VLM-based Prompts as the Optimal Assistant for Unpaired Histopathology Virtual Staining

In histopathology, tissue sections are typically stained using common H&E staining or special stains (MAS, PAS, PASM, etc.) to clearly visualize specific tissue structures. The rapid advancement of deep learning offers an effective solution for generating virtually stained images, significantly reducing the time and labor costs associated with traditional histochemical staining. However, a new challenge arises in separating the fundamental visual characteristics of tissue sections from the visual differences induced by staining agents. Additionally, virtual staining often overlooks essential pathological knowledge and the physical properties of staining, resulting in only style-level transfer. To address these issues, we introduce, for the first time in virtual staining tasks, a pathological vision-language large model (VLM) as an auxiliary tool. We integrate contrastive learnable prompts, foundational concept anchors for tissue sections, and staining-specific concept anchors to leverage the extensive knowledge of the pathological VLM. This approach is designed to describe, frame, and enhance the direction of virtual staining. Furthermore, we have developed a data augmentation method based on the constraints of the VLM. This method utilizes the VLM's powerful image interpretation capabilities to further integrate image style and structural information, proving beneficial in high-precision pathological diagnostics. Extensive evaluations on publicly available multi-domain unpaired staining datasets demonstrate that our method can generate highly realistic images and enhance the accuracy of downstream tasks, such as glomerular detection and segmentation. Our code is available at: https://github.com/CZZZZZZZZZZZZZZZZZ/VPGAN-HARBOR

Cross-Asset Risk Management: Integrating LLMs for Real-Time Monitoring of Equity, Fixed Income, and Currency Markets

Large language models (LLMs) have emerged as powerful tools in the field of finance, particularly for risk management across different asset classes. In this work, we introduce a Cross-Asset Risk Management framework that utilizes LLMs to facilitate real-time monitoring of equity, fixed income, and currency markets. This innovative approach enables dynamic risk assessment by aggregating diverse data sources, ultimately enhancing decision-making processes. Our model effectively synthesizes and analyzes market signals to identify potential risks and opportunities while providing a holistic view of asset classes. By employing advanced analytics, we leverage LLMs to interpret financial texts, news articles, and market reports, ensuring that risks are contextualized within broader market narratives. Extensive backtesting and real-time simulations validate the framework, showing increased accuracy in predicting market shifts compared to conventional methods. The focus on real-time data integration enhances responsiveness, allowing financial institutions to manage risks adeptly under varying market conditions and promoting financial stability through the advanced application of LLMs in risk analysis.

Dynamic Hedging Strategies in Derivatives Markets with LLM-Driven Sentiment and News Analytics

Dynamic hedging strategies are essential for effective risk management in derivatives markets, where volatility and market sentiment can greatly impact performance. This paper introduces a novel framework that leverages large language models (LLMs) for sentiment analysis and news analytics to inform hedging decisions. By analyzing textual data from diverse sources like news articles, social media, and financial reports, our approach captures critical sentiment indicators that reflect current market conditions. The framework allows for real-time adjustments to hedging strategies, adapting positions based on continuous sentiment signals. Backtesting results on historical derivatives data reveal that our dynamic hedging strategies achieve superior risk-adjusted returns compared to conventional static approaches. The incorporation of LLM-driven sentiment analysis into hedging practices presents a significant advancement in decision-making processes within derivatives trading. This research showcases how sentiment-informed dynamic hedging can enhance portfolio management and effectively mitigate associated risks.

VGAT: A Cancer Survival Analysis Framework Transitioning from Generative Visual Question Answering to Genomic Reconstruction

Multimodal learning combining pathology images and genomic sequences enhances cancer survival analysis but faces clinical implementation barriers due to limited access to genomic sequencing in under-resourced regions. To enable survival prediction using only whole-slide images (WSI), we propose the Visual-Genomic Answering-Guided Transformer (VGAT), a framework integrating Visual Question Answering (VQA) techniques for genomic modality reconstruction. By adapting VQA's text feature extraction approach, we derive stable genomic representations that circumvent dimensionality challenges in raw genomic data. Simultaneously, a cluster-based visual prompt module selectively enhances discriminative WSI patches, addressing noise from unfiltered image regions. Evaluated across five TCGA datasets, VGAT outperforms existing WSI-only methods, demonstrating the viability of genomic-informed inference without sequencing. This approach bridges multimodal research and clinical feasibility in resource-constrained settings. The code link is https://github.com/CZZZZZZZZZZZZZZZZZ/VGAT.

Music-Driven Legged Robots: Synchronized Walking to Rhythmic Beats

We address the challenge of effectively controlling the locomotion of legged robots by incorporating precise frequency and phase characteristics, which is often ignored in locomotion policies that do not account for the periodic nature of walking. We propose a hierarchical architecture that integrates a low-level phase tracker, oscillators, and a high-level phase modulator. This controller allows quadruped robots to walk in a natural manner that is synchronized with external musical rhythms. Our method generates diverse gaits across different frequencies and achieves real-time synchronization with music in the physical world. This research establishes a foundational framework for enabling real-time execution of accurate rhythmic motions in legged robots. Video is available at website: https://music-walker.github.io/.

Continuous Control of Diverse Skills in Quadruped Robots Without Complete Expert Datasets

Learning diverse skills for quadruped robots presents significant challenges, such as mastering complex transitions between different skills and handling tasks of varying difficulty. Existing imitation learning methods, while successful, rely on expensive datasets to reproduce expert behaviors. Inspired by introspective learning, we propose Progressive Adversarial Self-Imitation Skill Transition (PASIST), a novel method that eliminates the need for complete expert datasets. PASIST autonomously explores and selects high-quality trajectories based on predefined target poses instead of demonstrations, leveraging the Generative Adversarial Self-Imitation Learning (GASIL) framework. To further enhance learning, We develop a skill selection module to mitigate mode collapse by balancing the weights of skills with varying levels of difficulty. Through these methods, PASIST is able to reproduce skills corresponding to the target pose while achieving smooth and natural transitions between them. Evaluations on both simulation platforms and the Solo 8 robot confirm the effectiveness of PASIST, offering an efficient alternative to expert-driven learning.

2DGS-Avatar: Animatable High-fidelity Clothed Avatar via 2D Gaussian Splatting

Real-time rendering of high-fidelity and animatable avatars from monocular videos remains a challenging problem in computer vision and graphics. Over the past few years, the Neural Radiance Field (NeRF) has made significant progress in rendering quality but behaves poorly in run-time performance due to the low efficiency of volumetric rendering. Recently, methods based on 3D Gaussian Splatting (3DGS) have shown great potential in fast training and real-time rendering. However, they still suffer from artifacts caused by inaccurate geometry. To address these problems, we propose 2DGS-Avatar, a novel approach based on 2D Gaussian Splatting (2DGS) for modeling animatable clothed avatars with high-fidelity and fast training performance. Given monocular RGB videos as input, our method generates an avatar that can be driven by poses and rendered in real-time. Compared to 3DGS-based methods, our 2DGS-Avatar retains the advantages of fast training and rendering while also capturing detailed, dynamic, and photo-realistic appearances. We conduct abundant experiments on popular datasets such as AvatarRex and THuman4.0, demonstrating impressive performance in both qualitative and quantitative metrics.

Towards Unified Molecule-Enhanced Pathology Image Representation Learning via Integrating Spatial Transcriptomics

Recent advancements in multimodal pre-training models have significantly advanced computational pathology. However, current approaches predominantly rely on visual-language models, which may impose limitations from a molecular perspective and lead to performance bottlenecks. Here, we introduce a Unified Molecule-enhanced Pathology Image REpresentationn Learning framework (UMPIRE). UMPIRE aims to leverage complementary information from gene expression profiles to guide the multimodal pre-training, enhancing the molecular awareness of pathology image representation learning. We demonstrate that this molecular perspective provides a robust, task-agnostic training signal for learning pathology image embeddings. Due to the scarcity of paired data, approximately 4 million entries of spatial transcriptomics gene expression were collected to train the gene encoder. By leveraging powerful pre-trained encoders, UMPIRE aligns the encoders across over 697K pathology image-gene expression pairs. The performance of UMPIRE is demonstrated across various molecular-related downstream tasks, including gene expression prediction, spot classification, and mutation state prediction in whole slide images. Our findings highlight the effectiveness of multimodal data integration and open new avenues for exploring computational pathology enhanced by molecular perspectives. The code and pre-trained weights are available at https://github.com/Hanminghao/UMPIRE.

Toward Robust Incomplete Multimodal Sentiment Analysis via Hierarchical Representation Learning

Multimodal Sentiment Analysis (MSA) is an important research area that aims to understand and recognize human sentiment through multiple modalities. The complementary information provided by multimodal fusion promotes better sentiment analysis compared to utilizing only a single modality. Nevertheless, in real-world applications, many unavoidable factors may lead to situations of uncertain modality missing, thus hindering the effectiveness of multimodal modeling and degrading the model's performance. To this end, we propose a Hierarchical Representation Learning Framework (HRLF) for the MSA task under uncertain missing modalities. Specifically, we propose a fine-grained representation factorization module that sufficiently extracts valuable sentiment information by factorizing modality into sentiment-relevant and modality-specific representations through crossmodal translation and sentiment semantic reconstruction. Moreover, a hierarchical mutual information maximization mechanism is introduced to incrementally maximize the mutual information between multi-scale representations to align and reconstruct the high-level semantics in the representations. Ultimately, we propose a hierarchical adversarial learning mechanism that further aligns and adapts the latent distribution of sentiment-relevant representations to produce robust joint multimodal representations. Comprehensive experiments on three datasets demonstrate that HRLF significantly improves MSA performance under uncertain modality missing cases.

Role Play: Learning Adaptive Role-Specific Strategies in Multi-Agent Interactions

Zero-shot coordination problem in multi-agent reinforcement learning (MARL), which requires agents to adapt to unseen agents, has attracted increasing attention. Traditional approaches often rely on the Self-Play (SP) framework to generate a diverse set of policies in a policy pool, which serves to improve the generalization capability of the final agent. However, these frameworks may struggle to capture the full spectrum of potential strategies, especially in real-world scenarios that demand agents balance cooperation with competition. In such settings, agents need strategies that can adapt to varying and often conflicting goals. Drawing inspiration from Social Value Orientation (SVO)-where individuals maintain stable value orientations during interactions with others-we propose a novel framework called \emph{Role Play} (RP). RP employs role embeddings to transform the challenge of policy diversity into a more manageable diversity of roles. It trains a common policy with role embedding observations and employs a role predictor to estimate the joint role embeddings of other agents, helping the learning agent adapt to its assigned role. We theoretically prove that an approximate optimal policy can be achieved by optimizing the expected cumulative reward relative to an approximate role-based policy. Experimental results in both cooperative (Overcooked) and mixed-motive games (Harvest, CleanUp) reveal that RP consistently outperforms strong baselines when interacting with unseen agents, highlighting its robustness and adaptability in complex environments.