Human Gaze-based Dual Teacher Guidance Learning for Semi-Supervised Medical Image Segmentation

In the field of medical image segmentation, the scarcity of labeled data poses a major challenge for existing models to accurately perceive target regions. Compared with manual annotation, gaze data is easier and cheaper to obtain. As a classical semi-supervised learning framework, mean-teacher can effectively use a large number of unlabeled medical images for stable training through self-teaching and collaborative optimization. Our study is based on the mean-teacher framework. By combining gaze data, it aims to address two crucial issues in semi-supervised medical image segmentation: 1) expand the scale and diversity of the dataset with limited labeled data; 2) enhance the network's perception ability. We propose the Human Gaze-based Dual Teacher Guidance Learning model (HG-DTGL). In this model, human gaze serves as an additional hidden `teacher' in the mean-teacher architecture. We introduce the GazeMix to generate reliable mixed data to expand the diversity and scale of the dataset, and the Multi-scale Gaze Perception (MGP) module is used to extract the multi-scale perception of the network. A Gaze Loss is designed to align the model's perception with human gaze. We have verified HG-DTGL on multiple datasets of different modalities and achieved superior performance on a total of ten different organs/tissues, with extensive experiments. This demonstrates that our method has strong generalization ability for medical images of different modalities, and shows the great application potential of gaze data in semi-supervised medical image segmentation.

Does Pass Rate Tell the Whole Story? Evaluating Design Constraint Compliance in LLM-based Issue Resolution

Repository-level issue resolution benchmarks have become a standard testbed for evaluating LLM-based agents, yet success is still predominantly measured by test pass rates. In practice, however, acceptable patches must also comply with project-specific design constraints, such as architectural conventions, error-handling policies, and maintainability requirements, which are rarely encoded in tests and are often documented only implicitly in code review discussions. This paper introduces \textit{design-aware issue resolution} and presents \bench{}, a benchmark that makes such implicit design constraints explicit and measurable. \bench{} is constructed by mining and validating design constraints from real-world pull requests, linking them to issue instances, and automatically checking patch compliance using an LLM-based verifier, yielding 495 issues and 1,787 validated constraints across six repositories, aligned with SWE-bench-Verified and SWE-bench-Pro. Experiments with state-of-the-art agents show that test-based correctness substantially overestimates patch quality: fewer than half of resolved issues are fully design-satisfying, design violations are widespread, and functional correctness exhibits negligible statistical association with design satisfaction. While providing issue-specific design guidance reduces violations, substantial non-compliance remains, highlighting a fundamental gap in current agent capabilities and motivating design-aware evaluation beyond functional correctness.

Improving Ensemble Forecasts of Abnormally Deflecting Tropical Cyclones with Fused Atmosphere-Ocean-Terrain Data

Deep learning-based tropical cyclone (TC) forecasting methods have demonstrated significant potential and application advantages, as they feature much lower computational cost and faster operation speed than numerical weather prediction models. However, existing deep learning methods still have key limitations: they can only process a single type of sequential trajectory data or homogeneous meteorological variables, and fail to achieve accurate forecasting of abnormal deflected TCs. To address these challenges, we present two groundbreaking contributions. First, we have constructed a multimodal and multi-source dataset named AOT-TCs for TC forecasting in the Northwest Pacific basin. As the first dataset of its kind, it innovatively integrates heterogeneous variables from the atmosphere, ocean, and land, thus obtaining a comprehensive and information-rich meteorological dataset. Second, based on the AOT-TCs dataset, we propose a forecasting model that can handle both normal and abnormally deflected TCs. This is the first TC forecasting model to adopt an explicit atmosphere-ocean-terrain coupling architecture, enabling it to effectively capture complex interactions across physical domains. Extensive experiments on all TC cases in the Northwest Pacific from 2017 to 2024 show that our model achieves state-of-the-art performance in TC forecasting: it not only significantly improves the forecasting accuracy of normal TCs but also breaks through the technical bottleneck in forecasting abnormally deflected TCs.

A Reasoning-Enabled Vision-Language Foundation Model for Chest X-ray Interpretation

Chest X-rays (CXRs) are among the most frequently performed imaging examinations worldwide, yet rising imaging volumes increase radiologist workload and the risk of diagnostic errors. Although artificial intelligence (AI) systems have shown promise for CXR interpretation, most generate only final predictions, without making explicit how visual evidence is translated into radiographic findings and diagnostic predictions. We present CheXOne, a reasoning-enabled vision-language model for CXR interpretation. CheXOne jointly generates diagnostic predictions and explicit, clinically grounded reasoning traces that connect visual evidence, radiographic findings, and these predictions. The model is trained on 14.7 million instruction and reasoning samples curated from 30 public datasets spanning 36 CXR interpretation tasks, using a two-stage framework that combines instruction tuning with reinforcement learning to improve reasoning quality. We evaluate CheXOne in zero-shot settings across visual question answering, report generation, visual grounding and reasoning assessment, covering 17 evaluation settings. CheXOne outperforms existing medical and general-domain foundation models and achieves strong performance on independent public benchmarks. A clinical reader study demonstrates that CheXOne-drafted reports are comparable to or better than resident-written reports in 55% of cases, while effectively addressing clinical indications and enhancing both report writing and CXR interpretation efficiency. Further analyses involving radiologists reveal that the generated reasoning traces show high clinical factuality and provide causal support for the final predictions, offering a plausible explanation for the performance gains. These results suggest that explicit reasoning can improve model performance, interpretability and clinical utility in AI-assisted CXR interpretation.

Knowdit: Agentic Smart Contract Vulnerability Detection with Auditing Knowledge Summarization

Smart contracts govern billions of dollars in decentralized finance (DeFi), yet automated vulnerability detection remains challenging because many vulnerabilities are tightly coupled with project-specific business logic. We observe that recurring vulnerabilities across diverse DeFi business models often share the same underlying economic mechanisms, which we term DeFi semantics, and that capturing these shared abstractions can enable more systematic auditing. Building on this insight, we propose Knowdit, a knowledge-driven, agentic framework for smart contract vulnerability detection. Knowdit first constructs an auditing knowledge graph from historical human audit reports, linking fine-grained DeFi semantics with recurring vulnerability patterns. Given a new project, a multi-agent framework leverages this knowledge through an iterative loop of specification generation, harness synthesis, fuzz execution, and finding reflection, driven by a shared working memory for continuous refinement. We evaluate Knowdit on 12 recent Code4rena projects with 75 ground-truth vulnerabilities. Knowdit detects all 14 high-severity and 77\% of medium-severity vulnerabilities with only 2 false positives, significantly outperforming all baselines. Applied to six real-world projects, Knowdit further discovers 12 high- and 10 medium-severity previously unknown vulnerabilities, proving its outstanding performance.

Activation Matters: Test-time Activated Negative Labels for OOD Detection with Vision-Language Models

Out-of-distribution (OOD) detection aims to identify samples that deviate from in-distribution (ID). One popular pipeline addresses this by introducing negative labels distant from ID classes and detecting OOD based on their distance to these labels. However, such labels may present poor activation on OOD samples, failing to capture the OOD characteristics. To address this, we propose \underline{T}est-time \underline{A}ctivated \underline{N}egative \underline{L}abels (TANL) by dynamically evaluating activation levels across the corpus dataset and mining candidate labels with high activation responses during the testing process. Specifically, TANL identifies high-confidence test images online and accumulates their assignment probabilities over the corpus to construct a label activation metric. Such a metric leverages historical test samples to adaptively align with the test distribution, enabling the selection of distribution-adaptive activated negative labels. By further exploring the activation information within the current testing batch, we introduce a more fine-grained, batch-adaptive variant. To fully utilize label activation knowledge, we propose an activation-aware score function that emphasizes negative labels with stronger activations, boosting performance and enhancing its robustness to the label number. Our TANL is training-free, test-efficient, and grounded in theoretical justification. Experiments on diverse backbones and wide task settings validate its effectiveness. Notably, on the large-scale ImageNet benchmark, TANL significantly reduces the FPR95 from 17.5\% to 9.8\%. Codes are available at \href{https://github.com/YBZh/OpenOOD-VLM}{YBZh/OpenOOD-VLM}.

Learning Generalizable 3D Medical Image Representations from Mask-Guided Self-Supervision

Foundation models have transformed vision and language by learning general-purpose representations from large-scale unlabeled data, yet 3D medical imaging lacks analogous approaches. Existing self-supervised methods rely on low-level reconstruction or contrastive objectives that fail to capture the anatomical semantics critical for medical image analysis, limiting transfer to downstream tasks. We present MASS (MAsk-guided Self-Supervised learning), which treats in-context segmentation as the pretext task for learning general-purpose medical imaging representations. MASS's key insight is that automatically generated class-agnostic masks provide sufficient structural supervision for learning semantically rich representations. By training on thousands of diverse mask proposals spanning anatomical structures and pathological findings, MASS learns what semantically defines medical structures: the holistic combination of appearance, shape, spatial context, and anatomical relationships. We demonstrate effectiveness across data regimes: from small-scale pretraining on individual datasets (20-200 scans) to large-scale multi-modal pretraining on 5K CT, MRI, and PET volumes, all without annotations. MASS demonstrates: (i) few-shot segmentation on novel structures, (ii) matching full supervision with only 20-40\% labeled data while outperforming self-supervised baselines by over 20 in Dice score in low-data regimes, and (iii) frozen-encoder classification on unseen pathologies that matches full supervised training with thousands of samples. Mask-guided self-supervised pretraining captures broadly generalizable knowledge, opening a path toward 3D medical imaging foundation models without expert annotations. Code is available: https://github.com/Stanford-AIMI/MASS.

Structure-aware Prompt Adaptation from Seen to Unseen for Open-Vocabulary Compositional Zero-Shot Learning

The goal of Open-Vocabulary Compositional Zero-Shot Learning (OV-CZSL) is to recognize attribute-object compositions in the open-vocabulary setting, where compositions of both seen and unseen attributes and objects are evaluated. Recently, prompt tuning methods have demonstrated strong generalization capabilities in the closed setting, where only compositions of seen attributes and objects are evaluated, i.e., Compositional Zero-Shot Learning (CZSL). However, directly applying these methods to OV-CZSL may not be sufficient to generalize to unseen attributes, objects and their compositions, as it is limited to seen attributes and objects. Normally, when faced with unseen concepts, humans adopt analogies with seen concepts that have the similar semantics thereby inferring their meaning (e.g., "wet" and "damp", "shirt" and "jacket"). In this paper, we experimentally show that the distribution of semantically related attributes or objects tends to form consistent local structures in the embedding space. Based on the above structures, we propose Structure-aware Prompt Adaptation (SPA) method, which enables models to generalize from seen to unseen attributes and objects. Specifically, in the training stage, we design a Structure-aware Consistency Loss (SCL) that encourages the local structure's consistency of seen attributes and objects in each iteration. In the inference stage, we devise a Structure-guided Adaptation Strategy (SAS) that adaptively aligns the structures of unseen attributes and objects with those of trained seen attributes and objects with similar semantics. Notably, SPA is a plug-and-play method that can be seamlessly integrated into existing CZSL prompt tuning methods. Extensive experiments on OV-CZSL benchmarks demonstrate that SPA achieves competitive closed-set performance while significantly improving open-vocabulary results.

A data- and compute-efficient chest X-ray foundation model beyond aggressive scaling

Foundation models for medical imaging are typically pretrained on increasingly large datasets, following a "scale-at-all-costs" paradigm. However, this strategy faces two critical challenges: large-scale medical datasets often contain substantial redundancy and severe class imbalance that bias representation learning toward over-represented patterns, and indiscriminate training regardless of heterogeneity in data quality incurs considerable computational inefficiency. Here we demonstrate that active, principled data curation during pretraining can serve as a viable, cost-effective alternative to brute-force dataset enlargement. We introduce CheXficient, a chest X-ray (CXR) foundation model that selectively prioritizes informative training samples. CheXficient is pretrained on only 22.7% of 1,235,004 paired CXR images and reports while consuming under 27.3% of the total compute budget, yet achieving comparable or superior performance to its full-data counterpart and other large-scale pretrained models. We assess CheXficient across 20 individual benchmarks spanning 5 task types, including non-adapted off-the-shelf evaluations (zero-shot findings classification and crossmodal retrieval) and adapted downstream tasks (disease prediction, semantic segmentation, and radiology report generation). Further analyses show that CheXficient systematically prioritizes under-represented training samples, improving generalizability on long-tailed or rare conditions. Overall, our work offers practical insights into the data and computation demands for efficient pretraining and downstream adaptation of medical vision-language foundation models.

Parallel Track Transformers: Enabling Fast GPU Inference with Reduced Synchronization

Efficient large-scale inference of transformer-based large language models (LLMs) remains a fundamental systems challenge, frequently requiring multi-GPU parallelism to meet stringent latency and throughput targets. Conventional tensor parallelism decomposes matrix operations across devices but introduces substantial inter-GPU synchronization, leading to communication bottlenecks and degraded scalability. We propose the Parallel Track (PT) Transformer, a novel architectural paradigm that restructures computation to minimize cross-device dependencies. PT achieves up to a 16x reduction in synchronization operations relative to standard tensor parallelism, while maintaining competitive model quality in our experiments. We integrate PT into two widely adopted LLM serving stacks-Tensor-RT-LLM and vLLM-and report consistent improvements in serving efficiency, including up to 15-30% reduced time to first token, 2-12% reduced time per output token, and up to 31.90% increased throughput in both settings.