Fusing Pixels and Genes: Spatially-Aware Learning in Computational Pathology

Recent years have witnessed remarkable progress in multimodal learning within computational pathology. Existing models primarily rely on vision and language modalities; however, language alone lacks molecular specificity and offers limited pathological supervision, leading to representational bottlenecks. In this paper, we propose STAMP, a Spatial Transcriptomics-Augmented Multimodal Pathology representation learning framework that integrates spatially-resolved gene expression profiles to enable molecule-guided joint embedding of pathology images and transcriptomic data. Our study shows that self-supervised, gene-guided training provides a robust and task-agnostic signal for learning pathology image representations. Incorporating spatial context and multi-scale information further enhances model performance and generalizability. To support this, we constructed SpaVis-6M, the largest Visium-based spatial transcriptomics dataset to date, and trained a spatially-aware gene encoder on this resource. Leveraging hierarchical multi-scale contrastive alignment and cross-scale patch localization mechanisms, STAMP effectively aligns spatial transcriptomics with pathology images, capturing spatial structure and molecular variation. We validate STAMP across six datasets and four downstream tasks, where it consistently achieves strong performance. These results highlight the value and necessity of integrating spatially resolved molecular supervision for advancing multimodal learning in computational pathology. The code is included in the supplementary materials. The pretrained weights and SpaVis-6M are available at: https://github.com/Hanminghao/STAMP.

Dolphin-v2: Universal Document Parsing via Scalable Anchor Prompting

Document parsing has garnered widespread attention as vision-language models (VLMs) advance OCR capabilities. However, the field remains fragmented across dozens of specialized models with varying strengths, forcing users to navigate complex model selection and limiting system scalability. Moreover, existing two-stage approaches depend on axis-aligned bounding boxes for layout detection, failing to handle distorted or photographed documents effectively. To this end, we present Dolphin-v2, a two-stage document image parsing model that substantially improves upon the original Dolphin. In the first stage, Dolphin-v2 jointly performs document type classification (digital-born versus photographed) alongside layout analysis. For digital-born documents, it conducts finer-grained element detection with reading order prediction. In the second stage, we employ a hybrid parsing strategy: photographed documents are parsed holistically as complete pages to handle geometric distortions, while digital-born documents undergo element-wise parallel parsing guided by the detected layout anchors, enabling efficient content extraction. Compared with the original Dolphin, Dolphin-v2 introduces several crucial enhancements: (1) robust parsing of photographed documents via holistic page-level understanding, (2) finer-grained element detection (21 categories) with semantic attribute extraction such as author information and document metadata, and (3) code block recognition with indentation preservation, which existing systems typically lack. Comprehensive evaluations are conducted on DocPTBench, OmniDocBench, and our self-constructed RealDoc-160 benchmark. The results demonstrate substantial improvements: +14.78 points overall on the challenging OmniDocBench and 91% error reduction on photographed documents, while maintaining efficient inference through parallel processing.

Exploring Physical Intelligence Emergence via Omni-Modal Architecture and Physical Data Engine

Physical understanding remains brittle in omni-modal models because key physical attributes are visually ambiguous and sparsely represented in web-scale data. We present OmniFysics, a compact omni-modal model that unifies understanding across images, audio, video, and text, with integrated speech and image generation. To inject explicit physical knowledge, we build a physical data engine with two components. FysicsAny produces physics-grounded instruction--image supervision by mapping salient objects to verified physical attributes through hierarchical retrieval over a curated prototype database, followed by physics-law--constrained verification and caption rewriting. FysicsOmniCap distills web videos via audio--visual consistency filtering to generate high-fidelity video--instruction pairs emphasizing cross-modal physical cues. We train OmniFysics with staged multimodal alignment and instruction tuning, adopt latent-space flow matching for text-to-image generation, and use an intent router to activate generation only when needed. Experiments show competitive performance on standard multimodal benchmarks and improved results on physics-oriented evaluations.

Stephanie2: Thinking, Waiting, and Making Decisions Like Humans in Step-by-Step AI Social Chat

Instant-messaging human social chat typically progresses through a sequence of short messages. Existing step-by-step AI chatting systems typically split a one-shot generation into multiple messages and send them sequentially, but they lack an active waiting mechanism and exhibit unnatural message pacing. In order to address these issues, we propose Stephanie2, a novel next-generation step-wise decision-making dialogue agent. With active waiting and message-pace adaptation, Stephanie2 explicitly decides at each step whether to send or wait, and models latency as the sum of thinking time and typing time to achieve more natural pacing. We further introduce a time-window-based dual-agent dialogue system to generate pseudo dialogue histories for human and automatic evaluations. Experiments show that Stephanie2 clearly outperforms Stephanie1 on metrics such as naturalness and engagement, and achieves a higher pass rate on human evaluation with the role identification Turing test.

Beyond Pixel Simulation: Pathology Image Generation via Diagnostic Semantic Tokens and Prototype Control

In computational pathology, understanding and generation have evolved along disparate paths: advanced understanding models already exhibit diagnostic-level competence, whereas generative models largely simulate pixels. Progress remains hindered by three coupled factors: the scarcity of large, high-quality image-text corpora; the lack of precise, fine-grained semantic control, which forces reliance on non-semantic cues; and terminological heterogeneity, where diverse phrasings for the same diagnostic concept impede reliable text conditioning. We introduce UniPath, a semantics-driven pathology image generation framework that leverages mature diagnostic understanding to enable controllable generation. UniPath implements Multi-Stream Control: a Raw-Text stream; a High-Level Semantics stream that uses learnable queries to a frozen pathology MLLM to distill paraphrase-robust Diagnostic Semantic Tokens and to expand prompts into diagnosis-aware attribute bundles; and a Prototype stream that affords component-level morphological control via a prototype bank. On the data front, we curate a 2.65M image-text corpus and a finely annotated, high-quality 68K subset to alleviate data scarcity. For a comprehensive assessment, we establish a four-tier evaluation hierarchy tailored to pathology. Extensive experiments demonstrate UniPath's SOTA performance, including a Patho-FID of 80.9 (51% better than the second-best) and fine-grained semantic control achieving 98.7% of the real-image. The meticulously curated datasets, complete source code, and pre-trained model weights developed in this study will be made openly accessible to the public.

Forging a Dynamic Memory: Retrieval-Guided Continual Learning for Generalist Medical Foundation Models

Multimodal biomedical Vision-Language Models (VLMs) exhibit immense potential in the field of Continual Learning (CL). However, they confront a core dilemma: how to preserve fine-grained intra-modality features while bridging the significant domain gap across different modalities. To address this challenge, we propose a comprehensive framework. Leveraging our 18-million multimodal and comprehensive medical retrieval database derived from PubMed scientific papers, we pioneer the integration of Retrieval-Augmented Generation (RAG) into CL. Specifically, we employ a multi-modal, multi-layer RAG system that provides real-time guidance for model fine-tuning through dynamic, on-demand knowledge retrieval. Building upon this, we introduce a dynamic knowledge distillation framework. This framework precisely resolves the aforementioned core dilemma by dynamically modulating the importance of the parameter space, the granularity of the distilled knowledge, and the data distribution of the reference dataset in accordance with the required level of detail. To thoroughly validate the clinical value of our strategy, we have designed a more rigorous \textbf{M}edical Generalist Task Incremental Learning (MGTIL) benchmark. This benchmark is engineered to simultaneously evaluate the model's capacity for adaptation to significant domain shifts, retention of subtle intra-domain features, and real-time learning of novel and complex medical tasks. Extensive experimental results demonstrate that our proposed method achieves state-of-the-art (SOTA) performance across all metrics. The code is provided in the supplementary materials.

FysicsWorld: A Unified Full-Modality Benchmark for Any-to-Any Understanding, Generation, and Reasoning

Despite rapid progress in multimodal large language models (MLLMs) and emerging omni-modal architectures, current benchmarks remain limited in scope and integration, suffering from incomplete modality coverage, restricted interaction to text-centric outputs, and weak interdependence and complementarity among modalities. To bridge these gaps, we introduce FysicsWorld, the first unified full-modality benchmark that supports bidirectional input-output across image, video, audio, and text, enabling comprehensive any-to-any evaluation across understanding, generation, and reasoning. FysicsWorld encompasses 16 primary tasks and 3,268 curated samples, aggregated from over 40 high-quality sources and covering a rich set of open-domain categories with diverse question types. We also propose the Cross-Modal Complementarity Screening (CMCS) strategy integrated in a systematic data construction framework that produces omni-modal data for spoken interaction and fusion-dependent cross-modal reasoning. Through a comprehensive evaluation of over 30 state-of-the-art baselines, spanning MLLMs, modality-specific models, unified understanding-generation models, and omni-modal language models, FysicsWorld exposes the performance disparities and limitations across models in understanding, generation, and reasoning. Our benchmark establishes a unified foundation and strong baselines for evaluating and advancing next-generation full-modality architectures.

DARTs: A Dual-Path Robust Framework for Anomaly Detection in High-Dimensional Multivariate Time Series

Multivariate time series anomaly detection (MTSAD) aims to accurately identify and localize complex abnormal patterns in the large-scale industrial control systems. While existing approaches excel in recognizing the distinct patterns under the low-dimensional scenarios, they often fail to robustly capture long-range spatiotemporal dependencies when learning representations from the high-dimensional noisy time series. To address these limitations, we propose DARTs, a robust long short-term dual-path framework with window-aware spatiotemporal soft fusion mechanism, which can be primarily decomposed into three complementary components. Specifically, in the short-term path, we introduce a Multi-View Sparse Graph Learner and a Diffusion Multi-Relation Graph Unit that collaborate to adaptively capture hierarchical discriminative short-term spatiotemporal patterns in the high-noise time series. While in the long-term path, we design a Multi-Scale Spatiotemporal Graph Constructor to model salient long-term dynamics within the high-dimensional representation space. Finally, a window-aware spatiotemporal soft-fusion mechanism is introduced to filter the residual noise while seamlessly integrating anomalous patterns. Extensive qualitative and quantitative experimental results across mainstream datasets demonstrate the superiority and robustness of our proposed DARTs. A series of ablation studies are also conducted to explore the crucial design factors of our proposed components. Our code and model will be made publicly open soon.

Improving Multimodal Sentiment Analysis via Modality Optimization and Dynamic Primary Modality Selection

Multimodal Sentiment Analysis (MSA) aims to predict sentiment from language, acoustic, and visual data in videos. However, imbalanced unimodal performance often leads to suboptimal fused representations. Existing approaches typically adopt fixed primary modality strategies to maximize dominant modality advantages, yet fail to adapt to dynamic variations in modality importance across different samples. Moreover, non-language modalities suffer from sequential redundancy and noise, degrading model performance when they serve as primary inputs. To address these issues, this paper proposes a modality optimization and dynamic primary modality selection framework (MODS). First, a Graph-based Dynamic Sequence Compressor (GDC) is constructed, which employs capsule networks and graph convolution to reduce sequential redundancy in acoustic/visual modalities. Then, we develop a sample-adaptive Primary Modality Selector (MSelector) for dynamic dominance determination. Finally, a Primary-modality-Centric Cross-Attention (PCCA) module is designed to enhance dominant modalities while facilitating cross-modal interaction. Extensive experiments on four benchmark datasets demonstrate that MODS outperforms state-of-the-art methods, achieving superior performance by effectively balancing modality contributions and eliminating redundant noise.

SAIL-Embedding Technical Report: Omni-modal Embedding Foundation Model

Multimodal embedding models aim to yield informative unified representations that empower diverse cross-modal tasks. Despite promising developments in the evolution from CLIP-based dual-tower architectures to large vision-language models, prior works still face unavoidable challenges in real-world applications and business scenarios, such as the limited modality support, unstable training mechanisms, and industrial domain gaps. In this work, we introduce SAIL-Embedding, an omni-modal embedding foundation model that addresses these issues through tailored training strategies and architectural design. In the optimization procedure, we propose a multi-stage training scheme to boost the multifaceted effectiveness of representation learning. Specifically, the content-aware progressive training aims to enhance the model's adaptability to diverse downstream tasks and master enriched cross-modal proficiency. The collaboration-aware recommendation enhancement training further adapts multimodal representations for recommendation scenarios by distilling knowledge from sequence-to-item and ID-to-item embeddings while mining user historical interests. Concurrently, we develop the stochastic specialization and dataset-driven pattern matching to strengthen model training flexibility and generalizability. Experimental results show that SAIL-Embedding achieves SOTA performance compared to other methods in different retrieval tasks. In online experiments across various real-world scenarios integrated with our model, we observe a significant increase in Lifetime (LT), which is a crucial indicator for the recommendation experience. For instance, the model delivers the 7-day LT gain of +0.158% and the 14-day LT gain of +0.144% in the Douyin-Selected scenario. For the Douyin feed rank model, the match features produced by SAIL-Embedding yield a +0.08% AUC gain.