustness by learning from positive/negative data pairs constructed from incomplete observations with different missing rates, ensuring semantic alignment across different missing rates. Therefore, Merlin is capable of effectively enhancing the robustness of existing models against unfixed missing rates while preserving forecasting accuracy. Experiments on four real-world datasets demonstrate the superiority of Merlin.

UdonCare: Hierarchy Pruning for Unseen Domain Discovery in Predictive Healthcare

Domain generalization has become a critical challenge in clinical prediction, where patient cohorts often exhibit shifting data distributions that degrade model performance. Typical domain generalization approaches struggle in real-world healthcare settings for two main reasons: (1) patient-specific domain labels are typically unavailable, making domain discovery especially difficult; (2) purely data-driven approaches overlook key clinical insights, leading to a gap in medical knowledge integration. To address these problems, we leverage hierarchical medical ontologies like the ICD-9-CM hierarchy to group diseases into higher-level categories and discover more flexible latent domains. In this paper, we introduce UdonCare, a hierarchy-guided framework that iteratively prunes fine-grained domains, encodes these refined domains, and applies a Siamese-type inference mechanism to separate domain-related signals from patient-level features. Experimental results on clinical datasets (MIMIC-III and MIMIC-IV) show that the proposed model achieves higher performance compared to other domain generalization baselines when substantial domain gaps presents, highlighting the untapped potential of medical knowledge for enhancing domain generalization in practical healthcare applications.