A Benchmark Dataset for MLLM-Generated Image Detection: GPT Image2 & Nano Banana2

The realism of images generated by multimodal large language models (MLLMs), such as GPT Image2 and Nano Banana2, has improved rapidly in recent years. Compared with early generative models, current models have made clear progress in text rendering. They can produce high-quality images that closely resemble real-world application scenarios. The enhanced generation capabilities of current MLLMs pose increasingly severe challenges to AI-generated image detection. Detection is no longer limited to identifying obvious artifacts left by early generators. Instead, it requires systematic and realistic benchmarks for the new generation of generated content. However, most existing benchmarks are still built around early generative models and cannot fully evaluate the forensic challenges introduced by high-quality and multi-form generated images. To address this gap, this paper constructs a benchmark dataset for detecting images generated by MLLMs. The benchmark covers several realistic application scenarios and adopts three generation protocols to simulate direct generation, reference-based reconstruction, and local editing. Based on this benchmark, we evaluate detector degradation from traditional scenarios to MLLM-generated images and analyze false positive rates and false negative rates across three sample types, revealing the failure modes of existing methods. We further propose a structural-artifact-prior-guided dual-stream prompt framework (SAP-DSP) as a strong baseline. SAP-DSP uses dual-stream prompt learning and structure-aware routing fusion to improve representation learning. Extensive experiments show that the proposed benchmark exposes the performance degradation of existing detectors on high-quality generated images, while SAP-DSP achieves more stable detection results on this benchmark. Our code and dataset are publicly available at https://github.com/xbrainnet/SAP-DSP.

FSDBN: Foreground-Aware EEG--Visual Alignment via Dynamic Brain Networks

EEG-based visual decoding provides a non-invasive pathway for interpreting visual semantics. However, existing methods often overlook the perceptual asymmetry between foreground and background in complex scenes, leading to background interference and semantic misalignment. EEG signals also exhibit rapid temporal dynamics and nonstationary spatial patterns, making it difficult to capture the time-varying brain connectivity associated with focal visual attention. To address these limitations, we propose FSDBN, a unified framework for robust EEG-visual decoding. FSDBN introduces Semantic-Consistent Saliency Alignment to separate semantically relevant foreground regions from background noise under joint saliency and semantic constraints. It further employs Semantic-Prior Dynamic Gating Foreground Fusion to adaptively regulate the contributions of foreground and background features. In parallel, EEG signals are modeled as adaptive spatiotemporal brain networks whose functional connectivity dynamically reorganizes to capture neural responses to salient foregrounds. Experiments on zero-shot brain-to-image retrieval demonstrate that FSDBN achieves 69.0 percent top-1 accuracy and 92.2 percent top-5 accuracy, outperforming previous state-of-the-art methods. Code is available at https://github.com/LiuYiheng1/FSDBN-EEG.

CAP: Towards PPG Universal Representation Learning with Patient-level Supervision

Photoplethysmography (PPG) plays a central role in wearable health monitoring and clinical decision support. Yet existing approaches to universal PPG representation learning largely focus on signal-level objectives and often overlook patient-level health context, which limits generalization to complex clinical tasks and heterogeneous cohorts. To address this gap, we construct a large-scale paired PPG-EHR multimodal dataset by distilling fragmented medical histories and clinical records into cohesive, patient-level electronic health records (EHR). Building on this resource, we propose Clinical Anchored Pretraining for PPG (CAP). During pretraining, CAP performs cross-modal contrastive alignment that anchors PPG representations to patient-level clinical semantics, guiding the encoder beyond waveform fitting toward modeling consistency in a patient's overall physiological state. During downstream adaptation, the pretrained PPG encoder provides clinically grounded representations that strengthen inductive bias and improve robustness and transferability. Experiments demonstrate that CAP consistently outperforms strong baselines on four diverse downstream tasks. CAP achieves a particularly large gain on respiratory rate prediction (up to +87.6% relative improvement over the state-of-the-art baseline) and delivers an average relative +26.7% across all tasks. We further enhance the interpretability of our approach through comprehensive analyses, including ablations and multiple complementary visualizations of the learned representations. The code for our experiments is available at: https://github.com/gody123gody/CAP .

InA-Probe: Instruction-Aware Active Probing for Time Series Forecasting with LLMs

Large Language Models (LLMs) have recently demonstrated impressive potential for time series forecasting. However, existing methods predominantly rely on passive modality alignment or static task reprogramming, which often fail to capture fine-grained, non-stationary temporal patterns or to adapt to nuanced task intents. In this paper, we propose Instruction-aware Active Probing (InA-Probe), which shifts the paradigm from passive alignment toward an active, instruction-driven probing mechanism. Specifically, we design a Multi-Level Instruction Injection mechanism that enriches the model with both global task objectives and fine-grained, patch-level semantic priors. Building on this, an Adaptive Query Generation module produces sample-specific probes that are dynamically modulated by the temporal context. These probes are then refined through a dual-stage attention process: they first internalize task-specific intents via Instruction-Aware Self-Attention, and subsequently interrogate the projected temporal representations through Temporal Cross-Attention to extract salient patterns. Comprehensive experiments on seven real-world benchmarks show that InA-Probe consistently outperforms state-of-the-art deep learning and LLM-based baselines, excelling in both one-for-all generalization and zero-shot transfer while reducing forecasting error by up to 37\% in challenging cross-domain scenarios. Ablation studies further confirm that the synergy between adaptive querying and fine-grained instructions is key to unlocking the reasoning power of LLMs for complex time series.

Physically-Constrained Mamba-SDE for Remaining Useful Life Prediction under Irregular Observations

Accurate Remaining Useful Life prediction is critical for industrial predictive maintenance. However, real-world deployment is challenging due to the irregular nature of sensor observations, characterized by asynchronous sampling, burst missingness, and temporal jitter. Compounding this issue, purely data-driven models often generate physically implausible degradation trajectories that violate the irreversible nature of damage accumulation. To address this, we propose PC-MambaSDE, a unified continuous-time framework for robust RUL prediction under irregular observations. Specifically, we design a Mask-Aware Continuous Mamba Encoder that explicitly leverages observation masks to extract context-rich control signals. Furthermore, we introduce a Physics-Guided Latent SDE with parametrically rectified hybrid drift, superimposing a global physical bias to enforce monotonic degradation even amid severe observation gaps. Additionally, we formulate RUL prediction as a boundary value problem via a Terminal Degradation Penalty, which decouples a Health Index dimension and applies a penalty loss to guide trajectories toward the failure state. Theoretically, we prove that our variational objective is mathematically equivalent to minimizing the KL divergence via Girsanov's theorem, and we guarantee the global asymptotic stability of the learned dynamics through Lyapunov analysis. To enable rigorous evaluation, we develop a Hybrid Irregularity Generation Scheme that simulates realistic industrial imperfections. Extensive experiments on public benchmarks demonstrate that PC-MambaSDE significantly outperforms state-of-the-art methods, particularly under extreme observation scarcity, validating the efficacy of embedding physical priors into continuous-time latent dynamics.

DARE-EEG: A Foundation Model for Mining Dual-Aligned Representation of EEG

Foundation models pre-trained through masked reconstruction on large-scale EEG data have emerged as a promising paradigm for learning generalizable neural representations across diverse brain-computer interface applications. However, a critical yet overlooked challenge is that EEG encoders must learn representations invariant to incomplete observations-when different masked views of the same signal have minimal overlap, existing methods fail to constrain them to a consistent latent subspace, leading to degraded transferability. To address this, we propose DARE-EEG, a self-supervised foundation model that explicitly enforces the mask-invariance property through dual-aligned representation learning during pre-training. Specifically, we introduce mask alignment that constrains representations from multiple masked views of the same EEG sample via contrastive learning, complementing anchor alignment that aligns masked representations to momentum-updated complete features for semantic stability. Additionally, we propose conv-linear-probing, a parameter-efficient strategy that adapts pre-trained representations to heterogeneous electrode configurations and sampling rates through decoupled spectro-spatial projections. Extensive experiments across diverse EEG benchmarks demonstrate that DARE-EEG consistently achieves state-of-the-art in accuracy performance while maintaining relatively low parameter complexity and superior cross-dataset portability compared to existing methods. Furthermore, DARE-EEG contributes to effectively discovering and utilizing the rich potential representations in EEG.

BehaviorGuard: Online Backdoor Defense for Deep Reinforcement Learning

Backdoor attacks pose a serious threat to deep reinforcement learning (DRL). Current defenses typically rely on reward anomalies to reverse-engineer triggers and model finetuning to remove backdoors. However, complex trigger patterns undermine their robustness, and fine-tuning entails high costs, limiting practical utility. Therefore, we shift defense concerns to trigger-agnostic backdoor output behaviors and propose BehaviorGuard, an online behavior-based backdoor detection and mitigation framework for DRL. Specifically, we find that regardless of attacks, backdoored policies induce consistent shifts in action distributions to ensure reliable activation, leaving detectable traces in high-quantile regions and distribution tails, even in the absence of triggers. Based on this, we design a novel metric that captures behavioral drift in action distributions to identify and suppress backdoor actions at runtime. To our knowledge, this is the first online backdoor defense that counters attacks both in single- and multi-agent DRL. Evaluated across diverse benchmarks with different backdoor attacks, BehaviorGuard consistently surpasses prior methods in both efficacy and efficiency.

Human Gaze-based Dual Teacher Guidance Learning for Semi-Supervised Medical Image Segmentation

In the field of medical image segmentation, the scarcity of labeled data poses a major challenge for existing models to accurately perceive target regions. Compared with manual annotation, gaze data is easier and cheaper to obtain. As a classical semi-supervised learning framework, mean-teacher can effectively use a large number of unlabeled medical images for stable training through self-teaching and collaborative optimization. Our study is based on the mean-teacher framework. By combining gaze data, it aims to address two crucial issues in semi-supervised medical image segmentation: 1) expand the scale and diversity of the dataset with limited labeled data; 2) enhance the network's perception ability. We propose the Human Gaze-based Dual Teacher Guidance Learning model (HG-DTGL). In this model, human gaze serves as an additional hidden `teacher' in the mean-teacher architecture. We introduce the GazeMix to generate reliable mixed data to expand the diversity and scale of the dataset, and the Multi-scale Gaze Perception (MGP) module is used to extract the multi-scale perception of the network. A Gaze Loss is designed to align the model's perception with human gaze. We have verified HG-DTGL on multiple datasets of different modalities and achieved superior performance on a total of ten different organs/tissues, with extensive experiments. This demonstrates that our method has strong generalization ability for medical images of different modalities, and shows the great application potential of gaze data in semi-supervised medical image segmentation.

CT-Conditioned Diffusion Prior with Physics-Constrained Sampling for PET Super-Resolution

PET super-resolution is highly under-constrained because paired multi-resolution scans from the same subject are rarely available, and effective resolution is determined by scanner-specific physics (e.g., PSF, detector geometry, and acquisition settings). This limits supervised end-to-end training and makes purely image-domain generative restoration prone to hallucinated structures when anatomical and physical constraints are weak. We formulate PET super-resolution as posterior inference under heterogeneous system configurations and propose a CT-conditioned diffusion framework with physics-constrained sampling. During training, a conditional diffusion prior is learned from high-quality PET/CT pairs using cross-attention for anatomical guidance, without requiring paired LR--HR PET data. During inference, measurement consistency is enforced through a scanner-aware forward model with explicit PSF effects and gradient-based data-consistency refinement. Under both standard and OOD settings, the proposed method consistently improves experimental metrics and lesion-level clinical relevance indicators over strong baselines, while reducing hallucination artifacts and improving structural fidelity.

Advancing Cancer Prognosis with Hierarchical Fusion of Genomic, Proteomic and Pathology Imaging Data from a Systems Biology Perspective

To enhance the precision of cancer prognosis, recent research has increasingly focused on multimodal survival methods by integrating genomic data and histology images. However, current approaches overlook the fact that the proteome serves as an intermediate layer bridging genomic alterations and histopathological features while providing complementary biological information essential for survival prediction. This biological reality exposes another architectural limitation: existing integrative analysis studies fuse these heterogeneous data sources in a flat manner that fails to capture their inherent biological hierarchy. To address these limitations, we propose HFGPI, a hierarchical fusion framework that models the biological progression from genes to proteins to histology images from a systems biology perspective. Specifically, we introduce Molecular Tokenizer, a molecular encoding strategy that integrates identity embeddings with expression profiles to construct biologically informed representations for genes and proteins. We then develop Gene-Regulated Protein Fusion (GRPF), which employs graph-aware cross-attention with structure-preserving alignment to explicitly model gene-protein regulatory relationships and generate gene-regulated protein representations. Additionally, we propose Protein-Guided Hypergraph Learning (PGHL), which establishes associations between proteins and image patches, leveraging hypergraph convolution to capture higher-order protein-morphology relationships. The final features are progressively fused across hierarchical layers to achieve precise survival outcome prediction. Extensive experiments on five benchmark datasets demonstrate the superiority of HFGPI over state-of-the-art methods.