Enabling Ultra-Fast Cardiovascular Imaging Across Heterogeneous Clinical Environments with a Generalist Foundation Model and Multimodal Database

Multimodal cardiovascular magnetic resonance (CMR) imaging provides comprehensive and non-invasive insights into cardiovascular disease (CVD) diagnosis and underlying mechanisms. Despite decades of advancements, its widespread clinical adoption remains constrained by prolonged scan times and heterogeneity across medical environments. This underscores the urgent need for a generalist reconstruction foundation model for ultra-fast CMR imaging, one capable of adapting across diverse imaging scenarios and serving as the essential substrate for all downstream analyses. To enable this goal, we curate MMCMR-427K, the largest and most comprehensive multimodal CMR k-space database to date, comprising 427,465 multi-coil k-space data paired with structured metadata across 13 international centers, 12 CMR modalities, 15 scanners, and 17 CVD categories in populations across three continents. Building on this unprecedented resource, we introduce CardioMM, a generalist reconstruction foundation model capable of dynamically adapting to heterogeneous fast CMR imaging scenarios. CardioMM unifies semantic contextual understanding with physics-informed data consistency to deliver robust reconstructions across varied scanners, protocols, and patient presentations. Comprehensive evaluations demonstrate that CardioMM achieves state-of-the-art performance in the internal centers and exhibits strong zero-shot generalization to unseen external settings. Even at imaging acceleration up to 24x, CardioMM reliably preserves key cardiac phenotypes, quantitative myocardial biomarkers, and diagnostic image quality, enabling a substantial increase in CMR examination throughput without compromising clinical integrity. Together, our open-access MMCMR-427K database and CardioMM framework establish a scalable pathway toward high-throughput, high-quality, and clinically accessible cardiovascular imaging.

VIRAL: Visual Sim-to-Real at Scale for Humanoid Loco-Manipulation

A key barrier to the real-world deployment of humanoid robots is the lack of autonomous loco-manipulation skills. We introduce VIRAL, a visual sim-to-real framework that learns humanoid loco-manipulation entirely in simulation and deploys it zero-shot to real hardware. VIRAL follows a teacher-student design: a privileged RL teacher, operating on full state, learns long-horizon loco-manipulation using a delta action space and reference state initialization. A vision-based student policy is then distilled from the teacher via large-scale simulation with tiled rendering, trained with a mixture of online DAgger and behavior cloning. We find that compute scale is critical: scaling simulation to tens of GPUs (up to 64) makes both teacher and student training reliable, while low-compute regimes often fail. To bridge the sim-to-real gap, VIRAL combines large-scale visual domain randomization over lighting, materials, camera parameters, image quality, and sensor delays--with real-to-sim alignment of the dexterous hands and cameras. Deployed on a Unitree G1 humanoid, the resulting RGB-based policy performs continuous loco-manipulation for up to 54 cycles, generalizing to diverse spatial and appearance variations without any real-world fine-tuning, and approaching expert-level teleoperation performance. Extensive ablations dissect the key design choices required to make RGB-based humanoid loco-manipulation work in practice.

SONIC: Supersizing Motion Tracking for Natural Humanoid Whole-Body Control

Despite the rise of billion-parameter foundation models trained across thousands of GPUs, similar scaling gains have not been shown for humanoid control. Current neural controllers for humanoids remain modest in size, target a limited behavior set, and are trained on a handful of GPUs over several days. We show that scaling up model capacity, data, and compute yields a generalist humanoid controller capable of creating natural and robust whole-body movements. Specifically, we posit motion tracking as a natural and scalable task for humanoid control, leverageing dense supervision from diverse motion-capture data to acquire human motion priors without manual reward engineering. We build a foundation model for motion tracking by scaling along three axes: network size (from 1.2M to 42M parameters), dataset volume (over 100M frames, 700 hours of high-quality motion data), and compute (9k GPU hours). Beyond demonstrating the benefits of scale, we show the practical utility of our model through two mechanisms: (1) a real-time universal kinematic planner that bridges motion tracking to downstream task execution, enabling natural and interactive control, and (2) a unified token space that supports various motion input interfaces, such as VR teleoperation devices, human videos, and vision-language-action (VLA) models, all using the same policy. Scaling motion tracking exhibits favorable properties: performance improves steadily with increased compute and data diversity, and learned representations generalize to unseen motions, establishing motion tracking at scale as a practical foundation for humanoid control.

GenesisGeo: Technical Report

We present GenesisGeo, an automated theorem prover in Euclidean geometry. We have open-sourced a large-scale geometry dataset of 21.8 million geometric problems, over 3 million of which contain auxiliary constructions. Specially, we significantly accelerate the symbolic deduction engine DDARN by 120x through theorem matching, combined with a C++ implementation of its core components. Furthermore, we build our neuro-symbolic prover, GenesisGeo, upon Qwen3-0.6B-Base, which solves 24 of 30 problems (IMO silver medal level) in the IMO-AG-30 benchmark using a single model, and achieves 26 problems (IMO gold medal level) with a dual-model ensemble.

3DKeyAD: High-Resolution 3D Point Cloud Anomaly Detection via Keypoint-Guided Point Clustering

High-resolution 3D point clouds are highly effective for detecting subtle structural anomalies in industrial inspection. However, their dense and irregular nature imposes significant challenges, including high computational cost, sensitivity to spatial misalignment, and difficulty in capturing localized structural differences. This paper introduces a registration-based anomaly detection framework that combines multi-prototype alignment with cluster-wise discrepancy analysis to enable precise 3D anomaly localization. Specifically, each test sample is first registered to multiple normal prototypes to enable direct structural comparison. To evaluate anomalies at a local level, clustering is performed over the point cloud, and similarity is computed between features from the test sample and the prototypes within each cluster. Rather than selecting cluster centroids randomly, a keypoint-guided strategy is employed, where geometrically informative points are chosen as centroids. This ensures that clusters are centered on feature-rich regions, enabling more meaningful and stable distance-based comparisons. Extensive experiments on the Real3D-AD benchmark demonstrate that the proposed method achieves state-of-the-art performance in both object-level and point-level anomaly detection, even using only raw features.

Label-Consistent Dataset Distillation with Detector-Guided Refinement

Dataset distillation (DD) aims to generate a compact yet informative dataset that achieves performance comparable to the original dataset, thereby reducing demands on storage and computational resources. Although diffusion models have made significant progress in dataset distillation, the generated surrogate datasets often contain samples with label inconsistencies or insufficient structural detail, leading to suboptimal downstream performance. To address these issues, we propose a detector-guided dataset distillation framework that explicitly leverages a pre-trained detector to identify and refine anomalous synthetic samples, thereby ensuring label consistency and improving image quality. Specifically, a detector model trained on the original dataset is employed to identify anomalous images exhibiting label mismatches or low classification confidence. For each defective image, multiple candidates are generated using a pre-trained diffusion model conditioned on the corresponding image prototype and label. The optimal candidate is then selected by jointly considering the detector's confidence score and dissimilarity to existing qualified synthetic samples, thereby ensuring both label accuracy and intra-class diversity. Experimental results demonstrate that our method can synthesize high-quality representative images with richer details, achieving state-of-the-art performance on the validation set.

Harmonizing and Merging Source Models for CLIP-based Domain Generalization

CLIP-based domain generalization aims to improve model generalization to unseen domains by leveraging the powerful zero-shot classification capabilities of CLIP and multiple source datasets. Existing methods typically train a single model across multiple source domains to capture domain-shared information. However, this paradigm inherently suffers from two types of conflicts: 1) sample conflicts, arising from noisy samples and extreme domain shifts among sources; and 2) optimization conflicts, stemming from competition and trade-offs during multi-source training. Both hinder the generalization and lead to suboptimal solutions. Recent studies have shown that model merging can effectively mitigate the competition of multi-objective optimization and improve generalization performance. Inspired by these findings, we propose Harmonizing and Merging (HAM), a novel source model merging framework for CLIP-based domain generalization. During the training process of the source models, HAM enriches the source samples without conflicting samples, and harmonizes the update directions of all models. Then, a redundancy-aware historical model merging method is introduced to effectively integrate knowledge across all source models. HAM comprehensively consolidates source domain information while enabling mutual enhancement among source models, ultimately yielding a final model with optimal generalization capabilities. Extensive experiments on five widely used benchmark datasets demonstrate the effectiveness of our approach, achieving state-of-the-art performance.

DriveSuprim: Towards Precise Trajectory Selection for End-to-End Planning

In complex driving environments, autonomous vehicles must navigate safely. Relying on a single predicted path, as in regression-based approaches, usually does not explicitly assess the safety of the predicted trajectory. Selection-based methods address this by generating and scoring multiple trajectory candidates and predicting the safety score for each, but face optimization challenges in precisely selecting the best option from thousands of possibilities and distinguishing subtle but safety-critical differences, especially in rare or underrepresented scenarios. We propose DriveSuprim to overcome these challenges and advance the selection-based paradigm through a coarse-to-fine paradigm for progressive candidate filtering, a rotation-based augmentation method to improve robustness in out-of-distribution scenarios, and a self-distillation framework to stabilize training. DriveSuprim achieves state-of-the-art performance, reaching 93.5% PDMS in NAVSIM v1 and 87.1% EPDMS in NAVSIM v2 without extra data, demonstrating superior safetycritical capabilities, including collision avoidance and compliance with rules, while maintaining high trajectory quality in various driving scenarios.

Generalized Trajectory Scoring for End-to-end Multimodal Planning

End-to-end multi-modal planning is a promising paradigm in autonomous driving, enabling decision-making with diverse trajectory candidates. A key component is a robust trajectory scorer capable of selecting the optimal trajectory from these candidates. While recent trajectory scorers focus on scoring either large sets of static trajectories or small sets of dynamically generated ones, both approaches face significant limitations in generalization. Static vocabularies provide effective coarse discretization but struggle to make fine-grained adaptation, while dynamic proposals offer detailed precision but fail to capture broader trajectory distributions. To overcome these challenges, we propose GTRS (Generalized Trajectory Scoring), a unified framework for end-to-end multi-modal planning that combines coarse and fine-grained trajectory evaluation. GTRS consists of three complementary innovations: (1) a diffusion-based trajectory generator that produces diverse fine-grained proposals; (2) a vocabulary generalization technique that trains a scorer on super-dense trajectory sets with dropout regularization, enabling its robust inference on smaller subsets; and (3) a sensor augmentation strategy that enhances out-of-domain generalization while incorporating refinement training for critical trajectory discrimination. As the winning solution of the Navsim v2 Challenge, GTRS demonstrates superior performance even with sub-optimal sensor inputs, approaching privileged methods that rely on ground-truth perception. Code will be available at https://github.com/NVlabs/GTRS.

Decoupling Multi-Contrast Super-Resolution: Pairing Unpaired Synthesis with Implicit Representations

Magnetic Resonance Imaging (MRI) is critical for clinical diagnostics but is often limited by long acquisition times and low signal-to-noise ratios, especially in modalities like diffusion and functional MRI. The multi-contrast nature of MRI presents a valuable opportunity for cross-modal enhancement, where high-resolution (HR) modalities can serve as references to boost the quality of their low-resolution (LR) counterparts-motivating the development of Multi-Contrast Super-Resolution (MCSR) techniques. Prior work has shown that leveraging complementary contrasts can improve SR performance; however, effective feature extraction and fusion across modalities with varying resolutions remains a major challenge. Moreover, existing MCSR methods often assume fixed resolution settings and all require large, perfectly paired training datasets-conditions rarely met in real-world clinical environments. To address these challenges, we propose a novel Modular Multi-Contrast Super-Resolution (MCSR) framework that eliminates the need for paired training data and supports arbitrary upscaling. Our method decouples the MCSR task into two stages: (1) Unpaired Cross-Modal Synthesis (U-CMS), which translates a high-resolution reference modality into a synthesized version of the target contrast, and (2) Unsupervised Super-Resolution (U-SR), which reconstructs the final output using implicit neural representations (INRs) conditioned on spatial coordinates. This design enables scale-agnostic and anatomically faithful reconstruction by bridging un-paired cross-modal synthesis with unsupervised resolution enhancement. Experiments show that our method achieves superior performance at 4x and 8x upscaling, with improved fidelity and anatomical consistency over existing baselines. Our framework demonstrates strong potential for scalable, subject-specific, and data-efficient MCSR in real-world clinical settings.