Fair Canonical Correlation Analysis

This paper investigates fairness and bias in Canonical Correlation Analysis (CCA), a widely used statistical technique for examining the relationship between two sets of variables. We present a framework that alleviates unfairness by minimizing the correlation disparity error associated with protected attributes. Our approach enables CCA to learn global projection matrices from all data points while ensuring that these matrices yield comparable correlation levels to group-specific projection matrices. Experimental evaluation on both synthetic and real-world datasets demonstrates the efficacy of our method in reducing correlation disparity error without compromising CCA accuracy.

Evaluate underdiagnosis and overdiagnosis bias of deep learning model on primary open-angle glaucoma diagnosis in under-served patient populations

In the United States, primary open-angle glaucoma (POAG) is the leading cause of blindness, especially among African American and Hispanic individuals. Deep learning has been widely used to detect POAG using fundus images as its performance is comparable to or even surpasses diagnosis by clinicians. However, human bias in clinical diagnosis may be reflected and amplified in the widely-used deep learning models, thus impacting their performance. Biases may cause (1) underdiagnosis, increasing the risks of delayed or inadequate treatment, and (2) overdiagnosis, which may increase individuals' stress, fear, well-being, and unnecessary/costly treatment. In this study, we examined the underdiagnosis and overdiagnosis when applying deep learning in POAG detection based on the Ocular Hypertension Treatment Study (OHTS) from 22 centers across 16 states in the United States. Our results show that the widely-used deep learning model can underdiagnose or overdiagnose underserved populations. The most underdiagnosed group is female younger (< 60 yrs) group, and the most overdiagnosed group is Black older (>=60 yrs) group. Biased diagnosis through traditional deep learning methods may delay disease detection, treatment and create burdens among under-served populations, thereby, raising ethical concerns about using deep learning models in ophthalmology clinics.

Deep Clustering Survival Machines with Interpretable Expert Distributions

Conventional survival analysis methods are typically ineffective to characterize heterogeneity in the population while such information can be used to assist predictive modeling. In this study, we propose a hybrid survival analysis method, referred to as deep clustering survival machines, that combines the discriminative and generative mechanisms. Similar to the mixture models, we assume that the timing information of survival data is generatively described by a mixture of certain numbers of parametric distributions, i.e., expert distributions. We learn weights of the expert distributions for individual instances according to their features discriminatively such that each instance's survival information can be characterized by a weighted combination of the learned constant expert distributions. This method also facilitates interpretable subgrouping/clustering of all instances according to their associated expert distributions. Extensive experiments on both real and synthetic datasets have demonstrated that the method is capable of obtaining promising clustering results and competitive time-to-event predicting performance.

Online Deep Learning from Doubly-Streaming Data

This paper investigates a new online learning problem with doubly-streaming data, where the data streams are described by feature spaces that constantly evolve, with new features emerging and old features fading away. The challenges of this problem are two folds: 1) Data samples ceaselessly flowing in may carry shifted patterns over time, requiring learners to update hence adapt on-the-fly. 2) Newly emerging features are described by very few samples, resulting in weak learners that tend to make error predictions. A plausible idea to overcome the challenges is to establish relationship between the pre-and-post evolving feature spaces, so that an online learner can leverage the knowledge learned from the old features to better the learning performance on the new features. Unfortunately, this idea does not scale up to high-dimensional media streams with complex feature interplay, which suffers an tradeoff between onlineness (biasing shallow learners) and expressiveness(requiring deep learners). Motivated by this, we propose a novel OLD^3S paradigm, where a shared latent subspace is discovered to summarize information from the old and new feature spaces, building intermediate feature mapping relationship. A key trait of OLD^3S is to treat the model capacity as a learnable semantics, yields optimal model depth and parameters jointly, in accordance with the complexity and non-linearity of the input data streams in an online fashion. Both theoretical analyses and empirical studies substantiate the viability and effectiveness of our proposal.

Clinical Evidence Engine: Proof-of-Concept For A Clinical-Domain-Agnostic Decision Support Infrastructure

Abstruse learning algorithms and complex datasets increasingly characterize modern clinical decision support systems (CDSS). As a result, clinicians cannot easily or rapidly scrutinize the CDSS recommendation when facing a difficult diagnosis or treatment decision in practice. Over-trust or under-trust are frequent. Prior research has explored supporting such assessments by explaining DST data inputs and algorithmic mechanisms. This paper explores a different approach: Providing precisely relevant, scientific evidence from biomedical literature. We present a proof-of-concept system, Clinical Evidence Engine, to demonstrate the technical and design feasibility of this approach across three domains (cardiovascular diseases, autism, cancer). Leveraging Clinical BioBERT, the system can effectively identify clinical trial reports based on lengthy clinical questions (e.g., "risks of catheter infection among adult patients in intensive care unit who require arterial catheters, if treated with povidone iodine-alcohol"). This capability enables the system to identify clinical trials relevant to diagnostic/treatment hypotheses -- a clinician's or a CDSS's. Further, Clinical Evidence Engine can identify key parts of a clinical trial abstract, including patient population (e.g., adult patients in intensive care unit who require arterial catheters), intervention (povidone iodine-alcohol), and outcome (risks of catheter infection). This capability opens up the possibility of enabling clinicians to 1) rapidly determine the match between a clinical trial and a clinical question, and 2) understand the result and contexts of the trial without extensive reading. We demonstrate this potential by illustrating two example use scenarios of the system. We discuss the idea of designing DST explanations not as specific to a DST or an algorithm, but as a domain-agnostic decision support infrastructure.