Learning latent progression states from spatial heterogeneity in uterine histopathology

Tumor progression is accompanied by changes in architecture, morphology and microenvironmental organization, yet progression-associated heterogeneity is usually compressed into static diagnostic categories in histopathology. Here we present SpaTIE, a uterus-specific computational pathology framework that learns morphology-aware representations and organizes spatial histopathological heterogeneity into progression-associated tumor states. SpaTIE was developed using 10,426 uterine hematoxylin and eosin whole-slide images and evaluated in TCGA-UCEC and TCGA-UCS cohorts. The learned representations formed morphology manifolds, supported diagnostic, molecular and survival-related prediction tasks, and localized attention to informative tumor regions. Beyond supervised prediction, SpaTIE inferred tumor-state axes from cross-sectional morphology without temporal or molecular supervision. These morphology-derived states were spatially coherent and showed associations with clinicopathological variables and survival outcomes, while not simply recapitulating staging or diagnostic labels. Integrative multi-omics analyses linked the inferred states to DNA methylation, somatic copy-number variation, mutation, RNA-seq and RPPA profiles, highlighting molecular programs related to chromatin regulation, copy-number-associated structural variation, receptor tyrosine kinase signaling, cell adhesion, extracellular-matrix remodeling and metabolic adaptation. Progression-guided virtual perturbation further prioritized molecular features coupled to the morphology-derived state organization. Together, these findings suggest that uterine histopathology contains recoverable progression-associated tumor-state information and establish SpaTIE as a framework for connecting spatial morphology with multi-omics-informed tumor-state discovery.

EATR-Stereo: Embodiment-Aware Routing of Paired Stereo Evidence for Humanoid Vision-Language-Action Control

Long-horizon humanoid vision--language--action (VLA) control with head-mounted stereo cameras requires visual interfaces that can exploit complementary views while maintaining compatibility with pretrained representations. Existing interfaces often discard complementary stereo evidence or fuse additional observations without preserving the native primary-view pathway and adapting auxiliary information to robot embodiment. We present EATR-Stereo, an embodiment-aware token-routing framework that retains primary-view tokens and constructs primary-aligned Cross-View Auxiliary Tokens (CVATs) by querying the synchronized auxiliary-view token sequence. A body-segmented proprioceptive encoder further conditions token-wise auxiliary usage on robot configuration history, enabling selective incorporation of stereo evidence during action generation. The routed auxiliary stream augments the language and primary-visual context of a pretrained VLA while keeping its vision--language model frozen. On a 33-DoF physical humanoid with a 37-D proprioceptive state, we evaluate nine configurations in over-100-s search--approach--grasp--place--return tasks. EATR-Stereo achieves 60.0% full-task success, 100.0% grasp success, and 80.0% stage success. Under severe asymmetric occlusion, it improves recovery to 80% compared with 30% for CVAT alone. Ablation studies further show the importance of preserving primary tokens and combining cross-view auxiliary features with structured proprioceptive routing. These results demonstrate that selectively routed paired stereo evidence improves spatial grounding for reliable long-horizon humanoid VLA control.

Tactile Sim2Real without Tactile Simulation via Bottlenecked Latent Reconstruction

Robot sensor designs, particularly tactile sensors, are highly diverse and evolve rapidly. Modeling each sensor in simulation demands substantial domain expertise and computational approximations can degrade the fidelity of the simulated signals. We propose Sim2Real via Bottlenecked Latent Reconstruction (SBLR), a framework that avoids sensor-specific simulation entirely by (1) training policies on a simulator-native oracle sensor that is easy to construct without modeling any particular sensor (e.g. we use a point-cloud and finger-tip forces as a tactile oracle), and (2) aligning real sensor latent embeddings to those of the oracle sensor at inference time. Policy training proceeds in two-stage: the policy first learns from the oracle sensor latents, then a bottlenecked latent reconstruction adapts it to the information loss expected when using the real sensor instead of the oracle. The alignment between oracle and real sensor is learned from unpaired random-play data collected in both simulation and the real world, using rectified-flow-based transformation networks trained on nearest-neighbor pseudo-pairs. Simulation experiments on three contact-rich tasks show that SBLR matches or approaches the performance of an oracle with direct access to tactile simulation. Hardware experiments on Peg Insertion and Gear Meshing with GelSight Mini and DIGIT sensors demonstrate 85-97.5% zero-shot success without requiring any sensor-specific modeling or calibration, outperforming a physics-based tactile simulation baseline by 7.5-15%.

From Reasoning Depth to Reasoning Breadth: Evaluating Multi-Point Associative Reasoning in Large Language Models

Large language models (LLMs) have made substantial progress on reasoning tasks that require increasingly long and complex inferential chains. This progress primarily reflects reasoning depth. A complementary and comparatively unexamined capability is reasoning breadth: exploring multiple semantic directions in parallel and integrating the resulting clues into one coherent answer. We introduce MPAR-Bench, a bilingual English-Chinese benchmark that isolates reasoning breadth through multi-point associative reasoning. Inspired by the cooperative game Just One, each item asks a model to recover a hidden target from several independently generated, semantically diverse clues. We construct 1,000 items using a multi-agent clue-generation pipeline, embedding-based diversity filtering, and human verification. Only the answer space is drawn from public word lists, whereas every clue set is generated from scratch. Beyond exact-match accuracy, we evaluate models using accuracy, ANLS, embedding similarity, reasoning-trace verification, and four perturbations: clue masking, order shuffling, distractor injection, and multi-step clues. Across evaluated models, perturbations reduce accuracy by 9-18 percentage points in English and 5-12 percentage points in Chinese. Thinking mode improves standard-setting accuracy, especially in English, but does not consistently reduce sensitivity to perturbations. Case-level analysis also shows that extended reasoning can overturn an initially correct hypothesis. These results indicate that greater reasoning depth does not automatically confer robust reasoning breadth, and that reasoning breadth remains largely uncovered by current benchmarks.

Agent Skills Can Be Harmful: An Empirical Study of Skill-Induced Failures in LLM Agents

Agent skills are the de facto mechanism for extending LLM agents with reusable guidance. A skill can shape the agent's task execution, including planning, tool use, problem-solving, and validation. Prior work reported mixed results of agent skills: some skills improve task success rates, while others have no effect, increase token use and execution time, and even reduce success rates. This paper presents a comprehensive analysis of skill-induced agent failures by attributing task failures and cost regressions to specific loaded skills. We introduce a differential analysis framework that attributes a failure or regression to a skill by comparing a target skill-guided run against a no-skill or semantically matched skill reference run that solves the same task, or solves it more cheaply. We instantiate this framework on SkillsBench and SWE-Skills-Bench, yielding 307 skill-induced failures, including 125 functional failures and 182 efficiency regressions. We also build SkillTriage, a taxonomy-guided attribution tool that normalizes paired cases, extracts differential evidence, and produces triage reports. Our major findings include: (1) Skill induced functional failures are rarely caused by obviously irrelevant skills; instead, seemingly relevant skills often make the agent incorrectly implement or omit task-required implementation elements. (2) Skill-induced efficiency regressions are not explained by prompt length alone. (3) The largest sources within Excessive Procedure are excessive verification and heavy implementation pipelines, contributing 67 and 30 cases, respectively. This shows that skills often turn validation checklists and construction recipes into mandatory work. Based on our findings, we propose research topics and tooling improvements for safer and more cost-aware skill reuse.

Rethinking Self-Evolving Agents: Do We Still Need Prescribed Optimization Pipelines?

Self-evolving agents are usually built around prescribed optimization pipelines: the framework decides how to gather evidence, revise a persistent artifact, select candidates, and stop. We ask whether this task-specific procedure remains necessary when a frontier model acts as the optimizer. We introduce Open-Ended Optimization (OEO), which keeps the objective, permitted interactions, resource budget, data boundary, and evaluation fixed while allowing the optimizer to compose the improvement process online. We compare OEO with two complementary prescribed approaches: SkillOpt, a staged pipeline with bounded edits, and GEPA, a reflective evolutionary search. Across 14 head-to-head comparisons over 8 benchmark-target-model settings, GPT-5.5-driven OEO records 12 wins, 1 tie, and 1 narrow loss of 0.21 percentage points. It uses a median 34.3 percent of SkillOpt's configured target-interaction token budget. A one-shot, zero-interaction control shows that the gains are not explained by a single prior-driven rewrite. However, delegation has a capability boundary: SkillOpt outperforms OEO with a medium optimizer, and a weak optimizer cannot operate through the unchanged OEO interface. In the fully instrumented OEO-SkillOpt pair, trajectory analysis further shows that prescription changes how optimization proceeds more consistently than it changes final behavior. Together, these findings recast prescribed pipelines as capability-dependent scaffolding: essential constraints remain external, but a sufficiently capable optimizer can compose the route from measurable feedback to persistent improvement.

AirFlow: Context Preserving and Multi-Rate State Modeling for Air Quality Forecasting

Accurate air quality forecasting is essential for public health and urban environmental management, but remains challenging because pollutant channels differ in periodicity and distribution drift, while their concentration trajectories contain both multi-scale dependencies and rapid changes. Recent methods have improved spatial dependency learning and meteorological covariate modeling. However, pollutant channels are still passed through the same normalization rule and temporal backbone, using a shared latent representation for channel-specific distributions and changes at different rates. To address this limitation, we propose AirFlow, a pollutant-aware dual-stream framework that operates on station multivariate observations without additional graph propagation or predefined signal decomposition. Specifically, AirFlow designs two novel blocks: (1) a statistic-guided normalization routing mechanism that selects a normalization path for each pollutant according to its 24-hour autocorrelation and distribution drift; and (2) a hierarchical dual-stream state model that combines multi-scale state space propagation with learnable response coefficients, where gated bidirectional cross-attention exchanges information and adaptively fuses the resulting representations. Experiments on real-world data from multiple cities show that AirFlow achieves the best performance in 34 of 36 metrics comparisons, with reductions of up to 11.11% root mean square error over the state-of-the-art baseline. AirFlow also requires only 0.0483M parameters and 0.0215G FLOPs, achieving high forecasting accuracy with low computational overhead.

SkillReason: Reasoning-Enhanced Agent Skill Retrieval for Implicit User Requests

Large language model agents increasingly rely on reusable skills to extend their capabilities beyond parametric knowl- edge. However, retrieving the appropriate skill from a large- scale library remains challenging because realistic user re- quests are often concise and underspecified, stating only the task goal while leaving the required capabilities and execu- tion steps implicit. Existing benchmarks provide limited cov- erage of such requests. To address this gap, we introduce SkillReason-Bench, a large-scale cross-domain benchmark containing 3,729 queries and a retrieval corpus of 61,228 skills spanning nine domains. We further propose SkillRea- son, a two-stage framework that uses chain-of-thought rea- soning as training-time supervision for skill retrieval. In Stage I, capability reasoning traces generated by a stronger teacher provide explicit supervision through contrastive learning, re- trieval distribution alignment, and language modeling, en- couraging the retriever to internalize capability reasoning in its query representation. In Stage II, a retrieval-guided GRPO objective encourages the model to explore reasoning trajecto- ries better suited to its own capabilities and more effective for retrieval. At inference, SkillReason directly encodes the orig- inal query without autoregressive CoT generation, preserv- ing efficient query-only retrieval. Extensive experiments on SkillReason-Bench, SkillRet, and SRA-Bench show that Skill- Reason achieves state-of-the-art performance across all three benchmarks, demonstrating that reasoning-enhanced training better bridges the semantic gap between high-level task goals and skill capabilities.

PushDualGen: Enabling LLMs to Generate Semantic IDs with Interpretable Copy for Industrial Push Recommendation

Push recommendation in KuaiShou proactively delivers personalized content to nearly one billion users to facilitate their engagement. Recently, generative recommendation has achieved end-to-end user personalization through semantic ID. However, their black- box characteristics make recommendation logics difficult to trace, hindering their deployment. OneRec-Thinking addresses this by incorporating CoT before generating SIDs, but this significantly increases inference cost. To support large-scale industrial applications, we propose PushDualGen, a lightweight generator, which first generates the SID and then produces a copy as a skippable explanation. PushDualGen has been deployed in Kuaishou's push recommendation system. Online A/B tests demonstrate the effectiveness of PushDualGen, delivering significant improvements in both user attraction and satisfaction. The effective play rate for videos recommended to users has relatively increased by 8.50%, while the dissatisfaction rate has relatively fallen by 37.70%. In the long term, PushDualGen optimises the content ecosystem, providing more exposure for long-tail videos.

Argus: A General-Purpose Agentic Reasoning Runtime for Long-Horizon Tasks

Long-horizon reasoning requires an agentic runtime that can persist when evidence supports its current approach and pivot when measurements reveal failure, hidden constraints, or a misspecified objective. We present Argus, a persistent, self-evolving runtime in which Manager, Planner, Engineer, and Reviewer execute bounded missions over durable project state. Argus separates stable user intent from operational objectives, constraints, and verification criteria, and admits memories, skills, procedures, verifiers, routing decisions, and rejected routes only after role-owned review and, when available, task-native verification. Model weights remain fixed; self-evolution occurs through persistent runtime state and control policy, with autonomous execution between operator-owned escalation points. Across seven GPT-5.5 benchmark arenas, Argus achieves about 78% on SWE-Bench Pro versus 59% for Direct Copilot while using 1.41 times the aggregate tokens. After verification-gated self-evolution, mature SWE-Bench waves use 21% fewer solve-input tokens and 15% less active workflow time per task than startup waves, while recording 34 verifier recoveries and 22 strict review-loop rescues. Argus also reaches 76.8% on AARRI-Bench and a 28.0-point gap on mathematical data synthesis, with competitive GPU-kernel and language-model-training results. Beyond benchmarks, an optimized RWKV6 kernel was merged upstream; a multi-day mathematics campaign retained falsified routes and proof-backed frontier updates; and six paper pipelines completed 254 missions with 16 stage rollbacks. These results show that a fixed-weight, self-evolving harness can revise, recover, and accumulate verified approaches while producing structured trajectories for future supervised and reinforcement learning.