MIRA: Medical Time Series Foundation Model for Real-World Health Data

A unified foundation model for medical time series -- pretrained on open access and ethics board-approved medical corpora -- offers the potential to reduce annotation burdens, minimize model customization, and enable robust transfer across clinical institutions, modalities, and tasks, particularly in data-scarce or privacy-constrained environments. However, existing generalist time series foundation models struggle to handle medical time series data due to their inherent challenges, including irregular intervals, heterogeneous sampling rates, and frequent missing values. To address these challenges, we introduce MIRA, a unified foundation model specifically designed for medical time series forecasting. MIRA incorporates a Continuous-Time Rotary Positional Encoding that enables fine-grained modeling of variable time intervals, a frequency-specific mixture-of-experts layer that routes computation across latent frequency regimes to further promote temporal specialization, and a Continuous Dynamics Extrapolation Block based on Neural ODE that models the continuous trajectory of latent states, enabling accurate forecasting at arbitrary target timestamps. Pretrained on a large-scale and diverse medical corpus comprising over 454 billion time points collect from publicly available datasets, MIRA achieves reductions in forecasting errors by an average of 10% and 7% in out-of-distribution and in-distribution scenarios, respectively, when compared to other zero-shot and fine-tuned baselines. We also introduce a comprehensive benchmark spanning multiple downstream clinical tasks, establishing a foundation for future research in medical time series modeling.

GridRoute: A Benchmark for LLM-Based Route Planning with Cardinal Movement in Grid Environments

Recent advancements in Large Language Models (LLMs) have demonstrated their potential in planning and reasoning tasks, offering a flexible alternative to classical pathfinding algorithms. However, most existing studies focus on LLMs' independent reasoning capabilities and overlook the potential synergy between LLMs and traditional algorithms. To fill this gap, we propose a comprehensive evaluation benchmark GridRoute to assess how LLMs can take advantage of traditional algorithms. We also propose a novel hybrid prompting technique called Algorithm of Thought (AoT), which introduces traditional algorithms' guidance into prompting. Our benchmark evaluates six LLMs ranging from 7B to 72B parameters across various map sizes, assessing their performance in correctness, optimality, and efficiency in grid environments with varying sizes. Our results show that AoT significantly boosts performance across all model sizes, particularly in larger or more complex environments, suggesting a promising approach to addressing path planning challenges. Our code is open-sourced at https://github.com/LinChance/GridRoute.

Revisiting Uncertainty Estimation and Calibration of Large Language Models

As large language models (LLMs) are increasingly deployed in high-stakes applications, robust uncertainty estimation is essential for ensuring the safe and trustworthy deployment of LLMs. We present the most comprehensive study to date of uncertainty estimation in LLMs, evaluating 80 models spanning open- and closed-source families, dense and Mixture-of-Experts (MoE) architectures, reasoning and non-reasoning modes, quantization variants and parameter scales from 0.6B to 671B. Focusing on three representative black-box single-pass methods, including token probability-based uncertainty (TPU), numerical verbal uncertainty (NVU), and linguistic verbal uncertainty (LVU), we systematically evaluate uncertainty calibration and selective classification using the challenging MMLU-Pro benchmark, which covers both reasoning-intensive and knowledge-based tasks. Our results show that LVU consistently outperforms TPU and NVU, offering stronger calibration and discrimination while being more interpretable. We also find that high accuracy does not imply reliable uncertainty, and that model scale, post-training, reasoning ability and quantization all influence estimation performance. Notably, LLMs exhibit better uncertainty estimates on reasoning tasks than on knowledge-heavy ones, and good calibration does not necessarily translate to effective error ranking. These findings highlight the need for multi-perspective evaluation and position LVU as a practical tool for improving the reliability of LLMs in real-world settings.

Rethinking Causal Mask Attention for Vision-Language Inference

Causal attention has become a foundational mechanism in autoregressive vision-language models (VLMs), unifying textual and visual inputs under a single generative framework. However, existing causal mask-based strategies are inherited from large language models (LLMs) where they are tailored for text-only decoding, and their adaptation to vision tokens is insufficiently addressed in the prefill stage. Strictly masking future positions for vision queries introduces overly rigid constraints, which hinder the model's ability to leverage future context that often contains essential semantic cues for accurate inference. In this work, we empirically investigate how different causal masking strategies affect vision-language inference and then propose a family of future-aware attentions tailored for this setting. We first empirically analyze the effect of previewing future tokens for vision queries and demonstrate that rigid masking undermines the model's capacity to capture useful contextual semantic representations. Based on these findings, we propose a lightweight attention family that aggregates future visual context into past representations via pooling, effectively preserving the autoregressive structure while enhancing cross-token dependencies. We evaluate a range of causal masks across diverse vision-language inference settings and show that selectively compressing future semantic context into past representations benefits the inference.

VEAttack: Downstream-agnostic Vision Encoder Attack against Large Vision Language Models

Large Vision-Language Models (LVLMs) have demonstrated remarkable capabilities in multimodal understanding and generation, yet their vulnerability to adversarial attacks raises significant robustness concerns. While existing effective attacks always focus on task-specific white-box settings, these approaches are limited in the context of LVLMs, which are designed for diverse downstream tasks and require expensive full-model gradient computations. Motivated by the pivotal role and wide adoption of the vision encoder in LVLMs, we propose a simple yet effective Vision Encoder Attack (VEAttack), which targets the vision encoder of LVLMs only. Specifically, we propose to generate adversarial examples by minimizing the cosine similarity between the clean and perturbed visual features, without accessing the following large language models, task information, and labels. It significantly reduces the computational overhead while eliminating the task and label dependence of traditional white-box attacks in LVLMs. To make this simple attack effective, we propose to perturb images by optimizing image tokens instead of the classification token. We provide both empirical and theoretical evidence that VEAttack can easily generalize to various tasks. VEAttack has achieved a performance degradation of 94.5% on image caption task and 75.7% on visual question answering task. We also reveal some key observations to provide insights into LVLM attack/defense: 1) hidden layer variations of LLM, 2) token attention differential, 3) M\"obius band in transfer attack, 4) low sensitivity to attack steps. The code is available at https://github.com/hfmei/VEAttack-LVLM

Circle-RoPE: Cone-like Decoupled Rotary Positional Embedding for Large Vision-Language Models

Rotary Position Embedding (RoPE) is a widely adopted technique for encoding relative positional information in large language models (LLMs). However, when extended to large vision-language models (LVLMs), its variants introduce unintended cross-modal positional biases. Specifically, they enforce relative positional dependencies between text token indices and image tokens, causing spurious alignments. This issue arises because image tokens representing the same content but located at different spatial positions are assigned distinct positional biases, leading to inconsistent cross-modal associations. To address this, we propose Per-Token Distance (PTD) - a simple yet effective metric for quantifying the independence of positional encodings across modalities. Informed by this analysis, we introduce Circle-RoPE, a novel encoding scheme that maps image token indices onto a circular trajectory orthogonal to the linear path of text token indices, forming a cone-like structure. This configuration ensures that each text token maintains an equal distance to all image tokens, reducing artificial cross-modal biases while preserving intra-image spatial information. To further enhance performance, we propose a staggered layer strategy that applies different RoPE variants across layers. This design leverages the complementary strengths of each RoPE variant, thereby enhancing the model's overall performance. Our experimental results demonstrate that our method effectively preserves spatial information from images while reducing relative positional bias, offering a more robust and flexible positional encoding framework for LVLMs. The code is available at [https://github.com/lose4578/CircleRoPE](https://github.com/lose4578/CircleRoPE).

Enhancing Privacy-Utility Trade-offs to Mitigate Memorization in Diffusion Models

Text-to-image diffusion models have demonstrated remarkable capabilities in creating images highly aligned with user prompts, yet their proclivity for memorizing training set images has sparked concerns about the originality of the generated images and privacy issues, potentially leading to legal complications for both model owners and users, particularly when the memorized images contain proprietary content. Although methods to mitigate these issues have been suggested, enhancing privacy often results in a significant decrease in the utility of the outputs, as indicated by text-alignment scores. To bridge the research gap, we introduce a novel method, PRSS, which refines the classifier-free guidance approach in diffusion models by integrating prompt re-anchoring (PR) to improve privacy and incorporating semantic prompt search (SS) to enhance utility. Extensive experiments across various privacy levels demonstrate that our approach consistently improves the privacy-utility trade-off, establishing a new state-of-the-art.

TarDiff: Target-Oriented Diffusion Guidance for Synthetic Electronic Health Record Time Series Generation

Synthetic Electronic Health Record (EHR) time-series generation is crucial for advancing clinical machine learning models, as it helps address data scarcity by providing more training data. However, most existing approaches focus primarily on replicating statistical distributions and temporal dependencies of real-world data. We argue that fidelity to observed data alone does not guarantee better model performance, as common patterns may dominate, limiting the representation of rare but important conditions. This highlights the need for generate synthetic samples to improve performance of specific clinical models to fulfill their target outcomes. To address this, we propose TarDiff, a novel target-oriented diffusion framework that integrates task-specific influence guidance into the synthetic data generation process. Unlike conventional approaches that mimic training data distributions, TarDiff optimizes synthetic samples by quantifying their expected contribution to improving downstream model performance through influence functions. Specifically, we measure the reduction in task-specific loss induced by synthetic samples and embed this influence gradient into the reverse diffusion process, thereby steering the generation towards utility-optimized data. Evaluated on six publicly available EHR datasets, TarDiff achieves state-of-the-art performance, outperforming existing methods by up to 20.4% in AUPRC and 18.4% in AUROC. Our results demonstrate that TarDiff not only preserves temporal fidelity but also enhances downstream model performance, offering a robust solution to data scarcity and class imbalance in healthcare analytics.

Functional Abstraction of Knowledge Recall in Large Language Models

Pre-trained transformer large language models (LLMs) demonstrate strong knowledge recall capabilities. This paper investigates the knowledge recall mechanism in LLMs by abstracting it into a functional structure. We propose that during knowledge recall, the model's hidden activation space implicitly entails a function execution process where specific activation vectors align with functional components (Input argument, Function body, and Return values). Specifically, activation vectors of relation-related tokens define a mapping function from subjects to objects, with subject-related token activations serving as input arguments and object-related token activations as return values. For experimental verification, we first design a patching-based knowledge-scoring algorithm to identify knowledge-aware activation vectors as independent functional components. Then, we conduct counter-knowledge testing to examine the independent functional effects of each component on knowledge recall outcomes. From this functional perspective, we improve the contextual knowledge editing approach augmented by activation patching. By rewriting incoherent activations in context, we enable improved short-term memory retention for new knowledge prompting.

Beyond One-Hot Labels: Semantic Mixing for Model Calibration

Model calibration seeks to ensure that models produce confidence scores that accurately reflect the true likelihood of their predictions being correct. However, existing calibration approaches are fundamentally tied to datasets of one-hot labels implicitly assuming full certainty in all the annotations. Such datasets are effective for classification but provides insufficient knowledge of uncertainty for model calibration, necessitating the curation of datasets with numerically rich ground-truth confidence values. However, due to the scarcity of uncertain visual examples, such samples are not easily available as real datasets. In this paper, we introduce calibration-aware data augmentation to create synthetic datasets of diverse samples and their ground-truth uncertainty. Specifically, we present Calibration-aware Semantic Mixing (CSM), a novel framework that generates training samples with mixed class characteristics and annotates them with distinct confidence scores via diffusion models. Based on this framework, we propose calibrated reannotation to tackle the misalignment between the annotated confidence score and the mixing ratio during the diffusion reverse process. Besides, we explore the loss functions that better fit the new data representation paradigm. Experimental results demonstrate that CSM achieves superior calibration compared to the state-of-the-art calibration approaches. Code is available at github.com/E-Galois/CSM.